Article
Biochemistry & Molecular Biology
Jakub Rech, Daniel Sypniewski, Dorota Zelaszczyk, Natalia Szkaradek, Wojciech Rogoz, Anna Waszkielewicz, Henryk Marona, Ilona Bednarek
Summary: The study revealed that four novel xanthone derivatives have the potential to inhibit proliferation, motility, and induce apoptosis in colon cancer cells, with comparable activity to cisplatin and 5-fluorouracil. Further research and development of these compounds as novel drugs for colorectal cancer treatment is recommended.
Article
Chemistry, Medicinal
Ilona Gurgul, Ewelina Janczy-Cempa, Olga Mazuryk, Malgorzata Lekka, Michal Lomzik, Franck Suzenet, Philippe C. Gros, Malgorzata Brindell
Summary: The effect of polypyridyl Ru(II) complexes on cancer cell migration and invasion was evaluated in this study. Low sub-toxic doses of these complexes were found to greatly inhibit cell detachment, migration, invasion, transmigration, and re-adhesion, as well as increase cell elasticity. Molecular studies revealed that these complexes impact the activity of integrins and upregulate the expression of focal adhesion components, leading to an increased number of focal adhesion contacts.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Cell Biology
Hamid A. Bakshi, Gerry A. Quinn, Mohamed M. Nasef, Vijay Mishra, Alaa A. A. Aljabali, Mohamed El-Tanani, Angel Serrano-Aroca, Mateus Webba Da Silva, Paul A. McCarron, Murtaza M. Tambuwala
Summary: Crocin derived from Himalayan crocus inhibits the growth of colon cancer cells by targeting NF-kB and blocking TNF-alpha/NF-kappa B/VEGF pathways, thus suppressing angiogenesis and colorectal cancer cell metastasis.
Article
Oncology
Shuyun Wang, Limin Nie, Yuxiao Song, Fang Zhang, Xiaozheng Chen, Wenjing Shi, Zijiang Yang, Yuping Sun, Qi Dang, Aiqin Gao
Summary: The study found that NRTN is enriched in colorectal cancer cells and predicts poor patient outcomes. Upregulated NRTN enhances cancer cell motility and angiogenesis, promoting tumor invasion and metastasis.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Sun-Il Yun, Chulhwan Kwak, Song-Yi Lee, Sanghee Shin, Changsuk Oh, Jong-Seo Kim, Hyun-Woo Rhee, Kyeong Kyu Kim
Summary: This study reveals that ubiquitin-specific protease 4 (USP4) is highly expressed in colon cancer and acts as a potent protooncogenic protein by deubiquitinating beta-catenin. In addition to its well-known role, it is also found that USP4 interacts with cortactin (CTTN) to promote cell dynamics and migration. The dual role of USP4 in cancer progression, involving the stabilization of beta-catenin and the interaction with CTTN, suggests that USP4 is an important target for cancer treatment or prevention.
Article
Biotechnology & Applied Microbiology
Bo Li, Xianyi Liu, Guogang Wu, Jiawen Liu, Shouliang Cai, Fuxin Wang, Chunyu Yang, Jisheng Liu
Summary: The study found that miR-934 is overexpressed in colorectal cancer cells and has effects on cell proliferation, migration, invasion, and angiogenesis. Knockdown of miR-934 can reverse these effects, suggesting that miR-934 promotes CRC progression by targeting BTG2.
Article
Pharmacology & Pharmacy
Mehmet A. A. Kisacam
Summary: Nobiletin, a compound found in citrus fruits, has been shown to have anti-cancer effects on various cancer cell lines. This study investigated the effects of nobiletin on different proteins involved in cancer progression. The results showed that nobiletin inhibited the activity of Akt, a protein associated with tumor growth and angiogenesis. It also decreased the levels of Bax, Bcl-2, and p70S6K, which are involved in cell survival and proliferation. Additionally, nobiletin reduced the levels of HO-1 and VEGF, proteins associated with angiogenesis and tumor growth. These findings suggest that nobiletin could be a potential therapy for preventing colon cancer progression by targeting Akt signaling and angiogenesis pathways.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zilu Cui, Wenkun Li, Yadan Wang, Mengran Zhao, Kuiliang Liu, Yi Yang, Shuo Teng, Nan Zhang, Li Min, Peng Li, Shutian Zhang, Junxuan Xu, Jing Wu
Summary: This study found that the protein level of ferritin heavy chain (FTH1) is upregulated in colon cancer, and M2 macrophages can deliver FTH1 through exosomes to promote colon cancer cell proliferation. These findings provide a new potential therapeutic target for the treatment of colon cancer.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Oncology
Kalika Kamat, Venkatesh Krishnan, Oliver Dorigo
Summary: Macrophage-secreted CCL23 contributes to the immune-suppressive TME in ovarian cancer by inducing exhausted phenotype of CD8+ T cells.
