期刊
IMMUNITY
卷 37, 期 5, 页码 905-916出版社
CELL PRESS
DOI: 10.1016/j.immuni.2012.07.019
关键词
-
类别
资金
- BMBF
- Deutsche Forschungsgemeinschaft (DFG) [1109 Ze 432/2-3, SFB542/B10, DFG Ta 434/2-1]
- Interdisciplinary Center for Clinical Research IZKF Aachen
- Immunohistochemisty and Confocal Laser Scanning Microscopy Facility of the IZKF, Faculty of Medicine, RWTH Aachen University
- Faculty of Medicine, RWTH Aachen University
- Grants-in-Aid for Scientific Research [24390077] Funding Source: KAKEN
Langerhans cells (LCs), the dendritic cells (DCs) in skin epidermis, possess an exceptional life cycle and developmental origin. Here we identified two types of LCs, short-term and long-term LCs, which transiently or stably reconstitute the LC compartment, respectively. Short-term LCs developed from Gr-1(hi) monocytes under inflammatory conditions and occurred independently of the transcription factor Id2. Long-term LCs arose from bone marrow in steady state and were critically dependent on Id2. Surface marker and gene expression analysis positioned short-term LCs close to Gr-1(hi) monocytes, which is indicative of their monocytic origin. We also show that LC reconstitution after UV light exposure occurs in two waves: an initial fast and transient wave of Gr-1(hi) monocyte-derived short-term LCs is followed by a second wave of steady-state precursor-derived long-term LCs. Our data demonstrate the presence of two types of LCs that develop through different pathways in inflammation and steady state.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据