Article
Biochemistry & Molecular Biology
Katie D. Hunter, Robert W. E. Crozier, Jessica L. Braun, Val A. Fajardo, Adam J. MacNeil
Summary: In this study, the role of SARCA in allergen-activated mast cells was characterized. Treatment with the SARCA activating compound, CDN1163, was found to attenuate early phase mast cell degranulation, reactive oxygen species (ROS) production, and secretion of IL-6, IL-13, and CCL3. These protective effects may be driven by the suppression of p38 MAPK signaling. These findings suggest that SARCA is an important regulator of the mast cell response to allergens and may have therapeutic potential in targeting allergic pathologies.
Review
Cell Biology
Yuka Nagata, Ryo Suzuki
Summary: Mast cells (MCs) have different roles in allergic responses, and the interactions between antigens and immunoglobulin E (IgE) can trigger diverse responses in MCs. The clustering of high-affinity IgE receptor Fc epsilon RI is crucial for signal transduction and determines the quality of MC responses. Antigen properties precisely regulate Fc epsilon RI dynamics, which can result in different outcomes by switching the intracellular signaling pathway, suggesting that antigen properties can control MC responses both qualitatively and quantitatively.
Article
Biochemistry & Molecular Biology
Phuc-Tan Nguyen, Yuki Nakamura, Nguyen Quoc Vuong Tran, Kayoko Ishimaru, Thuy-An Nguyen, Yoshiaki Kobayashi, Fumie Watanabe-Saito, Tohru Okuda, Nobuhiro Nakano, Atsuhito Nakao
Summary: Ethyl caffeate (EC) is a natural phenolic compound found in medicinal plants and shows anti-allergic activity by inhibiting aryl hydrocarbon receptor (AhR) signaling. EC inhibits AhR activation and downregulates AhR target gene expressions. It also inhibits mast cell activation and IL-6 production induced by AhR ligands. These findings suggest a novel mechanism for the anti-inflammatory activity of EC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Satoshi Tanaka, Kazuyuki Furuta
Summary: IgE plays a role in protecting mast cells from apoptosis and promoting their maturation, as well as activating immature mast cells to release pro-inflammatory mediators in the absence of antigens. Additionally, IgE indirectly modulates local mast cell maturation and decreased serum IgE concentrations may be associated with therapeutic effects of anti-IgE antibodies in inflammatory diseases.
Review
Immunology
Chiara Tontini, Silvia Bulfone-Paus
Summary: Allergy is a type-I hypersensitivity reaction that can lead to life-threatening systemic symptoms. Novel therapeutic options targeting mast cells activation, such as monoclonal antibodies and allergen-specific immunotherapy, are promising for severe allergies treatment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Allergy
Chen Ji, Yue Huang, Long Him Yeung, Oliver Hemmings, Zainab Jama, Matthew Kwok, Gideon Lack, Alexandra F. Santos
Summary: This study found that Arah2-sIgE levels and Ara h 2/total IgE ratios are important factors in determining clinical reactions to peanut allergy, and that most children sensitized to Ara h 2 are peanut-allergic. Specific activity and Arah2-sIgE titers are the major determinants of mast cell response to Ara h 2.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Review
Allergy
Peter Valent, Karin Hartmann, Juliana Schwaab, Ivan Alvarez-Twose, Knut Brockow, Patrizia Bonadonna, Olivier Hermine, Marek Niedoszytko, Melody C. Carter, Gregor Hoermann, Wolfgang R. Sperr, Joseph H. Butterfield, Celalettin Ustun, Roberta Zanotti, Deepti H. Radia, Mariana Castells, Massimo Triggiani, Lawrence B. Schwartz, Alberto Orfao, Tracy George, Karl Sotlar, Jason Gotlib, Andreas Reiter, Hans-Peter Horny, Michel Arock, Cem Akin, Dean D. Metcalfe
Summary: Mastocytosis is a myeloid neoplasm characterized by the accumulation of clonal mast cells in organs, leading to various symptoms and complications. The disease is categorized into different types, with KIT gene mutations associated with the condition. Early-stage cases have a better prognosis, while advanced cases have a poorer prognosis, and severe symptoms may be diagnosed as mast cell activation syndrome.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Review
Allergy
Atsuhito Nakao, Yuki Nakamura
Summary: Mast cell activation plays a crucial role in the development of allergic diseases. Recent studies have revealed that mast cell activation, both IgE-dependent and -independent, is temporally regulated by the circadian clock. This regulation is associated with the day-night changes in symptom occurrence and severity of allergic diseases. Factors that disturb the circadian rhythm, such as irregular eating habits, can lead to the loss of control over mast cell activation, resulting in worsened allergic symptoms.
