Article
Pharmacology & Pharmacy
Mitchell E. Granade, Laryssa C. Manigat, Michael C. Lemke, Benjamin W. Purow, Thurl E. Harris
Summary: The diacylglycerol kinase (DGK) family of lipid enzymes plays a crucial role in converting diacylglycerol (DAG) to phosphatidic acid (PA). Both DAG and PA are important lipid signaling molecules that regulate cell processes such as proliferation, apoptosis, and migration. DGK alpha has emerged as a promising therapeutic target for various cancers, including glioblastoma and melanoma, as it has shown to reduce tumor sizes and improve survival. Additionally, DGK alpha has been identified as an immune checkpoint and inhibiting it has been shown to improve T cell activation. Screening compounds structurally similar to the DGK alpha inhibitor ritanserin led to the discovery of two compounds that are more potent and selective in inhibiting DGK alpha, with one of them demonstrating similar cytotoxicity to ritanserin in GBM and melanoma cells. These findings support the search for DGK isoform-selective inhibitors to develop effective cancer therapies.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Immunology
Anna Sophie Thomann, Theresa Schneider, Laura Cyran, Ina Nathalie Eckert, Andreas Kerstan, Manfred B. Lutz
Summary: The study illustrates the induction of anergic CD4(+) T cells in vivo through high doses of antigen, converting them into suppressive Foxp3(-) IL-10(+) Tr1 cells. The up-regulation kinetics of several markers and the necessity for transient intracellular CTLA-4 expression in the conversion process are discussed.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Mikel M. Arbulo-Echevarria, Inmaculada Vico-Barranco, Fanghui Zhang, Luis M. Fernandez-Aguilar, Martyna Chotomska, Isaac Narbona-Sanchez, Lichen Zhang, Bernard Malissen, Yinming Liang, Enrique Aguado
Summary: The LAT transmembrane adaptor is crucial for transducing intracellular signals triggered by the TCR. A mutation in LAT(G135D) affects T cell development and activation, leading to changes in thymic cell populations and an increased percentage of central memory CD8+ T cells in mutant mice.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Maria Tredicine, Chiara Camponeschi, Davide Pirolli, Matteo Lucchini, Mariagrazia Valentini, Maria Concetta Geloso, Massimiliano Mirabella, Marco Fidaleo, Benedetta Righino, Camilla Moliterni, Ezio Giorda, Mario Rende, Maria Cristina De Rosa, Maria Foti, Gabriela Constantin, Francesco Ria, Gabriele Di Sante
Summary: The modulation of leukocyte trafficking, specifically the effect of TLR2 ligands on the reshuffling of CD44 isoforms repertoire in T helper cells, plays a crucial role in the pathogenesis of autoimmune disorders. The strain background and TLR2 haplotype also affect the Wnt/β-catenin signaling pathway and expression of splicing factors. This study suggests that TLRs regulation of CD44 isoform repertoire may control the distribution of lesions in the central nervous system.
Article
Immunology
Julia W. Chang, Samuel D. Reyes, Emmanuelle Faure-Kumar, Sandi K. Lam, Michael W. Lawlor, Richard J. Leventer, Sean M. Lew, Paul J. Lockhart, Kathryn Pope, Howard L. Weiner, Noriko Salamon, Harry V. Vinters, Gary W. Mathern, Aria Fallah, Geoffrey C. Owens
Summary: Using a targeted transcriptomics approach, researchers analyzed resected brain tissue from 53 pediatric epilepsy surgery cases and found a spectrum of involvement of both the innate and adaptive immune systems, with some cases showing clonally restricted T cells. The study also identified public and private T cell clones in the brain tissue, some of which were similar to viral epitopes, and observed changes in T cell clone frequency in the blood and brain following surgery and seizure recurrence.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Katharina Radakovics, Claire Battin, Judith Leitner, Sabine Geiselhart, Wolfgang Paster, Johannes Stoeckl, Karin Hoffmann-Sommergruber, Peter Steinberger
Summary: Toll-like receptors (TLRs) are essential for recognizing microbial components and initiating immune responses. Although impurities containing TLR ligands can be problematic, this study developed a highly sensitive platform for detecting TLR ligands. By using specific reporter cell lines, the study demonstrated high specificity and sensitivity in detecting various TLR ligands. This system can be used to characterize different TLR ligands, including complex samples like bacterially expressed proteins or allergen extracts, and can help define the structural requirements for TLR agonists.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Mohammad Tarique, Huma Naz, Mohd Suhail, Ali Turan, Chaman Saini, Naoshad Muhammad, Hari Shankar, Torki A. Zughaibi, Tabish H. Khan, Neena Khanna, Alpana Sharma
Summary: The overexpression of PD-1 in various immune cells is associated with disease severity in leprosy. Inhibition of PD-1 can restore the immunosuppressive activity of Treg cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Junchen Gu, Cindy Wang, Carolyn Cao, Jinwen Huang, Sandra Holzhauer, Heshani Desilva, Erin M. Wesley, Douglas B. Evans, Joseph Benci, Michael Wichroski, Susan Wee, Matthew J. Riese
Summary: Studies have shown that mice deficient in DGK zeta exhibit better control of tumors, and deficiency of DGK zeta acts additively with anti-PD1 in tumor control. Additionally, DGK zeta imparts greater regulation in human T cells compared to DGK alpha.
