期刊
IMMUNOBIOLOGY
卷 218, 期 11, 页码 1411-1415出版社
ELSEVIER GMBH, URBAN & FISCHER VERLAG
DOI: 10.1016/j.imbio.2013.06.002
关键词
Anti-ds-DNA antibodies; Immunomodulation; Lupus; Soluble human; CD83
类别
In the present study we explored the immunomodulatory potential of prokaryotically expressed soluble CD83 in the treatment of murine lupus using the NZB/W Fl mouse model. Therefore female NZB/W Fl lupus mice were treated either with sCD83 or PBS for 4 weeks sCD83 treated mice showed a significantly delayed onset of anti-dsDNA autoantibody production when compared with the control group. Importantly, during the treatment period with sCD83 none of the mice showed elevated levels of anti-dsDNA autoantibodies. In addition, NZB/W Fl mice which received sCD83 displayed lower concentrations of anti-histone IgG autoantibodies. Furthermore, there was no difference in total IgG antibodies, indicating a modulatory role for sCD83 in the production of self-reactive antibodies without decreasing total IgG. These results indicate that administration of sCD83 has profound immune-modulatory effects on the induction of autoantibodies in NZB/W Fl lupus mice and may thus be a promising approach to interfere with autoimmunity in SLE and other autoantibody-driven diseases. (C) 2013 Elsevier GmbH. All rights reserved.
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