Maturation of the enteric mucosal innate immune system during the postnatal period

Gut Dysbiosis Promotes M2 Macrophage Polarization and Allergic Airway Inflammation via Fungi-Induced PGE2

(2014) Yun-Gi Kim et al.   Cell Host & Microbe

The gut microbiota and the metabolic health of the host

(2014) Susan A. Joyce et al.   CURRENT OPINION IN GASTROENTEROLOGY

Oral Tolerance Can Be Established via Gap Junction Transfer of Fed Antigens from CX3CR1+ Macrophages to CD103+ Dendritic Cells

(2014) Elisa Mazzini et al.   IMMUNITY

Toll-like Receptor 4-mediated Endoplasmic Reticulum Stress in Intestinal Crypts Induces Necrotizing Enterocolitis

(2014) Amin Afrazi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reciprocal Expression and Signaling of TLR4 and TLR9 in the Pathogenesis and Treatment of Necrotizing Enterocolitis

(2014) S. C. Gribar et al.   JOURNAL OF IMMUNOLOGY

Maturation of Paneth Cells Induces the Refractory State of Newborn Mice to Shigella Infection

(2014) M.-I. Fernandez et al.   JOURNAL OF IMMUNOLOGY

Enterocyte-Derived TAK1 Signaling Prevents Epithelium Apoptosis and the Development of Ileitis and Colitis

(2014) R. Kajino-Sakamoto et al.   JOURNAL OF IMMUNOLOGY

Loss of Epithelial RelA Results in Deregulated Intestinal Proliferative/Apoptotic Homeostasis and Susceptibility to Inflammation

(2014) K. A. Steinbrecher et al.   JOURNAL OF IMMUNOLOGY

Interleukin-13-Mediated Paneth Cell Degranulation and Antimicrobial Peptide Release

(2014) Silvia Stockinger et al.   Journal of Innate Immunity

Paneth Cells: Maestros of the Small Intestinal Crypts

(2013) Hans C. Clevers et al.   Annual Review of Physiology

Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders

(2013) Elaine Y. Hsiao et al.   CELL

The Intestinal Crypt, A Prototype Stem Cell Compartment

(2013) Hans Clevers   CELL

Intestinal Epithelial Autophagy Is Essential for Host Defense against Invasive Bacteria

(2013) Jamaal L. Benjamin et al.   Cell Host & Microbe

Innate and Adaptive Immunity Interact to Quench Microbiome Flagellar Motility in the Gut

(2013) Tyler C. Cullender et al.   Cell Host & Microbe

Cryptosporidium Pathogenicity and Virulence

(2013) Maha Bouzid et al.   CLINICAL MICROBIOLOGY REVIEWS

The intestinal microbiome and necrotizing enterocolitis

(2013) Erica M. Carlisle et al.   CURRENT OPINION IN PEDIATRICS

Dendritic cell subsets in the intestinal lamina propria: Ontogeny and function

(2013) Emma K. Persson et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis

(2013) Malin E V Johansson et al.   GUT

Altered Innate Defenses in the Neonatal Gastrointestinal Tract in Response to Colonization by Neuropathogenic Escherichia coli

(2013) George M. H. Birchenough et al.   INFECTION AND IMMUNITY

Murine Neonates Infected with Yersinia enterocolitica Develop Rapid and Robust Proinflammatory Responses in Intestinal Lymphoid Tissues

(2013) David T. Siefker et al.   INFECTION AND IMMUNITY

Early Life Stress Triggers Persistent Colonic Barrier Dysfunction and Exacerbates Colitis in Adult IL-10−/− Mice

(2013) E. M. Lennon et al.   INFLAMMATORY BOWEL DISEASES

Soluble Ecto-5′-nucleotidase (5′-NT), Alkaline Phosphatase, and Adenosine Deaminase (ADA1) Activities in Neonatal Blood Favor Elevated Extracellular Adenosine

(2013) Matthew Pettengill et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Critical Role for TLR4 Induction of Autophagy in the Regulation of Enterocyte Migration and the Pathogenesis of Necrotizing Enterocolitis

(2013) M. D. Neal et al.   JOURNAL OF IMMUNOLOGY

Poly(I:C)-Induced Protection of Neonatal Mice Against Intestinal Cryptosporidium parvum Infection Requires an Additional TLR5 Signal Provided by the Gut Flora

