Review
Biochemistry & Molecular Biology
Iason Psilopatis, Eleni Souferi-Chronopoulou, Kleio Vrettou, Constantinos Troungos, Stamatios Theocharis
Summary: EPHs/ephrins appear to be promising treatment targets in the future for breast cancer, with EPHA2 being the most studied target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Junhao Lin, Chunting Zeng, JiaKang Zhang, Zhenghui Song, Na Qi, Xinhui Liu, Ziyan Zhang, Aimin Li, Fengsheng Chen
Summary: EFNA4 plays a crucial role in promoting proliferation and migration of HCC cells, and its overexpression is associated with poor prognosis. EFNA4 regulates the PIK3R2/GSK3 beta/beta-catenin loop to influence the survival and migration of HCC cells.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Review
Biochemistry & Molecular Biology
Radoslaw Kaczmarek, Katarzyna Zimmer, Pawel Gajdzis, Malgorzata Gajdzis
Summary: The cornea, though simple in appearance, is a highly complex structure that requires perfect organization of cells for maintaining its biomechanical and optical properties. Eph receptors and ephrins play a crucial role in tissue organization, cell migration, and communication, particularly in the regeneration process following injuries and diseases. This review examines the current understanding of Eph and ephrins in corneal physiology and diseases, with a focus on the epithelium and endothelium, as well as their influence on corneal neovascularization.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Iason Psilopatis, Ioannis Karniadakis, Konstantinos Stylianos Danos, Kleio Vrettou, Kleita Michaelidou, Konstantinos Mavridis, Sofia Agelaki, Stamatios Theocharis
Summary: Lung cancer is the leading cause of cancer death in the United States. Erythropoietin-producing hepatocellular receptors (EPHs) and their ligands ephrins play a defining role in the development and progression of lung cancer. Targeting EPHs/ephrins may provide effective treatment options for precision cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Sho Kohara, Kazushige Ogawa
Summary: Kupffer cells are maintained through self-renewal within liver sinusoidal endothelial cells (LSECs). In this study, liver macrophages (Mo) were propagated from mice using mixed culture with hepatic fibroblastic cells. The propagated liver Mo expressed specific transcription factors and exhibited similar gene expression and surface markers as primary LSECs, suggesting that their properties resemble those of Kupffer cells. Further investigation revealed the expression of certain Eph receptors and ephrin ligands, as well as integrin subunits and corresponding ligands, potentially contributing to the adhesion and residence of Kupffer cells within the liver sinusoid.
Review
Pharmacology & Pharmacy
Massimiliano Tognolini, Alessio Lodola, Carmine Giorgio
Summary: The recent advancement in computer power and AI algorithms has led to inexperienced scientists attempting to use computer aided drug design to discover new drugs, potentially overshadowing the importance of wet lab data and neglecting the synergy between in silico and biological data in successful drug discovery.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Review
Cell Biology
Lujuan Wang, Wei Li, Yong Pan
Summary: The Eph/Ephrins system plays a dual role in both suppressing and promoting tumors in primary bone tumors and bone cancer pain. Understanding the intracellular mechanisms of the Eph/Ephrins system in tumorigenesis and metastasis of bone tumors may provide a foundation for the development of targeted anti-cancer therapy.
Article
Biology
Wenqing Li, Lai Wen, Bhavisha Rathod, Anne-Claude Gingras, Klaus Ley, Ho-Sup Lee
Summary: This study reveals that kindlin2 can mediate bi-directional ephrinB signaling through binding to a conserved NIYY motif in the ephrinB2 cytoplasmic tail. The interaction is important for EphB/ephrinB-mediated integrin activation in mammalian cells and blood vessel morphogenesis in zebrafish development.
LIFE SCIENCE ALLIANCE
(2022)
Article
Cell Biology
Michael P. Vu, Catherine Cheng
Summary: The eye lens plays a crucial role in focusing light onto the retina, while cataracts are a major cause of blindness worldwide. Recent studies have shown the importance of Eph-ephrin bidirectional signaling in maintaining lens transparency. This study investigated the expression of Eph receptors and ephrin ligands in different cell fractions of the lens, revealing the presence of multiple receptor-ligand pairs that may contribute to lens homeostasis.
