Role of Ras/Raf/MEK/ERK signaling in physiological hematopoiesis and leukemia development

The MAPK ERK1 is a negative regulator of the adult steady-state splenic erythropoiesis

(2010) S. Guihard et al.   BLOOD

Targets of Raf in tumorigenesis

(2010) T. S. Niault et al.   CARCINOGENESIS

Genetic Demonstration of a Redundant Role of Extracellular Signal-Regulated Kinase 1 (ERK1) and ERK2 Mitogen-Activated Protein Kinases in Promoting Fibroblast Proliferation

(2010) L. Voisin et al.   MOLECULAR AND CELLULAR BIOLOGY

Tight control of MEK-ERK activation is essential in regulating proliferation, survival, and cytokine production of CD34+-derived neutrophil progenitors

(2009) C. R. Geest et al.   BLOOD

Critical role for ERK1/2 in bone marrow and fetal liver–derived primary megakaryocyte differentiation, motility, and proplatelet formation

(2009) Alexandra Mazharian et al.   EXPERIMENTAL HEMATOLOGY

The mitogen-activated protein kinase signaling pathways: role in megakaryocyte differentiation

(2009) S. SÉVERIN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Oncogenic Kras Initiates Leukemia in Hematopoietic Stem Cells

(2009) Amit J Sabnis et al.   PLOS BIOLOGY

Oncogenic Kras-induced leukemogeneis: hematopoietic stem cells as the initial target and lineage-specific progenitors as the potential targets for final leukemic transformation

(2008) J. Zhang et al.   BLOOD

Advances in the Development of Cancer Therapeutics Directed against the RAS-Mitogen-Activated Protein Kinase Pathway

(2008) J. S. Sebolt-Leopold   CLINICAL CANCER RESEARCH

The N-Terminal Domain of ERK1 Accounts for the Functional Differences with ERK2

(2008) Matilde Marchi et al.   PLoS One

Oncostatin M-Mediated Regulation of KIT-Ligand-Induced Extracellular Signal-Regulated Kinase Signaling Maintains Hematopoietic Repopulating Activity of Lin−CD34+CD133+Cord Blood Cells

(2008) Robert A.J. Oostendorp et al.   STEM CELLS