Article
Medicine, Research & Experimental
Aaditya Khatri, Jamie L. . Todd, Fran L. . Kelly, Andrew Nagler, Zhicheng Ji, Vaibhav Jain, Simon G. Gregory, Kent J. Weinhold, Scott M. Palmer
Summary: Chronic lung allograft dysfunction (CLAD), characterized by decline in pulmonary function and bronchiolitis obliterans, lacks approved therapies. Single-cell RNA-Seq and spatial transcriptomic analysis identified the important role of JAK-STAT signaling in airway epithelial cells in CLAD. Activation of JAK-STAT signaling leads to upregulation of MHC-I in airway basal cells, resulting in cytotoxic T cell-mediated basal cell death. This study provides mechanistic insight and potential therapeutic strategy for CLAD.
Article
Critical Care Medicine
Jarrod E. Dalton, Carli J. Lehr, Paul R. Gunsalus, Lyla Mourany, Maryam Valapour
Summary: This study examined the performance of models predicting waitlist and posttransplant survival in lung transplant allocation. The results showed that different models had similar performance in predicting waitlist and posttransplant survival, and using alternative modeling strategies and contemporary cohorts did not improve the models' performance in determining access to lung transplant.
Article
Immunology
Vaidehi Kaza, Chengsong Zhu, Lance S. Terada, Li Wang, Fernando Torres, Srinivas Bollineni, Manish Mohanka, Amit Banga, John Joerns, T. Mohanakumar, Quan-Zhen Li
Summary: This study found that pre-existing elevated IgG autoantibodies are significantly correlated with progressive BOS and worse survival in lung transplant recipients. The findings suggest important implications for predicting long term survival after lung transplantation.
Article
Cardiac & Cardiovascular Systems
Ahad Firoz, Mohammed Kashem, Huaqing Zhao, Steven Geier, Yoshiya Toyoda
Summary: This study found that HLA mismatch is associated with the development of bronchiolitis obliterans syndrome (BOS), and a decrease in overall survival is only apparent when there are 6 mismatches. HLA-A and -DR mismatches are associated with an increased risk of mortality and BOS development. Lung transplantation offers an extended lifespan and improved quality of life for many patients with advanced refractory lung disease.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Hematology
Yifan Pang, Ananth Charya, Michael B. Keller, Arlene Sirajuddin, Yi-Ping Fu, Noa G. Holtzman, Steven Z. Pavletic, Sean Agbor-Enoh
Summary: This study adapted the 2019 International Society for Heart and Lung Transplantation criteria to define novel phenotypes of pulmonary chronic graft-versus-host disease (PcGVHD) and compared its performance with the NIH criteria in identifying high-risk PcGVHD patients. The adapted criteria were found to be effective in identifying high-risk PcGVHD patients that were missed by the NIH criteria.
Review
Biochemistry & Molecular Biology
Dalila Cavallaro, Marco Guerrieri, Stefano Cattelan, Gaia Fabbri, Sara Croce, Martina Armati, David Bennett, Antonella Fossi, Luca Voltolini, Luca Luzzi, Alberto Salvicchi, Piero Paladini, Adriano Peris, Miriana d'Alessandro, Paolo Cameli, Elena Bargagli, Tuscany Transplant Group, Laura Bergantini
Summary: Bronchiolitis obliterans syndrome is the most common form of CLAD, and its pathogenesis and markers play a crucial role in early diagnosis and treatment.
Article
Immunology
Tatsuaki Watanabe, Christina Lam, Jillian Oliver, Hisashi Oishi, Grace Teskey, Samuel Beber, Kristen Boonstra, Juan Mauricio Umana, Hifza Buhari, Betty Joe, Zehong Guan, Miho Horie, Shaf Keshavjee, Tereza Martinu, Stephen C. Juvet
Summary: Chronic lung allograft dysfunction (CLAD) is a major obstacle in the survival of lung transplant patients. This study investigated the role of a specific type of dendritic cells (cDC1) in CLAD using a mouse lung transplant model. The results showed that cDC1s accumulated in the transplanted lungs and their activation was enhanced by airway inflammation. Furthermore, the absence of BATF3, a transcription factor essential for cDC1 development, had differential effects on acute rejection and T-cell expansion depending on the presence of airway inflammation.
