Review
Biochemistry & Molecular Biology
Nadine Abu-Ghazaleh, Shaun Brennecke, Padma Murthi, Vijaya Karanam
Summary: Recurrent miscarriage (RM) refers to the occurrence of two or more consecutive miscarriages before 20 weeks' gestation. Vascular endothelial growth factors (VEGFs) are found to be lower in the endometrium of RM cases compared to controls. However, there are inconsistencies in the findings regarding VEGFs levels in decidua, fetoplacental tissues, and serum. Future studies should aim to use consistent definitions, sample collection methods, and laboratory analyses to clarify the association between VEGF and RM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Emily M. Whettlock, Ee Woon, Antonia O. Cuff, Brendan Browne, Mark R. Johnson, Victoria Male
Summary: Uterine natural killer cells (uNK) have been found to play an important role in regulating pregnancy. Recent studies have shown that uNK can be divided into three subsets, each with different functions during pregnancy. These subsets are most active during the secretory phase of the menstrual cycle and have the highest frequency of interaction with placental cells. This research provides important insights for studying subfertility, recurrent miscarriage, pre-eclampsia, and pre-term labor.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Hsien-Ming Wu, Tzu-Chi Lo, Chia-Lung Tsai, Liang-Hsuan Chen, Hong-Yuan Huang, Hsin-Shih Wang, John Yu
Summary: This study investigates the involvement of miR-138-5p and GPR124 in NLRP3 inflammasome activation during embryo implantation and early pregnancy. The results indicate that these factors play important roles in decidual programming and placentation, suggesting their potential as modulators in human pregnancy.
Article
Multidisciplinary Sciences
Juliette Krop, Anita van der Zwan, Marieke E. Ijsselsteijn, Hanneke Kapsenberg, Sietse J. Luk, Sanne H. Hendriks, Carin van der Keur, Lotte J. Verleng, Antonis Somarakis, Lotte van der Meeren, Geert Haasnoot, Manon Bos, Noel F. C. C. de Miranda, Susana M. Chuva de Sousa Lopes, Marie-Louise P. van der Hoorn, Frits Koning, Frans H. J. Claas, Sebastiaan Heidt, Michael Eikmans
Summary: This study highlights the dynamic role of myeloid cells at the human maternal-fetal interface throughout gestation.
Review
Physiology
Inmaculada Moreno, Antonio Capalbo, Aymara Mas, Tamara Garrido-Gomez, Beatriz Roson, Maurizio Poli, Eva Dimitriadis, Xavier Santamaria, Felipe Vilella, Carlos Simon
Summary: Pregnancy is established during the periconceptional period from blastocyst attachment to placenta formation, significantly impacting the health of both the child and the mother. Advances in understanding the periconceptional space, including the preimplantation human embryo and maternal endometrium, offer opportunities for preventative interventions. This review discusses the role of maternal decidua, the maternal-embryonic interface, the endometrial microbiome, and the myometrium in pregnancy health during the periconceptional period.
PHYSIOLOGICAL REVIEWS
(2023)
Article
Immunology
Shafat Ali, Sabhiya Majid, Md. Niamat Ali, Shahnaz Taing, Muneeb U. Rehman, Azher Arafah
Summary: Recurrent pregnancy loss (RPL) is a reproductive disease that involves two or more successive spontaneous abortions, with causes often related to dysfunction of endometrial cytokines and dysregulation of decidual cytokines. Cytokine modulatory therapies are considered promising for preventing RPL.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Ken-Go Hayashi, Ryosuke Sakumoto
Summary: This study aimed to investigate the mRNA expression of pro- and anti-angiogenic factors, protein localization of thrombospondin (TSP), and vascularity in the endometrium of repeat breeder (RB) and normally fertile (non-RB) cows. RB cows had higher mRNA expression levels of TSP ligands and receptors than non-RB cows. RB cows also had higher mRNA expression of FGFR1, ANGPT1, and ANGPT2, and lower mRNA expression of VEGFB than non-RB cows.
ANIMAL REPRODUCTION SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Monika Baczkowska, Magdalena Zgliczynska, Jan Faryna, Ewa Przytula, Blazej Nowakowski, Michal Ciebiera
Summary: Placental abruption, a rare perinatal complication, involves the separation of the placenta from the uterus lining before childbirth, posing serious consequences and a high risk of maternal and fetal mortality. Disruption of immunological processes on the maternal-fetal interface plays a crucial role in the pathophysiology of this condition, requiring further research to fully understand this complex process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Tamara Garrido-Gomez, Nerea Castillo-Marco, Monica Clemente-Ciscar, Teresa Cordero, Irene Munoz-Blat, Alicia Amadoz, Jorge Jimenez-Almazan, Rogelio Monfort-Ortiz, Reyes Climent, Alfredo Perales-Marin, Carlos Simon
Summary: Through global RNA sequencing, a fingerprint comprising 120 genes encoding the decidualization defect in women who developed severe preeclampsia has been identified. These findings implicate dysregulated hormonal signaling in the decidual endometria of women with severe preeclampsia, providing a potential footprint for preconception or early prenatal screening of risk, aimed at improving prevention and early treatments.
