Article
Biotechnology & Applied Microbiology
Yali Zhou, Renao Bai, Yifeng Huang, Weina Li, Jiana Chen, Zhiyun Cheng, Xunxun Wu, Yong Diao
Summary: This study investigated the potential protective effects of C-phycocyanin (C-PC) on UVB-induced skin aging using molecular biology tools. The results showed that C-PC has significant anti-aging activity and can improve the macroscopic features of mouse skin under UVB irradiation, as well as reduce epidermal thickening and prevent dermal collagen fiber loosening.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Cell & Tissue Engineering
Mariko Tsuruda, Saori Morino-Koga, Minetaro Ogawa
Summary: Experimental findings suggest that VE-cad(+) cells from late-stage embryos can differentiate into MCs independently of HSCs in vitro, and have the potential to generate connective tissue MCs in vivo, shedding light on the differentiation mechanism of hematopoietic cells.
Article
Immunology
Theres Klewer, Ljubica Bakic, Thomas Mueller-Reichert, Robert Kiewisz, Gregor Jessberger, Nadine Kiessling, Axel Roers, Rolf Jessberger
Summary: The study shows that E-Cadherin plays a role in restricting premature activation of mast cells, with in vitro and in vivo experiments confirming this conclusion. A deficiency of E-Cadherin in mast cells leads to enhanced degranulation and decreased release of newly synthesized inflammatory cytokines, indicating a stronger response to IgE-dependent stimuli and increased risk of anaphylactic shock.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Pier Giorgio Puzzovio, Thayse R. Brueggemann, Hadas Pahima, David Mankuta, Bruce D. Levy, Francesca Levi-Schaffer
Summary: The study found that Cromolyn Sodium has immunomodulatory actions in allergic inflammation that go beyond just stabilizing mast cells, indicating broader mechanisms at play.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Ji-Won Park, Jinseon Choi, Juhyun Lee, Jin-Mi Park, Seong-Man Kim, Jae-Hong Min, Da-Yun Seo, Soo-Hyeon Goo, Ju-Hee Kim, Ok-Kyoung Kwon, Kihoon Lee, Kyung-Seop Ahn, Sei-Ryang Oh, Jae-Won Lee
Summary: In this study, the ameliorative effects of Methyl p-coumarate (MH) on airway inflammation in an experimental model of allergic asthma were evaluated. The results showed that MH exerted anti-inflammatory activity by suppressing the secretion of inflammatory cytokines, inhibiting cell adhesion, and reducing lung inflammation in mice. The findings suggest that MH has the potential to be used as an adjuvant in asthma therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Joanna Baran, Anna Sobiepanek, Anna Mazurkiewicz-Pisarek, Marta Rogalska, Aleksander Gryciuk, Lukasz Kuryk, Soman N. Abraham, Monika Staniszewska
Summary: Mast cells are immune cells found in various tissues and their overactivity can lead to health hazards. They can cause allergic reactions and play a role in tumor biology. However, the mechanisms of mast cell actions are still poorly understood, making it challenging to develop therapies for their pathological condition.
