Article
Immunology
Amelia Barilli, Rossana Visigalli, Francesca Ferrari, Giuseppe Borsani, Valeria Dall'Asta, Bianca Maria Rotoli
Summary: The study demonstrates that flagellin from Pseudomonas aeruginosa can increase intracellular amino acids in human respiratory epithelial cells by activating ATB(0,+) and inflammatory transcription factors. In experiments using a model of airway epithelial cells, flagellin is also shown to upregulate the amount of certain other amino acid substrates.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ji-Won Park, Jinseon Choi, Juhyun Lee, Jin-Mi Park, Seong-Man Kim, Jae-Hong Min, Da-Yun Seo, Soo-Hyeon Goo, Ju-Hee Kim, Ok-Kyoung Kwon, Kihoon Lee, Kyung-Seop Ahn, Sei-Ryang Oh, Jae-Won Lee
Summary: In this study, the ameliorative effects of Methyl p-coumarate (MH) on airway inflammation in an experimental model of allergic asthma were evaluated. The results showed that MH exerted anti-inflammatory activity by suppressing the secretion of inflammatory cytokines, inhibiting cell adhesion, and reducing lung inflammation in mice. The findings suggest that MH has the potential to be used as an adjuvant in asthma therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Yinbiao Wang, Rui Zhang, Fuyun Yang, Lin Yang, Qingmei Li, Junqing Guo, Xiao Liu, Jie Song, Guofu Zhang, Juan Li, Zhen An, Neil E. Alexis, Ilona Jaspers, Weidong Wu
Summary: This study investigated the effects of PM2.5 exposure on influenza virus (H3N2) infection and the subsequent modulation of inflammation and antiviral immune response in human bronchial epithelial cells. The results showed that PM2.5 exposure alone increased pro-inflammatory cytokines but decreased the production of antiviral cytokine IFN-beta. Importantly, prior exposure to PM2.5 enhanced subsequent H3N2 infectivity, expression of viral protein, and upregulation of pro-inflammatory cytokines. Additionally, inhibition of NF-kappa B suppressed cytokine production induced by PM2.5 and H3N2.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Fisheries
Chohelee Choudhury, Ritwik Mazumder, Rajib Biswas, Mahuya Sengupta
Summary: The study investigated the effects of cadmium exposure on the immune response and molecular changes in monocytes/macrophages of Channa punctatus. Results showed alterations in hematological profile, tissue damage, impaired innate immune parameters, ROS generation, and induced inflammation, highlighting the role of NF-kappa B pathway and proinflammatory cytokines such as TNF-alpha, IL-1 beta, IL-6, and IL-12.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Cell Biology
Gina M. Gallucci, Bader Alsuwayt, Adam M. Auclair, James L. Boyer, David N. Assis, Nisanne S. Ghonem
Summary: Fenofibrate has anti-inflammatory effects in chronic liver diseases by inhibiting NF-kappa B signaling and reducing the secretion of pro-inflammatory cytokines.
Article
Cell Biology
Zhongqian Lu, Xing Li, Peng Yang, Genhua Mu, Lei He, Chunmei Song, Feng Xu
Summary: Heparin-binding protein (HBP) modulates the inflammatory response in sepsis by regulating lactate-dependent glycolysis in macrophages, increasing NF-κB pathway activation and TNF-α expression. This mechanism plays a crucial role in the initial inflammatory reaction, highlighting the importance of lactate in regulating proinflammatory factor release.
Article
Genetics & Heredity
Ambreen Iqbal, Pan Ziyi, Haibin Yu, Li Jialing, Wu Haochen, Fan Jing, Jiang Ping, Zhao Zhihui
Summary: The study reveals that C4BPA plays a role in regulating lipid metabolism through the PPAR signaling pathway and contributes to the inflammatory response through TLR-4/NF-kappa B and the complement and coagulation cascade pathways.
