Review
Immunology
Takumi Kawasaki, Moe Ikegawa, Taro Kawai
Summary: The lungs have an immune defense mechanism that uses various cells to eliminate harmful pathogens and activate T cell immune response. In addition to immune cells, other lung cells also participate in antigen presentation and T cell activation.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Stefan Schuelke, Stefanie Gilles, Adan C. Jirmo, Johannes U. Mayer
Summary: Antigen-presenting cells (APCs) play a critical role in bridging innate and adaptive immune responses by presenting antigens to T cells. In allergies, APCs drive immune responses against harmless antigens. Different types of APCs contribute differently to tissue-specific immune tolerance, allergen sensitization, and allergic inflammation.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Oncology
Mirela Kremenovic, Alfred A. Chan, Bing Feng, Lukas Baeriswyl, Steve Robatel, Thomas Gruber, Li Tang, Delphine J. Lee, Mirjam Schenk
Summary: In this study, a novel BCG lysate was developed and formulated into a thermosensitive hydrogel. The BCG lysate exhibited enhanced antitumor efficacy and promoted a proinflammatory tumor microenvironment in vivo. The underlying mechanisms of BCG lysate-mediated tumor immunity relied on macrophages (M phi) and dendritic cells (DCs). The BCG hydrogel treatment induced systemic immunity, suppressed lung metastases, and improved survival in melanoma-bearing mice. Furthermore, BCG hydrogel treatment enhanced antigen processing and presentation, and increased the frequency of melanoma-reactive CD8(+) T cells. In human melanoma patients, intralesional-BCG treatment was associated with enhanced M1 M phi, mature DCs, antigen processing and presentation, and increased patient survival.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Cell Biology
Bastien Dolfi, Alexandre Gallerand, Maria M. Firulyova, Yingzheng Xu, Johanna Merlin, Adelie Dumont, Alexia Castiglione, Nathalie Vaillant, Sandrine Quemener, Heidi Gerke, Marion I. Stunault, Patricia R. Schrank, Seung-Hyeon Kim, Alisha Zhu, Jie Ding, Jerome Gilleron, Virginie Magnone, Pascal Barbry, David Dombrowicz, Christophe Duranton, Abdelilah Wakkach, Claudine Blin-Wakkach, Burkhard Becher, Sophie Pagnotta, Rafael J. Arguello, Pia Rantakari, Svetoslav Chakarov, Florent Ginhoux, Konstantin Zaitsev, Ki-Wook Kim, Laurent Yvan-Charvet, Rodolphe R. Guinamard, Jesse W. Williams, Stoyan Ivanov
Summary: This study reveals the diversity, origin, and function of adrenal gland macrophages using single-cell RNA sequencing and genetic models. The study identifies monocyte-derived and embryonically seeded adrenal gland macrophage populations, as well as a subset of macrophages in females with low MHC II expression. The distribution and functions of adrenal gland macrophages show sex-dimorphic patterns, with MHC IIlow macrophages located at the cortico-medullary junction. Depletion of adrenal gland macrophages leads to altered tissue homeostasis, modulated lipid metabolism, and decreased local aldosterone production during stress exposure.
Article
Oncology
Carmen Aguilar-Gurrieri, Ana Barajas, Carla Rovirosa, Raquel Ortiz, Victor Urrea, Nuria de la Iglesia, Bonaventura Clotet, Julia Blanco, Jorge Carrillo
Summary: Neoantigens are tumor-specific antigens that can elicit a specific immune response. They have potential for the development of personalized cancer vaccines. The presentation of neoantigens to T cells is influenced by vaccine delivery strategies, including the use of specific linkers. The efficiency of neoantigen processing and presentation by MHC-I molecules can be improved with alanine-based linkers.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Review
Immunology
Ray A. Ohara, Kenneth M. Murphy
Summary: Cross-priming, initially recognized in cytotoxic T lymphocyte (CTL) responses, involves the presentation of minor histocompatibility antigens by antigen presenting cells (APCs) derived from immunizing cells. As understanding of T cell receptor antigen recognition progressed, cross-priming was redefined as cross-presentation and expanded to include different forms of antigens and APCs not involved in in vivo CTL priming. In vitro cell models have been utilized for studying cross-presentation, but recent studies have shown differences between these models and in vivo APCs. Current research focuses on validating in vivo pathways and gene candidates for cross-presentation, and evaluating their contributions to CTL responses across different antigens and immunologic settings.
