Article
Environmental Sciences
Nichole Nidey, Katherine Bowers, Lili Ding, Hong Ji, Robert T. Ammerman, Kimberly Yolton, E. Melinda Mahabee-Gittens, Alonzo T. Folger
Summary: This study investigated the effects of in-utero exposure to maternal smoking on DNA methylation of AVPR1a gene in infants. The findings suggest that infants with in-utero exposure to maternal smoking have reduced DNA methylation at AVPR1a CpG sites.
Review
Immunology
Erin Strachan, Xavier Clemente-Casares, Sue Tsai
Summary: Maternal influences on the immune health and development of an infant begin in utero and continue after birth, shaping and educating the child's immune system. Two important provisions from the mother include early microbial colonizers and the transfer of antibodies. These provisions help educate the developing neonatal immune system, connecting with the microbiota and influencing disease development.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Jeng-Chang Chen
Summary: Immunologic tolerance is the state of immune nonreactivity to specific antigens, which originated from Owen's and Medawar's observations and theories. In utero marrow transplantation may help establish donor-specific tolerance, but does not reliably cure diseases or universally induce graft tolerance as anticipated.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Akinobu Nakata, Fumio Tanaka, Yuji Nadatani, Shusei Fukunaga, Koji Otani, Shuhei Hosomi, Noriko Kamata, Koichi Taira, Yasuaki Nagami, Toshio Watanabe, Yasuhiro Fujiwara
Summary: The study found that patients with eosinophilic esophagitis can be categorized into three groups based on allergic sensitization patterns. These groups showed significant differences in dysphagia prevalence and endoscopic reference scores, indicating a correlation between allergic sensitization and clinical features among EE patients.
JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Giorgia Sebastiani, Elisabet Navarro-Tapia, Laura Almeida-Toledano, Mariona Serra-Delgado, Anna Lucia Paltrinieri, Oscar Garcia-Algar, Vicente Andreu-Fernandez
Summary: Hypoxia and oxidative stress are crucial for fetal development during pregnancy, but an imbalance in oxidative molecules can lead to complications. Antioxidants may be a promising tool for treating these complications.
Article
Pediatrics
Melinda Matyas, Madalina Valeanu, Monica Hasmasanu, Bianca Voina, Adelina Tutu, Gabriela C. Zaharie
Summary: This study aimed to analyze the impact of maternal SARS-CoV-2 infection on neonatal outcome. The results showed that none of the infants had SARS-CoV-2 infection at birth or within the first two months of life. More than half of the newborns started breastfeeding after discharge from the hospital, and the negative experience of separation from their babies influenced breastfeeding continuation.
Article
Allergy
Sandra G. Tedner, Cilla Soderhall, Jon R. Konradsen, Karen E. S. Bains, Magnus P. Borres, Kai-Hakon Carlsen, Karin C. L. Carlsen, Martin Fardig, Sabina W. Gerdin, Hrefna K. Gudmundsdottir, Guttorm Haugen, Gunilla Hedlin, Christine M. Jonassen, Ina Kreyberg, Caroline-Aleksi O. Magi, Live S. Nordhagen, Eva M. Rehbinder, Knut Rudi, Havard O. Skjerven, Anne C. Staff, Riyas Vettukattil, Marianne van Hage, Bjorn Nordlund, Anna Asarnoj
Summary: At 3 months of age, 7% of infants were sensitized to food, mostly without detectable s-IgE to food allergen molecules, and <1% to inhalant allergens. Maternal food sensitization was associated with infants' sensitization.
Review
Pediatrics
Chrysoula Kosmeri, Dimitrios Rallis, Maria Kostara, Ekaterini Siomou, Sophia Tsabouri
Summary: This narrative review summarizes the latest evidence on allergen characteristics in human milk that may influence oral tolerance induction. The diet of the mother directly impacts the amount of allergens in breast milk, and the kinetics of antigens in human milk vary between women and depending on the specific antigen. The mode of antigen consumption, such as cooking, may also affect the allergenicity of antigens in breast milk. Despite the low dose of antigens in human milk, they still have a tolerogenic effect, and antigen-specific immunoglobulins forming immune complexes with antigens are found to be more tolerogenic compared to free allergens.