Article
Biochemistry & Molecular Biology
Marissa J. Harmsen, Arda Arduc, Maaike C. G. Bleeker, Lynda J. M. Juffermans, Arjan W. Griffioen, Ekaterina S. Jordanova, Judith A. F. Huirne
Summary: Evidence suggests that adenomyosis patients have increased angiogenesis and lymphangiogenesis in both ectopic and eutopic endometrium. This finding indicates a potential link between adenomyosis and blood vessel and lymph vessel formation in the endometrium.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Qi Guo, Yajie Chang, Jingjie Li, Chuanchuan Zhou, Rui Huang, Xing Yang, Guihua Liu, Xiaoyan Liang
Summary: This study compares the engraftment, retaining time, and therapeutic efficiency of differently administered BMSCs. Intra-arterial administration of BMSCs showed longer retainment, better recruitment, and higher expression of growth factors, indicating its superiority in clinical practice.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Deviyani Mahajan, Neeta Raj Sharma, Sudhakar Kancharla, Prachetha Kolli, Ashutosh Tripathy, Amarish Kumar Sharma, Sanjeev Singh, Sudarshan Kumar, Ashok Kumar Mohanty, Manoj Kumar Jena
Summary: This review article focuses on the significance of NK cells during pregnancy and their role in pregnancy-related diseases. The article provides an in-depth review of cellular and molecular interactions during pregnancy and related disorders, with NK cells playing a pivotal role. Moreover, this study helps researchers understand the physiology of normal pregnancy and related complications with respect to NK cells, so that future research work can be designed to alleviate these complications.
Article
Endocrinology & Metabolism
Ruofan Qi, Tao Zhang, Yingying Zhang, Jacqueline Pui Wah Chung, Wen-Jui Yang, Chi Chiu Wang
Summary: The aim of this study was to investigate the differences in local angiotensin II (AngII) and its receptors (AT1R, AT2R) in the endometrium and their correlation with microvessel density in women with reproductive failure. The results showed that compared to fertile women, the expression of AT2R was significantly lower and the AT1R/AT2R expression ratio was significantly higher in the stroma of women with recurrent implantation failure. The endometrium arteriole microvessel density was significantly lower and negatively correlated with the AT1R/AT2R expression ratio in the stroma of women with recurrent implantation failure. The study concludes that the local renin-angiotensin system dysregulation is associated with abnormal angiogenesis in women with recurrent implantation failure.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Immunology
Nupur Mukherjee, Richa Sharma, Deepak Modi
Summary: Recurrent implantation failure (RIF) can be caused by uterine factors, male factors, or embryo factors. It is associated with disrupted endometrial receptivity, altered gene expression, immunologic disturbances, and epigenetic alterations. RIF is a heterogeneous condition with varied immune responses, and personalized therapies based on the patient's immune status are being tested.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Article
Engineering, Biomedical
Sara Lopez-Martinez, Adolfo Rodriguez-Eguren, Lucia de Miguel-Gomez, Emilio Frances-Herrero, Amparo Faus, Ana Diaz, Antonio Pellicer, Hortensia Ferrero, Irene Cervello
Summary: The study demonstrated that using decellularized endometrial hydrogel supplemented with growth factors could potentially treat endometrial conditions such as Asherman's syndrome and endometrial atrophy. This bioengineered system showed promising results in promoting endometrial regeneration and fertility restoration in a mouse model of endometrial damage.
ACTA BIOMATERIALIA
(2021)
Meeting Abstract
Obstetrics & Gynecology
Rinat Hackmon, Matthew Bucher, Caroline Dunk, Jiahong Zhang, Dan Geraghty, Leslie Myatt
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2020)
Article
Developmental Biology
Oksana Shynlova, Lubna Nadeem, Jianhong Zhang, Caroline Dunk, Stephen Lye
Article
Obstetrics & Gynecology
Smriti Kala, Caroline Dunk, Sebastian Acosta, Lena Serghides
HUMAN REPRODUCTION
(2020)
Article
Endocrinology & Metabolism
Jelena Brkic, Caroline Dunk, Yanan Shan, Jacob Anderson O'Brien, Phetcharawan Lye, Sheza Qayyum, Peifeng Yang, Stephen G. Matthews, Stephen J. Lye, Chun Peng
FRONTIERS IN ENDOCRINOLOGY
(2020)
Article
Obstetrics & Gynecology
Enrrico Bloise, Jianhong Zhang, Jittanan Nakpu, Hirotaka Hamada, Caroline E. Dunk, Siliang Li, Guinever E. Imperio, Lubna Nadeem, Mark Kibschull, Phetcharawan Lye, Stephen G. Matthews, Stephen J. Lye
Summary: The study aims to investigate the expression pattern of specific severe acute respiratory syndrome coronavirus 2 cell entry genes, angiotensin-converting enzyme 2 and transmembrane protease serine 2, in the placenta across human pregnancy and in paired samples of decidua and placenta in pregnancies complicated by preterm birth or preeclampsia compared with those in term uncomplicated pregnancies. The increased expression of these genes in the placenta in the first trimester of pregnancy compared with later stages suggests differential susceptibility to placental entry of SARS-CoV-2 across pregnancy.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Developmental Biology
Michael Yampolsky, Oleksandr Shlakhter, Dianna Deng, Smriti Kala, Sharon L. Walmsley, Kellie E. Murphy, Mark H. Yudin, Jay MacGillivray, Mona Loutfy, Caroline Dunk, Lena Serghides
Summary: The study suggests that HIV infection and antiretroviral therapy can lead to smaller placenta weight and area, which in turn are associated with small for gestational age births. HIV+ status is linked to a 6-fold greater odds of having placenta area in the lowest quartile.