(2013) Louis Lantier et al.   JOURNAL OF INFECTIOUS DISEASES

Oxidative Stress and Antioxidant Enzyme Activities in Newborns with Oesophageal Atresia and Their Mothers

(2013) M Melek et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Immunosuppressive CD71+ erythroid cells compromise neonatal host defence against infection

(2013) Shokrollah Elahi et al.   NATURE

Microbial colonization influences early B-lineage development in the gut lamina propria

(2013) Duane R. Wesemann et al.   NATURE

Human gut microbiota alleviate behavioural symptoms in a mouse model of autism spectrum disorder

(2013) Hemi Malkki   Nature Reviews Neurology

Exposure of Bifidobacterium longum subsp. infantis to Milk Oligosaccharides Increases Adhesion to Epithelial Cells and Induces a Substantial Transcriptional Response

(2013) Devon W. Kavanaugh et al.   PLoS One

Mathematical modeling of primary succession of murine intestinal microbiota

(2013) S. Marino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endothelial TLR4 activation impairs intestinal microcirculatory perfusion in necrotizing enterocolitis via eNOS–NO–nitrite signaling

(2013) Ibrahim Yazji et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microbiome Assembly across Multiple Body Sites in Low-Birthweight Infants

(2013) E. K. Costello et al.   mBio

Intestinal CD103+ Dendritic Cells Are Key Players in the Innate Immune Control of Cryptosporidium parvum Infection in Neonatal Mice

(2013) Louis Lantier et al.   PLoS Pathogens

The intestinal epithelium tuft cells: specification and function

(2012) François Gerbe et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Development and function of intestinal innate lymphoid cells

(2012) M Cherrier et al.   CURRENT OPINION IN IMMUNOLOGY

Early life antibiotic-driven changes in microbiota enhance susceptibility to allergic asthma

(2012) Shannon L Russell et al.   EMBO REPORTS

Development of Interleukin-17-Producing γδ T Cells Is Restricted to a Functional Embryonic Wave

(2012) Jan D. Haas et al.   IMMUNITY

Innate Immune Function by Toll-like Receptors: Distinct Responses in Newborns and the Elderly

(2012) Tobias R. Kollmann et al.   IMMUNITY

Can Nutritional Modulation of Maternal Intestinal Microbiota Influence the Development of the Infant Gastrointestinal Tract?

(2012) Caroline Thum et al.   JOURNAL OF NUTRITION

Peyer's Patch M Cells Derived from Lgr5+ Stem Cells Require SpiB and Are Induced by RankL in Cultured "Miniguts"

(2012) W. de Lau et al.   MOLECULAR AND CELLULAR BIOLOGY

Targeted deletion of MyD88 in intestinal epithelial cells results in compromised antibacterial immunity associated with downregulation of polymeric immunoglobulin receptor, mucin-2 and antibacterial peptides

(2012) A L Frantz et al.   Mucosal Immunology

Extrathymically generated regulatory T cells control mucosal TH2 inflammation

(2012) Steven Z. Josefowicz et al.   NATURE

The Ets transcription factor Spi-B is essential for the differentiation of intestinal microfold cells

(2012) Takashi Kanaya et al.   NATURE IMMUNOLOGY

Neonatal Plasma Polarizes TLR4-Mediated Cytokine Responses towards Low IL-12p70 and High IL-10 Production via Distinct Factors

(2012) Mirjam E. Belderbos et al.   PLoS One

Amniotic fluid inhibits Toll-like receptor 4 signaling in the fetal and neonatal intestinal epithelium

(2012) M. Good et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The gut endocrine system as a coordinator of postprandial nutrient homoeostasis

(2012) Fiona M. Gribble   PROCEEDINGS OF THE NUTRITION SOCIETY

Human  -Defensin 6 Promotes Mucosal Innate Immunity Through Self-Assembled Peptide Nanonets

(2012) H. Chu et al.   SCIENCE

Microbial Exposure During Early Life Has Persistent Effects on Natural Killer T Cell Function

(2012) T. Olszak et al.   SCIENCE

Bringing balance by force: live cell extrusion controls epithelial cell numbers

(2012) George T. Eisenhoffer et al.   TRENDS IN CELL BIOLOGY

The Early Settlers: Intestinal Microbiology in Early Life

(2012) Petra A.M.J. Scholtens et al.   Annual Review of Food Science and Technology

miR-27b Targets KSRP to Coordinate TLR4-Mediated Epithelial Defense against Cryptosporidium parvum Infection

