Article
Urology & Nephrology
Dimas Abdirama, Sebastian Tesch, Anna-Sophie Griessbach, Caroline von Spee-Mayer, Jens Y. Humrich, Ulrik Stervbo, Nina Babel, Christian Meisel, Tobias Alexander, Robert Biesen, Petra Bacher, Alexander Scheffold, Kai-Uwe Eckardt, Falk Hiepe, Andreas Radbruch, Gerd-Rudiger Burmester, Gabriela Riemekasten, Philipp Enghard
Summary: Systemic lupus erythematosus is characterized by loss of tolerance towards nuclear antigens with autoreactive CD4(+) T cells implicated in disease pathogenesis. The frequencies of nuclear antigen specific CD4(+) T cells correlate with disease severity, and these cells produce multiple effector cytokines. These previously unrecognized characteristics support a role for nuclear antigen-specific CD4(+) T cells in systemic lupus erythematosus.
KIDNEY INTERNATIONAL
(2021)
Article
Rheumatology
Yu Shan, Shingo Nakayamada, Aya Nawata, Kaoru Yamagata, Koshiro Sonomoto, Hiroaki Tanaka, Yurie Satoh-Kanda, Mai-Phuong Nguyen, Yasuyuki Todoroki, Atsushi Nagayasu, Masanobu Ueno, Ryuichiro Kanda, Yuya Fujita, Tong Zhang, He Hao, Jieqing Zhou, Xiaoxue Ma, Junpei Anan, Anh Phuong Nguyen, Yoshiya Tanaka
Summary: This study found that in patients with SLE, the proportion of Tph cells is increased and is correlated with disease activity and severity of organ manifestations. Transforming growth factor (TGF)-beta 3 is highly expressed in macrophages and induces the generation of Tph-like cells, which enhances B-cell differentiation and antibody production.
Article
Biochemistry & Molecular Biology
Rakesh Mishra, Ramalingam Bethunaickan, Celine C. Berthier, Zhengzi Yi, Joshua J. Strohl, Patricio T. Huerta, Weijia Zhang, Anne Davidson
Summary: The study found significant disruption of renal circadian rhythms in mice with lupus nephritis, affecting multiple renal pathways including homeostasis, metabolism, and blood pressure regulation. Induction of remission therapy partially reversed this circadian dysregulation.
MOLECULAR MEDICINE
(2021)
Article
Immunology
Juan Tian, Xiaowei Li, Yiru Jiang, Feng Gao, Bomiao Ju, Jiayue Chen, Wenhua Zhu, Lan He, Liesu Meng, Shemin Lu
Summary: SLC7A5 expression is increased in CD4+ T cells and CD19+ B cells of SLE patients, and this up-regulation is positively correlated with kidney function. SLC7A5 may play a potential role in mediating renal damage in SLE.
CLINICAL IMMUNOLOGY
(2022)
Article
Immunology
Shogo Ijima, Yuki Saito, Kentaro Nagaoka, Sena Yamamoto, Tsukasa Sato, Norihiro Miura, Taiki Iwamoto, Maki Miyajima, Takako S. Chikenji
Summary: Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease, and lupus nephritis (LN) is a major risk factor. This study found that fisetin has the potential to be used in the treatment of LN, with its effects varying depending on the cell type and potentially providing therapeutic effects in different LN pathologies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Weiqian Chen, Weishan Huang, Youqiu Xue, Ye Chen, Wenbin Qian, Jilin Ma, Avery August, Julie Wang, Song Guo Zheng, Jin Lin
Summary: This study found that Nrp-1 is not only a marker for tTreg, but also a marker for a new subset of iTreg with enhanced suppressive function, indicating the potential application of Nrp-1(+)iTreg cell therapy for autoimmune and inflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Samir V. Parikh, Ana Malvar, John Shapiro, James M. Turman, Huijuan Song, Valeria Alberton, Bruno Lococo, Juan M. Mejia-Vilet, Sethu Madhavan, Jianying Zhang, Lianbo Yu, Anjali A. Satoskar, Dan Birmingham, Wael N. Jarjour, Brad H. Rovin, Latha P. Ganesan
Summary: The study identified a novel inflammatory dendritic cell (infDC) population highly expressed in the kidneys of patients with proliferative LN. Further investigation revealed that these infDCs interact with T cells in the kidney during LN flare, potentially playing a role in renal injury.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Anika Wiechmann, Benjamin Wilde, Bartosz Tyczynski, Kerstin Amann, Wayel H. Abdulahad, Andreas Kribben, Karl Sebastian Lang, Oliver Witzke, Sebastian Dolff
Summary: This study found that the expression of CD107a on CD8(+) T-cells is decreased in patients with systemic lupus erythematosus, particularly in those with inactive disease. There is a significant correlation between the percentage of CD107a(+)CD8(+) T-cells and disease activity, suggesting a potential association with disease activity and a role in the pathogenesis of lupus nephritis.