SEMINARS IN IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Marta Canel, Aleksandra Dominika Slawinska, David W. Lonergan, Ashwin Adrian Kallor, Rosie Upstill-Goddard, Catherine Davidson, Alex von Kriegsheim, Andrew Biankin, Adam Byron, Javier Alfaro, Alan Serrels
Summary: In this study, the authors found that focal adhesion kinase (FAK) has an immunoregulatory function in pancreatic ductal adenocarcinoma (PDAC) by promoting the expression of immunoproteasome and MHC-I, leading to increased antigen diversity and antigen presentation. Co-depletion of FAK and STAT3 can further enhance this immune response and inhibit tumor growth. This finding suggests that therapies targeting FAK degradation may provide additional therapeutic benefits for PDAC treatment.
Article
Cell Biology
Jinyu Wang, Michela Manni, Anne Baerenwaldt, Ronja Wieboldt, Nicole Kirchhammer, Robert Ivanek, Michal Stanczak, Alfred Zippelius, David Koenig, Natalia Rodrigues Manutano, Heinz Laeubli
Summary: Interactions between sialylated glycans and Siglec receptors have been identified as a potential new immune checkpoint to improve anticancer immunity. In this study, it was found that cancer-associated dendritic cells (DCs) have a high expression of inhibitory Siglecs, which can impair their maturation states. Furthermore, removing these inhibitory Siglecs from DCs enhances their capability to prime antigen-specific T cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Immunology
Jiri Brezina, Matous Voboril, Dominik Filipp
Summary: The evolution of the adaptive immune system leads to the generation of self-reactive clones, which must be eliminated to prevent autoimmunity. This process occurs in the thymic medulla, where the interaction between T cell receptor and self-peptide MHC complexes determines the fate of thymocytes. Thymic antigen presenting cells, including medullary thymic epithelial cells and dendritic cells, play a fundamental role in presenting self-antigens in the thymus for the establishment of T cell central tolerance. Recent studies have revealed the heterogeneity of these cell subsets and their roles in T cell selection processes, adding complexity to our understanding. Identification of molecular determinants controlling the presentation of self-antigens would advance our knowledge in this area.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Ryosuke Tashiro, Kuniyasu Niizuma, Jun Kasamatsu, Yuko Okuyama, Sherif Rashad, Atsuo Kikuchi, Miki Fujimura, Shigeo Kure, Naoto Ishii, Teiji Tominaga
Summary: The study found that RNF213 plays a critical role in antigen uptake, processing, and presentation, with Rnf213-KO and Rnf213-KI mice experiments showing that RNF213 deficiency leads to decreased antigen uptake and processing capabilities, resulting in the inability to effectively activate antigen-specific T cells.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Immunology
Andrea Kristina Horst, Kingsley Gideon Kumashie, Katrin Neumann, Linda Diehl, Gisa Tiegs
Summary: The liver is a crucial immunological organ responsible for maintaining immune balance through interactions between different cells within the liver. Disruption of this balance in response to pathogens or autoantigens may lead to autoimmune liver diseases.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Immunology
Kavita Rawat, Anita Tewari, Xin Li, Arlind B. B. Mara, William T. T. King, Sophie L. L. Gibbings, Chinaza F. F. Nnam, Fred W. W. Kolling, Bart N. N. Lambrecht, Claudia V. V. Jakubzick
Summary: Dendritic cells and monocytes capture, transport, and present antigen to cognate T cells in the draining lymph nodes in a CCR7-dependent manner. It is unclear how monocytes reach the lymph nodes since only migratory dendritic cells express this chemokine receptor.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Anna Alwani, Aneta Andreasik, Rafal Szatanek, Maciej Siedlar, Monika Baj-Krzyworzeka
Summary: Monocytes, as a type of blood cells, serve as a link between innate and adaptive immunity, being both precursors of macrophages and effector cells like phagocytes or cytotoxic cells. At the tumor site, monocytes/macrophages are important indicators for cancer recovery. The role of small regulatory miRNA in monocyte formation, maturation, and function is crucial.
Review
Cell Biology
Irina A. Ishina, Maria Y. Zakharova, Inna N. Kurbatskaia, Azad E. Mamedov, Alexey A. A. Belogurov Jr, Alexander G. G. Gabibov
Summary: Antigen presentation by MHC-II is crucial for immune response and self-antigen tolerance. Certain MHC-II alleles are associated with autoimmune diseases. The process of MHC-II-mediated presentation plays a significant role in understanding the mechanisms of autoimmune diseases and the protective effect of certain MHC-II alleles.
Biographical-Item
Biochemistry & Molecular Biology
Anne Hosmalin, Benedicte Manoury
Summary: This Special Issue is dedicated to the 10th Antigen Processing and Presentation Workshop, featuring reviews and original articles from contributors to the workshop. It also serves as a heartfelt tribute to Nilabh Shastri, the founder of the APP Workshops, who sadly passed away in 2021 and is greatly missed by his colleagues and friends.
MOLECULAR IMMUNOLOGY
(2022)