Article
Cell Biology
Jose Martinez-Hernandez, Julie Parato, Aditi Sharma, Jean-Marc Soleilhac, Xiaoyi Qu, Ellen Tein, Andrew Sproul, Annie Andrieux, Yves Goldberg, Marie-Jo Moutin, Francesca Bartolini, Leticia Peris
Summary: This study found an accumulation of tubulin acetylation in post-mortem brain tissues from Alzheimer's disease patients and human neurons with the Alzheimer's familial APP-V717I mutation. Impaired tubulin re-tyrosination may contribute to this acetylation accumulation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Rong Huang, Liyan Sui, Cong Fu, Yanhui Zhai, Xiangpeng Dai, Sheng Zhang, Ziyi Li
Summary: Inhibition of HDAC11 significantly affects meiosis by altering acetylation levels of key molecules, leading to disrupted maturation of porcine oocytes and compromised subsequent embryo development.
Article
Biochemistry & Molecular Biology
David Siegel, Stephanie Bersie, Peter Harris, Andrea Di Francesco, Michael Armstrong, Nichole Reisdorph, Michel Bernier, Rafael de Cabo, Kristofer Fritz, David Ross
Summary: The localization of NQO1 near acetylated microtubules suggests its potential synergy with the NAD(+)-dependent deacetylase SIRT2 in regulating acetyl alpha-tubulin levels. While knock-down or knock-out of NQO1 or SIRT2 did not change acetyl alpha-tubulin levels, treatment with a mechanism-based inhibitor of NQO1 led to a temporary increase in acetyl alpha-tubulin levels. The disruption in NQO1 binding to microtubules may disturb the interactions of enzymes maintaining microtubule acetylation temporarily.
Article
Cardiac & Cardiovascular Systems
Edith Renguet, Marine De Loof, Natacha Fourny, Audrey Ginion, Caroline Bouzin, Christian Pous, Sandrine Horman, Christophe Beauloye, Laurent Bultot, Luc Bertrand
Summary: Our study demonstrates that modulation of α-tubulin K40 acetylation level affects glucose transport in cardiomyocytes, offering new putative therapeutic insights regarding modulation of glucose metabolism in insulin-resistant and diabetic hearts.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Liangliang Li, Xinyao Hu, Shuwen Li, Ying Li, Shengmiao Zhao, Fengzhen Shen, Changfa Wang, Yubao Li, Tongtong Wang
Summary: Equid alphaherpesvirus type 8 (EqHV-8) infection causes severe respiratory disease, abortions, and neurological syndromes in equines, resulting in significant economic losses in the donkey industry. Currently, there are no therapeutic molecules available for controlling EqHV-8 infection. This study demonstrates that cobalt protoporphyrin (CoPP) possesses antiviral activity against EqHV-8 and inhibits its replication through the HO-1 mediated type I interferon response. CoPP shows promise as a potential molecule for developing an effective therapeutic strategy for preventing and controlling EqHV-8.
Article
Multidisciplinary Sciences
Xuan Xie, Shaogang Wang, Mingyi Li, Lei Diao, Xingyu Pan, Jijun Chen, Weiguo Zou, Xu Zhang, Wenfeng Feng, Lan Bao
Summary: The post-translational modification α-TubK40me3 plays a crucial role in neuronal polarization and migration by promoting microtubule formation. This modification is enriched in the mouse cerebral cortex during embryonic development, and its deficiency leads to defects in neuronal migration that can be rescued by overexpression of specific proteins. Additionally, α-TubK40me3 potently promotes tubulin nucleation and is involved in tubulin acetylation regulation, highlighting its importance in microtubule dynamics and neuronal development.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Ming-Kai Tsai, Mei-Lan Tsai, Zhi-Hong Wen, Wei-Ting Liao, Yi-Ching Lin, Hsin-Ying Clair Chiou, Ming-Hong Lin, Chih-Hsing Hung
Summary: This study demonstrated that 4-PSB-2 has an anti-inflammatory effect on CCL-1 production, possibly through intracellular signaling pathways and epigenetic regulation.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Cell Biology
Changhan Ouyang, Jian Li, Xiaoxu Zheng, Jing Mu, Gloria Torres, Qilong Wang, Ming-Hui Zou, Zhonglin Xie
Summary: This study demonstrates that Ulk1 deletion inhibits neointima formation by reducing autophagic degradation of KAT2A and increasing TUBA acetylation in VSMCs.