Article
Peripheral Vascular Disease
Caroline E. Dunk, Marie van Dijk, Ruhul Choudhury, Thomas J. Wright, Brian Cox, Katherine Leavey, Lynda K. Harris, Rebecca L. Jones, Stephen J. Lye
Summary: This study suggests that the STOX1 Y153H gene mutation in the placenta may contribute to preterm birth and placental preeclampsia by affecting early utero-placental development.
Article
Immunology
Oksana Shynlova, Adam Boros-Rausch, Tali Farine, Kristina M. Adams Waldorf, Caroline Dunk, Stephen J. Lye
Summary: The study reveals the critical role of cytokines secreted by decidual and myometrial cells in activating inflammatory pathways leading to labor in humans. Targeting these pathways may provide potential therapeutic interventions for preterm labor.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Yanxing Wei, Tianyu Wang, Lishi Ma, Yanqi Zhang, Yuan Zhao, Kathryn Lye, Lu Xiao, Chunlin Chen, Zhijian Wang, Yanlin Ma, Xiaohua Zhou, Fei Sun, Weili Li, Caroline Dunk, Siliang Li, Andras Nagy, Yanhong Yu, Guangjin Pan, Stephen J. Lye, Yongli Shan
Summary: This passage discusses the successful generation of trophoblast stem cells from primed human pluripotent stem cells, with BMP4 playing a significant role in the process. The derived TSCs are similar to blastocyst-derived hTSCs in various characteristics, and the chromatin accessibility dynamics and histone modifications involved in specifying hPSC-derived TSCs are defined. Additionally, knockout of H3K27 methyltransferases (EZH1/2) is shown to increase the efficiency of hTSC derivation from primed hPSCs.
Article
Cell Biology
Phetcharawan Lye, Caroline E. Dunk, Jianhong Zhang, Yanxing Wei, Jittanan Nakpu, Hirotaka Hamada, Guinever E. Imperio, Enrrico Bloise, Stephen G. Matthews, Stephen J. Lye
Summary: The study found that in pregnancies complicated by chorioamnionitis, the mRNA expression of ACE2 and CCL2 increased, while treatment with lipopolysaccharide led to an increase in cytokines and ACE2 mRNA in placental explants. The research also revealed that some immune cells from pregnant women's peripheral blood express ACE2 mRNA and protein, indicating a potential pathway for SARS-CoV-2 virus to access the placenta in cases of chorioamnionitis.
Review
Immunology
Caroline E. Dunk, Lena Serghides
Summary: The use of antiretroviral therapy (ART) in pregnancy is crucial for maternal health and has successfully reduced vertical transmission rates. However, reports suggest that women with HIV using ART during pregnancy may have higher rates of low birthweight and preterm births, particularly with the use of ritonavir-boosted lopinavir, which may affect placental and uteroplacental pathology.
Article
Medicine, General & Internal
Julian C. Gilmore, Md Tozammel Hoque, Wanying Dai, Haneesha Mohan, Caroline Dunk, Lena Serghides, Reina Bendayan
Summary: This study investigates the effect of dolutegravir (DTG) exposure on the functional expression of folate transporters in the placenta. The findings demonstrate that DTG exposure leads to a reduction in the expression of RFC and PCFT, as well as decreased folate uptake.
Article
Obstetrics & Gynecology
Caroline E. Dunk, Matthew Bucher, Jianhong Zhang, Heyam Hayder, Daniel E. Geraghty, Stephen J. Lye, Leslie Myatt, Rinat Hackmon
Summary: This study found that complications of pregnancy caused by immune inflammation, such as preeclampsia and preterm labor, can lead to altered expression profiles of nonclassical human leukocyte antigens. The level of human leukocyte antigen G increases in pregnancies complicated by severe early-onset preeclampsia with small-for-gestational-age neonates.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Meeting Abstract
Obstetrics & Gynecology
Amanda Mary Rampersaud, Caroline Dunk, Stephen J. Lye, Stephen J. Renaud
REPRODUCTIVE SCIENCES
(2020)
Meeting Abstract
Obstetrics & Gynecology
Adam J. Boros-Rausch, Caroline E. Dunk, Anna Dorogin, Kristina Adams Waldorf, Oksana P. Shynlova, Stephen J. Lye
REPRODUCTIVE SCIENCES
(2020)
