Article
Multidisciplinary Sciences
Zhongshun Liu, Congwei Jiang, Zhangmengxue Lei, Sihan Dong, Linlin Kuang, Chenxu Huang, Ying Gao, Mu Liu, Hui Xiao, Patrick Legembre, Jae U. Jung, Huaping Liang, Xiaozhen Liang
Summary: Type I interferons (IFNs) are the first line of defense against invading pathogens. This study identified a previously unknown protein, PINLYP, that interacts with TBK1 to induce the production of type I IFN. Loss of PINLYP impaired the activation of IRF3 and the production of IFN induced by various viruses and Toll-like receptor ligands. Mice lacking PINLYP were more susceptible to lethal virus infection, highlighting the importance of PINLYP in the host defense against viral infections.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Immunology
Joseph K. Sampson Duncan, Danyang Xu, Maria Licursi, Michael A. Joyce, Holly A. Saffran, Kaiwen Liu, Jin Gohda, D. Lorne Tyrrell, Yasushi Kawaguchi, Kensuke Hirasawa
Summary: Interferon regulatory factors (IRFs) play important roles in regulating the antiviral response against human coronaviruses. Activation of IRF1, IRF3, and IRF7 is observed during infection with different strains of coronaviruses. Knockdown and overexpression experiments demonstrate that IRF1 and IRF3 have antiviral properties against OC43, while IRF3 and IRF7 are effective in restricting 229E infection. Our study highlights the potential of IRFs as antiviral regulators against human coronavirus infection.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Mi He, Bhavesh Soni, Petra C. Schwalie, Tamara Huesser, Caroline Waltzinger, Duvini De Silva, Ylva Prinz, Laura Kruempelmann, Samuele Calabro, Ines Matos, Christine Trumpfheller, Marina Bacac, Pablo Umana, Mitchell P. Levesque, Reinhard Dummer, Maries van den Broek, Stephan Gasser
Summary: TL8-506 in combination with IFN-γ or Poly(I:C) can activate human tumor-associated dendritic cells (DCs), inducing the expression of chemokines and cytokines, and enhancing the immunostimulatory capacity of DCs. This finding provides new insights for the research and development of cancer immunotherapies.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Fisheries
Sylvie M. A. Quiniou, Jonathan Crider, Kristianna L. Felch, Eva Bengten, Pierre Boudinot
Summary: In this study, we identified the complete repertoire of IFNs and IFN receptor genes in channel catfish. We found 16 type I IFN genes representing six previously defined subgroups, as well as two type II IFN genes and their respective receptors. Our findings provide a comprehensive resource for future research on the innate antiviral immunity of channel catfish.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Immunology
Yu-Qing Lu, Jing Wu, Xiang-Ji Wu, Hui Ma, Yan-Xiu Ma, Rong Zhang, Meng-Nan Su, Nan Wu, Gong-Yin Chen, Hong-Song Chen, Xiao-Ben Pan
Summary: Research shows that IFI16 plays a role in sensing HBV infection and early changes in IFI16 mRNA in PBMCs can predict HBeAg seroconversion. Additionally, interferons can influence IFI16 degradation and subcellular location.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Immunology
Dongwei Xu, Yizhu Tian, Qiang Xia, Bibo Ke
Summary: Liver diseases are a major global health burden, with the cGAS-STING pathway playing a crucial role in their development. Overactivation of cGAS-STING has been linked to liver disorders, suggesting that this pathway may be a promising therapeutic target.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Virology
Sam Drury, Grace Claussen, Allison Zetterman, Hideaki Moriyama, Etsuko N. N. Moriyama, Luwen Zhang
Summary: The study identified the existence of the IRF9 gene in cartilaginous fish and discovered unique isoforms of IRF9 in old world monkeys and great apes. These isoforms, named primate-specific IRF9 (PS-IRF9), have a different C-terminal region compared to canonical IRF9. Two PS-IRF9s were found in humans, and their RNA transcripts and proteins were detected. PS-IRF9 may have unique biological functions and be involved in the regulation of the IFN pathway in a primate-specific manner.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Infectious Diseases
Trine H. Mogensen
Summary: This article discusses the discovery of IEIs in COVID-19 patients, focusing on the impact on susceptibility and outcomes of SARS-CoV-2 infection. The study provides important clinical implications for personalized prophylaxis and treatment.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Article
Immunology
Jing-Ping Huang, Jing Li, Yan-Ping Xiao, Liang-Guo Xu
