Article
Cell Biology
Ryosuke Tashiro, Kuniyasu Niizuma, Jun Kasamatsu, Yuko Okuyama, Sherif Rashad, Atsuo Kikuchi, Miki Fujimura, Shigeo Kure, Naoto Ishii, Teiji Tominaga
Summary: The study found that RNF213 plays a critical role in antigen uptake, processing, and presentation, with Rnf213-KO and Rnf213-KI mice experiments showing that RNF213 deficiency leads to decreased antigen uptake and processing capabilities, resulting in the inability to effectively activate antigen-specific T cells.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Immunology
Takumi Kawasaki, Moe Ikegawa, Taro Kawai
Summary: The lungs have an immune defense mechanism that uses various cells to eliminate harmful pathogens and activate T cell immune response. In addition to immune cells, other lung cells also participate in antigen presentation and T cell activation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Jie Zhang, Biao Fan, Guoliang Cao, Wenping Huang, Fuhao Jia, Guangjun Nie, Hai Wang
Summary: This study developed a personalized DC-mimicking nanovaccine for stimulating TAAs-specific T cell populations. By inducing BMDCs maturation and delivering TAAs through nanostructures, the nanoDCs efficiently generated potent antigen-specific T cell responses, leading to inhibition of tumor growth and metastases formation.
ADVANCED MATERIALS
(2022)
Review
Immunology
Christian Moebs, Martin Salheiser, Fabian Bleise, Marie Witt, Johannes U. Mayer
Summary: This review aims to highlight the role of basophils in antigen presentation and T cell priming, as well as resolving the debate on whether basophils influence antigen presentation through direct or indirect mechanisms. Tissue-specific differences in basophil phenotypes and their interactions with other antigen-presenting cells will be discussed, along with their implications on immunological and clinical outcomes of disease.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Shinji Morisaki, Hideya Onishi, Takafumi Morisaki, Makoto Kubo, Masayo Umebayashi, Hiroto Tanaka, Norihiro Koya, Shinichiro Nakagawa, Kenta Tsujimura, Sachiko Yoshimura, Poh Yin Yew, Kazuma Kiyotani, Yusuke Nakamura, Masafumi Nakamura, Takanari Kitazono, Takashi Morisaki
Summary: Through analysis of four patients, we found that intranodal vaccination with hybrid neoantigen-pulsed DCs successfully induced a strong immune response and provided insight into the mechanisms of action, suggesting future directions in neoantigen vaccine design.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Takuya Sakamoto, Terutsugu Koya, Misa Togi, Kenichi Yoshida, Tomohisa Kato, Yasuhito Ishigaki, Shigetaka Shimodaira
Summary: This study evaluated the function and preclinical validation of human dendritic cell (DC) dexosomes, small DC-secreted vesicles that contain immune signals, for cancer vaccination. The researchers characterized a potential dexosome model using immature and mature DCs derived from a cell line called MUTZ3, and found that one type of MUTZ3-derived DC dexosomes exhibited potential immunogenicity and higher antigen presentation potency, making them potential resources for cancer immunotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Hejin Jiang, Rui Liu, Lu Wang, Xinyue Wang, Mengmeng Zhang, Sisi Lin, Zhenping Cao, Feng Wu, Yingbin Liu, Jinyao Liu
Summary: Chirality plays a critical role in biological systems, and this study demonstrates the potential of using supramolecular chiral polymer micelles (SCPMs) to activate the immune system for disease prevention and treatment.
ADVANCED MATERIALS
(2023)
Article
Oncology
Tim B. Fessenden, Lauren E. Stopfer, Fiona Chatterjee, Julian Zulueta, Josh Mesfin, Therese Cordero Dumit, Irene Reijers, Esmee P. Hoefsmit, Christian Blank, Forest White, Stefani Spranger
Summary: Cytotoxic CD8(+) T cells must recognize tumor-derived antigens to achieve effective tumor elimination. Our study shows that dendritic cells induce cytotoxic CD8(+) T-cell responses by cross-presenting tumor-derived peptides, and the proportion of membrane-derived neoantigens is associated with reduced survival and treatment response.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Immunology
Ray A. Ohara, Kenneth M. Murphy
Summary: Cross-priming, initially recognized in cytotoxic T lymphocyte (CTL) responses, involves the presentation of minor histocompatibility antigens by antigen presenting cells (APCs) derived from immunizing cells. As understanding of T cell receptor antigen recognition progressed, cross-priming was redefined as cross-presentation and expanded to include different forms of antigens and APCs not involved in in vivo CTL priming. In vitro cell models have been utilized for studying cross-presentation, but recent studies have shown differences between these models and in vivo APCs. Current research focuses on validating in vivo pathways and gene candidates for cross-presentation, and evaluating their contributions to CTL responses across different antigens and immunologic settings.