FRONTIERS IN PEDIATRICS
(2022)
Article
Cell & Tissue Engineering
Karthikeyan Kandasamy, Nuryanti Binti Johana, Lay Geok Tan, Yvonne Tan, Julie Su Li Yeo, Nur Nazneen Binte Yusof, Zhihui Li, Jiayu Koh, Florent Ginhoux, Jerry K. Y. Chan, Mahesh Choolani, Citra N. Z. Mattar
Summary: Maternal immune cells trafficked into the recipient's body through the placenta can directly influence immune responses to donor cells, limiting donor cell chimerism. Depleting maternal dendritic cells reduces recipient alloresponsiveness and enhances donor cell chimerism, suggesting a novel approach to improving donor cell tolerance.
STEM CELL RESEARCH & THERAPY
(2023)
Review
Immunology
Coco R. R. Beudeker, Daniel C. C. Vijlbrief, Joris M. van Montfrans, Suzan H. M. Rooijakkers, Michiel van der Flier
Summary: Neonates, especially preterm neonates, have the highest risk of sepsis due to the immaturity of their immune system. Strategies to improve neonatal host-defense, such as boosting immunity and increasing complement activity, have shown promising results in preclinical studies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Katherine Z. Sanidad, Mohammed Amir, Aparna Ananthanarayanan, Anvita Singaraju, Nicholas B. Shiland, Hanna S. Hong, Nobuhiko Kamada, Naohiro Inohara, Gabriel Nunez, Melody Y. Zeng
Summary: The gut microbiome-specific IgG antibodies play a critical role in promoting immunity against enteric pathogens and shaping the development of the gut microbiome and immune cells in early life.
SCIENCE IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Sze Lei Pang, Sri Anusha Matta, Yang Yie Sio, Yu Ting Ng, Yee-How Say, Chyan Leong Ng, Fook Tim Chew
Summary: The study identified K44 and E46 residues as major IgE-binding residues of the Der p 23 allergen for HDM-sensitized individuals. Individuals sensitized only to HDM have a higher number of IgE-binding residues compared to polysensitized individuals. Those with allergic multimorbidity and moderate-to-severe allergic rhinitis also exhibit a higher number of IgE-binding residues.
SCIENTIFIC REPORTS
(2021)
Article
Pediatrics
Mary Veena Mathew, Peter Prasanth K. Kumar, R. Sivaa, Satish Kuruvilla, K. Ravichandran, Lalitha Krishnan
Summary: The study found that breastmilk sodium steadily declines in the first 72 hours after birth, with feeding <= 8 times per day significantly associated with high breastmilk sodium at 72 hours of age. Other maternal and neonatal variables showed no significant correlation with high breastmilk sodium.
Article
Environmental Sciences
Zhujie Ran, Ben Wang, Shu-Yun Zhang
Summary: The study found an association between metal exposure and total and allergen-specific IgE in American adults, showing both positive and negative correlations that need further validation in populations of other countries.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Allergy
Jun Tanaka, Yuma Fukutomi, Yoshiki Shiraishi, Asako Kitahara, Tsuyoshi Oguma, Yuto Hamada, Kentaro Watai, Tadashi Nagai, Masami Taniguchi, Koichiro Asano
Summary: This study found a high prevalence of allergen-specific IgE antibodies to inhaled allergens among healthy adults in Japan, with regional variations.
