Article
Microbiology
Kate Sutton, Tessa Nash, Samantha Sives, Dominika Borowska, Jordan Mitchell, Prerna Vohra, Mark P. Stevens, Lonneke Vervelde
Summary: This study investigated the host response to early stages of Salmonella infection in chicken enteroids. The findings indicate that Salmonella infection disrupts the epithelial barrier integrity and induces inflammatory responses. Additionally, the 3D model provides a more accurate representation of host responses.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Alessandra Fusco, Vittoria Savio, Donatella Cimini, Sergio D'Ambrosio, Adriana Chiaromonte, Chiara Schiraldi, Giovanna Donnarumma
Summary: This study aimed to evaluate the ability of different strains of Lactobacillus spp. to improve the integrity of the intestinal barrier, exert anti-inflammatory and immunomodulatory activity, and prevent Salmonella Typhimurium and enteroinvasive Escherichia coli (EIEC) infections. The results showed that L. brevis, L. reuteri, and L. rhamnosus were the most effective in protecting the intestinal epithelium.
Article
Immunology
Tao Dong, Weiwei Wang, Minhao Xia, Shujie Liang, Guangzhong Hu, Hui Ye, Qingyun Cao, Zemin Dong, Changming Zhang, Dingyuan Feng, Jianjun Zuo
Summary: The study reveals the important role of HtpG in Salmonella Typhimurium infection by regulating the bacterial motility, biofilm formation, adhesion, invasion, and inflammation-inducing abilities.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Immunology
Xianqi Peng, Abdelaziz Ed-Dra, Yan Song, Mohammed Elbediwi, Reshma B. Nambiar, Xiao Zhou, Min Yue
Summary: This study investigated the protective effects and mechanisms of Lacticaseibacillus rhamnosus on the intestinal mucosal barrier of chicks infected with Salmonella. The results showed that L. rhamnosus significantly reduced diarrhea, improved gut immunity, and inhibited intestinal inflammation in infected chicks. Pre-treatment with L. rhamnosus balanced the expression of immune factors, regulated endotoxin and D-lactic acid levels, and enhanced the function of intestinal mucosal epithelial cells. Additionally, L. rhamnosus weakened the adhesion of Salmonella and increased intestinal microbiota diversity in infected chicks.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Tamisa Seeko Bandeira Honda, John Ku, Hans-Joachim Anders
Summary: The NLRP3 inflammasome plays a crucial role in monocytes, macrophages, and neutrophils, but is absent in non-immune cells according to most published evidence. However, an increasing number of studies have reported the presence and functionality of the NLRP3 inflammasome in almost every cell type.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Veterinary Sciences
Elisabetta Razzuoli, Chiara Grazia De Ciucis, Barbara Chirullo, Katia Varello, Roberto Zoccola, Lisa Guardone, Paola Petrucci, Danja Rubini, Elena Bozzetta, Maria Goria, Floriana Fruscione, Paola Modesto
Summary: Canine mammary cancer shares many similarities with human breast cancer in terms of risk factors, behavior, and clinical course. These breast tumors are resistant to conventional therapies, making the study of alternative treatments necessary. The CF33 cell line can serve as an in vitro model for evaluating innovative therapeutic approaches involving bacteria.
VETERINARY SCIENCES
(2022)
Article
Immunology
Laura Robrahn, Aline Dupont, Sandra Jumpertz, Kaiyi Zhang, Christian H. Holland, Joel Guillaume, Sabrina Rappold, Johanna Roth, Vuk Cerovic, Julio Saez-Rodriguez, Mathias W. Hornef, Thorsten Cramer
Summary: HIF-1 plays an important role in bacterial infections of the gastrointestinal tract. However, its function varies in intestinal epithelial cells and macrophages. Deletion of Hif1a in intestinal epithelial cells does not affect inflammatory gene expression or bacterial spread, whereas deletion of Hif1a in myeloid cells enhances the inflammatory response and reduces bacterial load in the intestines.
