Article
Multidisciplinary Sciences
Stephen G. Aller, Jere P. Segrest
Summary: ABCA1 and ABCA4 are enigmatic proteins that transport substrates in opposite directions but share similarities in amino acid sequences. ABCA4 imports lipid conjugates while ABCA1 exports lipids. They both contain specific domains in their tertiary structures, which are conserved in the ABC-A subfamily. The study reveals a previously overlooked sequence in ABCA1 and proposes a refined model that suggests a distinct transport mechanism for ABCA1.
Article
Immunology
Hyunju Oh, Jingyao Zhao, Yenkel Grinberg-Bleyer, Thomas S. Postler, Pingzhang Wang, Sung-Gyoo Park, Raul Rabadan, Matthew S. Hayden, Sankar Ghosh
Summary: This study demonstrates the essential role of PDK1 in both T cell activation and Treg cell suppressive activity, with PDK1 regulating Treg cell gene expression and suppressor function primarily through the NF-κB pathway.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Immunology
Dandan Yang, Xueqiang Zhao, Xin Lin
Summary: Bcl10 plays a critical role in the development and function of regulatory T (Treg) cells, deficiency of which leads to impaired development and suppressive function of Treg cells, even causing lethal autoimmunity. Bcl10-deficient Treg cells can undergo conversion into proinflammatory cells and decrease in effector Treg cell populations. The study provides genetic evidence that Bcl10 is essential for Treg cell development and function.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Immunology
Xinlin Xiong, Zhenhua Luo, Haiyan Zhou, Zonggang Duan, Li Niu, Kai Zhang, Guangwei Huang, Wei Li
Summary: This study investigated the role and alterations of TIGIT+Tregs in acute coronary syndrome (ACS) patients. The results showed that TIGIT+Tregs levels were significantly reduced in ACS patients, accompanied by increased IL-6 expression and decreased TGF-I3 expression. Downregulated TIGIT+Tregs were independent predictors of ACS.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Lu Bai, Xiaolei Hao, Julia Keith, Yongqiang Feng
Summary: DNA methylation as an epigenetic marker plays a crucial role in regulating the differentiation and function of regulatory T cells. The dynamic regulation of DNA methylation affects various stages of Treg cell lifespan and immunological function. Further research is needed to fully understand the differential DNA methylation and its regulatory role in Treg cell fate and immunological function.
Article
Immunology
Fangwei Leng, Wenxiang Zhang, Ricardo N. Ramirez, Juliette Leon, Yi Zhong, Lifei Hou, Koichi Yuki, Joris van der Veeken, Alexander Y. Rudensky, Christophe Benoist, Sun Hur
Summary: It has been discovered that FoxP3 can exist in two different dimerization forms, head-to-head dimerization and swap dimerization, with the former being associated with functional specificity and the latter being associated with functional impairment.
Article
Immunology
Kathryn A. Knoop, Keely G. McDonald, Chyi-Song Hsieh, Phillip Tarr, Rodney D. Newberry
Summary: Atopic disorders are on the rise in Western societies, characterized by immune responses to environmental triggers. Early life exposure to diet and microbes shapes the intestinal Treg population significantly. Tregs developed early in life play a crucial role in restraining systemic inflammatory responses into adulthood.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Christina Seitz, Anne-Laure Joly, Fang Fang, Katie Frith, Paul Gray, John Andersson
Summary: The transcription factor FOXP3 is crucial for the development and function of CD4(+)FOXP3(+) regulatory T (Treg) cells. Alterations in the expression of FOXP3 isoforms are associated with inflammatory disease progression. This study investigates the effects of a specific FOXP3 mutation on Treg cell subsets. The findings suggest that the full-length FOXP3 isoform is important for maintaining Treg cell lineage stability but not essential for Treg cell activation.
