Article
Gastroenterology & Hepatology
Gintare Lasaviciute, Myriam Barz, Marieke van der Heiden, Claudia Arasa, Kanwal Tariq, Jaclyn Quin, Ann-Kristin Ostlund Farrants, Eva Sverremark-Ekstrom
Summary: The secretome of the gut probiotic bacterium L. reuteri has an effect on memory responses in human immune cells, resulting in a secondary response phenotype different from other training agents. This has potential implications for therapeutic interventions targeting T cell responses.
Review
Biochemistry & Molecular Biology
Yuan-Tung Chu, Min-Tser Liao, Kuo-Wang Tsai, Kuo-Cheng Lu, Wan-Chung Hu
Summary: A comprehensive framework has been established to understand immunological pathways, and specific associations between immune responses and immune receptors have been identified. These findings contribute to the identification of biomarkers for immune cells and provide insights into host immunological pathways.
Review
Pharmacology & Pharmacy
Connie W. Woo, Patrick Tso, Jensen H. C. Yiu
Summary: This opinion article discusses how gut bacteria survive in the harsh environment and explores how their components penetrate the body from the perspective of the bacteria and the host's proactivity. It also discusses the potential development of orally administered therapeutic proteins that utilize similar mechanisms to enter the body.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2022)
Article
Immunology
Maarten K. Nijen Twilhaar, Lucas Czentner, Rianne G. Bouma, Katarzyna Olesek, Joanna Grabowska, Aru Zeling Wang, Alsya J. Affandi, Saskia C. Belt, Hakan Kalay, Cornelus F. van Nostrum, Yvette van Kooyk, Gert Storm, Joke M. M. den Haan
Summary: TLR-containing GM3 liposomes are effective vectors to induce DC maturation and T cell priming. Incorporation of PGPC or MDP does not enhance immune responses. These findings provide guidance for the optimal selection of liposomal components to stimulate anti-cancer immune responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biology
Daniela Amaral-Silva, Rita C. Torrao, Rita Torres, Sandra Falcao, Maria Joao Goncalves, Maria Paula Araujo, Maria Jose Martins, Carina Lopes, Agna Neto, Jose Marona, Tiago Costa, Walter Castelao, Ana Bento Silva, Ines Silva, Maria Helena Lourenco, Margarida Mateus, Nuno Pina Goncalves, Santiago Manica, Manuela Costa, Fernando Pimentel-Santos, Ana Filipa Mourao, Jaime C. Branco, Helena Soares
Summary: CD4(+) T cells in Rheumatoid Arthritis (RA) exhibit pathogenic functions through both antibody-dependent and independent mechanisms. The presence of a TLR4(+) follicular helper T cell-like population in synovial fluid was identified, which can switch from an IL-21 response to an IL-17 inflammatory program, thus regulating both systemic antibody production and local tissue damage.
COMMUNICATIONS BIOLOGY
(2021)
Article
Immunology
Laurent Bartolo, Sumbul Afroz, Yi-Gen Pan, Ruozhang Xu, Lea Williams, Chin-Fang Lin, Ceylan Tanes, Kyle Bittinger, Elliot S. Friedman, Phyllis A. Gimotty, Gary D. Wu, Laura F. Su
Summary: The baseline composition of T cells has a direct impact on the response to pathogens, and the precursor states of these cells are complex and not well defined. This study examined the baseline state of T cells specific to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in prepandemic blood samples. The data revealed a diverse range of preexisting memory states in these cells, with distinct features and potential for trafficking to barrier tissues. The study also found cross-reactivity between T cell clones and antigens from commensal bacteria, highlighting the importance of noninfectious exposures to shaping preexisting immunity to SARS-CoV-2.
SCIENCE IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Jipeng Jiang, Jie Mei, Shasha Jiang, Jian Zhang, Liuxiang Wang, Jing Yuan, Shaoqiong Yi, Yongfu Ma, Yang Liu
Summary: The tumor microenvironment is a crucial niche for tumorigenesis and progression, and commensal microbiota plays a significant role in this process. While commensal microbiota can affect tumor cells through various mechanisms, the mechanisms by which tumor cells exert influence on commensal microbiota remain unclear.
Article
Microbiology
Alla Splichalova, Zdislava Kindlova, Jiri Killer, Vera Neuzil Bunesova, Eva Vlkova, Barbora Valaskova, Radko Pechar, Katerina Polakova, Igor Splichal
Summary: In this study, the host-pathogen interactions were investigated using the GN animal model. The results showed that previous association with RP37 alleviated intestinal damage caused by Salmonella infection, and RP37 and LA downregulated the inflammatory response.
