Article
Allergy
Graham A. W. Rook, Sally F. Bloomfield
Summary: This article highlights the importance of children being exposed to microbiotas from their mothers, other family members, and the natural environment, while deeming exposure to modern home microbiota less relevant. Additionally, the nonspecific effects of vaccines may partially replace the benefits of exposure to childhood infections in the household setting. Effective hygiene practices should be targeted at key risk moments and sites to maximize protection against infection.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Xin-Yi Yu, Zhao-Qiang Zhang, Jia-Chang Huang, Jia-Yu Lin, Xue-Pei Cai, Chu-Feng Liu
Summary: This study investigated the combined effect of human periodontal ligament cells (hPDLCs) and interleukin (IL)-7 on CD4(+)T cells, as well as the effect of IL-7 on the immunomodulatory properties of hPDLCs. The results showed that IL-7 promoted proliferation and inhibited apoptosis in hPDLCs, leading to the polarization of CD4(+)T cells into Treg cells but had no significant effect on Th17 cell differentiation.
FRONTIERS IN MEDICINE
(2022)
Article
Multidisciplinary Sciences
Anissa Fries, Fanny Saidoune, Francois Kuonen, Isabelle Dupanloup, Nadine Fournier, Ana Cristina Guerra de Souza, Muzlifah Haniffa, Feiyang Ma, Johann E. Gudjonsson, Lennart Roesner, Yang Li, Thomas Werfel, Curdin Conrad, Raphael Gottardo, Robert L. Modlin, Jeremy Di Domizio, Michel Gilliet
Summary: This study establishes the role of interleukin 26 (IL-26) in the generation of IL-17A producing Th17 CD4(+) T cells, indicating its involvement in the pathogenic response of psoriasis. IL-26-producing cells infiltrate psoriatic skin and promote their own differentiation into IL17A-producing T(H)17 cells through epithelial crosstalk involving paracrine production of TGF-& beta;1.
NATURE COMMUNICATIONS
(2023)
Article
Cell Biology
Zhenhua Deng, Jinren Zhou, Xiaoxin Mu, Jian Gu, Xiangyu Li, Qing Shao, Jinyang Li, Chao Yang, Guoyong Han, Jie Zhao, Yongxiang Xia
Summary: The co-infusion of hAMSC and Treg was found to prevent liver fibrosis, with Treg improving the function of hAMSC by regulating the TGF-β-IDO signaling. This provides a promising approach for treating liver cirrhosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chengyi Huang, Fucheng Zhang, Peng Li, Cai Song
Summary: Microglia activation, increased IL-6 and decreased TGF-beta are observed in depressed patients or animal models of depression. This study found imbalances between IL-6 and TGF-beta and between Th17 and Treg in a mouse model of depression, and IL-2 treatment restored these imbalances and improved depressive symptoms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Manu Kupani, Smriti Sharma, Rajeev Kumar Pandey, Rajiv Kumar, Shyam Sundar, Sanjana Mehrotra
Summary: Nitric oxide (NO) is an important anti-microbial effector of the innate immune system, but suboptimal production is often found in patients with visceral leishmaniasis (VL). This is associated with significantly lower levels of NO and elevated arginase activity in the plasma of VL patients. Furthermore, VL patients also show higher levels of IL-10 and TGF-beta, which regulate the expression of arginase and contribute to the suppression of NO production.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
En-ming Tian, Ming-cheng Yu, Mei Feng, Li-xue Lu, Cheng-long Liu, Li-an Shen, Yong-hui Wang, Qiong Xie, Di Zhu
Summary: The study demonstrates that JG-1, a potent and selective small-molecule ROR gamma t agonist, promotes Th17 cells differentiation and inhibits regulatory T cells, leading to robust tumor growth inhibition in multiple syngeneic models. JG-1 also shows a synergistic effect with CTLA-4 antibody, indicating its potential as a promising therapeutic agent for tumor immunity.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Cell Biology
Zhaohong Liao, Haiqiang Lan, Xiaoting Jian, Jingwen Huang, Han Wang, Jijie Hu, Hua Liao
Summary: This study investigated the role of skeletal muscle specific TGF-beta signaling in macrophages efferocytosis in inflamed muscle caused by Cardiotoxin (CTX) injection. The results showed that deficiency of muscle TGF-beta signaling led to more severe muscle inflammation and altered macrophage populations. Furthermore, the lack of TGF-beta signaling in myofibers significantly impaired the ability of macrophages to phagocytose apoptotic cells.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Immunology
Jialing Liu, Xingqiang Lai, Yingying Bao, Wenfeng Xie, Zhishan Li, Jieying Chen, Gang Li, Tao Wang, Weijun Huang, Yuanchen Ma, Jiahao Shi, Erming Zhao, Andy Peng Xiang, Qiuli Liu, Xiaoyong Chen
Summary: Intraperitoneally delivered mesenchymal stem cells (MSCs) secrete THBS1 to boost IL-10(+)Bregs and control the progression and recurrence of inflammatory bowel disease (IBD).