Article
Cell Biology
Jessica Eira, Joana Magalhaes, Nidia Macedo, Maria Elena Pero, Thomas Misgeld, Monica M. Sousa, Francesca Bartolini, Marcia A. Liz
Summary: TTR plays a role in promoting axon elongation by modulating microtubule dynamics and alpha-tubulin acetylation, and TTR knockout results in increased dynamic microtubules and decreased regenerative capacity of axons.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Physical
Davide Rigo, Nadia Alessandra Carmo Dos Santos, Alvise Perosa, Maurizio Selva
Summary: An unprecedented two-step sequence was designed using batch and continuous flow (CF) protocols to upgrade two aminodiol regioisomers derived from glycerol. The substrates were quantitatively converted into amides under batch conditions, followed by a selective CF-acetalisation reaction to produce double-functionalized products.
Article
Biochemistry & Molecular Biology
Olga M. Koper-Lenkiewicz, Kinga Sutkowska, Natalia Wawrusiewicz-Kurylonek, Ewa Kowalewska, Joanna Matowicka-Karna
Summary: Studies have shown that the relationship between SNPs in proinflammatory cytokines genes and susceptibility to developing RA is inconclusive and varies among different ethnic populations. These polymorphisms also have an impact on clinicopathological features of RA and patients' response to treatment. Further research on larger cohorts and diverse populations is needed to elucidate the role of these SNPs in RA patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Amir Mohammad Rahimi, Mingfang Cai, Irem Kilic, Zahra Basir Kazerouni, Constanza Tapia Contreras, Sigrid Hoyer-Fender
Summary: The study found that the ability of NIH3T3 fibroblasts to form cilia is related to the acetylation of cytoplasmic tubulin, mainly due to the reduced expression of alpha-tubulin acetyltransferase 1 (Atat1). Cells with decreased expression of Atat1 and tubulin acetylation proliferate faster, eventually gaining an advantage in cell competition.
Article
Multidisciplinary Sciences
Cuiying Peng, Xiyu Gong, Zhiping Hu, Chunli Chen, Zheng Jiang
Summary: A large body of evidence suggests that inhibiting HDAC6 activity can attenuate neuronal apoptosis in intracerebral hemorrhage (ICH). This study used in vitro and in vivo models to evaluate the effect of HDAC6 inhibition on ICH. The results showed that HDAC6 inhibition reduced neurological impairments, histological impairments, brain edema, and neuronal apoptosis. These findings suggest that pharmacological inhibition of HDAC6 could be a promising therapeutic strategy for ICH by up-regulating acetylated a-tubulin and reducing neuronal apoptosis.