Article
Pharmacology & Pharmacy
Peishan Qiu, Daojiang Li, Cong Xiao, Fei Xu, Xiaoyu Chen, Ying Chang, Lan Liu, Lei Zhang, Qiu Zhao, Yuhua Chen
Summary: The extent of gut inflammation depends on the gut barrier's integrity and enteric neuroimmune interactions. The role of Eph/ephrin signaling in regulating gut homeostasis, inflammation, neuroimmune interactions, and pain pathways is critical. Targeting the Eph/ephrin system provides innovative treatments for gut inflammation disorders.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Alessandra Cecchini, D. D. W. Cornelison
Summary: Intracellular signal transduction is a linear process involving interactions between membrane-associated proteins. The Eph/ephrin family is a group of molecules that regulate cell activities through lateral interactions at the cell surface. The response to Eph/ephrin interaction varies greatly between cell types and is dependent on the cellular context.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Review
Oncology
Stavros P. Papadakos, Ioanna E. Stergiou, Nikolina Gkolemi, Konstantinos Arvanitakis, Stamatios Theocharis
Summary: This narrative literature review focuses on the role of EPH/ephrin signaling in liver cancer and its implications for tumor progression and potential therapeutic strategies. It highlights the upregulation of HIF-1α in HCC cells under low oxygen conditions and explores the significance of the EPH/ephrin axis in regulating the hypoxic tumor microenvironment. The review also emphasizes the potential of targeting the EPH/ephrin signaling pathway in liver cancer treatment.
Review
Reproductive Biology
Enoch Appiah Adu-Gyamfi, Armin Czika, Tai-Hang Liu, Philip Narteh Gorleku, Linda Ahenkorah Fondjo, Francis Tanam Djankpa, Yu-Bin Ding, Ying-Xiong Wang
Summary: Ephrins and Eph receptors play important roles in the female reproductive system, regulating various processes and being associated with obstetric and gynecologic disorders.
BIOLOGY OF REPRODUCTION
(2021)
Article
Chemistry, Medicinal
Maricel Gomez-Soler, Erika J. Olson, Elena Rubio de la Torre, Chunxia Zhao, Ilaria Lamberto, Dillon T. Flood, Waleed Danho, Bernhard C. Lechtenberg, Stefan J. Riedl, Elena B. Pasquale, Philip E. Dawson
Summary: The EphA4 receptor tyrosine kinase is involved in several diseases and inhibiting its activity could have therapeutic potential. Researchers have identified a peptide antagonist that specifically inhibits the binding of ephrin ligands to EphA4. They have also modified the peptide to improve its stability and activity. These derivatives could be useful for studying EphA4 in vivo and for testing EphA4 inhibition in animal models.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Minjie Li, Zhongyuan Tang, Chengfei Zhang, Lijian Jin, Koichi Matsuo, Yanqi Yang
Summary: Simultaneous stimulation by LPS and CF significantly suppresses EphB4 expression and enhances ephrinA2 expression. This stimulation also intensifies osteoclastic differentiation, while sequential exposure to LPS and CF only slightly increases osteoclastic cell numbers.
Review
Medicine, General & Internal
David Alfaro, Mariano R. Rodriguez-Sosa, Agustin G. Zapata
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Biotechnology & Applied Microbiology
Miguel Angel Rodriguez-Milla, Alvaro Morales-Molina, Ana Judith Perise-Barrios, Teresa Cejalvo, Javier Garcia-Castro
Summary: The study found that ICOCAV17 induces a more limited host response in canine MSCs, which may be related to a better clinical outcome; Infection of human MSCs with ICOVIR-5 increased the phosphorylation of a number of proteins, including AKT and c-JUN.
CANCER GENE THERAPY
(2021)
Article
Hematology
Sara Fananas-Baquero, Israel Orman, Federico Becerra Aparicio, Silvia Bermudez de Miguel, Jordi Garcia Merino, Rosa Yanez, Yolanda Fernandez Sainz, Rebeca Sanchez, Mercedes Dessy-Rodriguez, Omaira Alberquilla, David Alfaro, Agustin Zapata, Juan A. Bueren, Jose Carlos Segovia, Oscar Quintana-Bustamante
Summary: This study found that natural estrogens E2 and E4 can expand human hematopoietic stem and progenitor cells, with E4 being the most tolerated estrogen that promotes cycling of human hematopoietic progenitors. Additionally, E2 and E4 can double human hematopoietic engraftment in immunodeficient mice without altering other HSPC properties, potentially mediated through the regulation of mesenchymal stromal cells in the bone marrow niche.