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sung Hwan Yoo, Ji Hae Nahm, Woon Kyu Lee, Hyun Woong Lee, Hye Young Chang, Jung Il Lee
Summary: The loss of KLF10 was found to promote the development of liver cancer and alter the TGF beta signaling. Experimental results showed that the loss of KLF10 increased tumor invasiveness and was associated with poor prognosis in human HCC patients.
MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Dandan Wu, Zhongli Wang
Summary: This study found that the tryptophan metabolite kynurenine may hyperactivate regulatory T cells (Tregs) and induce chemotherapy resistance in gastric cancer cells through the IL-10/STAT3/BCL2 signaling pathway.
DNA AND CELL BIOLOGY
(2022)
Article
Cell Biology
Valeria Aparecida Belo, Jessica Assis Pereira, Sara Franchin D. Souza, Fernanda de Lima Tana, Bruna P. Pereira, Debora de Oliveira Lopes, Carla S. Ceron, Romulo D. Novaes, Patricia Paiva Corsetti, Leonardo Augusto de Almeida
Summary: The lung inflammatory response to Pseudomonas aeruginosa infection in mice is regulated by endogenous IL-10, with IL-10 KO mice exhibiting higher bacterial loads and more severe tissue damage.
CELL AND TISSUE RESEARCH
(2021)
Review
Immunology
Junying Wang, Xingqi Zhao, Yisong Y. Wan
Summary: Balanced immunity is crucial for maintaining health and homeostasis. CD4(+) helper T (Th) cells play a central role in regulating immune tolerance and immune rejection. Regulatory T (Treg) and Th17 cells are important cell types involved in immune tolerance, homeostasis, pathogenicity, and pathogen clearance. Understanding the regulation of Treg and Th17 cell function by the TGF-beta superfamily and its signaling pathways is of great importance for both health and disease.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Article
Immunology
Kang Li, Jiaqi Li, Xiumei Wei, Junya Wang, Ming Geng, Kete Ai, Wei Liang, Jiansong Zhang, Kunming Li, Haiyou Gao, Jialong Yang
Summary: The study investigated the suppression of T cell immunity by IL-10 in a Nile tilapia model. The findings reveal that IL-10 inhibits T cell activation and differentiation through the activation of JAK1/STAT3 axis and suppression of NF-KB and MAPK/ERK signaling pathways.
JOURNAL OF IMMUNOLOGY
(2023)
Article
Neurosciences
Faezeh-sadat Khorram, Ali Mehdipour, Amir Moghadam-Ahmadi, Habib Farahmand, Azadeh Askari, Seyed Mohsen Moosavi, Ahmad Shabanizadeh, Masoumeh Parsi, Mohammad Kazemi Arababadi
Summary: This study showed that brain MRI without contrast can increase protein levels of IL-6 in the peripheral serum, but has no effect on IL-10, IL-17A, and TGF-beta levels. Participants with mild anxiety had higher IL-6 mRNA levels after MRI compared to those without anxiety.
Article
Oncology
Jonathan S. Cebon, Martin Gore, John F. Thompson, Ian D. Davis, Grant A. McArthur, Euan Walpole, Mark Smithers, Vincenzo Cerundolo, P. Rod Dunbar, Duncan MacGregor, Cyril Fisher, Michael Millward, Paul Nathan, Michael P. N. Findlay, Peter Hersey, T. R. Jeffry Evans, Christian Hermann Ottensmeier, Jeremy Marsden, Angus G. Dalgleish, Pippa G. Corrie, Marples Maria, Margaret Brimble, Geoff Williams, Sintia Winkler, Heather M. Jackson, Liliana Endo-Munoz, Candani S. A. Tutuka, Ralph Venhaus, Lloyd J. Old, Dennis Haack, Eugene Maraskovsky, Andreas Behren, Weisan Chen
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2020)
Article
Oncology
P. L. Smith, Y. Yogaratnam, M. Samad, S. Kasow, A. G. Dalgleish
Summary: Chemotherapy for advanced pancreatic cancer is limited in efficacy due to difficulty in treating established tumors and tumor resistance. This study investigated the impact of combining Gemcitabine with immune modulatory chemotherapies on the immunogenicity of pancreatic tumor cells and T-cell responses, showing both additive and inhibitory effects on immune recognition markers. The findings highlight complex interactions in designing chemo-immunogenic combinations for use with immunotherapy.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2021)
Article
Immunology
Emma L. Sparrow, Daniel W. Fowler, Joe Fenn, Jonathan Caron, John Copier, Angus G. Dalgleish, Mark D. Bodman-Smith
Article
Oncology
Tanzeel Khan, Alan M. Seddon, Angus G. Dalgleish, Said Khelwatty, Nikolaos Ioannou, Satvinder Mudan, Helmout Modjtahedi
Review
Medicine, Research & Experimental
Gustav van Niekerk, Angus G. Dalgleish, Fourie Joubert, Annie Joubert, Anna-Mart Engelbrecht
Summary: Insulin regulates immune cell phenotypes through the PI3K/Akt/mTOR pathway, potentially impacting ICB therapy; Insulin interacts with immune pathways such as JAK/STAT, and is regulated by PD-1 and CTLA-4.