MUCOSAL IMMUNOLOGY
(2023)
Article
Respiratory System
David Ross Darley, Jin Ma, Ella Huszti, Rasheed Ghany, Michael Hutcheon, Chung-Wai Chow, Jussi Tikkanen, Shaf Keshavjee, Lianne Gail Singer, Tereza Martinu
Summary: This study aims to determine the prognostic significance of D-LCOcor on chronic lung allograft dysfunction (CLAD) and survival. The results show that low baseline D-LCOcor is significantly associated with death, and declines in D-LCOcor are associated with shorter survival. This suggests that D-LCOcor may be a useful marker for predicting poor outcomes after lung transplantation.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Medicine, General & Internal
Jesper Romhild Davidsen, Christian B. Laursen, Mikkel Hojlund, Thomas Kromann Lund, Klaus Nielsen Jeschke, Martin Iversen, Anna Kalhauge, Elisabeth Bendstrup, Jorn Carlsen, Michael Perch, Daniel Pilsgaard Henriksen, Hans Henrik Lawaetz Schultz
Summary: This study found that pleural thickening identified by lung ultrasound may serve as a potential surrogate marker to distinguish restrictive allograft syndrome (RAS) from bronchiolitis obliterans syndrome (BOS) in chronic lung allograft dysfunction (CLAD) patients after lung transplant. This discovery provides a new method for clinical diagnosis of CLAD patients post lung transplant.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Sudip Das, Eric Bernasconi, Angela Koutsokera, Daniel-Adrien Wurlod, Vishwachi Tripathi, German Bonilla-Rosso, John-David Aubert, Marie-France Derkenne, Louis Mercier, Celine Pattaroni, Alexis Rapin, Christophe von Garnier, Benjamin J. Marsland, Philipp Engel, Laurent P. Nicod
Summary: This study examined the viable bacterial community in bronchoalveolar lavage samples from 64 lung transplant recipients and identified four distinct compositional states, called "pneumotypes," which were associated with immune activity, lung function, and risks of infection and rejection. The findings highlight the link between the lung microbial ecosystem, human lung function, and clinical stability post-transplant.
NATURE COMMUNICATIONS
(2021)
Article
Respiratory System
Micheal C. McInnis, Jin Ma, Gauri Rani Karur, Christian Houbois, Liran Levy, Jan Havlin, Eyal Fuchs, Jussi Tikkanen, Chung-Wai Chow, Ella Huszti, Tereza Martinu
Summary: In this study, a machine learning computed tomography (CT) lung texture analysis tool was used for phenotyping and prognostication of chronic lung allograft dysfunction (CLAD) in lung transplant recipients. The results showed that machine learning could effectively distinguish different CLAD phenotypes, and the associated parameters were able to predict the risk of graft failure.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Respiratory System
Auke E. S. de Zwart, Annelies Riezebos-Brilman, Gerton A. Lunter, Ewald C. U. Neerken, Coretta C. van Leer-Buter, Jan-Willem C. Alffenaar, Anna P. van Gemert, Michiel E. Erasmus, Christiaan T. Gan, Huib A. M. Kerstjens, Judith M. Vonk, Erik A. M. Verschuuren
Summary: The social distancing measures during COVID-19 led to a reduction in respiratory virus infection rates, which correlated with less decline in lung function, fewer episodes of TDLF, and possibly lower incidence of CLAD in lung transplant recipients.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Surgery
Naofumi Miyahara, Alberto Benazzo, Felicitas Oberndorfer, Akinori Iwasaki, Viktoria Laszlo, Balasz Dome, Mir Ali Hoda, Peter Jaksch, Walter Klepetko, Konrad Hoetzenecker
Summary: miR-21 expression was higher in restrictive allograft syndrome (RAS) than in bronchiolitis obliterans syndrome (BOS) specimens, with a significant increase in serum concentration over time in RAS patients. Vimentin, NICD, and p-SMAD 2/3 were positive in a higher proportion of BOS patients compared to RAS cases.
TRANSPLANT INTERNATIONAL
(2022)
Article
Hematology
Matt S. Zinter, Caroline A. Lindemans, Birgitta A. Versluys, Madeline Y. Mayday, Sara Sunshine, Gustavo Reyes, Marina Sirota, Anil Sapru, Michael A. Matthay, Sandhya Kharbanda, Christopher C. Dvorak, Jaap J. Boelens, Joseph L. DeRisi
Summary: This study analyzed biospecimens from 181 pediatric HCT candidates to investigate the association between pre-HCT pulmonary metatranscriptomes and post-HCT lung injury. The results showed that certain gene expression patterns and microbiome compositions in the lungs prior to transplantation were linked to an increased risk of developing lung injury after the procedure. Data from this study suggest that assessment of pre-HCT BAL fluid could potentially help identify high-risk pediatric HCT candidates who may benefit from targeted interventions.
Article
Respiratory System
Jesper M. Magnusson, Petrea Ericson, Sara Tengvall, Marit Stockfelt, Bettina Brundin, Anders Linden, Gerdt C. Riise
Summary: This pilot study revealed a significant increase in extracellular IL-26 protein concentration in BAL samples from patients with BOS, but not in samples from patients with AR. Macrophages and lymphocytes were identified as cellular sources of IL-26 protein in BAL cells obtained from BOS patients.
