RIG-I-like receptors: cytoplasmic sensors for non-self RNA

RIG-I Detects Viral Genomic RNA during Negative-Strand RNA Virus Infection

(2010) Jan Rehwinkel et al.   CELL

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Structural and functional insights into 5′-ppp RNA pattern recognition by the innate immune receptor RIG-I

(2010) Yanli Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal structure of RIG-I C-terminal domain bound to blunt-ended double-strand RNA without 5′ triphosphate

(2010) Cheng Lu et al.   NUCLEIC ACIDS RESEARCH

LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses

(2010) T. Satoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Structural Basis of 5′ Triphosphate Double-Stranded RNA Recognition by RIG-I C-Terminal Domain

(2010) Cheng Lu et al.   STRUCTURE

Virus-Infection or 5′ppp-RNA Activates Antiviral Signal through Redistribution of IPS-1 Mediated by MFN1

(2010) Kazuhide Onoguchi et al.   PLoS Pathogens

RNA Polymerase III Detects Cytosolic DNA and Induces Type I Interferons through the RIG-I Pathway

(2009) Yu-Hsin Chiu et al.   CELL

A Nonself RNA Pattern: Tri-p to Panhandle

(2009) Takashi Fujita   IMMUNITY

Solution Structures of Cytosolic RNA Sensor MDA5 and LGP2 C-terminal Domains

(2009) Kiyohiro Takahasi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The RIG-I-like Receptor LGP2 Recognizes the Termini of Double-stranded RNA

(2009) Xiaojun Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MAVS Self-Association Mediates Antiviral Innate Immune Signaling

(2009) E. D. Tang et al.   JOURNAL OF VIROLOGY

Activation of MDA5 Requires Higher-Order RNA Structures Generated during Virus Infection

(2009) A. Pichlmair et al.   JOURNAL OF VIROLOGY

RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III–transcribed RNA intermediate

(2009) Andrea Ablasser et al.   NATURE IMMUNOLOGY

REUL Is a Novel E3 Ubiquitin Ligase and Stimulator of Retinoic-Acid-Inducible Gene-I

(2009) Dong Gao et al.   PLoS One

Mitofusin 2 Inhibits Mitochondrial Antiviral Signaling

(2009) K. Yasukawa et al.   Science Signaling

Negative regulation of cytoplasmic RNA-mediated antiviral signaling

(2008) Akihiko Komuro et al.   CYTOKINE

The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response

(2008) Constantin S Friedman et al.   EMBO REPORTS

The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation

(2008) Bo Zhong et al.   IMMUNITY

Riplet/RNF135, a RING Finger Protein, Ubiquitinates RIG-I to Promote Interferon-β Induction during the Early Phase of Viral Infection

(2008) Hiroyuki Oshiumi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5

(2008) Hiroki Kato et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Herpes simplex virus infection is sensed by both Toll-like receptors and retinoic acid-inducible gene- like receptors, which synergize to induce type I interferon production

(2008) S. B. Rasmussen et al.   JOURNAL OF GENERAL VIROLOGY

Murine Coronavirus Mouse Hepatitis Virus Is Recognized by MDA5 and Induces Type I Interferon in Brain Macrophages/Microglia

(2008) J. K. Roth-Cross et al.   JOURNAL OF VIROLOGY

The C-Terminal Regulatory Domain Is the RNA 5′-Triphosphate Sensor of RIG-I

(2008) Sheng Cui et al.   MOLECULAR CELL

Nonself RNA-Sensing Mechanism of RIG-I Helicase and Activation of Antiviral Immune Responses

(2008) Kiyohiro Takahasi et al.   MOLECULAR CELL

Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA

(2008) Takeshi Saito et al.   NATURE

NLRX1 is a regulator of mitochondrial antiviral immunity

(2008) Chris B. Moore et al.   NATURE

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE

Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1

(2008) Huazhang An et al.   NATURE IMMUNOLOGY

Processing of Genome 5′ Termini as a Strategy of Negative-Strand RNA Viruses to Avoid RIG-I-Dependent Interferon Induction

(2008) Matthias Habjan et al.   PLoS One

RIG-I and dsRNA-Induced IFNβ Activation

(2008) Stéphane Hausmann et al.   PLoS One

MDA-5 Recognition of a Murine Norovirus

(2008) Stephen A. McCartney et al.   PLoS Pathogens

UbcH8 regulates ubiquitin and ISG15 conjugation to RIG-I

(2007) Kei-Ichiro Arimoto et al.   MOLECULAR IMMUNOLOGY