Article
Pharmacology & Pharmacy
Sara Sattar, Arham Shabbir, Muhammad Shahzad, Tasleem Akhtar, Syed Muneeb Anjum, Mohammed Bourhia, Hiba-Allah Nafidi, Yousef A. Bin Jardan, Musaab Dauelbait, Aisha Mobashar
Summary: The study found that Lawsone possesses anti-arthritic properties and can ameliorate arthritis symptoms through immunomodulatory and anti-inflammatory effects. The results demonstrate that Lawsone inhibits the progression of arthritis and reduces paw edema.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Immunology
Wenjing Xiang, Nanyan Yu, Aihua Lei, Xiaofang Li, Shui Tan, Lijun Huang, Zhou Zhou
Summary: Chlamydial infection causes clinically relevant diseases and significant morbidity in humans. Immune and inflammatory responses play crucial roles in both clearing the infection and causing pathology in host tissues. Cytokines produced in response to Chlamydia infection can regulate immune responses, but excessive production can lead to overreactive inflammation, affecting host and Chlamydia metabolism.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Beata Tokarz-Deptula, Joanna Palma, Lukasz Baraniecki, Michal Stosik, Roman Kolacz, Wieslaw Deptula
Summary: Platelets play a role in inflammation and infections by reacting with the endovascular environment and cells of the immune system. This role is influenced by biologically active substances present in platelet granules and EV structures.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Gael Galli, Maya Saleh
Summary: Macrophages play crucial roles in tissue homeostasis, inflammation, and host defense by recognizing microbial or danger signals and eliciting immune responses. The interaction between cellular metabolism and macrophage innate immunity involves metabolic adaptations that modulate immune signaling and macrophage function. Intracellular bacterial pathogens can exploit macrophage metabolic pathways to evade immune defenses. This review highlights recent evidence on host-bacterial immunometabolic interactions.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Immunology
Ioannis Kienes, Ella L. Johnston, Natalie J. Bitto, Maria Kaparakis-Liaskos, Thomas A. Kufer
Summary: This article summarizes the subversion strategies used by bacterial pathogens to evade host immune detection, focusing on the well-studied NLRs NOD1/2, NLRP3, and NLRC4. The authors discuss how bacterial pathogens activate these NLRs to promote inflammation and disease, as well as mechanisms used by bacteria to attenuate NLR activation and interfere with host immunity. They also highlight the role of NLRs in facilitating immunotolerance and persistence of bacteria in the host, and the therapeutic potential of harnessing bacterial immune subversion strategies for chronic inflammatory conditions.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Zheng Zhou, Wenjing Yang, Tianming Yu, Yu Yu, Xiaojing Zhao, Yanbo Yu, Chuncai Gu, Anthony J. Bilotta, Suxia Yao, Qihong Zhao, George Golovko, Mingsong Li, Yingzi Cong
Summary: This study investigated the role of GPR120 in regulating neutrophil function against enteric bacteria. Gpr120 (-/-) mice showed altered gut microbiota composition and exhibited more severe intestinal inflammation upon infection or DSS insults. GPR120 agonist enhanced neutrophil production of reactive oxygen species and extracellular traps, leading to inhibition of bacterial growth.
Review
Cell Biology
Nils Schmerer, Leon N. Schulte
Summary: This article provides an overview of the roles of lncRNAs in the interaction of human and rodent host cells with bacterial pathogens, as well as their important roles in controlling immune responses. Further research on the underlying lncRNA networks could offer new insights into the mechanisms of pathological inflammation and immune subversion.
WILEY INTERDISCIPLINARY REVIEWS-RNA
(2021)
Article
Microbiology
Andrew Foey, Neama Habil, Alex Strachan, Jane Beal
Summary: This study found that the probiotic Lacticaseibacillus casei strain Shirota (LcS) selectively modulates epithelial barrier integrity, pathogen sensing, and inflammatory cytokine profile. The specific effects depend on the subset of macrophages and their activation status.