Review
Cell Biology
Sebastien This, Stefanie F. Valbon, Marie-Eve Lebel, Heather J. Melichar
Summary: T cell tolerance is tightly regulated by various mechanisms, with the strength of antigen receptor signaling influencing the fate and immune response of autoreactive T cells. Understanding and manipulating this signaling strength can have significant clinical implications for autoimmune diseases and immunotherapy outcomes.
Article
Immunology
Shohei Harabuchi, Omar Khan, Hamid Bassiri, Taku Yoshida, Yohei Okada, Masaomi Takizawa, Osamu Ikeda, Akihiro Katada, Taku Kambayashi
Summary: This study investigates the role of TCR signaling pathways in chronic viral infection, revealing the distinct effects of DAG and ERK on CD8+ T cell activation and survival.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Mario Bunse, Janina Pfeilschifter, Julia Bluhm, Maria Zschummel, Jara J. Joedicke, Anthea Wirges, Helen Stark, Vivien Kretschmer, Markus Chmielewski, Wolfgang Uckert, Hinrich Abken, Joerg Westermann, Armin Rehm, Uta E. Hoepken
Summary: The study demonstrates that CAR-T cells targeting CXCR5 effectively inhibit tumor growth by depleting both B cells and follicular T helper cells in lymphoma models, suggesting a promising treatment strategy for nodal B-NHLs.
NATURE COMMUNICATIONS
(2021)
Article
Environmental Sciences
Jie Gu, Kongdong Li, Hong Lin, Yanwei Wang, Yang Zhou, Dongfeng Chen, Xin Gu, Haifeng Shi
Summary: Cadmium exposure inhibits the expression of TNF-alpha and IFN-gamma, and may affect the NF kappa B signaling pathway in mouse spleen tissues. By promoting autophagy-lysosomal degradation of TLR9, cadmium suppresses immune response under ConA activation condition.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biochemistry & Molecular Biology
Nathan D. Mathewson, Orr Ashenberg, Itay Tirosh, Simon Gritsch, Elizabeth M. Perez, Sascha Marx, Livnat Jerby-Arnon, Rony Chanoch-Myers, Toshiro Hara, Alyssa R. Richman, Yoshinaga Ito, Jason Pyrdol, Mirco Friedrich, Kathrin Schumann, Michael J. Poitras, Prafulla C. Gokhale, L. Nicolas Gonzalez Castro, Marni E. Shore, Christine M. Hebert, Brian Shaw, Heather L. Cahill, Matthew Drummond, Wubing Zhang, Olamide Olawoyin, Hiroaki Wakimoto, Orit Rozenblatt-Rosen, Priscilla K. Brastianos, X. Shirley Liu, Pamela S. Jones, Daniel P. Cahill, Matthew P. Frosch, David N. Louis, Gordon J. Freeman, Keith L. Ligon, Alexander Marson, E. Antonio Chiocca, David A. Reardon, Aviv Regev, Mario L. Suva, Kai W. Wucherpfennig
Summary: This study utilized single-cell RNA sequencing to uncover the gene expression and clonal landscape of T cells in diffuse gliomas, identifying potential effectors of anti-tumor immunity. The research revealed that KLRB1 and its associated transcriptional program play an inhibitory role in tumor immunity, and blocking its function enhances T cell killing of glioma cells.
