期刊
IMMUNOLOGIC RESEARCH
卷 52, 期 1-2, 页码 34-41出版社
HUMANA PRESS INC
DOI: 10.1007/s12026-012-8276-8
关键词
IL-17; Hematopoiesis; Myeloid and erythroid progenitors; Bone marrow; Spleen
类别
资金
- Ministry of Education and Science, Republic of Serbia [175062]
It has long been known that T cells have the potential to modulate hematopoietic response in different ways. More recently, the importance of interleukin (IL)-17-secreting Th17 cells in T-cell-mediated regulation of hematopoiesis was indicated by the line of evidence that IL-17 links T-cell function and hematopoiesis through stimulation of granulopoiesis and neutrophil trafficking. Furthermore, our data demonstrated that IL-17 also affects other cells of hematopoietic system, such as erythroid progenitors, as well as mesenchymal stem cells. In order to better understand the regulatory role of IL-17 in hematopoiesis, molecular mechanisms underlying the effects of IL-17 on hematopoietic and mesenchymal stem cells were also studied.
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