Editorial Material
Evolutionary Biology
Graham A. W. Rook
EVOLUTION MEDICINE AND PUBLIC HEALTH
(2021)
Review
Oncology
Wai M. Liu, Angus G. Dalgleish
Summary: Considering the increase in anecdotal reports, LDN shows potential in cancer treatment through its effects on receptors, immune function, and signaling pathways involved in cancer cell control. Clinical trials, especially in combination with certain chemotherapy, are recommended.
EXPERT REVIEW OF ANTICANCER THERAPY
(2022)
Article
Biotechnology & Applied Microbiology
Katarzyna Piadel, Amin Haybatollahi, Angus George Dalgleish, Peter Lawrence Smith
Summary: The study investigates alternative vaccine strategies to broaden T-cell responses and provide cross-immunity against SARS-CoV-2 variants and future coronavirus outbreaks. Highly conserved peptides containing immunogenic epitopes were synthesized and demonstrated antigenicity against T-cells from individuals with previous SARS-CoV-2 infection.
JOURNAL OF GENERAL VIROLOGY
(2022)
Article
Oncology
Wai M. Liu, Nadine K. Hall, Harry S. Y. Liu, Francis L. Hood, Angus G. Dalgleish
Summary: The combination of CBD and LDN, administered in a specific sequence, significantly reduces cancer cell numbers and enhances sensitivity to chemotherapy. This effect is also observed in a mouse model, with no significant toxicity.
Article
Immunology
Peter Lawrence Smith, Katarzyna Piadel, Angus George Dalgleish
Summary: Cancer vaccination and immunotherapy have revolutionized cancer treatment, but only a minority of patients respond to this treatment and some cancers are resistant to it. CD4(+) and CD8(+) alpha beta T-cells play a crucial role in the anti-tumor immune response, but their function is often compromised in cancer patients.
Article
Immunology
J. Fenn, L. A. Ridgley, A. White, C. Sarfas, M. Dennis, A. Dalgleish, R. Reljic, S. Sharpe, M. Bodman-Smith
Summary: This study demonstrates that Bacillus Calmette-Guerin (BCG) can expand V delta 2(+) T cells and enhance their cytotoxicity against tumor cells, suggesting its potential in enhancing anti-tumor responses. Compared to zoledronic acid (ZA) expanded cells, BCG-expanded cells exhibit a more diverse range of cytokine production and lower upregulation of exhaustion marker CD57. These findings highlight the potential of BCG treatment in potentiating anti-tumor V delta 2(+) T cell responses.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2022)
Editorial Material
Oncology
John T. Schiller, Douglas R. Lowy
Summary: Given the renewed interest in vaccine development sparked by the COVID-19 pandemic, this article revisits the current state of vaccine development for cancer prevention and treatment. Experts discuss different vaccine types, their antigens and modes of action, and provide insights into the clinical development progress and challenges that need to be overcome for wide implementation.
Article
Oncology
Angus G. Dalgleish, Wai M. Liu
Summary: This study described the use of a novel immunotherapy, IMM-101, in combination with conventional treatments in patients with prostate cancer. The results showed that IMM-101 treatment, along with an anti-inflammatory agent, led to clinical improvements and reduction in prostate-specific antigen levels in some patients.
Editorial Material
Oncology
Christine Galustian, Angus Dalgleish, Mark Bodman-Smith, Sergei Kusmartsev, Prokar Dasgupta
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Laura A. Ridgley, Jonathan Caron, Angus Dalgleish, Mark Bodman-Smith
Summary: The expression of activatory and inhibitory receptors on V gamma 9V delta 2 T-cells was assessed to explore the potential regulation of their activity. The results showed that V gamma 9V delta 2 T-cells expressed high levels of activatory markers and variable levels of inhibitory receptors, which were upregulated upon stimulation. However, immune checkpoint blockade had no effect on the cytotoxic capacity or cytokine production of V delta 2+ T-cells when cultured with tumor cells expressing cognate ligands.
FRONTIERS IN IMMUNOLOGY
(2023)