SEMINARS IN IMMUNOLOGY
(2023)
Review
Immunology
Jiri Brezina, Matous Voboril, Dominik Filipp
Summary: The evolution of the adaptive immune system leads to the generation of self-reactive clones, which must be eliminated to prevent autoimmunity. This process occurs in the thymic medulla, where the interaction between T cell receptor and self-peptide MHC complexes determines the fate of thymocytes. Thymic antigen presenting cells, including medullary thymic epithelial cells and dendritic cells, play a fundamental role in presenting self-antigens in the thymus for the establishment of T cell central tolerance. Recent studies have revealed the heterogeneity of these cell subsets and their roles in T cell selection processes, adding complexity to our understanding. Identification of molecular determinants controlling the presentation of self-antigens would advance our knowledge in this area.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Benedicte Manoury, Lucie Maisonneuve, Katrina Podsypanina
Summary: Dendritic cells have the unique ability to link innate and adaptive immunity and guide T cells to initiate immune responses. The compartments for protein degradation and synthesis are crucial for dendritic cell function and are modulated by the endoplasmic reticulum. However, the relationship between ER stress and antigen presentation in dendritic cells remains to be explored.
MOLECULAR IMMUNOLOGY
(2022)
Review
Immunology
Karthik Dhatchinamoorthy, Jeff D. Colbert, Kenneth L. Rock
Summary: Loss of MHC I antigen presentation is common in many cancers, which may impair immune responses and affect the efficacy of immunotherapy. Studies have discussed underlying mechanisms through which some cancers evade immune killing by shutting down the MHC I pathway, and proposed potential strategies to overcome this limitation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jufang Jia, Mengnan Zeng, Denghui Zhu, Xinmian Jiao, Beibei Zhang, Ruolan Yang, Weisheng Feng, Xiaoke Zheng
Summary: This study demonstrates for the first time that EB-A can ameliorate allergic asthma by inhibiting mast cell activation and dendritic cell maturation, and the molecular mechanism of EB-A's anti-asthmatic activity might be mediated by inhibiting PAR2 activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Mirela Kremenovic, Alfred A. Chan, Bing Feng, Lukas Baeriswyl, Steve Robatel, Thomas Gruber, Li Tang, Delphine J. Lee, Mirjam Schenk
Summary: In this study, a novel BCG lysate was developed and formulated into a thermosensitive hydrogel. The BCG lysate exhibited enhanced antitumor efficacy and promoted a proinflammatory tumor microenvironment in vivo. The underlying mechanisms of BCG lysate-mediated tumor immunity relied on macrophages (M phi) and dendritic cells (DCs). The BCG hydrogel treatment induced systemic immunity, suppressed lung metastases, and improved survival in melanoma-bearing mice. Furthermore, BCG hydrogel treatment enhanced antigen processing and presentation, and increased the frequency of melanoma-reactive CD8(+) T cells. In human melanoma patients, intralesional-BCG treatment was associated with enhanced M1 M phi, mature DCs, antigen processing and presentation, and increased patient survival.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Pediatrics
Sebastian Wirsching, Marina Machtakova, Frauke Borgans, Leah Pretsch, Michael Fichter, Maximiliano L. Cacicedo, Heloise Therien-Aubin, Katharina Landfester, Stephan Gehring
Summary: Childhood mortality is a significant issue, with a large number of deaths attributed to preventable infectious diseases. The study demonstrates the superior ability of the TLR7/8 agonist R848 in activating the immune system of both adults and neonates. Furthermore, R848 can be efficiently delivered along with antigens using nanocapsules, offering new possibilities for vaccine development.
FRONTIERS IN PEDIATRICS
(2022)