Article
Respiratory System
Anna Birnhuber, Katharina Jandl, Valentina Biasin, Elisabeth Fliesser, Francesco Valzano, Leigh M. Marsh, Christina Krolczik, Andrea Olschewski, Jochen Wilhelm, Wolfgang Toller, Akos Heinemann, Horst Olschewski, Malgorzata Wygrecka, Grazyna Kwapiszewska
Summary: This study shows that pirfenidone may have limited effectiveness in treating SSc-ILD, and caution should be taken in patients with high T-helper type 2 inflammation to avoid unwanted interactions.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Review
Biochemistry & Molecular Biology
Dorina Lauritano, Filiberto Mastrangelo, Cristian D'Ovidio, Gianpaolo Ronconi, Alessandro Caraffa, Carla E. Gallenga, Ilias Frydas, Spyros K. Kritas, Matteo Trimarchi, Francesco Carinci, Pio Conti
Summary: Mast cells (MCs) are tissue cells derived from bone marrow stem cells and play a role in various diseases and disorders. They communicate with microglia in the brain through the production of mediators and can have pathological effects. MCs release preformed chemical mediators and cytokines, and can interact with neuropeptides, leading to inflammation in the central nervous system. This article explores the activation of MCs by neuropeptides and the therapeutic potential of anti-inflammatory cytokines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Victor Gustavo Balera Brito, Mariana Sousa Patrocinio, Maria Carolina Linjardi Sousa, Ayna Emanuelli Alves Barreto, Sabrina Cruz Tfaile Frasnelli, Vanessa Soares Lara, Carlos Ferreira Santos, Sandra Helena Penha Oliveira
Summary: The study revealed the significant role of mast cells in periodontal disease-induced alveolar bone loss, especially in spontaneously hypertensive rats. Depletion of mast cells effectively inhibited alveolar bone loss caused by periodontal disease, reducing inflammatory status and mediator production, and decreasing osteoclast-related response markers.
Article
Medicine, Research & Experimental
Yu Mi, Chaoqun Wei, Liyao Sun, Huirui Liu, Jiayue Zhang, Jialin Luo, Xiaohan Yu, Jie He, Hongyan Ge, Ping Liu
Summary: UVB-induced oxidative stress may enhance the sensitivity of lens epithelial cells to ferroptotic stress, leading to age-related cataracts.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Immunology
Marco De Zuani, Chiara Dal Secco, Silvia Tonon, Alessandra Arzese, Carlo E. M. Pucillo, Barbara Frossi
Summary: Mast cells are important innate immune cells that can sense and respond to different stimuli. Studies have shown that mast cells can develop immunological memory, and their responses can be shaped by different stimulatory environments.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Ghalya H. Banafea, Sherin Bakhashab, Huda F. Alshaibi, Peter Natesan Pushparaj, Mahmood Rasool
Summary: Mast cells play a crucial role in inflammatory diseases of the airway tract, releasing various mediators that contribute to immune cell accumulation and tissue remodeling.
Article
Biochemistry & Molecular Biology
Genta Takebayashi, Yoichi Chiba, Keiji Wakamatsu, Ryuta Murakami, Yumi Miyai, Koichi Matsumoto, Naoya Uemura, Ken Yanase, Gotaro Shirakami, Yuichi Ogino, Masaki Ueno
Summary: The expression of E-cadherin in the lateral membrane of choroid plexus epithelium (CPE) has been confirmed in mice and humans, suggesting its possible correlation with the expression of other cadherins and cytoplasmic proteins.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Anna S. Thomann, Courtney A. McQuade, Katarina Pinjusic, Anna Kolz, Rosa Schmitz, Daisuke Kitamura, Hartmut Wekerle, Anneli Peters Ab
Summary: In multiple sclerosis, pathogenic T cell responses play a major role in autoimmune inflammation, but B cells may also contribute to the pathogenesis through antigen presentation and the production of proinflammatory cytokines. This study developed a new model to study the roles of pathogenic B cells in the development of multiple sclerosis, providing insights into the disease's pathogenic processes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Kristin Franke, Zhao Wang, Torsten Zuberbier, Magda Babina
Summary: This study found that IL-33 activates various cytokines in cutaneous MCs through different mechanisms, with NF-kappa B playing a significant role in the process. The research highlights the diversity of cytokine responses to IL-33 in different MC subsets and suggests that IL-33 may synergize with other activation networks to amplify skin inflammation, particularly in the presence of allergens or MRGPRX2 agonists.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
E. N. Sholikhah, M. Mustofa, D. A. A. Nugrahaningsih, F. S. Yuliani, S. Purwono, S. Sugiyono, S. Widyarini, N. Ngatidjan, J. Jumina, D. Santosa, M. Koketsu
BIOMED RESEARCH INTERNATIONAL
(2020)
Article
Integrative & Complementary Medicine
Asih Triastuti, Dimas Adhi Pradana, Didit Erwin Saputra, Namira Lianika, Hilmy Ramadhan Wicaksono, Thessy Dewi Anisari, Sitarina Widyarini
Summary: This study demonstrates the anti-inflammatory effects and improvement of pathological manifestations in rheumatoid arthritis by Plantago major.