ALLERGOLOGY INTERNATIONAL
(2022)
Article
Immunology
Jada Suber, Yugen Zhang, Ping Ye, Rishu Guo, A. Wesley Burks, Michael D. Kulis, Scott A. Smith, Onyinye I. Iweala
Summary: Novel, human allergen-specific IgE monoclonal antibodies were used to design an in vitro system to evaluate potential therapeutics targeting sensitized effector cells. The antibodies were shown to trigger degranulation in response to peanut stimulation and could be attenuated by engaging inhibitory receptors.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Virginie Doyen, Carine Truyens, Hoa Nhu Thi, Hiep Tran Thi Mong, Thanh Le Chi, Frederic De Blay, Phuong Thi Ngoe Huynh, Olivier Michel, Francis Corazza
Summary: This study found that during natural helminth infection, non-allergic infected individuals had higher levels of Dpt IgE, which were non-functional in vitro. These IgE did not recognize the usual major allergens of Dpt, but rather other component allergens belonging to different protein families.
Review
Immunology
Marine Michelet, Bianca Balbino, Laurent Guilleminault, Laurent L. Reber
Summary: Food allergy poses a significant public health issue without an approved therapy, with IgE antibodies playing a crucial role in diagnosis and treatment. Recent advances in regulating IgE production and understanding its function in food allergy offer hope for better management and treatment options. Clinical studies on anti-IgE therapeutic monoclonal antibodies provide insights into blocking IgE effector functions and improving outcomes for individuals with food allergies.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Review
Immunology
Jeremy A. O'Sullivan, Bradford A. Youngblood, Robert P. Schleimer, Bruce S. Bochner
Summary: Siglecs are a family of glycan-binding cell-surface proteins in vertebrates that mediate cellular inhibitory activity. They are now being studied for their potential to therapeutically dampen unwanted cellular responses. This review focuses on a subset of Siglecs and their ligands that regulate eosinophil and mast cell function and summarizes the development of novel therapies for allergic and other related diseases.
SEMINARS IN IMMUNOLOGY
(2023)
Article
Immunology
Robert W. E. Crozier, Val A. Fajardo, Adam J. MacNeil
Summary: This study aimed to evaluate the potential therapeutic target of GSK3 in allergic inflammation. The results revealed that GSK3 inhibition reduced ROS production and degranulation, and decreased the production/release of pro-inflammatory mediators. Additionally, CHIR99021-mediated GSK3 inhibition altered the pro-inflammatory phenotype of mast cells.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Immunology
Xin Liu, Yufei Zhang, Xu Cui, Ting Fan, Jin Shu, Hui Li, Xiaojing Huo, Chao Lu
Summary: Gd-DTPA induced severe allergic reactions and mast cells activation, leading to histamine, tryptase, and cytokines release in both mice serum and LAD2 cells supernatant. RNAseq analysis showed changes in mRNA levels related to inflammation signaling pathways after Gd-DTPA activated MCs.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Kazuki Nagata, Chiharu Nishiyama
Summary: Mast cells play critical roles in immune responses as initiators and suppressors, with IL-10 serving as a key anti-inflammatory cytokine in regulating their functions. IL-10 exerts diverse effects on mast cells in vivo and in vitro, influencing tissue homeostasis and immune-related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Hans C. Oettgen, Oliver T. Burton
CURRENT OPINION IN IMMUNOLOGY
(2015)
Article
Allergy
Magali Noval Rivas, Oliver T. Burton, Hans C. Oettgen, Talal Chatila
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2016)
Article
Allergy
Oliver T. Burton, Amanda J. Stranks, Jaciel M. Tamayo, Kyle J. Koleoglou, Lawrence B. Schwartz, Hans C. Oettgen
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2017)
Article
Cell Biology
Sonia Aguera-Gonzalez, Oliver T. Burton, Elena Vazquez-Chavez, Celine Cuche, Floriane Herit, Jerome Bouchet, Remi Lasserre, Iratxe del Rio-Iniguez, Vincenzo Di Bartolo, Andres Alcover