(2012) Rui Zhou et al.   PLoS Pathogens

Age-Dependent TLR3 Expression of the Intestinal Epithelium Contributes to Rotavirus Susceptibility

(2012) Johanna Pott et al.   PLoS Pathogens

TLR2 polymorphisms influence neonatal regulatory T cells depending on maternal atopy

(2011) J. Liu et al.   ALLERGY

Cord blood Tregs with stable FOXP3 expression are influenced by prenatal environment and associated with atopic dermatitis at the age of one year

(2011) D. Hinz et al.   ALLERGY

Transition from parenteral to enteral nutrition induces immediate diet-dependent gut histological and immunological responses in preterm neonates

(2011) Jayda Siggers et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Denaturing gradient gel electrophoresis of neonatal intestinal microbiota in relation to the development of asthma

(2011) Carl Vael et al.   BMC MICROBIOLOGY

Role of microbiota in postnatal maturation of intestinal T-cell responses

(2011) Valérie Gaboriau-Routhiau et al.   CURRENT OPINION IN GASTROENTEROLOGY

Human foetal intestinal fibroblasts are hyper-responsive to lipopolysaccharide stimulation

(2011) Adora C. Okogbule-Wonodi et al.   DIGESTIVE AND LIVER DISEASE

Intestinal development and differentiation

(2011) Taeko K. Noah et al.   EXPERIMENTAL CELL RESEARCH

Cathelicidin Signaling via the Toll-like Receptor Protects Against Colitis in Mice

(2011) Hon Wai Koon et al.   GASTROENTEROLOGY

Cesarean section and offspringʼs risk of inflammatory bowel disease: A national cohort study

(2011) Peter Bager et al.   INFLAMMATORY BOWEL DISEASES

Host Defense Peptide LL-37 Selectively Reduces Proinflammatory Macrophage Responses

(2011) K. L. Brown et al.   JOURNAL OF IMMUNOLOGY

FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation

(2011) Patrick-Simon Welz et al.   NATURE

Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis

(2011) Claudia Günther et al.   NATURE

Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis

(2011) Charles L. Bevins et al.   NATURE REVIEWS MICROBIOLOGY

Mucin dynamics and enteric pathogens

(2011) Michael A. McGuckin et al.   NATURE REVIEWS MICROBIOLOGY

Exposure to Environmental Microorganisms and Childhood Asthma

(2011) Markus J. Ege et al.   NEW ENGLAND JOURNAL OF MEDICINE

Neonatal maternal separation in male rats increases intestinal permeability and affects behavior after chronic social stress

(2011) E. Øines et al.   PHYSIOLOGY & BEHAVIOR

Oligosaccharide Binding Proteins from Bifidobacterium longum subsp. infantis Reveal a Preference for Host Glycans

(2011) Daniel Garrido et al.   PLoS One

The Mechanism of Excessive Intestinal Inflammation in Necrotizing Enterocolitis: An Immature Innate Immune Response

(2011) Nanda Nanthakumar et al.   PLoS One

Active Transport of Bile Acids Decreases Mucin 2 in Neonatal Ileum: Implications for Development of Necrotizing Enterocolitis

(2011) Nina A. Martin et al.   PLoS One

The transcriptional repressor Blimp1/Prdm1 regulates postnatal reprogramming of intestinal enterocytes

(2011) J. Harper et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial antiviral signaling protein (MAVS) monitors commensal bacteria and induces an immune response that prevents experimental colitis

(2011) X.-D. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

   intraepithelial lymphocytes are essential mediators of host-microbial homeostasis at the intestinal mucosal surface

(2011) A. S. Ismail et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Antibacterial Lectin RegIII  Promotes the Spatial Segregation of Microbiota and Host in the Intestine

(2011) S. Vaishnava et al.   SCIENCE

Necrotizing enterocolitis: An update

(2011) Loren Berman et al.   Seminars in Fetal & Neonatal Medicine

Blimp1 regulates the transition of neonatal to adult intestinal epithelium

(2011) Vanesa Muncan et al.   Nature Communications

Defensins play a crucial role in protecting mice against oral Shigella flexneri infection

(2010) Doo-Hee Shim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Homeostasis and Inflammation in the Intestine

