Bridging the gap from genetic association to functional understanding: the next generation of mouse models of multiple sclerosis

Uncoupling the Roles of HLA-DRB1 and HLA-DRB5 Genes in Multiple Sclerosis

(2014) S. J. Caillier et al.   JOURNAL OF IMMUNOLOGY

A Transgenic Model of Central Nervous System Autoimmunity Mediated by CD4+ and CD8+ T and B Cells

(2012) A. C. Anderson et al.   JOURNAL OF IMMUNOLOGY

The changes that count

(2012) Monya Baker   NATURE

The problems and promises of research into human immunology and autoimmune disease

(2012) Bart O Roep et al.   NATURE MEDICINE

Autoimmunity's next top models

(2012) Hartmut Wekerle et al.   NATURE MEDICINE

A Modified RMCE-Compatible Rosa26 Locus for the Expression of Transgenes from Exogenous Promoters

(2012) Jan S. Tchorz et al.   PLoS One

Epistatic Selection between Coding and Regulatory Variation in Human Evolution and Disease

(2011) Tuuli Lappalainen et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A Rapid and Scalable System for Studying Gene Function in Mice Using Conditional RNA Interference

(2011) Prem K. Premsrirut et al.   CELL

Initial impact of the sequencing of the human genome

(2011) Eric S. Lander   NATURE

Control of TH17 cells occurs in the small intestine

(2011) Enric Esplugues et al.   NATURE

Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination

(2011) Kerstin Berer et al.   NATURE

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

(2011) Stephen Sawcer et al.   NATURE

Fate mapping of IL-17-producing T cells in inflammatory responses

(2011) Keiji Hirota et al.   NATURE IMMUNOLOGY

Needles in stacks of needles: finding disease-causal variants in a wealth of genomic data

(2011) Gregory M. Cooper et al.   NATURE REVIEWS GENETICS

Physiological Induction of Regulatory Qa-1-Restricted CD8+ T Cells Triggered by Endogenous CD4+ T Cell Responses

(2011) Aditi Varthaman et al.   PLoS One

A Comparison of Exogenous Promoter Activity at the ROSA26 Locus Using a PhiC31 Integrase Mediated Cassette Exchange Approach in Mouse ES Cells

(2011) Chiann-mun Chen et al.   PLoS One

Gene-environment interaction in induction of autoimmunity

(2011) Marie Wahren-Herlenius et al.   SEMINARS IN IMMUNOLOGY

Infectious triggers protect from autoimmunity

(2011) Paola Zaccone et al.   SEMINARS IN IMMUNOLOGY

Gut, bugs, and brain: Role of commensal bacteria in the control of central nervous system disease

(2010) Javier Ochoa-Repáraz et al.   ANNALS OF NEUROLOGY

Phylogeny of Gammaproteobacteria

(2010) K. P. Williams et al.   JOURNAL OF BACTERIOLOGY

Constitutive and conditional RNAi transgenesis in mice

(2010) Aljoscha Kleinhammer et al.   METHODS

Serine recombinases as tools for genome engineering

(2010) William R.A. Brown et al.   METHODS

A map of human genome variation from population-scale sequencing

(2010) Richard M. Durbin et al.   NATURE

Viral infection triggers central nervous system autoimmunity via activation of CD8+ T cells expressing dual TCRs

(2010) Qingyong Ji et al.   NATURE IMMUNOLOGY

Gene–environment-wide association studies: emerging approaches

(2010) Duncan Thomas   NATURE REVIEWS GENETICS

Multiple sclerosis genetics—is the glass half full, or half empty?

(2010) Jorge R. Oksenberg et al.   Nature Reviews Neurology

Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis

(2010) Y. K. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genotype to Phenotype: A Complex Problem

(2010) R. D. Dowell et al.   SCIENCE

The challenge of multiple sclerosis: How do we cure a chronic heterogeneous disease?

(2009) Howard L. Weiner   ANNALS OF NEUROLOGY

The relation between inflammation and neurodegeneration in multiple sclerosis brains

(2009) Josa M. Frischer et al.   BRAIN

The NIH Human Microbiome Project

(2009) et al.   GENOME RESEARCH

T Cell-Mediated Autoimmune Disease Due to Low-Affinity Crossreactivity to Common Microbial Peptides

(2009) Maria Harkiolaki et al.   IMMUNITY

Encephalitogenicity of Complete Freund's Adjuvant Relative to CpG Is Linked to Induction of Th17 Cells

(2009) J. T. Tigno-Aranjuez et al.   JOURNAL OF IMMUNOLOGY

Twin studies and the heritability of MS: a conclusion

(2009) CH Hawkes et al.   Multiple Sclerosis Journal

Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20

(2009) Melanie Bahlo et al.   NATURE GENETICS

Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci

(2009) Philip L De Jager et al.   NATURE GENETICS

Mutant LRRK2 R1441G BAC transgenic mice recapitulate cardinal features of Parkinson's disease

(2009) Yanping Li et al.   NATURE NEUROSCIENCE

Recombineering: a homologous recombination-based method of genetic engineering

(2009) Shyam K Sharan et al.   Nature Protocols

A Prescription for Human Immunology

(2008) Mark M. Davis   IMMUNITY

The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

(2008) Marc Veldhoen et al.   NATURE

Progress and challenges in genome-wide association studies in humans

(2008) Peter Donnelly   NATURE

Accurate whole human genome sequencing using reversible terminator chemistry

(2008) David R. Bentley et al.   NATURE

Innate immunity and intestinal microbiota in the development of Type 1 diabetes

(2008) Li Wen et al.   NATURE

Next-generation DNA sequencing

(2008) Jay Shendure et al.   NATURE BIOTECHNOLOGY

Opposing effects of HLA class I molecules in tuning autoreactive CD8+ T cells in multiple sclerosis

(2008) Manuel A Friese et al.   NATURE MEDICINE

Interleukin-17 Production in Central Nervous System-Infiltrating T Cells and Glial Cells Is Associated with Active Disease in Multiple Sclerosis

(2007) John S. Tzartos et al.   AMERICAN JOURNAL OF PATHOLOGY