JOURNAL OF TRADITIONAL AND COMPLEMENTARY MEDICINE
(2022)
Article
Agriculture, Dairy & Animal Science
Jossie Intan Cahyani, Sitarina Widyarini, Michael Haryadi Wibowo
Article
Pharmacology & Pharmacy
Nanang Fakhrudin, Krisna Kharisma Pertiwi, Marce Inggrita Takubessi, Eka Fitri Susiani, Arief Nurrochmad, Sitarina Widyarini, Ari Sudarmanto, Arief Adi Nugroho, Subagus Wahyuono
Review
Agriculture, Dairy & Animal Science
Alsi Dara Paryuni, Soedarmanto Indarjulianto, Sitarina Widyarini
Meeting Abstract
Toxicology
E. N. Sholikhah, M. Mustofa, F. S. Yuliani, S. Purwono, S. Widyarini, S. Sugiyono, N. Ngatidjan
TOXICOLOGY LETTERS
(2019)
Article
Agriculture, Dairy & Animal Science
Agnesia Endang Tri Hastuti Wahyuni, Dhasia Ramandani, Vinsa Cantya Prakasita, Sitarina Widyarini
Proceedings Paper
Biotechnology & Applied Microbiology
Rumiyati, Sismindari, Arief Nurrochmad, Endang Semiarti, Sitarina Widyarini, Dinar Prastiandari, Andrea Dhieta Utama, Dianni Anggita Dewi
1ST INTERNATIONAL CONFERENCE ON BIOINFORMATICS, BIOTECHNOLOGY, AND BIOMEDICAL ENGINEERING (BIOMIC 2018)
(2019)
Article
Agriculture, Dairy & Animal Science
Vinsa Cantya Prakasita, Widya Asmara, Sitarina Widyarini, Agnesia Endang Tri Hastuti Wahyuni
Proceedings Paper
Multidisciplinary Sciences
Tri Wiyono, Arief Nurrochmad, Sitarina Widyarini, Nanang Fakhrudin
8TH ANNUAL BASIC SCIENCE INTERNATIONAL CONFERENCE: COVERAGE OF BASIC SCIENCES TOWARD THE WORLD'S SUSTAINABILITY CHALLANGES
(2018)
Proceedings Paper
Engineering, Multidisciplinary
Ifandari, Sitarina Widyarini, Rarastoeti Pratiwi, L. Hartanto Nugroho
PROCEEDINGS OF THE INTERNATIONAL CONFERENCE ON APPLIED SCIENCE AND ENGINEERING (ICASE 2018)
(2018)
Proceedings Paper
Chemistry, Medicinal
L. H. Nurani, A. Mursyidi, S. Widyarini, A. Rohman
INTERNATIONAL PHARMACY CONFERENCE UAD 2017 ON PRODUCT AUTHENTICATION: KEY FACTOR IN QUALITY CONTROL OF PHARMACEUTICAL PRODUCTS
(2017)
Article
Medicine, Research & Experimental
Wahyu Widyaningsih, Suwidjiyo Pramono, Zulaela, Sugiyanto, Sitarina Widyarini
MALAYSIAN JOURNAL OF MEDICAL SCIENCES
(2017)
Article
Medicine, General & Internal
Ida Ayu Ika Wahyuniari, I. G. K. Nyoman Arijana, Ni Putu Sriwidyani, Ida Ayu Dewi Wiryanthini, Hery Suwito, Sitarina Widyarini, Muhammad Ghufron, Mustofa, Sofia Mubarika
BALI MEDICAL JOURNAL
(2017)
Article
Pharmacology & Pharmacy
Yustina Sri Hartini, Sitarina Widyarini, Laurentius Hartanto Nugroho
ORIENTAL PHARMACY AND EXPERIMENTAL MEDICINE
(2018)