FRONTIERS IN GENETICS
(2022)
Article
Neurosciences
Philippa Malko, Xiaoling Jia, Ian Wood, Lin-Hua Jiang
Summary: Microglial cell function and inflammation are regulated by the activation of Piezo1 channel. This study found that the activation of Piezo1 channel can inhibit the pro-inflammatory activation and production of pro-inflammatory cytokines in microglial cells by initiating intracellular Ca2+ signaling to inhibit the NF-kappa B inflammatory signaling pathway.
Article
Multidisciplinary Sciences
Masaki Wakai, Ryohei Hayashi, Yoshitaka Ueno, Kana Onishi, Takeshi Takasago, Takuro Uchida, Hidehiko Takigawa, Ryo Yuge, Yuji Urabe, Shiro Oka, Yasuhiko Kitadai, Shinji Tanaka
Summary: This study found higher expression of serum amyloid A (SAA) in the intestinal tract of ulcerative colitis (UC) mouse models compared to C-reactive protein. The expression of SAA1 was promoted by interleukin-6, tumor necrosis factor-alpha, flagellin, and lipopolysaccharide. The nuclear factor-kappa B (NF-kappa B) pathway may be involved in flagellin-induced SAA1 expression, which was inhibited by 5-aminosalicylic acid (5-ASA).
Article
Biochemistry & Molecular Biology
Panpan Tan, Jiaqi Yang, Fanxuan Yi, Linshan Mei, Yazhou Wang, Chenxu Zhao, Baoyu Zhao, Jianguo Wang
Summary: Subacute ruminal acidosis (SARA) is a common nutritional metabolic disease in ruminants that causes significant economic losses to dairy farming. This study found that strontium (Sr) can reduce LPS-induced inflammation and exert anti-inflammatory effects through the TLR4/MyD88/NF-kappa B pathway, suggesting its potential as a treatment for bovine ruminal acidosis.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Cell Biology
Sayantani Goswami, Juan Flores, Iyshwarya Balasubramanian, Sheila Bandyopadhyay, Ivor Joseph, Jared Bianchi-Smak, Puneet Dhawan, Derya M. Mucahit, Shiyan Yu, Sylvia Christakos, Nan Gao
Summary: Studies have shown that vitamin D supplementation can effectively reduce intestinal inflammation in mice with IEC-specific Rab11a defects, leading to decreased production of inflammatory cytokines, improved body weights, reduced immune cell infiltration, and decreased inflammatory cytokine secretion.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Medicine, Research & Experimental
Mingkwan Na Takuathung, Saranyapin Potikanond, Siriwoot Sookkhee, Pitchaya Mungkornasawakul, Thanathorn Jearanaikulvanich, Kittinan Chinda, Nitwara Wikan, Wutigri Nimlamool
Summary: The study demonstrated that Kaempferia parviflora extract has significant anti-inflammatory and anti-psoriatic effects by suppressing key inflammatory markers and inhibiting NF-kappa B pathway activation and protein phosphorylation. The results suggest that KP extract has potential as a promising agent for treating inflammation and psoriasis.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Food Science & Technology
Imam Hossen, Zhang Kaiqi, Wu Hua, Xiao Junsong, Huang Mingquan, Cao Yanping
Summary: In this study, the anti-inflammatory effect of epigallocatechin-3-gallate (EGCG) in tea polyphenol extract was investigated using lipopolysaccharide-induced inflammation in RAW 264.7 cells. The results showed that EGCG reduced the production of nitric oxide and reactive oxygen species, suppressed the expression of inflammatory cytokines, and inhibited the signaling pathways associated with inflammation. These findings suggest that EGCG exerts its anti-inflammatory effect by modulating multiple molecular mechanisms.