Article
Anatomy & Morphology
Javier Garcia-Ceca, Sara Montero-Herradon, Agustin G. Zapata
DEVELOPMENTAL DYNAMICS
(2020)
Article
Oncology
Ana Gomez, David Sardon, Teresa Cejalvo, Fernando Vazquez, Javier Garcia-Castro, Ana Judith Perise-Barrios
MOLECULAR THERAPY-ONCOLYTICS
(2020)
Article
Oncology
Berta Segura-Collar, Maria Garranzo-Asensio, Beatriz Herranz, Esther Hernandez-SanMiguel, Teresa Cejalvo, Barbara S. Casas, Ander Matheu, Angel Perez-Nunez, Juan Manuel Sepulveda-Sanchez, Aurelio Hernandez-Lain, Veronica Palma, Ricardo Gargini, Pilar Sanchez-Gomez
Summary: This study identifies the EGFR-related mechanisms that govern the capacity of glioma cells to transdifferentiate into pericytes, regulating the vascular and immune phenotypes of the tumors.
Editorial Material
Immunology
Sara Montero-Herradon, Javier Garcia-Ceca, Agustin G. Zapata
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
David Garcia-Bernal, Mariano Garcia-Arranz, Rosa M. Yanez, Rosario Hervas-Salcedo, Alfonso Cortes, Maria Fernandez-Garcia, Miriam Hernando-Rodriguez, Oscar Quintana-Bustamante, Juan A. Bueren, Damian Garcia-Olmo, Jose M. Moraleda, Jose C. Segovia, Agustin G. Zapata
Summary: MSCs are widely used in advanced therapies for various purposes, mainly related to inflammatory processes. Despite their demonstrated efficacy in preclinical models and early clinical trials, there are still controversies regarding their specific phenotype, delivery methods, and varied cell products. Strategies for bioengineering MSCs are being explored to enhance their properties and functional capabilities.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Hematology
Lidia M. Fernandez-Sevilla, Jaris Valencia, Paula Ortiz-Sanchez, Alberto Fraile-Ramos, Pilar Zuluaga, Eva Jimenez, Rosa Sacedon, Maria V. Martinez-Sanchez, Janez Jazbec, Marusa Debeljak, Birthe Fedders, Martin Stanulla, Denis Schewe, Gunnar Cario, Alfredo Minguela, Manuel Ramrez, Alberto Varas, Angeles Vicente
Summary: A retrospective study found that BMP4 expression levels in leukemic cells could serve as a new biomarker for prognosis in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL). High BMP4 expression was associated with higher relapse rates and worse survival outcomes. Furthermore, BMP4 may be a potential therapeutic target for blocking leukemic central nervous system disease.
Article
Immunology
Silvia Sevilla-Movilla, Patricia Fuentes, Yaiza Rodriguez-Garcia, Nohemi Arellano-Sanchez, Peter W. Krenn, Soledad Isern de Val, Sara Montero-Herradon, Javier Garcia-Ceca, Valeria Burdiel-Herencia, Sofia R. Gardeta, Noemi Aguilera-Montilla, Celia Barrio-Alonso, Georgiana Crainiciuc, Daniel Bouvard, Angeles Garcia-Pardo, Agustin G. Zapata, Andres Hidalgo, Reinhard Fassler, Yolanda R. Carrasco, Maria L. Toribio, Joaquin Teixido
Summary: ICAP-1 plays an important role in the development of SP CD8(+) thymocytes and the control of marginal zone B-cell numbers.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Javier Garcia-Ceca, Sara Montero-Herradon, Ana Gonzalez, Rosa Plaza, Agustin G. Zapata
Summary: The lack of EphA4 alters T-cell differentiation and the histological organization of the thymus, impacting various T cell subsets as well as the proportions of thymocytes selected positively and negatively.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Letter
Dermatology
Rosa Sacedon, M. Carmen de Arriba, Lucia Martinez-Santamaria, Rocio Maseda, Sara Herraiz-Gil, Eva Jimenez, Isabel Rosales, Lucia Quintana, Nuria Illera, Marta Garcia, Nora Butta, Ihosvany Fernandez-Bello, Su M. Lwin, Miguel Fernandez-Arquero, Carlos Leon, John A. Mcgrath, M. Angeles Vicente, Marcela del Rio, Raul de Lucas, Silvia Sanchez-Ramon, Maria Jose Escamez
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Oncology
Teresa Cejalvo, Ricardo Gargini, Berta Segura-Collar, Pablo Mata-Martinez, Beatriz Herranz, Diana Cantero, Yolanda Ruano, Daniel Garcia-Perez, Angel Perez-Nunez, Ana Ramos, Aurelio Hernandez-Lain, Maria Cruz Martin-Soberon, Pilar Sanchez-Gomez, Juan M. Sepulveda-Sanchez