Review
Immunology
Guanyu Qu, Shengli Wang, Zhenlong Zhou, Dawei Jiang, Aihua Liao, Jing Luo
Summary: This article summarizes the current knowledge of the γδT cell phenotype in various tissues in mice and humans, describing the similarities and differences of tissue-resident γδT cells in these two species.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Shigeo Tokumaru, Yuta Yamamoto, Kazuki Yoshizawa, Yuji Soejima, Hideki Sanjo, Shinsuke Taki
Summary: CD8 alpha alpha(+) intestinal intraepithelial lymphocytes (iIELs) play a unique role in maintaining the integrity of the intestinal epithelial barrier. The transcriptional regulator interferon regulatory factor-2 (IRF-2) is found to be essential for the development and maturation of iIELs. Mice lacking IRF-2 show a severe reduction in CD8 alpha alpha(+)IELs, while CD8 alpha beta(+)IELs remain unaffected. Therefore, IRF-2 plays a crucial role in regulating the development and maturation of iIELs.
INTERNATIONAL IMMUNOLOGY
(2023)
Article
Oncology
Juan-Pablo Cerapio, Marion Perrier, Camille-Charlotte Balanca, Pauline Gravelle, Frederic Pont, Christel Devaud, Don-Marc Franchini, Virginie Feliu, Marie Tosolini, Carine Valle, Frederic Lopez, Anne Quillet-Mary, Loic Ysebaert, Alejandra Martinez, Jean Pierre Delord, Maha Ayyoub, Camille Laurent, Jean-Jacques Fournie
Summary: This study provides the first detailed view of human gamma delta T cell differentiation in cancer, revealing a different differentiation pattern from healthy state. The majority of infiltrating T cells in solid tumors and lymphomas are TCRV gamma non9 gamma delta T cells, which shows quantitative correlation and remarkable alignment with T CD8 in terms of differentiation, exhaustion, gene expression profile, and response to immune checkpoint therapy, highlighting the importance of this cancer-wide association for developing cancer immunotherapies.
Article
Immunology
Sara Costa, Dalila Bevilacqua, Elena Caveggion, Sara Gasperini, Elena Zenaro, Francesca Pettinella, Marta Donini, Stefano Dusi, Gabriela Constantin, Silvia Lonardi, William Vermi, Francesco De Sanctis, Stefano Ugel, Tiziana Cestari, Clare L. Abram, Clifford A. Lowell, Pamela Rodegher, Franco Tagliaro, Giampiero Girolomoni, Marco A. Cassatella, Patrizia Scapini
Summary: This study reveals the negative regulatory role of neutrophils in psoriasis development by inhibiting gammadelta T cell effector functions and reducing oxidative stress.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Kieran D. James, Andrea J. White, William E. Jenkinson, Graham Anderson
Summary: Gamma delta T-cell development and effector priming in adulthood are controlled by the medulla, with the medullary epithelial product CCL21 playing a crucial role in this process.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Mei Lan Chen, Xiangsheng Huang, Hongtao Wang, Courtney Hegner, Yujin Liu, Jinsai Shang, Amber Eliason, Huitian Diao, HaJeung Park, Blake Frey, Guohui Wang, Sarah A. Mosure, Laura A. Solt, Douglas J. Kojetin, Alex Rodriguez-Palacios, Deborah A. Schady, Casey T. Weaver, Matthew E. Pipkin, David D. Moore, Mark S. Sundrud
Summary: The study identified the nuclear xenobiotic receptor CAR as a regulator of MDR1 expression in T cells, protecting the small intestine from bile acid toxicity and inflammation. Activation of CAR in T-eff cells infiltrating the small intestine induced large-scale transcriptional reprogramming and promoted the expression of the anti-inflammatory cytokine IL-10.
Article
Biochemistry & Molecular Biology
Rebecca L. O'Brien, Jennifer Matsuda, M. Kemal Aydintug, Niyun Jin, Swati Phalke, Willi K. Born
Summary: Previous studies have shown inconsistent results regarding the role of gamma delta T cells in the development of type 1 diabetes. This study focused on NOD mice and found that NOD V γ4+ γδ T cells inhibit diabetes development, while NOD V γ1+ cells promote it. Additionally, changes in the abundance of other T cell types were observed in NOD mice deficient in specific gamma delta T cell subsets.
