Article
Oncology
Ziwen Zhu, Pooja Parikh, Hongyun Zhao, Nathan T. Givens, Damien B. Beck, Conner M. Willson, Qian Bai, Mark R. Wakefield, Yujiang Fang
Summary: Tumor metabolism has emerged as a prominent research area, leading to new opportunities in metabolism-based cancer therapy. Intratumoral heterogeneity in tumors results in complex energy metabolism phenotypes in tumor cells, with metabolic reprogramming during tumor progression.
Article
Immunology
Tarannum Taznin, Kaushalya Perera, Yann Gibert, Alister C. Ward, Clifford Liongue
Summary: This study investigated the expression and function of CRLF3, an evolutionarily significant protein, in early development, particularly in blood and immune cells, using zebrafish as a model. The study found that CRLF3 was expressed in multiple embryonic tissues and played a crucial role in primitive hematopoiesis and early definitive hematopoiesis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Physiology
Sai Sindhu Thangaraj, Helle Charlotte Thiesson, Per Svenningsen, Jane Stubbe, Yaseelan Palarasah, Claus Bistrup, Boye L. Jensen, Line Aas Mortensen
Summary: The mineralocorticoid receptor antagonist spironolactone had no direct anti-inflammatory effects on pro-hypertensive interleukin-17A or distal nephron epithelial injury markers in kidney transplant recipients.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2022)
Article
Oncology
Michelle K. Becker-Hapak, Niraj Shrestha, Ethan McClain, Michael J. Dee, Pallavi Chaturvedi, Gilles M. Leclerc, Lynne I. Marsala, Mark Foster, Timothy Schappe, Jennifer Tran, Sweta Desai, Carly C. Neal, Patrick Pence, Pamela Wong, Julia A. Wagner, David A. Russler-Germain, Xiaoyun Zhu, Catherine M. Spanoudis, Victor L. Gallo, Christian A. Echeverri, Laritza L. Ramirez, Lijing You, Jack O. Egan, Peter R. Rhode, Jin-an Jiao, Gabriela J. Muniz, Emily K. Jeng, Caitlin A. Prendes, Ryan P. Sullivan, Melissa M. Berrien-Elliott, Hing C. Wong, Todd A. Fehniger
Summary: NK cells show promise as a cellular therapy for cancer, but challenges in production of required reagents exist. A novel HFPC platform was developed to activate NK cells against cancer, showing potential for advancement in clinical GMP-grade memory-like NK cell production.
CANCER IMMUNOLOGY RESEARCH
(2021)
Article
Astronomy & Astrophysics
Z. Celik Orhan, M. Yildiz, C. Kayhan
Summary: Asteroseismology using space-based telescopes is crucial for understanding stellar structure and evolution. By analyzing data from observations of 15 evolved solar-like oscillating stars, precise determination of fundamental stellar parameters was achieved through constructing interior models and fitting reference frequencies. The study revealed that fitting reference frequencies typically increased the accuracy of asteroseismic radius, mass, and age, with uncertainties of mass and radius around 3-6% and 1-2% respectively.
MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY
(2021)
Review
Cell Biology
Sahar Najafi, Majid Ghanavat, Saied Shahrabi, Zahra Gatavizadeh, Najmaldin Saki
Summary: Inflammatory cytokines play a critical role in the differentiation of HSCs, stimulating or inhibiting hematopoietic progenitors to combat inflammation and leukemic conditions.
CELL BIOLOGY INTERNATIONAL
(2021)
Review
Immunology
John Le, Yathushigan Kulatheepan, Samithamby Jeyaseelan
Summary: The respiratory system has various innate immune mechanisms to cope with microbial infections and limit tissue damage. Macrophages, neutrophils, dendritic cells, epithelial cells, and endothelial cells play key roles in this immune response. Recognition of invading microorganisms by the myeloid and structural cells of the respiratory system triggers a signaling cascade that leads to the activation of transcription factors, induction of cytokines/chemokines, recruitment of immune cells, and subsequent clearance of microbes.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biology
Abdullahi Rabiu Abubakar, Rahnuma Ahmad, Adekunle Babajide Rowaiye, Sayeeda Rahman, Katia Iskandar, Siddhartha Dutta, Angus Nnamdi Oli, Sameer Dhingra, Maryam Abba Tor, Ayukafangha Etando, Santosh Kumar, Mohammed Irfan, Marshall Gowere, Kona Chowdhury, Farhana Akter, Dilshad Jahan, Natalie Schellack, Mainul Haque
Summary: This article reported various checkpoints and drugs targeted to manage the cytokine storm induced by SARS-CoV-2, which can reduce inflammation and decrease mortality caused by COVID-19.
Article
Multidisciplinary Sciences
Kazuya Anzai, Kota Tsuruya, Kinuyo Ida, Tatehiro Kagawa, Yutaka Inagaki, Akihide Kamiya
Summary: KLF15 induces hepatic maturation through transcriptional activation of target genes and cell cycle control.
