Molecular control of Tfh-cell differentiation by Roquin family proteins

ICOS Controls the Pool Size of Effector-Memory and Regulatory T Cells

(2014) Y. Burmeister et al.   JOURNAL OF IMMUNOLOGY

Heterozygosity for Roquinsan leads to angioimmunoblastic T-cell lymphoma-like tumors in mice

(2012) J. I. Ellyard et al.   BLOOD

The RNA-binding E3 ubiquitin ligase MEX-3C links ubiquitination with MHC-I mRNA degradation

(2012) Florencia Cano et al.   EMBO JOURNAL

Interferon-γ Excess Leads to Pathogenic Accumulation of Follicular Helper T Cells and Germinal Centers

(2012) Sau K. Lee et al.   IMMUNITY

Breakdown in Repression of IFN-  mRNA Leads to Accumulation of Self-Reactive Effector CD8+ T Cells

(2012) P.-P. Chang et al.   JOURNAL OF IMMUNOLOGY

Eri1 degrades the stem-loop of oligouridylated histone mRNAs to induce replication-dependent decay

(2012) Kai P Hoefig et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Transcription factor IRF4 determines germinal center formation through follicular T-helper cell differentiation

(2012) N. Bollig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-Islet Autoantibodies Trigger Autoimmune Diabetes in the Presence of an Increased Frequency of Islet-Reactive CD4 T Cells

(2011) D. G. Silva et al.   DIABETES

Early Th1 Cell Differentiation Is Marked by a Tfh Cell-like Transition

(2011) Shingo Nakayamada et al.   IMMUNITY

ICOS Receptor Instructs T Follicular Helper Cell versus Effector Cell Differentiation via Induction of the Transcriptional Repressor Bcl6

(2011) Youn Soo Choi et al.   IMMUNITY

Functional and Epigenetic Studies Reveal Multistep Differentiation and Plasticity of In Vitro-Generated and In Vivo-Derived Follicular T Helper Cells

(2011) Kristina T. Lu et al.   IMMUNITY

NF-κB–inducing kinase plays an essential T cell–intrinsic role in graft-versus-host disease and lethal autoimmunity in mice

(2011) Susan E. Murray et al.   JOURNAL OF CLINICAL INVESTIGATION

Loss of Roquin induces early death and immune deregulation but not autoimmunity

(2011) Arianna Bertossi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Abrogation of CD30 and OX40 signals prevents autoimmune disease in FoxP3-deficient mice

(2011) Fabrina M.Gaspal et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Selective Upregulation of microRNA Expression in Peripheral Blood Leukocytes in IL-10-/- Mice Precedes Expression in the Colon

(2011) J. S. Schaefer et al.   JOURNAL OF IMMUNOLOGY

OX40 Complexes with Phosphoinositide 3-Kinase and Protein Kinase B (PKB) To Augment TCR-Dependent PKB Signaling

(2011) T. So et al.   JOURNAL OF IMMUNOLOGY

Control of Immunity by the TNFR-Related Molecule OX40 (CD134)

(2010) Michael Croft   Annual Review of Immunology

Regulation of CD4 T cell activation and effector function by inducible costimulator (ICOS)

(2010) Tyler R Simpson et al.   CURRENT OPINION IN IMMUNOLOGY

The ROQUIN family of proteins localizes to stress granules via the ROQ domain and binds target mRNAs

(2010) Vicki Athanasopoulos et al.   FEBS Journal

Phosphoinositide 3-Kinase Activity in T Cells Regulates the Magnitude of the Germinal Center Reaction

(2010) J. Rolf et al.   JOURNAL OF IMMUNOLOGY

Germinal Center T Follicular Helper Cell IL-4 Production Is Dependent on Signaling Lymphocytic Activation Molecule Receptor (CD150)

(2010) I. Yusuf et al.   JOURNAL OF IMMUNOLOGY

Roquin binds inducible costimulator mRNA and effectors of mRNA decay to induce microRNA-independent post-transcriptional repression

(2010) Elke Glasmacher et al.   NATURE IMMUNOLOGY

Roquin Differentiates the Specialized Functions of Duplicated T Cell Costimulatory Receptor Genes Cd28 and Icos

(2009) Michelle A. Linterman et al.   IMMUNITY

Analysis of Interleukin-21-Induced Prdm1 Gene Regulation Reveals Functional Cooperation of STAT3 and IRF4 Transcription Factors

(2009) Hyokjoon Kwon et al.   IMMUNITY

Follicular helper T cells are required for systemic autoimmunity

(2009) Michelle A. Linterman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control TH2 responses

(2009) Ye Zheng et al.   NATURE

Inducible costimulator promotes helper T-cell differentiation through phosphoinositide 3-kinase

(2009) M. Gigoux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'

(2008) T. E. Mullen et al.   GENES & DEVELOPMENT

IRF-4-Binding Protein Inhibits Interleukin-17 and Interleukin-21 Production by Controlling the Activity of IRF-4 Transcription Factor

(2008) Qinzhong Chen et al.   IMMUNITY

The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells

(2008) Aurelie T Bauquet et al.   NATURE IMMUNOLOGY