FOOD SCIENCE & NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Han-Hee Park, Hwa-Ryeon Kim, Sang-Yeong Park, Sung-Min Hwang, Sun Mi Hong, Sangwook Park, Ho Chul Kang, Michael J. Morgan, Jong-Ho Cha, Dakeun Lee, Jae-Seok Roe, You-Sun Kim
Summary: The study identifies TRIM28 as a co-repressor regulating transcriptional activity during necroptosis. Activated RIPK3 phosphorylates TRIM28, inhibiting its chromatin binding activity and contributing to increased cytokine expression and immunoregulatory processes. RIPK3 activation-dependent derepression of TRIM28 in cancer cells leads to enhanced immunostimulatory cytokine production and robust anti-tumor immunity.
Article
Biochemistry & Molecular Biology
Hongrui Li, Jiazheng Quan, Xibao Zhao, Jing Ling, Weilin Chen
Summary: USP14 acts as a negative regulator of RIG-I-mediated inflammatory response by inhibiting NF-kappa B activation and deubiquitinating K63-linked RIG-I, leading to decreased pro-inflammatory cytokine production in macrophages and HeLa cells. Additionally, USP14 inhibitor IU1 significantly promotes pro-inflammatory cytokines production in VSV-infected mice in vivo.
MOLECULAR IMMUNOLOGY
(2021)
Article
Immunology
Michal Pazdernik, Helena Bedanova, Zhi Chen, Josef Kautzner, Vojtech Melenovsky, Ivan Malek, Antonij Slavcev, Michaela Bartonova, Vladimir Karmazin, Tomas Eckhardt, Ales Tomasek, Eva Ozabalova, Tomas Kovarnik, Peter Wohlfahrt, Milan Sonka
Summary: The study found a significant reduction in coronary luminal area and progression in intimal thickness post-heart transplantation, but no clear association between the presence of donor-specific antibodies and MHC-I polypeptide-related sequence A antibodies and intimal thickness progression. However, a significant relationship was observed between donor-specific antibodies and media thickness progression.
TRANSPLANT IMMUNOLOGY
(2021)
Editorial Material
Immunology
Lisa Mumford, Susan V. Fuggle, Jaume Martorell, Antonij Slavcev, Aliki Iniotaki, Geert W. Haasnoot, Sebastiaan Heidt, Frans H. J. Claas
Summary: Immunisation against HLA can be caused by various factors, affecting waiting time for transplant patients. Sharing kidneys between European countries can increase chances of transplantation for highly sensitised patients who have been waiting for a long time.
TRANSPLANT IMMUNOLOGY
(2021)
Review
Immunology
Hana Malcova, Zuzana Strizova, Tomas Milota, Ilja Striz, Anna Sediva, Dita Cebecauerova, Rudolf Horvath
Summary: Autoinflammatory diseases (AIDs) comprise a rare and diverse group of disorders characterized by recurrent inflammation and a wide range of clinical manifestations. Therapeutic approaches aim to inhibit cytokines from the IL-1 family, which play a central pathogenic role in these diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Health Care Sciences & Services
Bart Smeulders, William Pettersson, Ana Viana, Tommy Andersson, Catarina Bolotinha, Pavel Chromy, Margherita Gentile, Karine Hadaya, Aline Hemke, Xenia Klimentova, Dirk Kuypers, David Manlove, Matthew Robb, Antonij Slavcev, Paolo Tubertini, Maria O. Valentin, Joris van de Klundert, Paolo Ferrari
Summary: Kidney Exchange Programs are valuable tools for increasing options for living donor kidney transplantation, requiring information systems to manage data and optimize transplants. Data recorded by different programs varies, reflecting different medical practices. The information system supports decision making throughout the kidney exchange programs.