Summary: Our research reveals that BAG6 is a critical regulator in the RIG-I/VISA-mediated innate immune response. It inhibits the aggregation of VISA and attenuates the recruitment of TRAF2, thereby inhibiting the activation of the RLR signaling pathway.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Elisabet Diaz-Beneitez, Liliana Lilibeth Cubas-Gaona, Oscar Candelas-Rivera, Ana Benito-Zafra, Maria Teresa Sanchez-Aparicio, Lisa Miorin, Jose F. Rodriguez, Adolfo Garcia-Sastre, Dolores Rodriguez
Summary: Infectious Bursal Disease Virus (IBDV) is an immunosuppressive disease that affects domestic chickens. This study found that TRIM25 plays an important role in the pathogenesis of IBDV by enhancing the activation of IFN-inducing pathway mediated by MDA5.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Oncology
Marc Pfefferle, Irina L. Dubach, Raphael M. Buzzi, Elena Duerst, Nadja Schulthess-Lutz, Livio Baselgia, Kerstin Hansen, Larissa Imhof, Sandra Koernig, Didier Le Roy, Thierry Roger, Rok Humar, Dominik J. Schaer, Florence Vallelian
Summary: The study revealed that CD40 signaling in Clec4f(+) Kupffer cells triggers anti-CD40 antibody-induced liver toxicity. However, controlled erythrophagocytosis and the linked anti-inflammatory signaling by the endogenous metabolite heme can be exploited to reprogram liver macrophages and prevent necroinflammatory liver disease caused by high-dose administration of anti-CD40 antibodies.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Immunology
Michelle Felicia Lee, Guan Zhong Voon, Hui Xuan Lim, Mun Lok Chua, Chit Laa Poh
Summary: Dengue is a mosquito-borne disease that poses significant public health concerns in tropical and subtropical countries. The dengue virus has evolved various strategies to manipulate the host's immune responses, and miRNAs and DENV non-structural proteins (NS) are promising targets for anti-dengue therapeutics.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Chemistry, Medicinal
Sourav Basu, Sandip Middya, Monali Banerjee, Rajib Ghosh, David C. C. Pryde, Dharmendra B. B. Yadav, Ritesh Shrivastava, Arjun Surya
Summary: STING activation for enhanced antigen recognition is being tested in cancer patients. Newly discovered STING agonists based on 3,4-dihydroquinazolin-2(1H)-one show high potency in activating all known human variants of STING.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Xinxin Tian, Chao Liu, Zhongquan Wang
Summary: The study revealed the presence of the cGAS-STING inflammatory pathway in human pulp tissue and dental pulp cells, indicating its potential important role in pulp inflammation and immune defense. Knock-down and inhibition experiments further confirmed the involvement of this signaling axis in the production of IFN-beta, TNF, and IL-6 induced by various stimuli.
INTERNATIONAL ENDODONTIC JOURNAL
(2022)
Review
Medicine, General & Internal
Brendan Antiochos, Livia Casciola-Rosen
Summary: Interferon (IFN) is an important part of the innate immune response and is upregulated in several rheumatic diseases, particularly those with autoantibody production. Many of the autoantigens targeted in these diseases are components of the IFN system, including IFN-stimulated genes (ISGs), pattern recognition receptors (PRRs), and modulators of the IFN response. This review also discusses the presence of anti-IFN autoantibodies in immunodeficiency states.
FRONTIERS IN MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Dustin A. Cobb, Ok-Kyung Kim, Lucy Golden-Mason, Hugo R. Rosen, Young S. Hahn
Editorial Material
Gastroenterology & Hepatology
Lucy Golden-Mason, Hugo R. Rosen
Article
Gastroenterology & Hepatology
Brett McGettigan, Rachel McMahan, David Orlicky, Matthew Burchill, Thomas Danhorn, Prashanth Francis, Lin Ling Cheng, Lucy Golden-Mason, Claudia V. Jakubzick, Hugo R. Rosen
Editorial Material
Gastroenterology & Hepatology
Upkar S. Gill, Lucy Golden-Mason
JOURNAL OF HEPATOLOGY
(2019)
Article
Medicine, Research & Experimental
Hugo R. Rosen, Lucy Golden-Mason
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE
(2020)
Article
Multidisciplinary Sciences
Michael Kriss, Lucy Golden-Mason, Jeffrey Kaplan, Faridoddin Mirshahi, V. Wendy Setiawan, Arun J. Sanyal, Hugo R. Rosen
Article
Gastroenterology & Hepatology
Nikos Stratakis, Lucy Golden-Mason, Katerina Margetaki, Yinqi Zhao, Damaskini Valvi, Erika Garcia, Lea Maitre, Sandra Andrusaityte, Xavier Basagana, Eva Borras, Mariona Bustamante, Maribel Casas, Serena Fossati, Regina Grazuleviciene, Line Smastuen Haug, Barbara Heude, Rosemary R. C. McEachan, Helle Margrete Meltzer, Eleni Papadopoulou, Theano Roumeliotaki, Oliver Robinson, Eduard Sabido, Jose Urquiza, Marina Vafeiadi, Nerea Varo, John Wright, Miriam B. Vos, Howard Hu, Martine Vrijheid, Kiros T. Berhane, David Conti, Rob McConnell, Hugo R. Rosen, Lida Chatzi
Summary: The study suggests that developmental exposure to mercury may contribute to liver injury and increased risk of NAFLD in early life.
