Article
Pharmacology & Pharmacy
Jorge Alves-Silva, Monica Zuzarte, Carlos Cavaleiro, Ligia Salgueiro
Summary: Fungal infections are prevalent with high morbidity and mortality rates, especially in patients with underlying health complications. Plant-based antifungal products show promise in mitigating these infections, and Lavandula multifida essential oil has been found to have strong inhibitory and disruptive effects on fungal biofilms. The oil significantly decreased biofilm mass and viability, and induced morphological alterations in fungal biofilms, making it a potential candidate for the development of effective antifungal products.
Review
Pharmacology & Pharmacy
Hui Lu, Ting Hong, Yuanying Jiang, Malcolm Whiteway, Shiqun Zhang
Summary: Candidiasis is a fungal infection caused by Candida, most commonly Candida albicans. It can cause various infections on mucous membranes and throughout the body, especially in immunocompromised individuals. However, the immune mechanisms of the host and current antifungal drugs are not fully understood. Therefore, it is important to uncover host immune defenses and develop new antifungal strategies.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Obstetrics & Gynecology
R. Sobel, P. Nyirjesy, M. A. Ghannoum, D. A. Delchev, N. E. Azie, D. Angulo, I. A. Harriott, K. Borroto-Esoda, J. D. Sobel
Summary: Ibrexafungerp has demonstrated statistical superiority over placebo in treating acute vulvovaginal candidiasis, with significantly higher rates of clinical cure, mycological eradication, overall success, and symptom resolution. It is a promising and effective one-day treatment for this condition.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Microbiology
Jizhou Li, Alix T. Coste, Daniel Bachmann, Dominique Sanglard, Frederic Lamoth
Summary: NSC319726 exhibited in vitro activity against C. auris and in vivo efficacy in an invertebrate model. It may have the potential to serve as a novel antifungal therapy for C. auris infection.
MICROBIOLOGY SPECTRUM
(2021)
Article
Biochemistry & Molecular Biology
Ellen A. Malveira, Tawanny K. B. Aguiar, Nilton A. S. Neto, Renato R. Roma, Maria H. C. Santos, Ana L. E. Santos, Ayrles F. B. Silva, Cleverson D. T. Freitas, Bruno A. M. Rocha, Pedro F. N. Souza, Claudener S. Teixeira
Summary: Lectins, such as DVL, have the ability to bind to carbohydrates and inhibit fungal growth. DVL demonstrates anti-candida activity and multiple mechanisms of action against yeast.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Microbiology
Ola E. Salama, Aleeza C. Gerstein
Summary: Candida albicans is the most common pathogenic fungus in vulvovaginal candidiasis, but increasing incidence of non-albicans species has led to resistance to antifungal drugs like fluconazole. Boric acid is an alternative treatment that shows effectiveness in complicated VVC infections. Research has found that boric acid inhibits hyphal formation and reduces biofilm biomass and metabolic activity in C. albicans in a dose-dependent manner.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Daniela Ailincai, Simona Morariu, Irina Rosca, Andreea Isabela Sandu, Luminita Marin
Summary: This study successfully synthesized and characterized new hydrogels based on chitosan and three halogenated monoaldehydes. These hydrogels were used as excipients for drug delivery systems, incorporating the antifungal drug fluconazole. The systems showed high degree of ordering at supramolecular level and good water-uptake, and exhibited sustained release of the drug for seven days, making them promising materials for bioapplications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Aitzol Perez-Rodriguez, Elena Eraso, Guillermo Quindos, Estibaliz Mateo
Summary: Mycoses are responsible for millions of infections worldwide each year, with invasive candidiasis being the most common and having high morbidity and mortality. The incidence of other Candida species, such as Candida parapsilosis, Candida glabrata, and Candida auris, is increasing. These pathogens often show reduced susceptibility to commonly used antifungal drugs, and the emergence of multi-drug-resistant strains continues to rise. Therefore, the search for new molecules that target these pathogens in a different way is urgent. Antimicrobial peptides, found in nature, have advantages over traditional antifungal agents and are considered a promising option for treating a wide range of microbial infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Dan Cristian Gheorghe, Adelina-Gabriela Niculescu, Alexandra Catalina Birca, Alexandru Mihai Grumezescu
Summary: This paper focuses on the newest therapeutic options against oral Candida infections, including compounds and biomaterials with inherent antifungal properties, improved materials for dental prostheses and denture adhesives, drug delivery systems, and combined approaches towards developing the optimum treatment. Novel treatments have to be developed and implemented in clinical practice to address the severe adverse effects often associated with traditional antifungal agents.