ALLERGOLOGY INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Thamires Rodrigues de-Sousa, Rodrigo Pessoa, Andrezza Nascimento, Beatriz Oliveira Fagundes, Fabio da Ressureicao Sgnotto, Alberto Jose da Silva Duarte, Sabri Saeed Sanabani, Jefferson Russo Victor
Summary: Maternal OVA immunization was found to inhibit the frequency of IL-17-producing gamma delta T cells in offspring thymus, possibly through an epigenetic mechanism mediated by miRNAs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Thamires Rodrigues de Sousa, Beatriz Oliveira Fagundes, Andrezza Nascimento, Lorena Abreu Fernandes, Fabio da Ressureicao Sgnotto, Raquel Leao Orfali, Valeria Aoki, Alberto Jose da Silva Duarte, Sabri Saeed Sanabani, Jefferson Russo Victor
Summary: This study aimed to evaluate the effect of serum IgG from adult atopic dermatitis (AD) patients on the thymic maturation of IL-22-producing T cells and CLA+ T cells of non-atopic infants, as well as the expression of miRNAs in cultured thymocytes. The results showed that IgG from AD patients could increase the frequency of CLA+ CD4+ T cells in non-atopic infant thymocytes, and miRNA expression was altered in AD IgG-treated thymocytes compared to control conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Beatriz Oliveira Fagundes, Thamires Rodrigues de Sousa, Andrezza Nascimento, Lorena Abreu Fernandes, Fabio da Ressureicao Sgnotto, Raquel Leao Orfali, Valeria Aoki, Alberto Jose da Silva Duarte, Sabri Saeed Sanabani, Jefferson Russo Victor
Summary: This study found that IgG from AD patients can modulate the production of IL-17 and IL-22 by intrathymic nonatopic gamma delta T cells and demonstrates epigenetic implications mediated by miRNAs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Danielle Rosa Beserra, Ricardo Wesley Alberca, Anna Claudia Calvielli Castelo Branco, Luana de Mendonca Oliveira, Milena Mary de Souza Andrade, Sarah Cristina Gozzi-Silva, Franciane Mouradian Emidio Teixeira, Tatiana Mina Yendo, Alberto Jose da Silva Duarte, Maria Notomi Sato
Summary: This study evaluated the expression of PD-1 in lymphocytes from COVID-19 patients and found that the PD-1/PDL-1 axis plays an important role in the disease. Severe/critical patients showed lymphocyte depletion and increased PD-1 expression in TCD4+ and CD19+ lymphocytes, as well as decreased monocyte frequency with increased PD-1 expression on CD14+ monocytes. Additionally, there was a correlation between disease severity and elevated sPD-L1 levels.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Article
Immunology
Franciane Mouradian Emidio Teixeira, Luana de Mendonca Oliveira, Anna Julia Pietrobon, Erika Machado de Salles, Maria Regina D'Imperio Lima, Isabelle Freire Tabosa Viana, Roberto Dias Lins, Paula Ordonhez Rigato, Ernesto Torres de Azevedo Marques, Alberto Jose da Silva Duarte, Maria Notomi Sato
Summary: Neonatal immunization with a LAMP-1/p55Gag DNA vaccine can enhance antibody production and contribute to the development of new vaccine approaches for other emerging pathogens in early life.
Article
Cell Biology
Sarah Cristina Gozzi-Silva, Luana de Mendonca Oliveira, Ricardo Wesley Alberca, Natalli Zanete Pereira, Fabio Seiti Yoshikawa, Anna Julia Pietrobon, Tatiana Mina Yendo, Milena Mary de Souza Andrade, Yasmim Alefe Leuzzi Ramos, Cyro Alves Brito, Emily Araujo Oliveira, Danielle Rosa Beserra, Raquel Leao Orfali, Valeria Aoki, Alberto Jose da Silva Duarte, Maria Notomi Sato
Summary: This study evaluated the characteristics of T lymphocytes in COVID-19 patients and found that patients with severe/critical conditions express more activation markers and the immunological checkpoint protein PD-1. In addition, the increased cytotoxicity of CD4+ T cells may compensate for the exhaustion of CD8+ T cells. These findings contribute to our understanding of the interplay of T cells in the severity of acute COVID-19 infection.
Article
Biochemistry & Molecular Biology
Milena M. de Souza Andrade, Vinicius N. C. Leal, Iara G. Fernandes, Sarah C. Gozzi-Silva, Danielle R. Beserra, Emily A. Oliveira, Franciane M. E. Teixeira, Tatiana M. Yendo, Maria da Gloria T. Sousa, Walcy R. Teodoro, Luana de M. Oliveira, Ricardo W. Alberca, Valeria Aoki, Alberto J. S. Duarte, Maria N. Sato
Summary: The formation of microthrombi in lung autopsies indicates the involvement of NETs in the immunopathogenesis of severe COVID-19. Therefore, using supplements inhibiting NET formation and drugs with fewer adverse effects may be an effective strategy to attenuate the disease. Resveratrol may serve as an adjunctive therapy to decrease neutrophil activation and NET formation, improving patient outcomes.
Article
Biology
Marta Angela Marcondes, Andrezza Nascimento, Rodrigo Pessoa, Jefferson Russo Victor, Alberto Jose da Silva Duarte, Patricia Bianca Clissa, Sabri Saeed Sanabani
Summary: This study describes the bacterial diversity and physicochemical properties in freshwater samples from the surface and bottom layers of the Billings Reservoir in Sao Paulo, Brazil. The results reveal a broad bacterial diversity and their involvement in multiple essential environmental processes.
