Article
Virology
Johannes S. Gach, Stephanie Y. Matsuno, Mayalen Mercado, Lars Hangartner, Donald N. Forthal
Summary: The low abundance of envelope spikes and the inability of IgG to aggregate virions make HIV-1 a poor target for antibody-mediated clearance. However, by generating multimers of the neutralizing antibody VRC01 and introducing complement, the internalization of HIV-1 virions can be improved, providing a potential therapeutic approach to clearing the virus.
JOURNAL OF VIROLOGY
(2022)
Review
Immunology
Antonio M. M. Seixas, Silvia A. Sousa, Jorge H. Leitao
Summary: The increasing antimicrobial resistance worldwide poses a significant threat to modern medicine, leading to infections that are untreatable by conventional therapies. Factors such as misuse and poor adherence by patients exacerbate the severity of this issue, highlighting the need for the development of more immunotherapies to replace antimicrobials.
Article
Biochemistry & Molecular Biology
Fabian Bohlaender, Sabrina Weissmueller, Dennis Riehl, Marcus Gutscher, Joerg Schuettrumpf, Stefanie Faust
Summary: The study aims to investigate the functional aspects of the IgA component in trimodulin, a new plasma-derived polyvalent immunoglobulin preparation, and demonstrates its potent immunomodulatory and anti-pathogenic effects, especially on neutrophil function.
Article
Biochemistry & Molecular Biology
Marlena Typiak, Piotr Trzonkowski, Monika Skotarczak, Anna Dubaniewicz
Summary: Sarcoidosis (SA) is a granulomatous disorder that affects the lungs, resembling tuberculosis (TB) in clinical characteristics but with different treatment approaches. By studying the phagocytic activity of monocytes in the blood of SA and TB patients using flow cytometry, we found higher phagocytic activity in SA patients and an increased frequency of Fc?RIII (CD16) receptors but a decreased frequency of CR1 (CD35) receptors compared to TB patients. This study provides insights into the pathomechanisms and differential diagnosis of SA and TB.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Gaoqian Feng, Liriye Kurtovic, Paul A. Agius, Elizabeth H. Aitken, Jahit Sacarlal, Bruce D. Wines, P. Mark Hogarth, Stephen J. Rogerson, Freya J. Fowkes, Carlota Dobano, James G. Beeson
Summary: The study provides new insights into the modest and time-limited efficacy of RTS,S in children and the induction of antibody functional activities. Improving the induction and maintenance of antibodies that promote phagocytosis and cellular functions, as well as combating the negative effect of malaria exposure on vaccine responses, are potential strategies for improving the efficacy and longevity of RTS,S.
Article
Immunology
Lee A. Meier, Jessica L. Faragher, Victoria Osinsk, Jennifer L. Auger, Rochus Voeller, Aubyn Marath, Bryce A. Binstadt
Summary: This study investigated the impact of the interaction between CD47-expressing apoptotic cells and signal regulatory protein a (SIRPa) on macrophages on disease progression in a model of autoimmune arthritis. The study found that blocking CD47 could prevent and treat valvular carditis, suggesting these molecules as potential therapeutic targets to reduce cardiovascular disease risk in autoantibody-driven inflammatory diseases.
JOURNAL OF IMMUNOLOGY
(2022)
Review
Cell Biology
Chiara Elisabeth Geyer, Lynn Mes, Melissa Newling, Jeroen den Dunnen, Willianne Hoepel
Summary: Macrophages play a crucial role in inflammatory responses induced by activation of pattern recognition receptors or cytokine receptors. Not only can antibodies and pentraxins activate Fc receptors to induce powerful inflammatory responses that surpass PRRs, but undesired activation of this mechanism can lead to various disorders. Understanding the signaling and metabolic pathways involved in antibody-dependent inflammation is essential for developing strategies to counteract pathological inflammation.