Article
Immunology
Khanyisile Mngomezulu, Gugulethu F. Mzobe, Andile Mtshali, Farzana Osman, Lenine J. P. Liebenberg, Nigel Garrett, Ravesh Singh, Anne Rompalo, Adrian Mindel, Salim S. Abdool Karim, Quarraisha Abdool Karim, Cheryl Baxter, Sinaye Ngcapu
Summary: The presence of partner semen may impact the immune and microbial environment of the female genital tract, increasing the risk of HIV infection. Recent sexual intercourse may affect the inflammation levels and bacterial vaginosis occurrence in the female genital tract.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Virology
Tarani Kanta Barman, Dennis W. Metzger
Summary: This review discusses the role of disease tolerance in viral-bacterial co-infection, focusing on host cytokines and cells that promote tissue protection and damage control.
Article
Biochemistry & Molecular Biology
Jazli Aziz, Rathna Devi Vaithilingam, Zamri Radzi, Mohammad Tariqur Rahman
Summary: Periodontitis and rheumatoid arthritis are linked by their common inflammatory responses. Salivary metallothionein, zinc, and calcium may serve as biomarkers for the severity of periodontitis with or without rheumatoid arthritis. The comorbidity of periodontitis and rheumatoid arthritis may have a cumulative immunopathological impact that requires further investigation.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Immunology
Grzegorz Majka, Henryk Mazurek, Magdalena Strus, Marta Ciszek-Lenda, Rafal Szatanek, Agnieszka Pac, Edyta Golinska, Janusz Marcinkiewicz
Summary: The high concentration of sputum bacteria in cystic fibrosis patients with advanced lung disease is associated with increased levels of inflammatory markers and low levels of certain cytokines. Specific inflammatory biomarkers including blood CRP, NLR, and sputum elastase, IL-6, IL-8, and IL-10 are recommended for monitoring the disease.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Ju-Hee Kang, Hwa-Yeong Lee, Na-Young Kim, Dong-seok Lee, Mijung Yim
Summary: The role of extracellular Prdx1 in bacterial infections and inflammatory bone disease has been investigated. The lack of Prdx1 increased susceptibility to infections, while blockade of extracellular Prdx1 provided protection against bacterial infections. These findings suggest that extracellular Prdx1 may be a potential therapeutic target for bacterial infections or inflammatory osteolytic diseases.
Article
Psychiatry
J. Blair Price, Clarissa G. Yates, Brooke A. Morath, Sam K. van de Wakker, Nathanael J. Yates, Kim Butters, Mark A. Frye, Sean L. McGee, Susannah J. Tye
Summary: The study showed that lithium augmentation of ketamine can improve the effectiveness of antidepressant drugs, reduce depressive behavioral responses, increase peripheral insulin efflux under stress, and enhance region-specific prefrontal cortical insulin signaling.
TRANSLATIONAL PSYCHIATRY
(2021)
Review
Immunology
Pamella Constantino-Teles, Albane Jouault, Lhousseine Touqui, Alessandra Mattos Saliba
Summary: Pseudomonas aeruginosa, an opportunistic pathogen, causes respiratory infections by utilizing various virulence factors, such as bacterial lipids and enzymes, and by interacting with host lipids. These mechanisms play important roles in the establishment and persistence of P. aeruginosa in the lungs, as well as in modulating host immune responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Kerstin Walter, Julia Kokesch-Himmelreich, Axel Treu, Franziska Waldow, Doris Hillemann, Nikolas Jakobs, Ann-Kathrin Lemm, Dominik Schwudke, Andreas Roempp, Christoph Hoelscher
Summary: This study evaluated the suitability of BALB/c IL-13(tg) mice as an animal model for determining the distribution of antibiotics within necrotizing lesions. MALDI-MS imaging analysis revealed drug-specific distribution within different lesion types. The study demonstrates that BALB/c IL-13(tg) mice recapitulate the penetration of antibiotics into human lesions.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Stefan Rose-John
Summary: Interleukin-6 is an inflammatory cytokine whose level is elevated in inflammatory states, triggering cell-specific responses. The activation of gp130 in hepatocytes produces both liver-specific and systemic effects.