INFECTION AND IMMUNITY
(2022)
Article
Immunology
Minghui Cui, Guangfu Tang, Fang Yan, Shunshan Wang, Xi Wang, Junhu Yao, Xiurong Xu
Summary: This study evaluated the protective effect of heat-inactivated Escherichia coli (IEC) on the intestines of weaned rats challenged with Salmonella Typhimurium (S.Typhimurium). The results showed that oral administration of IEC during suckling alleviated S.Typhimurium-induced injury in ileal morphology by increasing the levels of tight junction proteins and secreted proteins in the intestinal mucosa. Furthermore, pre-stimulation with IEC enhanced immune responses and decreased certain bacterial abundances after intestinal infection.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yuhan Wang, Bing Yu, Yuheng Luo, Ping Zheng, Xiangbing Mao, Zhiqing Huang, Jie Yu, Junqiu Luo, Hui Yan, Aimin Wu, Jun He
Summary: In this study, the protective effects of porcine interferon-lambda 3 (PIFN-lambda 3) on intestinal inflammation and injury induced by porcine rotavirus (PRV) were explored. PIFN-lambda 3 decreased the concentrations of inflammatory cytokines, increased the concentrations of immunoglobulins, and restored the damaged intestinal structure. These findings suggest that PIFN-lambda 3 could be a promising candidate for preventing pathogen-induced bowel diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Immunology
Iris Stolzer, Laura Schickedanz, Mircea T. Chiriac, Rocio Lopez-Posadas, Guntram A. Grassl, Jochen Mattner, Stefan Wirtz, Beate Winner, Markus F. Neurath, Claudia Guenther
Summary: This study elucidated the central mechanisms and upstream regulatory components of cell death regulation during gastrointestinal infection, revealing that the lack of Caspase-8 in intestinal epithelial cells leads to increased sensitivity to Salmonella infection. Additionally, it was found that epithelial STAT1 plays a crucial role in regulating both Caspase-8-dependent and -independent cell death pathways in the intestinal epithelium.
MUCOSAL IMMUNOLOGY
(2022)
Article
Immunology
Zhiqiang Li, Dimitra Peirasmaki, Staffan Svard, Magnus Abrink
Summary: The proteoglycan serglycin plays a regulatory role in intestinal immune responses by influencing the expression levels of chemokines and cytokines, leading to delayed weight gain in young SG(-/-) mice infected with Giardia intestinalis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Joao D. Magalhaes, Emanuel Candeias, Ines Melo-Marques, Diana F. Silva, A. Raquel Esteves, Nuno Empadinhas, Sandra Morais Cardoso
Summary: Parkinson's disease is a neurodegenerative disease characterized by the loss of dopaminergic neurons. It has been found that autonomic symptoms and a-synuclein pathology in peripheral tissues are related in the early stage. By infecting the gut with Listeria monocytogenes, we observed oligomerization of a-synuclein in the ileum, along with a pro-inflammatory response and neuronal mitochondria dysfunction.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Medicine, Research & Experimental
Harleen Kaur, Anjeza Erickson, Regis Moreau
Summary: mTORC1 plays a differential role in the immune responses of THP-1-derived macrophages and Caco-2 epithelial cells in a pro-inflammatory microenvironment, impacting cytokine gene expression through manipulation of mTORC1 activity.
Article
Biochemistry & Molecular Biology
Qifeng Deng, Sidi Yang, Lanqing Sun, Kai Huang, Kedi Dong, Yuan Zhu, Yu Cao, Yuanyuan Li, Shuyan Wu, Rui Huang
Summary: Maintaining host iron homeostasis is crucial for nutritional immunity, and this study reveals a novel role of NLRP6 in regulating host iron metabolism and bacterial infection resistance. The mechanism involves NRF2 regulation through NLRP6/AKT interaction and AKT phosphorylation, affecting NRF2 nuclear translocation and KEAP1 transcription.
Article
Immunology
Diana Boraschi
Summary: Interleukin-1 (IL-1) is a cytokine that plays a significant role in inflammation and immune response, primarily produced by macrophages during defensive reactions. It belongs to a superfamily of structurally similar proteins and acts through binding to specific receptors on the plasma membrane of target cells. IL-1 family cytokines not only have innate immune and inflammatory effects but also appear to be involved in the development of adaptive immunity in vertebrates.
FRONTIERS IN IMMUNOLOGY
(2022)