期刊
IMMUNOLOGY LETTERS
卷 116, 期 2, 页码 168-173出版社
ELSEVIER
DOI: 10.1016/j.imlet.2007.12.016
关键词
inhibitory B cell receptors; complement receptor 1 (CD35); SLE
类别
There is an urgent and unmet need for therapeutic agents targeting selectively disease-associated B-lymphocytes in autoantibody-mediated diseases. We have constructed a chimeric molecule able to cross-link cell surface immunoglobulin with the inhibitory complement receptor type 1 (CD35) on DNA-specific B cells from SLE (systemic lupus erythematosus) patients with the aim of selectively silencing them. This engineered molecule is made of copies of the DNA-mimotope peptide DWEYSVWLSN coupled to a monoclonal anti-CD35 antibody. We found that the DNA-like peptide chimera induced a dose-dependent decrease in the number of IgG anti-dsDNA antibody producing cells when PBMCs of lupus patients were cultured in its presence. Our data present evidence that clustering BCR and the inhibitory CRI on disease-associated autoreactive B-lymphocytes selectively suppresses autoantibody production. (C) 2008 Elsevier B.V. All rights reserved.
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