Article
Rheumatology
Huixian Hong, Fatima Alduraibi, David Ponder, Wayne L. Duck, Casey D. Morrow, Jeremy B. Foote, Trenton R. Schoeb, Huma Fatima, Charles O. Elson, Hui-Chen Hsu, John D. Mountz
Summary: The study aims to determine the influence of the gut microbiome on systemic autoimmunity in a mouse model of lupus. The findings suggest that the gut microbiome may regulate certain aspects of systemic autoimmunity.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Immunology
Maria Vono, Beatris Mastelic-Gavillet, Elodie Mohr, Malin Ostensson, Josefine Persson, Thorunn A. Olafsdottir, Sylvain Lemeille, David Pejoski, Oliver Hartley, Dennis Christensen, Peter Andersen, Arnaud M. Didierlaurent, Ali M. Harandi, Paul-Henri Lambert, Claire-Anne Siegrist
Summary: C-type lectin receptor (CLR) agonists have been found to be more effective than Toll-like receptor (TLR) agonists in inducing primary B cell responses in early life. This study investigates the mechanisms behind the difference in neonatal adjuvanticity between CLR-based (CAF(R)01) and TLR4-based (GLA-SE) adjuvants. The results demonstrate that CAF01 induces mixed Th1/Th17 neonatal responses and Tfh cells that are crucial for germinal center formation.
FRONTIERS IN IMMUNOLOGY
(2023)
Editorial Material
Immunology
June-Young Koh, Eui-Cheol Shin
Summary: This study revealed that human KIR(+)CD8(+) T cells suppress autoimmunity by eliminating pathogenic CD4(+) T cells.
Article
Immunology
Bingying Du, Jiaming Teng, Rongkun Yin, Yuanyuan Tian, Tingwang Jiang, Yanan Du, Wei Cai
Summary: The study found that the frequency of T follicular helper (Tfh) cells significantly increased in HBV-ACLF patients, correlating with MELD score. Additionally, HBV-ACLF patients had higher serum levels of IL-12 and IL-21. Naive CD4(+) T cells from healthy controls differentiated into Tfh cells when exposed to serum from HBV-ACLF patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Han Feng, Zixuan Zhao, Xiaohong Zhao, Xue Bai, Weiwei Fu, Liangtao Zheng, Boxi Kang, Xiaohu Wang, Zemin Zhang, Chen Dong
Summary: Using single-cell transcriptomic analysis, researchers identified a novel T follicular helper cell subset with stem cell-like transcriptional features and long-term survival ability, which can give rise to effector Tfh cells in recall immune responses.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Eunjeong Lee, Jasmina S. Redzic, Travis Nemkov, Anthony J. Saviola, Monika Dzieciatkowska, Kirk C. Hansen, Angelo D'Alessandro, Charles Dinarello, Elan Z. Eisenmesser
Summary: This study used a combination of biophysical and biochemical methods to investigate the dynamic behavior and functional interactions of bacterial TIR-containing proteins and mammalian receptor TIR domains. The findings highlight the differences in dynamics and functionality between bacterial and mammalian TIR domains, as well as the variations in oligomeric interactions.
Article
Cell Biology
Stefanie Scheid, Adrien Lejarre, Jakob Wollborn, Hartmut Buerkle, Ulrich Goebel, Felix Ulbrich
Summary: Argon preconditioning protects neuronal cells from cell death by reducing apoptosis, decreasing the expression of Toll-like receptors (TLRs), enhancing phosphorylation of ERK1/2, and suppressing NF-kappa B and Akt expression. It also inhibits the expression of caspase-3, Bcl-2, interleukin-8, and heat shock proteins. Argon preconditioning may be a promising therapeutic alternative for conditions like stroke.
NEURAL REGENERATION RESEARCH
(2023)
Article
Immunology
Robertus van Aalst, Ellyn M. Russo, Nabin Neupane, Salaheddin M. Mahmud, Jan Wilschut, Sandrine Samson, Ayman Chit, Maarten Postma, Yinong Young-Xu
Summary: In a study conducted in the US VHA population, high-dose influenza vaccination was found to significantly reduce hospitalization risks for cardiovascular and respiratory diseases. Reduction in hospitalizations for cardiovascular diseases contributed more to cost savings per high-dose recipient compared to respiratory diseases.