Review
Medicine, General & Internal
Hafsa Qadri, Abdul Haseeb Shah, Mustfa Alkhanani, Abdullah Almilaibary, Manzoor Ahmad Mir
Summary: Ongoing struggles with infectious diseases highlight the global public health threat they pose, including the current SARS-Co-V2 outbreak. Drug-resistant pathogens have led to severe infectious diseases with rising fatality rates. To overcome the limitations of current management and control processes, new treatment solutions, such as immunotherapies, hold potential in strengthening the body's immune system to fight infections. Immunotherapies are being researched as alternative treatments for infectious diseases, improving our understanding of the relationship between pathogens and the host immune system.
FRONTIERS IN MEDICINE
(2023)
Review
Oncology
Khiyam Hussain, Mark S. Cragg, Stephen A. Beers
Summary: Tumors are composed of various cell types, including macrophages, which can either promote or suppress tumor growth. Anti-cancer therapeutics like Rituximab, Herceptin, and Cetuximab work by directly targeting cancer cells and aiding macrophages in eliminating them through the process of antibody-dependent cellular phagocytosis. However, some patients do not respond well to this treatment, prompting the development of new therapies that target macrophages within tumors to improve their ability to eliminate cancer cells.
Article
Immunology
Babette Wolf, Mateusz Piksa, Isabelle Beley, Agnes Patoux, Thierry Besson, Valerie Cordier, Bernd Voedisch, Patrick Schindler, Daniela Stoellner, Ludovic Perrot, Stephan von Gunten, Dominique Brees, Michael Kammueller
Summary: This study demonstrates the relevance of glycosylation in immune recognition of therapeutic antibodies, and the ability of defined glycan structures to modulate immunogenicity and anti-drug antibody responses. Glyco-engineering may be a useful strategy to reduce clinical immunogenicity and adverse events associated with antibodies.
Article
Veterinary Sciences
Artur Summerfield, Heidi Gerber, Rebeka Schmitt, Matthias Liniger, Santina Grazioli, Emiliana Brocchi
Summary: This study demonstrates that monoclonal antibodies targeting FMDV O and A serotypes are able to opsonize the virus and induce cell death. Opsonization shows broader reactivity within the serotype and correlates better with vaccine dose compared to neutralization. Neutralization and opsonization titers are similarly predictive of protection.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Fabiola Vacca, Claudia Sala, Rino Rappuoli
Summary: Monoclonal antibody therapy has significant potential in the pharmaceutical field, particularly in combating antibiotic resistance in bacteria. However, there is a need for further improvement in the efficacy of antibacterial monoclonal antibodies.
Review
Immunology
D. Herbert Opi, Liriye Kurtovic, Jo-Anne Chan, Jessica L. Horton, Gaoqian Feng, James G. Beeson
Summary: It is increasingly clear that multiple antibody effector functions play a role in immunity to malaria. Evaluating vaccine candidates should move beyond individual assays or measuring IgG magnitude alone, and instead incorporate a wider range of assays measuring functional antibody responses. A 3-tier approach to implementing assays to inform vaccine evaluation is proposed.
EXPERT REVIEW OF VACCINES
(2021)
Review
Immunology
Yu Hao, Xinxuan Zhou, Yiling Li, Bolei Li, Lei Cheng
Summary: Cluster of differentiation 47 (CD47) is a transmembrane protein that is widely present on cell surfaces and overexpressed by cancer cells. It interacts with signal-regulatory protein a (SIRPa) to inhibit macrophage-mediated phagocytosis and achieve immune escape. Targeting the CD47-SIRPa axis as a cancer immunotherapy has shown promising results in pre-clinical studies.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Immunology
Louisa Katherine James