Article
Immunology
Henry W. Nabeta, Amanda B. Lasnik, Joshua L. Fuqua, Lin Wang, Lisa C. Rohan, Kenneth E. Palmer
Summary: Resistance to antifungal agents in vulvovaginal candidiasis has become a global issue. This study demonstrates that Q-GRFT has significant preventive and therapeutic activity in vaginal candidiasis, offering additional benefit as a topical microbicide for prevention of HIV-1 and HSV-2 transmission.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Shakti Singh, Sunna Nabeela, Ashley Barbarino, Ashraf S. Ibrahim, Priya Uppuluri
Summary: Prevention of disseminated candidiasis in neonates is important and vaccination with recombinant forms of the C. albicans N-termini of cell wall proteins Als3 and Hyr1, as well as the transfer of antibodies, can offer protection. These findings highlight the potential clinical relevance of active and passive vaccination strategies using these antigens.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Food Science & Technology
Jose Carlos Andrade, Sunil Kumar, Awanish Kumar, Lucia Cernakova, Celia F. Rodrigues
Summary: Candidiasis poses a worldwide growing problem due to antifungal resistance and immunosuppression, with limited treatment options available. Probiotics show potential for managing oral and vulvovaginal candidiasis, particularly with strains like Lactobacillus, Bifidobacterium, and Saccharomyces. Further research, including in vitro and in vivo studies, is necessary to establish the utility of probiotics in managing candidiasis, especially in areas like skin candidiasis.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Microbiology
Hazrat Bilal, Dongxing Zhang, Muhammad Shafiq, Muhammad Nadeem Khan, Canhua Chen, Sabir Khan, Qian Wang, Lin Cai, Rehmat Islam, Haibin Hu, Yuebin Zeng
Summary: This study provides important information on the burden of candidiasis, particularly candidemia, and the antifungal susceptibility of Candida species among hospitalized patients in an underdeveloped region of China. The finding that azoles were least effective against Candida species causing candidemia suggests the possibility of resistance to this class of antifungal agents. This information can guide the choice of empirical therapy and help in the selection of appropriate antifungal agents for the treatment of candidemia, thereby reducing the risk of resistance development.
MICROBIOLOGY SPECTRUM
(2023)
Review
Dermatology
Koray K. Demir, Guillaume Butler-Laporte, Olivier Del Corpo, Taline Ekmekjian, Donald C. Sheppard, Todd C. Lee, Matthew P. Cheng
Summary: A systematic review and network meta-analysis compared the efficacy of echinocandins, amphotericin B, and triazoles in the treatment of invasive candidiasis, finding that echinocandins were associated with the highest treatment success rate. Overall survival did not significantly differ between groups. Echinocandins were deemed the most effective choice in about 98% of rank probability analysis.
Review
Microbiology
Ben Y. Parslow, Christopher R. Thornton
Summary: Invasive candidiasis is a serious infection in immunocompromised individuals, but it is often neglected by public health authorities. Increasing incidence rates, driven by at-risk populations, and the lack of fast, accurate diagnostics have led to unnecessary use of antifungal drugs, contributing to emerging drug resistance. Preserving and expanding the utility of antifungals should be a top priority, potentially through the use of biomarker tests and development of novel antifungals targeting Candida pathogenesis mechanisms.