Article
Immunology
Marta Sanz, Brendan T. Mann, Paul L. Ryan, Alberto Bosque, Daniel J. Pennington, Holger Hackstein, Natalia Soriano-Sarabia
Summary: Under non-pathological conditions, human ?d T cells represent a small fraction of CD3(+) T cells in peripheral blood (1-10%). They constitute a unique subset of T lymphocytes that recognize stress ligands or non-peptide antigens through MHC-independent presentation. Major human ?d T cell subsets, Vd1 and Vd2, expand in response to microbial infection or malignancy, but possess distinct tissue localization, antigen recognition, and effector responses. By comparing highly purified Vd1 and Vd2 cells, this study found distinct genetic and phenotypic signatures that define functional differences in ?d T cell populations, suggesting that Vd1 and Vd2 T cells are different lineages. These findings will facilitate further investigation into the ligand specificity and unique role of Vd1 and Vd2 cells in early immune responses.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Anne B. C. Cherry, Nicholas A. Gherardin, Hafiz I. Sikder
Summary: This minireview explores the biology of gamma delta T cells, including their unique ability to recognize intracellular disturbances and non-peptide-based antigens, and proposes a framework for understanding gamma delta T cell-inspired therapeutic strategies in cancer treatment.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Shivkumar Biradar, Yash Agarwal, Michael T. Lotze, Moses T. Bility, Robbie B. Mailliard
Summary: This study characterizes the interactions between gamma-delta T cells and HIV in a mouse model and explores the immunotherapeutic potential of V delta 2 T cells in controlling HIV replication. The findings reveal that HIV infection affects the proportion and ex vivo expansion of V delta 2 T cells in BLT humanized mice, and the adoptive transfer of activated V delta 2 T cells does not control HIV replication but exacerbates viremia.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Eline van Diest, Mara J. T. Nicolasen, Lovro Kramer, Jiali Zheng, Patricia Hernandez-Lopez, Dennis X. Beringer, Jurgen Kuball
Summary: In this study, we developed a novel T cell engager concept called GAB by utilizing γδTCR as a tumor targeting domain. The γδ ECTO-alpha CD3-dimer design was found to be superior in function compared to monomers and does not induce T cell activation without simultaneous tumor engagement.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sara Scaramuzzino, Delphine Potier, Robin Ordioni, Pierre Grenot, Dominique Payet-Bornet, Herve Luche, Bernard Malissen
Summary: The study demonstrated that γδ T-cell lineage development not only relies on the signaling of γδ TCR but also requires the regulatory role of LAT in mice lacking LAT expression.
Review
Immunology
Kevin Joannou, Troy A. Baldwin
Summary: The immune system consists of various T-cell lineages distributed in both lymphoid and non-lymphoid tissues. The intestinal epithelium contains intraepithelial lymphocytes that play a crucial role in maintaining barrier homeostasis. This review focuses on T-cell receptor alpha beta (TCR alpha beta) CD8 alpha alpha intraepithelial lymphocytes, discussing their development and functions in the intestines. The available evidence suggests an ontogenic story starting from agonist selection of T cells in the thymus and ending with the specific signaling environment of the intestinal epithelium. The development of different waves of TCR alpha beta CD8 alpha alpha intraepithelial lymphocytes and their importance for intestinal epithelial homeostasis raise further key questions.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Zhenhua Li, Quanli Yang, Xin Tang, Yiming Chen, Shanshan Wang, Xiaojie Qi, Yawen Zhang, Zonghua Liu, Jing Luo, Hui Liu, Yongbing Ba, Lianxia Guo, Baojian Wu, Fang Huang, Guangchao Cao, Zhinan Yin
Summary: This study explores the heterogeneity of gamma delta T cells in different tissues and uncovers potential regulatory mechanisms. It identifies a novel subset of immature gamma delta T cells localized to the thymus and validates the circadian transcription factor NR1D1 as a negative regulator of gamma delta T17 cell differentiation.