Summary: Expression of the appropriate antibody isotype is critical for effective humoral immunity. Understanding the cellular level mechanisms governing the induction, expansion, and maintenance of B cells expressing different antibody subclasses is valuable for developing B cell targeting treatments and strategic manipulation of immune responses for human health.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2022)
Article
Immunology
D. Califano, Y. Furuya, S. Roberts, D. Avram, A. N. J. McKenzie, D. W. Metzger
MUCOSAL IMMUNOLOGY
(2018)
Article
Immunology
Yoichi Furuya, Girish S. Kirimanjeswara, Sean Roberts, Rachael Racine, Jennifer Wilson-Welder, Alan M. Sanfilippo, Sharon L. Salmon, Dennis W. Metzger
Article
Immunology
Donald J. Steiner, Yoichi Furuya, Dennis W. Metzger
INFECTION AND IMMUNITY
(2018)
Article
Microbiology
Tiffany M. Zarrella, Dennis W. Metzger, Guangchun Bai
JOURNAL OF BACTERIOLOGY
(2018)
Article
Immunology
Danielle Califano, Yoichi Furuya, Dennis W. Metzger
JOURNAL OF IMMUNOLOGY
(2018)
Article
Immunology
Sean Roberts, Dennis W. Metzger, Steven M. Szczepanek
Article
Multidisciplinary Sciences
Steven M. Szczepanek, Sean Roberts, Kara Rogers, Christina Cotte, Alexander J. Adami, Sonali J. Bracken, Sharon Salmon, Eric R. Secor, Roger S. Thrall, Biree Andemariam, Dennis W. Metzger
Article
Microbiology
Tarani Kanta Barman, Rachael Racine, Jesse L. Bonin, Danielle Califano, Sharon L. Salmon, Dennis W. Metzger
Summary: Bacterial co-infections are a common and challenging clinical complication of influenza. This study found that mice lacking both type-I and type-II interferon (IFN) pathways demonstrated minimal lung pathology and increased survival in a pneumococcal-influenza virus superinfection model. Therapeutic neutralization of both type-I and type-II IFN pathways provided optimal protection to superinfected wild-type mice.
Article
Virology
Amit K. Singh, Kathleen A. Stellrecht, Thilaka Arunachalam, Tarani K. Barman, Michael D. Robek, Michael J. Waxman, Sarah L. Elmendorf, Dennis W. Metzger
Summary: This study found active SARS-CoV-2 virus in only a small percentage of samples from congregate care patients, primarily in those with high viral loads/low antibody titers and early in the disease progression.
JOURNAL OF CLINICAL VIROLOGY
(2021)
Review
Virology
Tarani Kanta Barman, Dennis W. Metzger
Summary: This review discusses the role of disease tolerance in viral-bacterial co-infection, focusing on host cytokines and cells that promote tissue protection and damage control.
Article
Multidisciplinary Sciences
Tarani Kanta Barman, Victor C. Huber, Jesse L. Bonin, Danielle Califano, Sharon L. Salmon, Andrew N. J. McKenzie, Dennis W. Metzger
Summary: This study reveals the interplay between host interferon (IFN)-gamma and viral PB1-F2 virulence protein in regulating the functions of innate lymphoid cells (ILCs) and T cells during influenza virus infection. In the absence of IFN-gamma, lung ILC2s initiate a robust IL-5 response, leading to improved tissue integrity and increased survival. However, the presence of functional PB1-F2 suppresses ILC2 responses and induces a dominant IL-13 CD8 T cell response. This study also demonstrates the importance of IFN-gamma in host resistance against lethal doses of the influenza virus.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Medicine, Research & Experimental
Tarani Kanta Barman, Amit K. Singh, Jesse L. Bonin, Tanvir Noor Nafiz, Sharon L. Salmon, Dennis W. Metzger
Summary: This study found that coinfection of SARS-CoV-2 and Streptococcus pneumoniae leads to lung inflammation and death, and the treatment methods differ. Treatment with murine GM-CSF can reduce bacteria and pathology, partially protecting from death, but therapeutic targeting of IFNs does not work. Combined vaccination provides 100% protection against subsequent coinfection.
Meeting Abstract
Immunology
Alicia Soucy, Dennis W. Metzger
JOURNAL OF IMMUNOLOGY
(2017)
Article
Immunology
Donald J. Steiner, Yoichi Furuya, Michael B. Jordan, Dennis W. Metzger
INFECTION AND IMMUNITY
(2017)
Meeting Abstract
Immunology
Keer Sun, Vijaya Kumar Yajjala, Christopher Bauer, Geoffrey A. Talmon, Karl K. Fischer, Tammy L. Kielian, Dennis W. Metzger
JOURNAL OF IMMUNOLOGY
(2016)