Article
Immunology
Alejandro E. Macias, Janet E. McElhaney, Sandra S. Chaves, Joshua Nealon, Marta C. Nunes, Sandrine Samson, Bruce T. Seet, Thomas Weinke, Hongjie Yu
Summary: Influenza, primarily known as a respiratory infection, also has broader consequences such as cardiovascular events, exacerbations of chronic illnesses, increased susceptibility to secondary infections, functional decline, and poor pregnancy outcomes. Understanding these broader consequences is crucial for assessing the full burden of influenza and the value of preventive measures among different populations.
Review
Immunology
Jason K. H. Lee, Gary K. L. Lam, Thomas Shin, Sandrine Samson, David P. Greenberg, Ayman Chit
Summary: Evidence over 10 consecutive influenza seasons and in more than 34 million individuals aged >= 65 years suggests that HD-IIV3 is consistently more effective than SD-IIV at reducing influenza cases as well as influenza-associated clinical complications irrespective of circulating strain and antigenic match.
Article
Critical Care Medicine
Ruvim Izikson, Daniel Brune, Jean-Sebastien Bolduc, Pierre Bourron, Marion Fournier, Tamala Mallett Moore, Aseem Pandey, Lucia Perez, Nessryne Sater, Anju Shrestha, Sophie Wague, Sandrine Samson
Summary: This study assessed the safety and immunogenicity of concomitant administration of high-dose quadrivalent influenza vaccine (QIV-HD) and mRNA-1273 vaccine booster in older adults. The results showed no safety concerns or immune interference in the coadministration group, supporting the recommendations for co-administration. The antibody responses to influenza and SARS-CoV-2 were similar between the coadministration and QIV-HD groups.
LANCET RESPIRATORY MEDICINE
(2022)
Letter
Biotechnology & Applied Microbiology
J. Kevin Yin, Stephanie Pepin, Robertus van Aalst, Matthew M. Loiacono, Sandrine I. Samson
Summary: The article challenges the recommendation of high-dose influenza vaccine and criticizes the authors of inaccurate numbers-needed-to-vaccinate (NNV) calculation. It emphasizes the importance of preferential recommendation for vaccines preventing influenza/complications and considering the impact of vaccination within the context of disease burden. To address the threat of the COVID-19 pandemic, the article suggests implementing concomitant influenza/COVID-19 vaccination to reduce the burden of co-circulation of influenza and SARS-CoV-2 viruses and increase vaccine coverage as per the WHO mandate.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Health Care Sciences & Services
Nell J. Marshall, Jennifer L. Lee, Jessica Schroeder, Wei-Nchih Lee, Jermyn See, Mohammad Madjid, Mrudula R. Munagala, John D. Piette, Litjen Tan, Orly Vardeny, Michael Greenberg, Jan Liska, Monica Mercer, Sandrine Samson
Summary: This personalized, evidence-based digital intervention proved effective in increasing vaccination rates among individuals with high-risk cardiovascular diseases. White and Asian individuals were more likely to get vaccinated, while the intervention had less impact on people of color.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Immunology
Jau-Yuan Chen, Szu-Min Hsieh, Shinn-Jang Hwang, Chiu-Shong Liu, Xiaoling Li, Marion Fournier, Ting-Yu Yeh, J. Kevin Yin, Sandrine Samson
Summary: This study evaluated the immunogenicity and safety of high-dose and standard-dose influenza vaccines in older adults in Taiwan. The results showed that the high-dose vaccine had higher immunogenicity for all four influenza strains compared to the standard-dose vaccine, and both vaccines had similar safety profiles.
Article
Biotechnology & Applied Microbiology
Xiaoqiang Liu, Juliana Park, Shengli Xia, Bin Liang, Shuangmin Yang, Yanxia Wang, Olga Syrkina, Nathalie Lavis, Shuzhen Liu, Chenyan Zhao, Jian Ding, Jieqiong Hu, Sandrine Samson, Iris A. de Bruijn
Summary: The safety and immunogenicity of the quadrivalent, split-virion influenza vaccine (Shz QIV) developed in China were assessed. The vaccine showed good tolerability and induced immune responses in different age groups, demonstrating non-inferiority against various strains of influenza virus.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Letter
Immunology
J. Kevin Yin, Rebecca C. Harris, Matthew M. Loiacono, Ayman Chit, Sandrine I. Samson
Article
Cardiac & Cardiovascular Systems
Niklas Dyrby Johansen, Muthiah Vaduganathan, Ankeet S. Bhatt, Simin Gharib Lee, Daniel Modin, Brian L. Claggett, Erica L. Dueger, Sandrine Samson, Matthew M. Loiacono, Lars Kober, Scott D. Solomon, Pradeesh Sivapalan, Jens Ulrik Staehr Jensen, Palle Valentiner-Branth, Tyra Grove Krause, Tor Biering-Sorensen
Summary: The NUDGE-FLU trial aims to investigate the effectiveness of digitally delivered behavioral nudges in increasing influenza vaccination uptake among older adults. It has randomized 964,870 Danish citizens aged 65 years and above to receive either no nudge or one of 9 electronic letters leveraging different behavioral science strategies. The trial will provide important insights into effective communication strategies to maximize vaccination uptake among high-risk groups.
AMERICAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Daniel Modin, Niklas Dyrby Johansen, Muthiah Vaduganathan, Ankeet S. Bhatt, Simin Gharib Lee, Brian L. Claggett, Erica L. Dueger, Sandrine I. Samson, Matthew M. Loiacono, Lars Kober, Scott D. Solomon, Pradeesh Sivapalan, Jens Ulrik Staehr Jensen, Cyril Jean-Marie Martel, Palle Valentiner-Branth, Tyra Grove Krause, Tor Biering-Sorensen
Summary: Digital behavioral nudges, such as electronic letters, emphasizing the potential cardiovascular benefits of influenza vaccination and using a reminder letter strategy, were found to be effective in increasing influenza vaccine uptake among older adults both with and without cardiovascular disease.
Article
Cardiac & Cardiovascular Systems
Niklas Dyrby Johansen, Muthiah Vaduganathan, Ankeet S. Bhatt, Simin Gharib Lee, Daniel Modin, Brian L. Claggett, Erica L. Dueger, Sandrine Samson, Matthew M. Loiacono, Rebecca C. Harris, Lars Kober, Scott D. Solomon, Pradeesh Sivapalan, Jens Ulrik Staehr Jensen, Cyril Jean-Marie Martel, Palle Valentiner-Branth, Tyra Grove Krause, Tor Biering-Sorensen
Summary: This study analyzed the effects of two behavioral nudging letter strategies on influenza vaccination rates in patients with heart failure (HF). The results showed that the vaccination rate in HF patients was relatively low, but the behavioral nudging letter strategies were effective in increasing the vaccination rate and had no negative impact on the use of guideline-directed medical therapy (GDMT) in the long term.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Medicine, General & Internal
Niklas Dyrby Johansen, Muthiah Vaduganathan, Ankeet S. Bhatt, Simin Gharib Lee, Daniel Modin, Brian L. Claggett, Erica L. Dueger, Sandrine Samson, Matthew M. Loiacono, Lars Kober, Scott Solomon, Pradeesh Sivapalan, Jens Ulrik Staehr Jensen, Cyril Jean-Marie Martel, Palle Valentiner-Branth, Tyra Grove Krause, Tor Biering-Sorensen
Summary: This study investigated whether behavioural nudges delivered via a governmental electronic letter system could increase influenza vaccination uptake among older adults in Denmark. The results showed that sending an electronic letter highlighting potential cardiovascular benefits of vaccination or sending repeated letters at randomisation and at day 14 significantly improved vaccination rates.
Review
Immunology
Jason K. H. Lee, Gary K. L. Lam, J. Kevin Yin, Matthew M. Loiacono, Sandrine I. Samson
Summary: This updated systematic review and meta-analysis assessed the relative performance of high-dose inactivated influenza vaccine (HD-IIV) and standard-dose influenza vaccines (SD-IIV) against influenza-associated outcomes in older adults (& GE;65 years). The analysis included studies conducted over 12 influenza seasons and showed that HD-IIV provided significantly better protection than SD-IIV against influenza-related outcomes. Subgroup analyses further demonstrated the consistent superiority of HD-IIV across different age groups and strains of influenza.
Article
Medicine, Research & Experimental
Niklas Dyrby Johansen, Daniel Modin, Joshua Nealon, Sandrine Samson, Camille Salamand, Carsten Schade Larsen, Brian L. Claggett, Scott D. Solomon, Martin J. Landray, Gunnar H. Gislason, Lars Kober, Jens Ulrik Staehr Jensen, Pradeesh Sivapalan, Lasse Skafte Vestergaard, Palle Valentiner-Branth, Tyra Grove Krause, Tor Biering-Sorensen
Summary: This study aims to investigate the feasibility of a pragmatic clinical trial in Denmark comparing high-dose and standard-dose influenza vaccines. The study utilizes existing vaccination infrastructure and the Danish nationwide health registries for data collection. The results will provide valuable insights for future vaccine trials and other interventions.
PILOT AND FEASIBILITY STUDIES
(2022)