SCIENTIFIC REPORTS
(2021)
Review
Virology
Hi Eun Jung, Heung Kyu Lee
Summary: The global COVID-19 pandemic, caused by SARS-CoV-2, has impacted the world significantly. Excessive inflammatory immune responses play a key role in the severity of COVID-19, with potential therapeutic treatments focusing on anti-inflammatory drugs. Targeting toll-like receptors (TLRs) may hold promise in controlling hyperinflammation in COVID-19 patients.
Review
Biology
Yaoguo Li, Tiaoyi Xiao, Jun Zou
Summary: This review summarizes recent advances in the study of fish TNF biology and focuses on the molecular properties and immunological functions of the TNF and TNFR superfamily. The research found that fish have a diversified TNF family, partly due to whole genome duplication events.
SCIENCE CHINA-LIFE SCIENCES
(2021)
Article
Genetics & Heredity
Norwin Kubick, Pavel Klimovich, Patrick Henckell Flournoy, Irmina Bienkowska, Marzena Lazarczyk, Mariusz Sacharczuk, Suniti Bhaumik, Michel-Edwar Mickael, Rajatava Basu
Summary: Understanding the evolution of interleukins and interleukin receptors is crucial for controlling the function of CD4+ T cells in various pathologies. Various interleukins emerged before the divergence of CD4+ T cells, with IL14 being the most ancient one. Some interleukins and their receptors gained new functions and evolved under positive selection, while overall evolution of interleukin receptors was not under significant positive selection.
Article
Physiology
Debbra Y. Knorr, Denise Hartung, Kristin Schneider, Luzia Hintz, Hanna S. Pies, Ralf Heinrich
Summary: This study identified a conserved endogenous cytokine in locust hemolymph that activates CRLF3 and connected anti-apoptotic processes in hemocytes and neurons, providing insights into cytokine evolution and potential clinical applications.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Psychiatry
Michal Korostynski, Dzesika Hoinkis, Marcin Piechota, Slawomir Golda, Joanna Pera, Agnieszka Slowik, Tomasz Dziedzic
Summary: TLR4-dependent cytokine synthesis was not associated with greater post-stroke depressive symptoms in this study. However, circulating IL-6 might be associated with depressive symptoms occurring at 3 months after stroke.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Cell Biology
M. Cyrus Maher, Istvan Bartha, Steven Weaver, Julia di Iulio, Elena Ferri, Leah Soriaga, Florian A. Lempp, Brian L. Hie, Bryan Bryson, Bonnie Berger, David L. Robertson, Gyorgy Snell, Davide Corti, Herbert W. Virgin, Sergei L. Kosakovsky Pond, Amalio Telenti
Summary: This study predicts future variants of SARS-CoV-2 by analyzing various factors affecting its evolution, including ACE2-mediated transmissibility and host immunity. The researchers successfully identified mutations that will emerge in different phases of the pandemic and assessed their impact on therapeutic antibodies. This modeling approach has important implications for predicting emerging variants of SARS-CoV-2 and can be applied to other rapidly evolving pathogens.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Immunology
Nadine Radomski, Axel Karger, Kati Franzke, Elisabeth Liebler-Tenorio, Rico Jahnke, Svea Matthiesen, Michael R. Knittler
INFECTION AND IMMUNITY
(2020)
Article
Infectious Diseases
A. Schulz, A. Karger, B. Bettin, A. Eisenbarth, M. A. Sas, C. Silaghi, M. H. Groschup
TICKS AND TICK-BORNE DISEASES
(2020)
Article
Immunology
Zhen Xu, Fumio Takizawa, Elisa Casadei, Yasuhiro Shibasaki, Yang Ding, Thomas J. C. Sauters, Yongyao Yu, Irene Salinas, J. Oriol Sunyer
SCIENCE IMMUNOLOGY
(2020)
Article
Biotechnology & Applied Microbiology
Magdalena Murr, Axel Karger, Constanze Steglich, Thomas C. Mettenleiter, Angela Roemer-Oberdoerfer
JOURNAL OF GENERAL VIROLOGY
(2020)
Article
Fisheries
Laura Taggart-Murphy, Gema Alama-Bermejo, Brian Dolan, Fumio Takizawa, Jerri Bartholomew
Summary: Infections caused by genotype 0 of Ceratonova shasta result in milder pathology and lower expression of cytokines, while infections caused by genotype IIR lead to more severe pathology and inflammatory response. Antibody expression is upregulated in both infections but seems to be less effective in the virulent genotype IIR infections.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Immunology
Xiao-Ting Zhang, Yong-Yao Yu, Hao-Yue Xu, Zhen-Yu Huang, Xia Liu, Jia-Feng Cao, Kai-Feng Meng, Zheng-Ben Wu, Guang-Kun Han, Meng-Ting Zhan, Li-Guo Ding, Wei-Guang Kong, Nan Li, Fumio Takizawa, J. Oriol Sunyer, Zhen Xu
Summary: The study analyzed the immune response of trout skin to Flavobacterium columnare infection, revealing that IgT is the main Ig isotype induced by the skin mucosa upon bacterial infection and that the SALT likely represents a prominent IgT-inductive site in fish.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Virology
Claudia Blaurock, Angele Breithaupt, David Scheibner, Ola Bagato, Axel Karger, Thomas C. Mettenleiter, Elsayed M. Abdelwhab, Colin R. Parrish
Summary: The highly pathogenic avian influenza viruses H5N8 clade 2.3.4.4A and 2.3.4.4B had devastating impacts on the poultry industry globally, with different pathotypes in ducks. The NS1 protein of these viruses showed preferential evolution towards different lengths, influencing virus replication, transmission, and interferon response in infected chickens and ducks. The NS1 C terminus was found to play a crucial role in the efficient transmission and fitness of H5N8 viruses in birds.
