期刊
IMMUNOLOGICAL REVIEWS
卷 245, 期 -, 页码 177-188出版社
WILEY
DOI: 10.1111/j.1600-065X.2011.01071.x
关键词
ROR?t; Th17 cells; innate lymphoid cells; IL-17; IL-22; symbiotic microbiota
类别
资金
- European Commission
- Agence Nationale de la Recherche
- Fondation de France
- Fondation de la Recherche Medicale
- Institut Pasteur
The nuclear hormone receptor retinoid-related orphan receptor ?t (ROR?t) induces a pro-inflammatory program in lymphoid cells, culminating in the expression of interleukin-6 (IL-6), IL-17, IL-22, granulocyte-macrophage colony-stimulating factor, and tumor necrosis factor. During ontogeny, the first type of cells expressing ROR?t are lymphoid tissue inducer cells, a type of innate lymphoid cell (ILC) generated in mammalian fetuses to induce the development of lymph nodes and Peyers patches. After birth, ROR?t+ ILCs and ROR?t+ T cells are involved in the defense of epithelial surfaces against extracellular microbes and play an important role in the intestinal homeostasis with symbiotic microbiota. The development and evolution of ROR?t+ cells is intimately associated with the construction of a stable hostmicrobe interface.
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