Article
Multidisciplinary Sciences
Sara Valpione, Piyushkumar A. Mundra, Elena Galvani, Luca G. Campana, Paul Lorigan, Francesco De Rosa, Avinash Gupta, John Weightman, Sarah Mills, Nathalie Dhomen, Richard Marais
Summary: High baseline T cell receptor diversity is predictive of favorable prognosis in multiple cancer types, while monoclonal expansion of T cells pre-treatment correlates with good response to immune checkpoint blockade therapy in metastatic melanoma patients.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Samyuktha Ramesh, Soohyung Park, Wonpil Im, Melissa J. Call, Matthew E. Call
Summary: The B cell receptor (BCR) and T cell receptor (TCR) share a common core transmembrane (TM) structure, which is vital for optimal receptor assembly and stability in the cell membrane.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Immunology
Wenhai Deng, Jialong Yang, Xingguang Lin, Jinwook Shin, Jimin Gao, Xiao-Ping Zhong
JOURNAL OF IMMUNOLOGY
(2017)
Article
Multidisciplinary Sciences
Minji Seo, Seong-Ok Lee, Ji-Hoon Kim, Yujin Hong, Seongchan Kim, Yeumin Kim, Dal-Hee Min, Young-Yun Kong, Jinwook Shin, Kwangseog Ahn
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2016)
Article
Biochemistry & Molecular Biology
Hong-Xia Wang, Jinwook Shin, Shang Wang, Balachandra Gorentla, Xingguang Lin, Jimin Gao, Yu-Rong Qiu, Xiao-Ping Zhong
Correction
Medicine, Research & Experimental
Jinhong Wu, Jialong Yang, Kai Yang, Hongxia Wang, Balachandra Gorentla, Jinwook Shin, Yurong Qiu, Loretta G. Que, W. Michael Foster, Zhenwei Xia, Hongbo Chi, Xiao-Ping Zhong
JOURNAL OF CLINICAL INVESTIGATION
(2017)
Article
Cell Biology
Hyung Chul Lee, Nam-Gu Her, Donghee Kang, Seung Hee Jung, Jinwook Shin, Minyoung Lee, In Hwa Bae, Young-Nyun Kim, Heon Joo Park, Young-Gyu Ko, Jae-Seon Lee
CELL DEATH & DISEASE
(2017)
Correction
Medicine, Research & Experimental
Jinhong Wu, Jialong Yang, Kai Yang, Hongxia Wang, Balachandra Gorentla, Jinwook Shin, Yurong Qiu, Loretta G. Que, W. Michael Foster, Zhenwei Xia, Hongbo Chi, Xiao-Ping Zhong
JOURNAL OF CLINICAL INVESTIGATION
(2018)
Article
Immunology
Valeriya Rakhmanova, Mirim Jin, Jinwook Shin
Article
Biochemistry & Molecular Biology
Valeriya Rakhmanova, Sukyoung Park, Sungwook Lee, Young Hyo Kim, Jinwook Shin
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Infectious Diseases
Sung-Suck Oh, Jihyun Song, Junghee Kim, Jinwook Shin
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2020)
Article
Microbiology
Jihyun Song, Sung-Suck Oh, Junghee Kim, Sukyoung Park, Jinwook Shin
FRONTIERS IN MICROBIOLOGY
(2020)
Article
Infectious Diseases
Jihyun Song, Junghee Kim, Sung-Suck Oh, Jinwook Shin
Summary: The study found ESBL-EC isolates resistant to multiple antibiotics in vegetable farm soil in Incheon, South Korea, carrying various bla(CTX-M) ESBL genes and belonging to different E. coli sequence types. These findings suggest that farm soil may act as a reservoir for multidrug-resistant ESBL-producing pathogens associated with humans.
MICROBIAL DRUG RESISTANCE
(2021)
Article
Multidisciplinary Sciences
Jihyun Song, Sung-Suck Oh, Junghee Kim, Jinwook Shin
SCIENTIFIC REPORTS
(2020)
Article
Biochemistry & Molecular Biology
Jinwook Shin, Mirim Jin
BIOMOLECULES & THERAPEUTICS
(2017)
Article
Cell Biology
Hyunbin D. Huh, Eunhye Lee, Jinwook Shin, Boyoun Park, Sungwook Lee
CELLULAR IMMUNOLOGY
(2017)
Meeting Abstract
Immunology
W. Deng, J. Yang, X. Lin, J. Shin, J. Gao, X. -P Zhong
EUROPEAN JOURNAL OF IMMUNOLOGY
(2016)