HEALTH INFORMATICS JOURNAL
(2021)
Article
Surgery
Maria Magicova, Martina Fialova, Ivan Zahradka, Silvie Rajnochova-Bloudickova, David Hackajlo, Petr Raska, Ilja Striz, Ondrej Viklicky
Summary: Kidney transplant recipients show a lower anti-SARS-CoV-2 IgG seroprevalence compared to healthcare workers, with those who had SARS-CoV-2 infection being younger and more likely to receive CNI-based immunosuppression. Interestingly, kidney transplant recipients had higher levels of anti-SARS-CoV-2 IgG antibodies compared to healthcare workers, with the presence of moderate to severe symptoms being the main factor affecting IgG levels in kidney transplant recipients.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Review
Genetics & Heredity
Eva Girmanova, Petra Hruba, Ondrej Viklicky, Antonij Slavcev
Summary: The ELISpot assay is a sensitive technique used to assess immune responses, and despite being difficult to standardize, it can provide valuable information for organ transplant recipients.
INTERNATIONAL JOURNAL OF IMMUNOGENETICS
(2022)
Editorial Material
Immunology
Antonij Slavcev, Caner Susal, Ilias Doxiadis
FRONTIERS IN IMMUNOLOGY
(2022)
Letter
Immunology
Vojtech Petr, Ivan Zahradka, Istvan Modos, Matej Roder, Adam Prewett, Martina Fialova, Jana Machkova, Petra Hruba, Maria Magicova, Antonij Slavcev, Ilja Striz, Ondrej Viklicky
Letter
Immunology
Ivan Zahradka, Vojtech Petr, Istvan Modos, Katerina Kabrtova, Antonij Slavcev, Ondrej Viklicky
Article
Immunology
Vojtech Petr, Dorottya Csuka, Petra Hruba, Agnes Szilagyi, Marek Kollar, Antonij Slavcev, Zoltan Prohaszka, Ondrej Viklicky
Summary: De novo thrombotic microangiopathy (TMA) is associated with poor kidney graft survival, and there is a recipient-driven process with suspected genetic background. Carriers of the MCPggaac haplotype have a higher risk of graft loss, and longer cold ischemia time is associated with worse graft survival.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Zuzana Diamant, Maurits van Maaren, Antonella Muraro, Milos Jesenak, Ilja Striz
Summary: Allergen specific immunotherapy (AIT) is the only causal therapeutic option for allergic airway diseases. Recent real life data on long-term effectiveness of AIT further underscored its unique therapeutic potential. More widespread use of this treatment should further move this promising therapeutic field.
RESPIRATORY MEDICINE
(2023)
Review
Medicine, Research & Experimental
Ilja Striz, Kornel Golebski, Zuzana Strizova, Stelios Loukides, Petros Bakakos, Nicola A. Hanania, Milos Jesenak, Zuzana Diamant
Summary: Asthma and chronic rhinosinusitis with nasal polyps often co-exist and are driven by type 2 inflammation. Targeted biologics have shown clinical efficacy in patients with refractory T2 airway inflammation, but no consistent efficacy has been observed in non-type-2 endotypes. Multiple therapeutic targets are being explored to expand current treatment options for severe asthma with and without comorbid CRSwNP.
Review
Medicine, Research & Experimental
Zuzana Strizova, Iva Benesova, Robin Bartolini, Rene Novysedlak, Eva Cecrdlova, Lily Koumbas Foley, Ilja Striz
Summary: Macrophages are a heterogeneous cell population with various roles in defense mechanisms and tissue homeostasis. They can adopt different activation states depending on the microenvironment and natural signals they receive.
Article
Urology & Nephrology
Michal Schmalz, Hana Vankova, Silvie Rajnochova-Bloudickova, Petra Hruba, Martina Fialova, Jiri Gurka, Maria Magicova, Ilja Striz, Ivan Zahradka, Ondrej Viklicky
Summary: Frailty syndrome assessment may determine the most vulnerable population for an impaired humoral immune response to SARS-CoV-2 mRNA vaccination in kidney transplant recipients.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Meeting Abstract
Cell Biology
Antonij Slavcev, Katerina Kabrtova, Martina Fialova, Janka Slatinska, Ondrej Viklicky