BRITISH JOURNAL OF CANCER
(2022)
Article
Biochemistry & Molecular Biology
Amin Esmaeilniakooshkghazi, Eric Pham, Sudeep P. George, Afzal Ahrorov, Fabian R. Villagomez, Michael Byington, Srijita Mukhopadhyay, Srinivas Patnaik, Jacinta C. Conrad, Monali Naik, Saathvika Ravi, Niall Tebbutt, Jennifer Mooi, Camilla M. Reehorst, John M. Mariadason, Seema Khurana
Summary: This study investigates the molecular mechanism of adherens junction (AJ) remodeling in colon cancer cells and the function of fascin1 in AJ remodeling. The researchers discovered that fascin1 renders AJs less stable but more dynamic by remodeling junctional actin and actomyosin contractility, which drives cell migration and mechanosensitive WNT/beta-catenin signaling activation. These findings highlight the role of AJ remodeling and mechanosensitive WNT/beta-catenin signaling in the growth and dissemination of colorectal carcinomas.
Article
Biotechnology & Applied Microbiology
Shengxun Mao, Zhaohong Mo, Runxin Wu, Bin Lai, Zhiyong Zhou, Yi Song, Xi Ouyang, Xingen Zhu
Summary: DUXAP8 is upregulated in colon cancer and is associated with advanced stages and lymph node metastases. High expression of DUXAP8 is correlated with shorter overall survival in patients. Silencing of DUXAP8 inhibits cellular proliferation, migration, and invasion, while overexpression accelerates these processes.
Article
Biochemistry & Molecular Biology
Zhengcheng Wang, Xiang Ao, Zhilin Shen, Luoquan Ao, Xiaofeng Wu, Chengxiu Pu, Wei Guo, Wei Xing, Min He, Hongfeng Yuan, Jianhua Yu, Ling Li, Xiang Xu
Summary: Chronic inflammation-induced metastases in cancer have been a significant obstacle in treatment. Recent studies have shown that TNF-alpha activates PI3K/Akt and p38 MAPK pathways to enhance CXCL10 transcription, promoting metastases in colon cancer cells. CXCL10, in turn, regulates EMT in colon cancer cells via the PI3K/Akt pathway, offering a new potential target for inhibiting colon cancer metastases.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Medicine, Research & Experimental
Elmira Roshani Asl, Mohammad Amini, Souzan Najafi, Behzad Mansoori, Ahad Mokhtarzadeh, Ali Mohammadi, Parisa Lotfinejad, Mehdi Bagheri, Solmaz Shirjang, Ziba Lotfi, Yousef Rasmi, Behzad Baradaran
Summary: The highly conserved MAPK signal transduction pathway plays a crucial role in cancer progression, while miRNAs act as critical regulators in cancer initiation and progression. The interaction between miRNAs and the MAPK signaling pathway is pivotal in the development of human cancers.
Article
Oncology
Yuichi Hayashi, Yoichi Matsuo, Yuki Denda, Keisuke Nonoyama, Hiromichi Murase, Goro Ueda, Yoshinaga Aoyama, Tomokatsu Kato, Kan Omi, Hiroyuki Imafuji, Kenta Saito, Mamoru Morimoto, Ryo Ogawa, Hiroki Takahashi, Akira Mitsui, Masahiro Kimura, Shuji Takiguchi
Summary: It is found that Girdin plays a role in promoting invasion and angiogenesis in pancreatic cancer, while the flavonoid Scutellarin (SCU) can inhibit Girdin signaling. High expression of Girdin is associated with poor survival and invasion in pancreatic cancer patients. Girdin knockdown reduces migration ability even under EGF stimulation. SCU inhibits pancreatic cancer cell migration by suppressing Girdin phosphorylation. Girdin is also involved in angiogenesis through a different pathway from SCU. Girdin may serve as a prognostic biomarker and targeting Girdin may improve the prognosis of pancreatic cancer.
Article
Oncology
Zhiliang Lu, Sufei Zheng, Chengming Liu, Xinfeng Wang, Guochao Zhang, Feng Wang, Sihui Wang, Jianbing Huang, Shuangshuang Mao, Yuanyuan Lei, ZhanYu Wang, Nan Sun, Jie He
Summary: S100A7 is significantly upregulated in ESCC tumor tissues and serum samples, serving as an independent prognostic factor and potential diagnostic marker. Mechanistically, S100A7 promotes tumor progression through JAB1 binding, RAGE interaction, M2 macrophage infiltration, and angiogenesis. These findings support the potential therapeutic targeting of S100A7 for cancer treatment.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