RESPIRATORY RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Peter H. Hagedorn, Robert Persson, Erik D. Funder, Nanna Albaek, Sanna L. Diemer, Dennis J. Hansen, Marianne R. Moller, Natalia Papargyri, Helle Christiansen, Bo R. Hansen, Henrik F. Hansen, Mads A. Jensen, Troels Koch
DRUG DISCOVERY TODAY
(2018)
Article
Chemistry, Multidisciplinary
Kim Mortensen, Chiara Tassone, Nicky Ehrlich, Thomas L. Andresen, Henrik Flyvbjerg
Article
Biochemistry & Molecular Biology
Christian L. Vestergaard, Paul C. Blainey, Henrik Flyvbjerg
NUCLEIC ACIDS RESEARCH
(2018)
Article
Biochemistry & Molecular Biology
Peter H. Hagedorn, Malene Pontoppidan, Tina S. Bisgaard, Marco Berrera, Andreas Dieckmann, Martin Ebeling, Marianne R. Moller, Heidi Hudlebusch, Marianne L. Jensen, Henrik F. Hansen, Troels Koch, Morten Lindow
NUCLEIC ACIDS RESEARCH
(2018)
Article
Medicine, Research & Experimental
Andreas Dieckmann, Peter H. Hagedorn, Yvonne Burki, Christine Brugmann, Marco Berrera, Martin Ebeling, Thomas Singer, Franz Schuler
MOLECULAR THERAPY-NUCLEIC ACIDS
(2018)
Article
Multidisciplinary Sciences
Nikolay Kutuzov, Henrik Flyvbjerg, Martin Lauritzen
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Multidisciplinary Sciences
Rodolphe Marie, Jonas N. Pedersen, Loic Baerlocher, Kamila Koprowska, Marie Podenphant, Celine Sabatel, Maksim Zalkovskij, Andrej Mironov, Brian Bilenberg, Neil Ashley, Henrik Flyvbjerg, Walter F. Bodmer, Anders Kristensen, Kalim U. Mir
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Editorial Material
Biochemistry & Molecular Biology
Lukasz J. Kielpinski, Peter H. Hagedorn, Morten Lindow, Jeppe Vinther
NUCLEIC ACIDS RESEARCH
(2019)
Article
Medicine, Research & Experimental
Natalia Papargyri, Malene Pontoppidan, Mikael R. Andersen, Troels Koch, Peter H. Hagedorn
MOLECULAR THERAPY-NUCLEIC ACIDS
(2020)
Article
Medicine, Research & Experimental
Lykke Pedersen, Peter Hagedorn, Jonas Vikesa, Signe Tang Karlsen, Pia Saermark, Troels Koch, Morten Lindow
MOLECULAR THERAPY-NUCLEIC ACIDS
(2020)
Article
Medicine, Research & Experimental
Brian R. Anderson, Marianne L. Jensen, Peter H. Hagedorn, Sean C. Little, Richard E. Olson, Ron Ammar, Bernadette Kienzle, John Thompson, Ivar McDonald, Stephen Mercer, Jonas Vikesaa, Bettina Nordbo, Larry Iben, Yang Cao, Joanne Natale, Greg Dalton-Kay, Angela Cacace, Bo R. Hansen, Maj Hedtjarn, Troels Koch, Linda J. Bristow
MOLECULAR THERAPY-NUCLEIC ACIDS
(2020)
Article
Physics, Multidisciplinary
Kim I. Mortensen, Henrik Flyvbjerg, Jonas N. Pedersen
Summary: This study presents explicit and exact expressions for measuring and mean-squared displacement of Brownian particles confined in different geometries, valid for all exposure times. The results apply not only to simple geometries, but also have generality for more complex shapes. The exact quantitative descriptions provided here can offer a qualitative and semi-quantitative understanding of a wide range of physics phenomena.
FRONTIERS IN PHYSICS
(2021)
Article
Physics, Multidisciplinary
Martin Schmidt, Adam C. Hundahl, Henrik Flyvbjerg, Rodolphe Marie, Kim I. Mortensen
Summary: Recent studies show that structured illumination plays an important role in super-resolution localization and tracking of fluorescent particles, combining conventional localization information significantly improves precision.
COMMUNICATIONS PHYSICS
(2021)
News Item
Physics, Multidisciplinary
Henrik Flyvbjerg
Summary: A study shows that cells prefer regions they have already visited when moving on microprinted tracks, suggesting a potential update to century-old dynamical models for cell trajectories.
Review
Biochemistry & Molecular Biology
Jannik Bruun Larsen, Nayere Taebnia, Alireza Dolatshahi-Pirouz, Anne Zebitz Eriksen, Claudia Hjorringgaard, Kasper Kristensen, Nanna Wichmann Larsen, Niels Bent Larsen, Rodolphe Marie, Ann-Kathrin Mundler, Ladan Parhamifar, Andrew James Urquhart, Arjen Weller, Kim I. Mortensen, Henrik Flyvbjerg, Thomas Lars Andresen
Summary: Oral delivery is preferred by patients, but poses challenges for drug classes like pharmaceutical peptides due to biological barriers. Improving peptide transport across the intestinal barrier is crucial for future treatments. Fluorescence imaging allows direct visualization of peptide transport, providing detailed mechanistic understanding.
RSC CHEMICAL BIOLOGY
(2021)