Article
Allergy
O. T. Burton, J. Medina Tamayo, A. J. Stranks, S. Miller, K. J. Koleoglou, E. O. Weinberg, H. C. Oettgen
CLINICAL AND EXPERIMENTAL ALLERGY
(2018)
Article
Allergy
Oliver T. Burton, Jaciel M. Tamayo, Amanda J. Stranks, Kyle J. Koleoglou, Hans C. Oettgen
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Diether Lambrechts, Els Wauters, Bram Boeckx, Sara Aibar, David Nittner, Oliver Burton, Ayse Bassez, Herbert Decaluwe, Andreas Pircher, Kathleen Van den Eynde, Birgit Weynand, Erik Verbeken, Paul De Leyn, Adrian Liston, Johan Vansteenkiste, Peter Carmeliet, Stein Aerts, Bernard Thienpont
Article
Immunology
Oliver T. Burton, Alexandra Epp, Manoussa E. Fanny, Samuel J. Miller, Amanda J. Stranks, Jessica E. Teague, Rachael A. Clark, Matt van de Rijn, Hans C. Oettgen
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Immunology
Maya Imbrechts, Anneleen Avau, Jessica Vandenhaute, Bert Malengier-Devlies, Karen Put, Tania Mitera, Nele Berghmans, Oliver Burton, Steffie Junius, Adrian Liston, Lien de Somer, Carine Wouters, Patrick Matthys
JOURNAL OF IMMUNOLOGY
(2018)
Article
Immunology
Aleksandra Brajic, Dean Franckaert, Oliver Burton, Simon Bornschein, Anna L. Calvanese, Sofie Demeyer, Jan Cools, James Dooley, Susan Schlenner, Adrian Liston
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Immunology
Annemarie van Nieuwenhuijze, Oliver Burton, Pierre Lemaitre, Alice E. Denton, Ana Cascalho, Rose E. Goodchild, Bert Malengier-Devlies, Benedicte Cauwe, Michelle A. Linterman, Stephanie Humblet-Baron, Adrian Liston
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Neurosciences
Renzo Mancuso, Johanna Van den Daele, Nicola Fattorelli, Leen Wolfs, Sriram Balusu, Oliver Burton, Adrian Liston, Annerieke Sierksma, Yannick Fourne, Suresh Poovathingal, Amaia Arranz-Mendiguren, Carlo Sala Frigerio, Christel Claes, Lutgarde Serneels, Tom Theys, V. Hugh Perry, Catherine Verfaillie, Mark Fiers, Bart De Strooper
NATURE NEUROSCIENCE
(2019)
Article
Multidisciplinary Sciences
Carlos P. Roca, Oliver T. Burton, Vaclav Gergelits, Teresa Prezzemolo, Carly E. Whyte, Richard Halpert, Lukasz Kreft, James Collier, Alexander Botzki, Josef Spidlen, Stephanie Humblet-Baron, Adrian Liston
Summary: AutoSpill is a novel method for calculating spillover coefficients in flow cytometry, which combines automated gating, calculation of an initial spillover matrix based on robust linear regression, and iterative refinement to reduce errors. It simplifies workflows and reduces compensation errors in high-parameter flow cytometry.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Steffie Junius, Adamantios Mavrogiannis, Pierre Lemaitre, Margaux Gerbaux, Frederik Staels, Vanshika Malviya, Oliver Burton, Vaclav Gergelits, Kailash Singh, Raul Yhossef Tito Tadeo, Jeroen Raes, Stephanie Humblet-Baron, Adrian Liston, Susan M. Schlenner
Summary: Regulatory T cells (T-regs) are essential for immune homeostasis and may be used as a cell therapy for autoimmune diseases. A study using mice found that T-reg stability is maintained even in complex microbial/antigenic environments, and that plasticity after transfer to a lymphopenic environment is limited to a subset of T-regs. The unstable T-reg fraction consists of diverse T-regs, with potential implications for improving cell transfer therapy.
SCIENCE IMMUNOLOGY
(2021)
Article
Immunology
Carly E. Whyte, Kailash Singh, Oliver T. Burton, Meryem Aloulou, Lubna Kouser, Rafael Valente Veiga, Amy Dashwood, Hanneke Okkenhaug, Samira Benadda, Alena Moudra, Orian Bricard, Stephanie Lienart, Pascal Bielefeld, Carlos P. Roca, Francisco Jose Naranjo-Galindo, Felix Lombard-Vadnais, Steffie Junius, David Bending, Masahiro Ono, Tino Hochepied, Timotheus Y. F. Halim, Susan Schlenner, Sylvie Lesage, James Dooley, Adrian Liston
Summary: The study reveals the contextual influence of IL-2 function and its effects on different cell circuits. Targeted IL-2 production has the potential to fine-tune therapeutic responses, based on the desired clinical outcomes.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