Article
Immunology
Ana C. Maretti-Mira, Lucy Golden-Mason, Matthew P. Salomon, Mariana J. Kaplan, Hugo R. Rosen
Summary: The degree of cholesterol oxidation has different impacts on the global gene expression of human M2-like macrophages, with highly oxidized LDL causing the most dramatic changes. This oxidation also affects the function of liver and peripheral macrophages, leading to functional changes and decreased expression of important markers.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Yuchang Li, Liting Chen, Lu Li, Chantal Sottas, Stephanie K. Petrillo, Anthoula Lazaris, Peter Metrakos, Hangyu Wu, Yuji Ishida, Takeshi Saito, Lucy Golden-Mason, Hugo R. Rosen, Jeremy J. Wolff, Cristina Silvescu, Samuel Garza, Garett Cheung, Tiffany Huang, Jinjiang Fan, Martine Culty, Bangyan Stiles, Kinji Asahina, Vassilios Papadopoulos
Summary: Translocator protein (TSPO) levels increase as nonalcoholic fatty liver disease progresses from simple steatosis to nonalcoholic steatohepatitis. TSPO deficiency accelerates the progression of simple steatosis but ameliorates liver fibrosis in nonalcoholic steatohepatitis by downregulating bile acid synthesis. These findings demonstrate a dynamic and complex role for TSPO in the evolution of NAFLD.
Article
Microbiology
Matthew A. Burchill, Matthew P. Salomon, Lucy Golden-Mason, Amanda Wieland, Ana C. Maretti-Mira, Michael Gale, Hugo R. Rosen
Summary: Chronic HCV infection leads to dysregulation of innate immune responses and impaired T cell function. DAA therapy can induce significant changes in gene expression in T cells, offering a valuable data source to investigate the effects of DAA treatment on T cell populations.
Article
Multidisciplinary Sciences
Lauriane Galle-Treger, Doumet Georges Helou, Christine Quach, Emily Howard, Benjamin P. Hurrell, German R. Aleman Muench, Pedram Shafiei-Jahani, Jacob D. Painter, Andrea Iorga, Lily Dara, Juliet Emamaullee, Lucy Golden-Mason, Hugo R. Rosen, Pejman Soroosh, Omid Akbari
Summary: This study shows that disruption of the autophagy pathway in CD11c(+) cells accelerates the development of non-alcoholic fatty liver disease (NAFLD) in mice. The production of IL-23 by hepatic CD11c(+) cells plays a role in NAFLD pathogenesis, and blocking IL-23 can reduce the disease. These findings provide insights into the function of autophagy and IL-23 production in NAFLD, and suggest potential therapeutic targets.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Ana C. Maretti-Mira, Matthew P. Salomon, Angela M. Hsu, Gary C. Kanel, Lucy Golden-Mason
Summary: This study found that the dietary cholesterol content directly affects the gene expression of hepatic macrophages. Prolonged high cholesterol intake induces long-lasting hepatic damage and expands a dysfunctional pro-fibrotic restorative macrophage population even after cholesterol reduction.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Ana C. Maretti-Mira, Matthew P. Salomon, Angela M. Hsu, Lily Dara, Lucy Golden-Mason
Summary: The natural killer (NK) cell population in the liver plays a critical role in innate immunity, and its functions are influenced by the surrounding environment. In the late stage of fibrosis, NK cells become dysfunctional, but the impact of disease etiology on NK cell behavior during cirrhosis is unclear. Using single-cell RNA sequencing (scRNA-seq), this study characterized hepatic NK cells in end-stage cirrhotic livers from subjects with different liver diseases, showing that disease etiology affects hepatic NK cell heterogeneity. Therapeutic strategies targeting NK cells for fibrosis prevention or treatment should consider the specific liver disease etiology.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Lucy Golden-Mason, Rachel H. McMahan, Michael S. Kriss, Alexandra L. Kilgore, Linling Cheng, Rachael J. Dran, Amanda Wieland, Hugo R. Rosen
HEPATOLOGY COMMUNICATIONS
(2018)