Article
Chemistry, Organic
Xu-Yang Hu, Hai-Feng Xu, Qiang Chen, You-Lu Pan, Jian-Zhong Chen
Summary: In this study, a novel synthesis method was developed for the indolo[2,1-alpha]isoquinoline core structure under air environment, resulting in the successful synthesis of various valuable derivatives with good yields. A radical pathway was proposed to explain the experimental results.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Miho Akimoto, Takao Susa, Noriyuki Okudaira, Nobuko Koshikawa, Harumi Hisaki, Masayoshi Iizuka, Hiroko Okinaga, Keizo Takenaga, Tomoki Okazaki, Mimi Tamamori-Adachi
Summary: As a decoy receptor, soluble ST2 (sST2) interferes with the function of IL-33 and decreased sST2 expression in CRC cells promotes tumor growth. Hypoxia reduces sST2 expression and restoration of sST2 in hypoxic tumor regions corrects the inflammatory microenvironment and suppresses tumor growth and lung metastasis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Oncology
Osamu Maeda, Yuichi Ando
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2019)
Article
Gastroenterology & Hepatology
Kazuyuki Mizuno, Takanori Ito, Masatoshi Ishigami, Yoji Ishizu, Teiji Kuzuya, Takashi Honda, Hiroki Kawashima, Yosuke Inukai, Hidenori Toyoda, Kenji Yokota, Tetsunari Hase, Osamu Maeda, Hitoshi Kiyoi, Masato Nagino, Hideharu Hibi, Yasuhiro Kodera, Yasushi Fujimoto, Michihiko Sone, Momokazu Gotoh, Yuichi Ando, Masashi Akiyama, Yoshinori Hasegawa, Mitsuhiro Fujishiro
JOURNAL OF GASTROENTEROLOGY
(2020)
Article
Gastroenterology & Hepatology
Takanori Ito, Masatoshi Ishigami, Takafumi Yamamoto, Kazuyuki Mizuno, Kenta Yamamoto, Norihiro Imai, Yoji Ishizu, Takashi Honda, Hiroki Kawashima, Satoshi Yasuda, Hidenori Toyoda, Kenji Yokota, Tetsunari Hase, Naoki Nishio, Osamu Maeda, Masashi Kato, Naozumi Hashimoto, Hideharu Hibi, Yasuhiro Kodera, Michihiko Sone, Yuichi Ando, Masashi Akiyama, Yoshie Shimoyama, Mitsuhiro Fujishiro
Summary: The occurrence pattern and therapeutic response to corticosteroids in immune-related liver injury differ according to the injury type, with corticosteroids effective for the hepatocellular pattern but not for refractory non-hepatocellular patterns, indicating the need for additional strategies in such cases.
HEPATOLOGY INTERNATIONAL
(2021)
Article
Gastroenterology & Hepatology
Kentaro Yamada, Tsunaki Sawada, Masanao Nakamura, Takeshi Yamamura, Keiko Maeda, Eri Ishikawa, Tadashi Iida, Yasuyuki Mizutani, Naomi Kakushima, Takuya Ishikawa, Kazuhiro Furukawa, Eizaburo Ohno, Takashi Honda, Hiroki Kawashima, Masatoshi Ishigami, Satoshi Furune, Tetsunari Hase, Kenji Yokota, Osamu Maeda, Naozumi Hashimoto, Masashi Akiyama, Yuichi Ando, Mitsuhiro Fujishiro
Summary: This study evaluated the clinical characteristics of GI-irAEs and their impact on survival in patients treated with ICIs. It found that patients receiving anti-CTLA-4 antibodies develop GI-irAEs more frequently and with higher severity, but continuing ICI treatment in patients with MM with GI-irAEs results in better overall survival.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Takafumi Yamamoto, Hikaru Morooka, Takanori Ito, Masatoshi Ishigami, Kazuyuki Mizuno, Shinya Yokoyama, Kenta Yamamoto, Norihiro Imai, Yoji Ishizu, Takashi Honda, Kenji Yokota, Tetsunari Hase, Osamu Maeda, Naozumi Hashimoto, Yuichi Ando, Masashi Akiyama, Hiroki Kawashima
Summary: The cumulative incidence of immune-related liver injury (liver-irAE) was investigated using a clustering analysis based on inflammatory markers. The study found that the combined assessment of multiple markers and body temperature may help stratify high-risk groups for developing liver-irAE.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Letter
Oncology
Osamu Maeda, Ayumu Matsuoka, Madoka Yanagawa, Yukie Muroyama, Kazuhisa Watanabe, Yao Liang, Takuya Ishikawa, Eizaburo Ohno, Hiroki Kawashima, Hiroyuki Umegaki, Masafumi Kuzuya, Yuichi Ando
JOURNAL OF GERIATRIC ONCOLOGY
(2022)
Article
Oncology
Yao Liang, Osamu Maeda, Kazushi Miyata, Mitsuro Kanda, Dai Shimizu, Shizuki Sugita, Tohru Okada, Junji Ito, Mariko Kawamura, Shunichi Ishihara, Masahiro Nakatochi, Masahiko Ando, Yasuhiro Kodera, Yuichi Ando
Summary: The feasibility of global standard chemoradiotherapy followed by surgery in patients with esophageal cancer was assessed in this study. The study conducted at Nagoya University Hospital reviewed the outcomes of patients who received global standard chemoradiotherapy followed by surgery compared to those who received lower drug doses. The results showed that the global standard regimen was associated with more severe adverse events but no significant difference in resection rate or complications.