CLINICAL IMMUNOLOGY
(2022)
Article
Immunology
Lauren Van Zeebroeck, Rebeca Arroyo Hornero, Beatriz F. Corte-Real, Ibrahim Hamad, Torsten B. Meissner, Markus Kleinewietfeld
Summary: Tregs are crucial for maintaining immune homeostasis and have potential therapeutic value in various diseases. While current genome editing protocols for Tregs are limited, our rapid and effective method may advance possibilities for Treg-based cellular therapies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Katrina M. Hawley, Rachel J. Eclov, Mathew R. Schnorenberg, Yu Tian, Rhea N. Shah, Anika T. Thomas-Toth, Marie Fefferman, Gregory H. Bird, Loren D. Walensky, Matthew V. Tirrell, James L. LaBelle
Summary: Researchers investigated the use of hydrocarbon stapled alpha-helical (SAH) peptides to target FOXP3 and disrupt its protein-protein interaction. They demonstrated that these peptides could inhibit Treg cell function and alter gene expression, suggesting their potential as a therapeutic approach to enhance immune responsiveness.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Immunology
Beatriz F. F. Corte-Real, Rebeca Arroyo Hornero, Aleksandra Dyczko, Ibrahim Hamad, Markus Kleinewietfeld
Summary: CSF2RB (CD131) may serve as a potential biomarker for autoimmune diseases in Tregs, with its overexpression potentially being linked to disease development.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Yiran Qiu, Shouyu Ke, Jieqiong Chen, Zhizhen Qin, Wenle Zhang, Yaqin Yuan, Dehua Meng, Gang Zhao, Kejin Wu, Bin Li, Dan Li
Summary: This review summarizes the latest findings on the dynamic connections and reciprocal regulations of non-lymphoid Treg cell subsets in the immune escape of tumour cells in solid tumors, providing new insights for the development of next-generation engineered T cell-based immune treatments for solid tumors.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Disha Rao, Johanna A. A. Stunnenberg, Ruben Lacroix, Petros Dimitriadis, Joanna Kaplon, Fabienne Verburg, Paula T. T. van van Royen, Esmee P. Hoefsmit, Kathrin Renner, Christian U. U. Blank, Daniel S. S. Peeper
Summary: Glucose limitation and increased lactic acid levels due to elevated glycolytic activity of tumor cells create a metabolic barrier for tumor infiltrating immune cells. Regulatory T cells (Tregs) are not inhibited in lactic acid-rich environments, and lactic acid enhances the induction of Tregs. Acidicity in the tumor microenvironment can be targeted therapeutically to reduce Treg-mediated immune suppression within tumors.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Review
Immunology
Tracoyia Roach, Laurence Morel
Summary: Immune homeostasis relies on the balance between effector T cells and regulatory T cells. Studies have identified genetic factors that maintain the stability and suppressive function of regulatory T cells, which could potentially be targeted for therapeutic intervention against autoimmunity.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Biaolong Deng, Weiqi Zhang, Yicheng Zhu, Yangyang Li, Dan Li, Bin Li
Summary: Regulatory T (Treg) cells play a critical role in maintaining immune homeostasis and their dysfunction in aged patients may contribute to age-related diseases. Immune therapies targeting Treg cells show promising results in treating cancers and autoimmune diseases. Understanding Treg cell function better may help in developing new immune therapies against aging.
Article
Biochemical Research Methods
James C. Stroud
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
(2013)
Correction
Immunology
Hozefa S. Bandukwala, Yongqing Wu, Markus Feuerer, Yongheng Chen, Bianca Barboza, Srimoyee Ghosh, James C. Stroud, Christophe Benoist, Diane Mathis, Anjana Rao, Lin Chen
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Biochemistry & Molecular Biology
Cosma D. Dellisanti, Sonya M. Hanson, Lin Chen, Cynthia Czajkowski
JOURNAL OF BIOLOGICAL CHEMISTRY
(2011)
Article
Biochemistry & Molecular Biology
Lei Gu, Cong Liu, James C. Stroud, Sam Ngo, Lin Jiang, Zhefeng Guo
JOURNAL OF BIOLOGICAL CHEMISTRY
(2014)
Article
Biochemistry & Molecular Biology
James C. Stroud, Amy Oltman, Aidong Han, Darren L. Bates, Lin Chen
JOURNAL OF MOLECULAR BIOLOGY
(2009)
Article
Biochemistry & Molecular Biology
Yongqing Wu, Raja Dey, Aidong Han, Nimanthi Jayathilaka, Michael Philips, Jun Ye, Lin Chen
JOURNAL OF MOLECULAR BIOLOGY
(2010)
Article
Neurosciences
Lin Chen
JOURNAL OF PHYSIOLOGY-LONDON
(2010)
Article
Neurosciences
Shu-Xing Li, Sun Huang, Nina Bren, Kaori Noridomi, Cosma D. Dellisanti, Steven M. Sine, Lin Chen
NATURE NEUROSCIENCE
(2011)
Article
Biochemistry & Molecular Biology
Ju He, Jun Ye, Yongfei Cai, Cecilia Riquelme, Jun O. Liu, Xuedong Liu, Aidong Han, Lin Chen
NUCLEIC ACIDS RESEARCH
(2011)
Article
Multidisciplinary Sciences
James C. Stroud, Cong Liu, Poh K. Teng, David Eisenberg
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2012)
Article
Multidisciplinary Sciences
Georg K. A. Hochberg, Heath Ecroyd, Cong Liu, Dezerae Cox, Duilio Cascio, Michael R. Sawaya, Miranda P. Collier, James Stroud, John A. Carver, Andrew J. Baldwin, Carol V. Robinson, David S. Eisenberg, Justin L. P. Benesch, Arthur Laganowsky
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2014)
Article
Biochemistry & Molecular Biology
Yongheng Chen, Raja Dey, Lin Chen
Meeting Abstract
Biochemistry & Molecular Biology
Georg Hochberg, Heath Ecroyd, Dezerea Cox, Michael Sawaya, Cong Liu, Duilio Cascio, Miranda Collier, James Stroud, John Carver, Andrew Baldwin, Carol Robinson, David Eisenberg, Justin Benesch, Arthur Laganowsky