JOURNAL OF VIROLOGY
(2021)
Article
Virology
Elisabeth Woehnke, Walter Fuchs, Luise Hartmann, Ulrike Blohm, Sandra Blome, Thomas C. Mettenleiter, Axel Karger
Summary: The study conducted the first proteome analysis of ASFV-infected primary porcine monocyte-derived macrophages, showing that there were no major differences in viral protein expression or host cell response between different infection models. However, some individual viral proteins did show cell-specific expression, while modulations of the host proteome were mainly related to cell characteristics and function. Overall, both infection models were deemed suitable for studying ASFV infection in vitro.
Article
Virology
Elisabeth Woehnke, Gwenny Cackett, Finn Werner, Sandra Blome, Thomas C. Mettenleiter, Axel Karger
Summary: Since the introduction of a highly virulent African swine fever virus (ASFV) strain in Georgia in 2007, ASF has become a global outbreak, posing a major threat to the pig industry. This study analyzed the protein expression patterns in primary porcine macrophages infected with two different ASFV strains of high and moderate virulence using mass spectrometry. The results showed similar viral gene expression patterns, with differences limited to genomic deletions in the less virulent strain. The study also identified new protein products from recently described transcripts in both strains. Pathway analysis revealed similar host proteome responses, but subtle differences were observed in the manipulation of proteins involved in the proinflammatory response mediated by the MAPK14/p38 signaling cascade.
Article
Virology
Katarzyna Magdalena Dolata, Walter Fuchs, Gregory Caignard, Juliette Dupre, Katrin Pannhorst, Sandra Blome, Thomas C. Mettenleiter, Axel Karger
Summary: This study reveals a novel virus-host protein interaction between ASFV protein CP204L and cellular protein VPS39, which modulates endolysosomal trafficking and promotes lysosome clustering. These findings improve our understanding of the complex interaction between virus and host during ASFV infection.
JOURNAL OF VIROLOGY
(2023)
Article
Virology
Martin Mueller, Kerstin Fischer, Elisabeth Woehnke, Luca M. Zaeck, Christoph Proennecke, Michael R. Knittler, Axel Karger, Sandra Diederich, Stefan Finke
Summary: This study reveals that Nipah virus infection and spread in differentiated respiratory tract epithelial cells induces significant inflammation and immune response in pigs, which contributes to efficient airborne transmission between pigs.
Article
Virology
Elisabeth Woehnke, Barbara G. Klupp, Sandra Blome, Thomas C. Mettenleiter, Axel Karger
Summary: African swine fever, caused by the African swine fever virus (ASFV), is spreading globally and posing a threat to pig husbandry. The virus has a strategy to shut down host protein synthesis, which has been observed in infected cells. However, it was unclear whether this shutdown was selective for specific host proteins. This study used a mass spectrometric approach to measure protein synthesis rates and found that ASFV infection had varying effects on the synthesis of different host proteins, with a strong shutoff observed for RNA metabolism proteins and a strong induction of proteins related to the innate immune system.
Review
Virology
Katarzyna Magdalena Dolata, Gang Pei, Christopher L. Netherton, Axel Karger
Summary: Viral replication relies on host cell machinery and interactions between viral and host proteins. Identifying these interactions provides insights into virus infection and is crucial for antiviral strategies.
Article
Fisheries
Tsuyoshi Katou, Mayuka Kitamura, Tomoki Maeda, Tomoyuki Odaka, Fumio Takizawa, Hiroaki Suetake, Tadashi Isshiki, Toshiaki Miyadai
Summary: Researchers attempted to clone the cDNA of the kuchijirosho virus genome and detected possible viral RNA in the infected fugu brains. Findings suggest that the detection of KARs can be effective for the molecular diagnosis of kuchijirosho, but the taxonomic family of the virus remains unclear.
Article
Immunology
Takuya Yamaguchi, Chia Jung Chang, Axel Karger, Markus Keller, Florian Pfaff, Eakapol Wangkahart, Tiehui Wang, Christopher J. Secombes, Azusa Kimoto, Mitsuru Furihata, Keiichiro Hashimoto, Uwe Fischer, Johannes M. Dijkstra
FRONTIERS IN IMMUNOLOGY
(2020)