(2010) Wendy S. Garrett et al.   CELL

miR-146a Mediates Protective Innate Immune Tolerance in the Neonate Intestine

(2010) Cécilia Chassin et al.   Cell Host & Microbe

Epithelial-specific blockade of MyD88-dependent pathway causes spontaneous small intestinal inflammation

(2010) Jianfeng Gong et al.   CLINICAL IMMUNOLOGY

Yersinia enterocolitica Promotes Robust Mucosal Inflammatory T-Cell Immunity in Murine Neonates

(2010) A. Echeverry et al.   INFECTION AND IMMUNITY

Neonatal Fc Receptor: From Immunity to Therapeutics

(2010) Timothy T. Kuo et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor–induced toxicity and experimental colitis

(2010) Lars Vereecke et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TGF- -Activated Kinase 1 Signaling Maintains Intestinal Integrity by Preventing Accumulation of Reactive Oxygen Species in the Intestinal Epithelium

(2010) R. Kajino-Sakamoto et al.   JOURNAL OF IMMUNOLOGY

Breast Milk as the Gold Standard for Protective Nutrients

(2010) Allan Walker   JOURNAL OF PEDIATRICS

Cesarean Delivery Is Associated With Celiac Disease but Not Inflammatory Bowel Disease in Children

(2010) E. Decker et al.   PEDIATRICS

Fecal Calprotectin Excretion in Preterm Infants during the Neonatal Period

(2010) Carole Rougé et al.   PLoS One

Cellular and Molecular Mechanisms Underlying the Strong Neonatal IL-12 Response of Lamb Mesenteric Lymph Node Cells to R-848

(2010) Stéphanie Ferret-Bernard et al.   PLoS One

MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands

(2010) K. Brandl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Environmental risk factors in inflammatory bowel diseases. Investigating the hygiene hypothesis: A Spanish case–control study

(2010) Pilar López-Serrano et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Colitis-Associated Variant of TLR2 Causes Impaired Mucosal Repair Because of TFF3 Deficiency

(2009) Daniel K. Podolsky et al.   GASTROENTEROLOGY

Localization of the lipopolysaccharide recognition complex in the human healthy and inflamed premature and adult gut

(2009) Tim G.A.M. Wolfs et al.   INFLAMMATORY BOWEL DISEASES

16S rRNA gene-based analysis of fecal microbiota from preterm infants with and without necrotizing enterocolitis

(2009) Yunwei Wang et al.   ISME Journal

MicroRNA-146a Feedback Inhibits RIG-I-Dependent Type I IFN Production in Macrophages by Targeting TRAF6, IRAK1, and IRAK2

(2009) J. Hou et al.   JOURNAL OF IMMUNOLOGY

Neonatal Innate TLR-Mediated Responses Are Distinct from Those of Adults

(2009) T. R. Kollmann et al.   JOURNAL OF IMMUNOLOGY

Gut endocrine cell development

(2009) Catherine Lee May et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Enteric defensins are essential regulators of intestinal microbial ecology

(2009) Nita H Salzman et al.   NATURE IMMUNOLOGY

Neonatal immunity: faulty T-helpers and the shortcomings of dendritic cells

(2009) Habib Zaghouani et al.   TRENDS IN IMMUNOLOGY

Stem Cells, Self-Renewal, and Differentiation in the Intestinal Epithelium

(2008) Laurens G. van der Flier et al.   Annual Review of Physiology

Regional variations in Paneth cell antimicrobial peptide expression along the mouse intestinal tract

(2008) Jenny Karlsson et al.   BMC IMMUNOLOGY

Caesarean delivery and risk of atopy and allergic disesase: meta-analyses

(2008) P. Bager et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Toll-Like Receptor Signaling in Small Intestinal Epithelium Promotes B-Cell Recruitment and IgA Production in Lamina Propria

(2008) Limin Shang et al.   GASTROENTEROLOGY

Secreted enteric antimicrobial activity localises to the mucus surface layer

(2008) U Meyer-Hoffert et al.   GUT

The immediate environment during postnatal development has long-term impact on gut community structure in pigs

(2008) Claire L Thompson et al.   ISME Journal

Delayed maturation of an IL-12–producing dendritic cell subset explains the early Th2 bias in neonatal immunity

(2008) Hyun-Hee Lee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Developmental switch of intestinal antimicrobial peptide expression

(2008) Sandrine Ménard et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface

(2008) S. Vaishnava et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA