期刊
IMMUNOLOGIC RESEARCH
卷 42, 期 1-3, 页码 210-218出版社
HUMANA PRESS INC
DOI: 10.1007/s12026-008-8075-4
关键词
Bcl-3; NF-kappa B; AP1; STAT3; I kappa B; CYLD; HDAC; HAT; Cancer
类别
The transcription factor, NF-kappa B (nuclear factor-kappa B) and associated regulatory factors make up a multi-component signaling pathway that regulates a wide range of biological processes, including cell survival, proliferation, differentiation, stress response, and death, as well as immunity and inflammation. Aberrant NF-kappa B pathway activity is known to be associated with a host of diseases, including immune deficiencies, inflammatory disorders, and cancer. Recent advances in our understanding of the inner workings of the NF-kappa B pathway have led to the development of new therapeutic strategies for the treatment of these diseases. In this review, we focus on the regulation of the NF-kappa B pathway by Bcl-3 (B cell leukemia-3), a nuclear member of the I kappa B (inhibitor of NF-kappa B) family. Both the regulation and the function of Bcl-3 will be discussed.
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