Article
Virology
Anna Claudia Calvielli Castelo Branco, Emily Araujo De Oliveira, Natalli Zanete Pereira, Ricardo Wesley Alberca, Amaro Nunes Duarte-Neto, Luiz Fernando Ferraz Da Silva, Fernanda Guedes Luiz, Naiura Vieira Pereira, Mirian Nacagami Sotto, Naiara Naiana Dejani, Patricia Helen Carvalho Rondo, Elyzabeth Avvad-Portari, Zilton Farias Meira De Vasconcelos, Alberto Jose da Silva Duarte, Tamiris Azamor, Maria Notomi Sato
Summary: The incidence of obesity is increasing worldwide, particularly in women, and this can affect pregnancy outcomes. During this period, viral infections pose a risk to the mother, placenta, and fetus. The Zika virus outbreak in Brazil has resulted in the congenital Zika syndrome (CZS) and devastating consequences such as microcephaly in newborns. This study examines the impact of maternal overweight/obesity on the expression of antiviral factors in the placental tissue of Zika-infected mothers.
Article
Biochemistry & Molecular Biology
Kelly Cristina Gomes Manfrere, Marina Passos Torrealba, Frederico Moraes Ferreira, Emanuella Sarmento Alho de Sousa, Denis Miyashiro, Franciane Mouradian Emidio Teixeira, Ricardo Wesley Alberca Custodio, Helder I. Nakaya, Yasmin Alefe Leuzzi Ramos, Mirian Nacagami Sotto, Anders Woetmann, Niels odum, Alberto Jose da Silva Duarte, Jose Antonio Sanches, Maria Notomi Sato
Summary: This study investigated the expression levels of inflammatory markers IL-1B and IL-18 in the skin, serum, blood cells, and lymph nodes of patients with Sezary syndrome, as potential markers of inflammasome activation. The findings showed compartmentalized expressions of IL-1B and IL-18, with increased expression of IL-1B in the epidermis and increased expression of IL-18 in the dermis. In advanced stages of the disease, enhanced expression of IL-18 and downregulation of IL-1B were observed in the lymph nodes. This study provided the first evidence of the imbalance of IL-1B and IL-18 in patients with Sezary syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Nicolle Rakanidis Machado, Beatriz Oliveira Fagundes, Iara Grigoletto Fernandes, Daniela Terra De Apoena Reche, Maria Notomi Sato, Jefferson Russo Victor
Summary: The study found that severe COVID-19 patients had lower levels of MAIT cells in their peripheral blood. Experimentally, it was discovered that IgG antibodies from both mild and severe COVID-19 patients had inhibitory effects on the frequency and IFN-γ production of MAIT cells from healthy individuals.
BIOMEDICAL REPORTS
(2023)
Article
Information Science & Library Science
Jefferson Russo Victor
Summary: This article discusses the impact of including early access items in the calculation of Journal Impact Factors (JIF) in the JCR 2020 release. A simplified evaluation was conducted in the field of Immunology to examine the effect of these alterations on JIFs and explore possible reasons for the observed effect, providing evidence for the next JCR release.
JOURNAL OF SCIENTOMETRIC RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Denis Miyashiro, Bruno de Castro e Souza, Marina Passos Torrealba, Kelly Cristina Gomes Manfrere, Maria Notomi Sato, Jose Antonio Sanches
Summary: Sezary syndrome is an aggressive variant of cutaneous T-cell lymphomas, with the progression of the disease being influenced by the tumor microenvironment. The tumor microenvironment is altered by a combination of cytokines, chemokines, and growth factors, and the interaction between malignant and reactive cells affects the immune response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Allergy
T. R. de Sousa, F. Da Ressureicao Sgnotto, B. Oliveira Fagundes, L. Souza Santos, A. J. Da Silva Duarte, J. R. Victor
Summary: Research has shown that IgG from allergic individuals can increase the frequency of specific types of T cells in non-allergic infants and adults, which is important for understanding the development of allergic conditions.
EUROPEAN ANNALS OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Allergy
Thamires Rodrigues de Sousa, Fabio da Ressureicao Sgnotto, Beatriz Oliveira Fagundes, Alberto Jose da Silva Duarte, Jefferson Russo Victor
Summary: The study identified rare ILC2 and ILC3 subsets in the human thymus, showing that purified Derp-At IgG can modulate ILC2 phenotype and regulate IL-13 levels. These findings contribute to a better understanding of human thymic ILCs and their regulatory role in allergy development.
FRONTIERS IN ALLERGY
(2021)