MOLECULAR AND CLINICAL ONCOLOGY
(2023)
Article
Medicine, Research & Experimental
Mitsuro Kanda, Dai Shimizu, Kazushi Miyata, Osamu Maeda, Chie Tanaka, Yoshikuni Inokawa, Norofumi Hattori, Masamichi Hayashi, Masahiko Ando, Yachiyo Kuwatsuka, Kenta Murotani, Goro Nakayama, Masahiko Koike, Yuichi Ando, Tomoki Ebata, Yasuhiro Kodera
Summary: This study aims to assess the safety and efficacy of neoadjuvant docetaxel, oxaliplatin, and S-1 combination therapy for patients with clinical stage III esophageal squamous cell carcinoma.
CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS
(2021)
Review
Medicine, Research & Experimental
Osamu Maeda, Fumiharu Ohka, Satoshi Maesawa, Ayumu Matsuoka, Tomoya Shimokata, Ayako Mitsuma, Hiroshi Urakawa, Shota Nakamura, Yoshic Shimoyamas, Masato S. Nakaguro, Toshihiko Wakabayashi, Yuichi Ando
NAGOYA JOURNAL OF MEDICAL SCIENCE
(2020)
Article
Medicine, Research & Experimental
Osamu Maeda, Tomoki Ebata, Tomoya Shimokata, Ayumu Matsuoka, Megumi Inada-Inoue, Sachi Morita, Yuko Takano, Hiroshi Urakawa, Yuki Miyai, Mihoko Sugishita, Ayako Mitsuma, Masahiko Ando, Takashi Mizuno, Masato Nagino, Yuichi Ando
NAGOYA JOURNAL OF MEDICAL SCIENCE
(2020)
Article
Medicine, Research & Experimental
Takahiro Inaishi, Ken-Ichi Fujita, Natsumi Matsumoto, Tomoya Shimokata, Osamu Maeda, Toyone Kikumori, Norifumi Hattori, Goro Nakayama, Yuichi Ando
Review
Medicine, Research & Experimental
Mitsuhiro Fujishiro, Kazuhiro Furukawa, Takeshi Yamamura, Masanao Nakamura, Takashi Honda, Osamu Maeda, Masatoshi Ishigami, Hiroki Kawashima
NAGOYA JOURNAL OF MEDICAL SCIENCE
(2020)
Article
Oncology
Osamu Maeda, Ayumu Matsuoka, Kazuhiro Furukawa, Ryoji Miyahara, Yoshiki Hirooka, Yuichi Ando
MOLECULAR AND CLINICAL ONCOLOGY
(2019)
Article
Medicine, Research & Experimental
Nao Takano, Suguru Yamada, Akihiro Hirakawa, Yukihiro Yokoyama, Hiroki Kawashima, Osamu Maeda, Tohru Okada, Eizaburo Ohno, Junpei Yamaguchi, Takuya Ishikawa, Fuminori Sonohara, Masaya Suenaga, Hideki Takami, Masamichi Hayashi, Yukiko Niwa, Yoshiki Hirooka, Yoshiyuki Ito, Shinji Naganawa, Yuichi Ando, Masato Nagino, Hidemi Goto, Tsutomu Fuji, Yasuhiro Kodera
NAGOYA JOURNAL OF MEDICAL SCIENCE
(2019)
Meeting Abstract
Gastroenterology & Hepatology
Osamu Maeda, Yuichi Ando, Ayumu Matsuoka, Kazuhiro Furukawa, Kohei Funasaka, Ryoji Miyahara, Yoshiki Hirooka, Hidemi Goto