期刊
IMMUNOBIOLOGY
卷 216, 期 10, 页码 1085-1093出版社
ELSEVIER GMBH
DOI: 10.1016/j.imbio.2011.05.007
关键词
Aging; Dendritic cells; Intra-epithelial lymphocytes; Oral tolerance; TGF-beta; IL-10
类别
资金
- Fogarty International Center [FIRCA/NIH TW007636-01]
- Conselho Nacional para o Desenvolvimento Cientifico e Tecnologico - CNPq, Brazil
Aging is reported to be associated with decline in oral tolerance induction, which is initiated at the intestinal mucosal surface. Herein, we examined the effect of aging in T cells and cytokines at the intestinal mucosa that might be involved in oral tolerance induction. Frequencies of regulatory-type IEL subsets such as TCR gamma delta(+) and TCR alpha beta(+)CD8 alpha alpha(+) were lower in aged mice. Mucosal CD4(+)CD25(+)Foxp3(+) and CD4(+)LAP(+) T cells increased with aging but activated CD44(+)CD4(+) mucosal T cells also augmented. Production of TGF-beta and IL-10 in the small intestine of old mice was reduced. Moreover, the ability of mucosal dendritic cells of aged mice to stimulate TGF-beta secretion and differentiation of CD4(+)LAP(+) T cells in co-culture studies also declined with aging. Reduction in these regulatory-type cytokines and T cells may help to explain the decline in susceptibility to oral induction during aging. However, not all mucosal regulatory elements were altered by aging and CD4(+)CD25(+)Foxp3(+) T cells were especially resistant to changes. Persistence of some mechanisms of regulation may play a critical role in maintaining mucosal homeostasis during aging. (c) 2011 Elsevier GmbH. All rights reserved.
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