Article
Biochemistry & Molecular Biology
Mako Tomogane, Maho Omura, Yusuke Sano, Daiki Shimizu, Yuki Toda, Shigekuni Hosogi, Shinya Kimura, Eishi Ashihara
Summary: The study shows that amplification of gamma delta T cells requires CD14(+) monocytes as accessory cells, and the surface expression of BTN3A1 on monocytes positively correlates with the expansion of gamma delta T cells. Additionally, treatment with BTN3A1-Fc can enhance the expansion efficiency of gamma delta T cells with poor expansion capacity.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Gastroenterology & Hepatology
Jinzhou Zhu, Zhengqi Tan, Kelseanna Hollis-Hansen, Yong Zhang, Chaohui Yu, Youming Li
DIGESTIVE DISEASES AND SCIENCES
(2017)
Review
Gastroenterology & Hepatology
Li Cen, Jiaqi Pan, Boyan Zhou, Chaohui Yu, Youming Li, Weixing Chen, Zhe Shen
Article
Gastroenterology & Hepatology
Lan Li, Yini Ke, Chaohui Yu, Guogang Li, Ningmin Yang, Jianzhong Zhang, Youming Li
Article
Biochemistry & Molecular Biology
Yi Chen, Haixiu Huang, Chengfu Xu, Chaohui Yu, Youming Li
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2017)
Article
Gastroenterology & Hepatology
Jinghua Wang, Wanlin Zhu, Shujun Huang, Lei Xu, Min Miao, Chenjiao Wu, Chaohui Yu, Youming Li, Chengfu Xu
LIVER INTERNATIONAL
(2017)
Article
Multidisciplinary Sciences
Tianlian Yan, Yini Ke, Yi Chen, Chengfu Xu, Chaohui Yu, Youming Li
Article
Gastroenterology & Hepatology
Yi Chen, Xin-Jue He, Min-Jian Zhou, You-Ming Li
WORLD JOURNAL OF GASTROENTEROLOGY
(2017)
Article
Infectious Diseases
D. -S. Liu, Y. -H. Wang, Z. -R. Zeng, Z. -Y. Zhang, H. Lu, J. -M. Xu, Y. -Q. Du, Y. Li, J. -B. Wang, S. -P. Xu, Y. Chen, C. -H. Lan, H. Cheng, M. -D. Jiang, L. -X. Zhang, L. -J. Huo, S. -Y. Chen, G. -X. Zhang, K. -C. Wu, X. Zhu, Y. -X. Chen, Y. Zhu, X. Shu, Y. Xie, N. -H. Lu
CLINICAL MICROBIOLOGY AND INFECTION
(2018)
Article
Gastroenterology & Hepatology
Jinghua Wang, Liang Ma, Shenghui Chen, Lei Xu, Min Miao, Chaohui Yu, Youming Li, Chengfu Xu
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2018)
Article
Multidisciplinary Sciences
Yun Hong, Sirui Li, Jifeng Wang, Youming Li
SCIENTIFIC REPORTS
(2018)
Editorial Material
Surgery
Z. Y. Fang, H. X. Huang, C. Lu, X. X. Zhou, F. Ji, C. H. Yu, Y. M. Li
ANNALS OF THE ROYAL COLLEGE OF SURGEONS OF ENGLAND
(2018)
Article
Multidisciplinary Sciences
Xi Jin, Jiang Liu, Yi-peng Chen, Zun Xiang, Jie-xia Ding, You-ming Li
Review
Medicine, General & Internal
Jiahui Hu, Dongdong Huang, Chengfu Xu, Yi Chen, Han Ma, Zhe Shen
Summary: We report a case of Epstein-Barr virus-positive inflammatory follicular dendritic cell sarcoma (EBV+ iFDCS) presenting as a colon polyp in a 52-year-old woman with a special family history. The excised polypoid mass showed histopathological features consistent with EBV+ iFDCS, including infiltration of IgG4+ cells and positive expression of CD21, CD23, CD35, and EBER. The patient remained disease-free during the 1-year follow-up. This case highlights the importance of identifying the pathogenesis sites and sharing diagnostic experiences of EBV+ iFDCS, as well as summarizing its clinicopathological features presenting as a colon polyp.
MEDICINA-LITHUANIA
(2023)
Article
Pharmacology & Pharmacy
C-J Lei, B. Wang, Z-X Long, H. Ren, Q-Y Pan, Y. Li
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2018)
Article
Endocrinology & Metabolism
Jinzhou Zhu, Xingyong Wan, Yuming Wang, Kefu Zhu, Chunxiao Li, Chaohui Yu, Youming Li