FRONTIERS IN MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Rajkumar Venkatadri, Vikram Sabapathy, Murat Dogan, Rahul Sharma
Summary: Lupus glomerulonephritis is a complex autoimmune disease with limited treatment options. Treg-enhancement and indirect Treg-modulation strategies are being investigated.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Li Zhou, Xuemin He, Peihong Cai, Ting Li, Rongdong Peng, Junlong Dang, Yue Li, Haicheng Li, Feng Huang, Guojun Shi, Chichu Xie, Yan Lu, Yanming Chen
Summary: The study found that TGF-beta-induced Tregs could ameliorate the development of T1D and preserve beta cell function in a mouse model. The preventive effect was associated with the inhibition of Tc1 cell function and rebalancing the Treg/Tc1 cell ratio. The underlying mechanisms involved the combinatorial actions of mTOR and TCF1 mediated by TGF-beta.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Rozita Mohd, Siok-Fong Chin, Syahrul Sazliyana Shaharir, Qin Shi Cham
Summary: Lupus nephritis is a severe manifestation of systemic lupus erythematosus (SLE) caused by immune dysregulation and kidney inflammation. Recent findings suggest that gut microbiota may play a key role in enhancing immune complex deposition and inflammation in the kidneys. In this review, we aim to explore the potential link between gut microbiota and the immune system, with a focus on renal inflammation, and discuss potential novel therapies to improve or complement current treatment of lupus nephritis.
Article
Immunology
Jing Song, Warren Anderson, Alex Hu, Kazushige Obata-Ninomiya, Steven F. Ziegler, David J. Rawlings, Jane H. Buckner
Summary: This study utilized gene editing to knock out the CBLB gene in human CD4+ T cells, revealing that CBLB knockout resulted in hyperproliferation and excessive IL-2 production in CD4+ T cells. The knockout cells showed resistance to Treg suppression and were able to overcome Treg inhibition by producing high levels of cytokines, promoting the proliferation and activation of T effector cells.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Immunology
Takashi MaruYama, Shuhei Kobayashi, Hiroko Nakatsukasa, Yuki Moritoki, Daiki Taguchi, Yoichi Sunagawa, Tatsuya Morimoto, Atsuko Asao, Wenwen Jin, Yuji Owada, Naoto Ishii, Yoshiharu Iwabuchi, Akihiko Yoshimura, WanJun Chen, Hiroyuki Shibata
Summary: Regulatory T cells (Tregs) orchestrate antitumor immune responses, with TGF-beta promoting Treg generation through NF-kappa B/p300 and SMAD signaling pathways. GO-Y030 inhibits Treg generation and stability by blocking these pathways, resulting in potent anticancer effects in vivo tumor models.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Mi-Ae Lyu, Ximing Tang, Joseph D. Khoury, Maria Gabriela Raso, Meixian Huang, Ke Zeng, Mitsutaka Nishimoto, Hongbing Ma, Tara Sadeghi, Christopher R. Flowers, Simrit Parmar
Summary: This study found that treatment with UCB-Tregs can reduce the inflammatory burden in SLE, decrease autoantibody production, and improve kidney function. UCB-Tregs have the potential to be a therapeutic option for lupus nephritis.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Joshua M. Moreau, Maria Velegraki, Chelsea Bolyard, Michael D. Rosenblum, Zihai Li
Summary: TGF-beta 1 plays a crucial role in the development and function of T-reg, although its pleiotropic and context-dependent activity makes it complicated.
SCIENCE IMMUNOLOGY
(2022)