Article
Cell Biology
Michael Dudek, Kerstin Lohr, Sainitin Donakonda, Tobias Baumann, Max Lu, Silke Hegenbarth, Lena Duebbel, Carola Eberhagen, Savvoula Michailidou, Abdallah Yassin, Marco Prinz, Bastian Popper, Stefan Rose-John, Hans Zischka, Percy A. Knolle
Summary: This study reveals distinct immunometabolic features of liver sinusoidal endothelial cells (LSECs) and LSEC-primed CD8 T cells compared with immunogenic dendritic cells and effector CD8 T cells, highlighting the local metabolism and function of T cells in the liver.
Article
Cell Biology
Alice Prieto Huarcaya, Susy Drobny, Andre R. A. Marques, Alessandro Di Spiezio, Jan Philipp Dobert, Denise Balta, Christian Werner, Tania Rizo, Lisa Gallwitz, Simon Bub, Iva Stojkovska, Nandkishore R. Belur, Jens Fogh, Joseph R. Mazzulli, Wei Xiang, Amitkumar Fulzele, Mario Dejung, Markus Sauer, Beate Winner, Stefan Rose-John, Philipp Arnold, Paul Saftig, Friederike Zunke
Summary: This study suggests that enhancing SNCA degradation through the application of rHsCTSD can reduce SNCA aggregates in the brains of PD patients and restore endo-lysosome and autophagy function.
Editorial Material
Biochemistry & Molecular Biology
Andreas Herrlich, Eirini Kefaloyianni, Stefan Rose-John
Article
Biochemistry & Molecular Biology
Sophia Kirschke, Ireti Ogunsulire, Balachandar Selvakumar, Neele Schumacher, Tanya Sezin, Stefan Rose-John, Alexander Scheffold, Christoph Garbers, Juliane Lokau
Summary: The cytokine IL-2 plays a crucial role in immune homeostasis. This study demonstrates that metalloproteases ADAM10 and ADAM17 can cleave the IL-2R alpha, generating a soluble ectodomain that inhibits IL-2 signaling in T cells. Manipulating the cleavage of IL-2R alpha offers a potential opportunity to alter IL-2 function.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Torben Mentrup, Anna Yamina Stumpff-Niggemann, Nadja Leinung, Christine Schlosser, Katja Schubert, Rebekka Wehner, Antje Tunger, Valentin Schatz, Patrick Neubert, Ann-Christine Gradtke, Janina Wolf, Stefan Rose-John, Paul Saftig, Alexander Dalpke, Jonathan Jantsch, Marc Schmitz, Regina Fluhrer, Ilse D. Jacobsen, Bernd Schroeder
Summary: Dectin-1 plays a critical role in recognizing fungal pathogens through pattern recognition receptors on immune cells. Activation of Dectin-1a results in the formation of a stable receptor fragment lacking the ligand binding domain, which contributes to signal transduction in phagosomal membranes and is terminated by intramembrane proteases SPPL2a and 2b.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Maria Angeles Rodriguez-Hernandez, David Carneros, Maria Nunez-Nunez, Ramon Coca, Rosario Baena, Gema M. Lopez-Ruiz, Maria Elena Cano-Serrano, Alberto Martinez-Telleria, Ana Fuentes-Lopez, Juan Manuel Praena-Fernandez, Christoph Garbers, Jose Hernandez-Quero, Federico Garcia, Stefan Rose-John, Matilde Bustos
Summary: IL-6 signaling variables serve as useful tools for early identification and stratification of COVID-19 patients, with significant implications for treatment and clinical decision-making.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Tor Henrik Anderson Tvedt, Stefan Rose-John, Galina Tsykunova, Aymen Bushra Ahmed, Tobias Gedde-Dahl, Elisabeth Ersvaer, Oystein Bruserud
Summary: Graft-versus-host disease (GVHD) is a common complication after stem cell transplantation and is mediated by T cells. IL-6 plays a role in both pro-inflammatory and anti-inflammatory effects, and it modulates T cell response. The study found that CD3(+)CD4(+) and CD3(+)C8(+) T cells have different responses to IL-6 signaling, and these responses are influenced by antithymocyte globulin treatment. These findings suggest that IL-6 targeting after transplantation may have varied effects on patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Aikaterini Gatsiou, Simon Tual-Chalot, Matteo Napoli, Almudena Ortega-Gomez, Tommy Regen, Rachit Badolia, Valeriana Cesarini, Claudia Garcia-Gonzalez, Raphael Chevre, Giorgia Ciliberti, Carlos Silvestre-Roig, Maurizio Martini, Jedrzej Hoffmann, Rana Hamouche, Joseph R. Visker, Nikolaos Diakos, Astrid Wietelmann, Domenico Alessandro Silvestris, Georgio Georgiopoulos, Ali Moshfegh, Andre Schneider, Wei Chan, Stefan Guenther, Johanne Backs, Shin Kwak, Craig H. Selzman, Kimon Stamatelopoulos, Stefan Rose-John, Christian Trautwein, Ioakim Spyridopoulos, Thomas Braun, Ari Waisman, Angela Gallo, Stavros G. Drakos, Stefanie Dimmeler, Markus Sperandio, Oliver Soehnlein, Konstantinos Stellos
Summary: RNA editor ADAR2 regulates endothelial responses to IL-6, controlling leukocyte trafficking in inflamed and ischemic tissues. ADAR2 is required for IL-6 trans-signaling and immune cell infiltration through suppressing primary microRNA processing.
Article
Neurosciences
Stephan A. Muller, Merav D. Shmueli, Xiao Feng, Johanna Tushaus, Neele Schumacher, Ryan Clark, Brad E. Smith, An Chi, Stefan Rose-John, Matthew E. Kennedy, Stefan F. Lichtenthaler
Summary: In this study, the researchers identified SEZ6 and gp130/IL6ST as physiological substrates of BACE1 in non-human-primate cerebrospinal fluid. They also found a reduction of gp130 in human CSF from a clinical trial with a BACE inhibitor and in plasma of BACE1-deficient mice. These findings provide insights into the relationship between BACE1 and gp130 in neuronal signaling and survival.
MOLECULAR NEURODEGENERATION
(2023)
Article
Immunology
Agatha Schwarz, Rebecca Philippsen, Serena G. Piticchio, Jan N. Hartmann, Robert Haesler, Stefan Rose-John, Thomas Schwarz
Summary: The organ-specific microbiome, particularly the skin microbiome, plays a crucial role in tissue homeostasis by regulating the inflammatory response. Short chain fatty acids (SCFA) induce regulatory T cells (Treg) in the skin and their signal is mediated by the receptor HCA2. Knock-out of HCA2 results in stronger inflammation and a switch of Treg from a suppressive to a proinflammatory type, indicating that the skin microbiome dictates the outcome of the inflammatory reaction.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Stefan Rose-John, Brendan J. Jenkins, Christoph Garbers, Jens M. Moll, Juergen Scheller
Summary: This review discusses the discovery of the IL-6 trans-signalling pathway and the development of biologics that specifically inhibit this pathway. Targeting IL-6 trans-signalling can decrease disease-promoting activities of IL-6 without blocking its protective actions.
NATURE REVIEWS IMMUNOLOGY
(2023)
Meeting Abstract
Immunology
P. Bradtke, J. Roesch, D. Reimers, K. Yan, S. Rose-John, H. -W. Mittruecker
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Meeting Abstract
Immunology
E. V. M. Huth, L. C. Heinig, K. Yan, P. Bradtke, N. Lory, T. Wiech, S. Rose-John, H. -W. Mittruecker
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
