Article
Immunology
Mikel M. Arbulo-Echevarria, Inmaculada Vico-Barranco, Fanghui Zhang, Luis M. Fernandez-Aguilar, Martyna Chotomska, Isaac Narbona-Sanchez, Lichen Zhang, Bernard Malissen, Yinming Liang, Enrique Aguado
Summary: The LAT transmembrane adaptor is crucial for transducing intracellular signals triggered by the TCR. A mutation in LAT(G135D) affects T cell development and activation, leading to changes in thymic cell populations and an increased percentage of central memory CD8+ T cells in mutant mice.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Sarka Janusova, Veronika Krchlikova, Tomas D. Hron, Daniel D. Elleder, Ondrej D. Stepanek
Summary: Linker for activation of T cells (LAT) is a key player in T-cell antigenic signaling in mammals. However, LAT orthologues were not found in most birds. This study discovered the presence of LAT gene in multiple extant birds' genomes, which was not properly assembled before due to its high GC content. The findings suggest that mammalian and avian LAT genes are functional homologues with a common role in T-cell signaling.
Article
Immunology
Anais Joachim, Rudy Aussel, Lena Gelard, Fanghui Zhang, Daiki Mori, Claude Gregoire, Sergio Villazala Merino, Mauro Gaya, Yinming Liang, Marie Malissen, Bernard Malissen
Summary: Mice with a loss-of-function mutation in the LAT adaptor (Lat(Y136F)) develop an autoimmune and type 2 inflammatory disorder called defective LAT signalosome pathology (DLSP). Through single-cell omics analysis, it was found that T follicular helper cells, CD4+ cytotoxic T cells, activated B cells, and plasma cells are present in Lat(Y136F) spleen and lung. This cell constellation is similar to the cell types involved in IgG4-related disease (IgG4-RD), indicating that Lat(Y136F) DLSP can serve as a model for IgG4-RD.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Review
Immunology
Wan-Lin Lo, Arthur Weiss
Summary: The discrimination between self and non-self ligands by T cells remains a complex and incompletely understood process. The kinetic proofreading model provides insights into T cell ligand discrimination. Specific phosphorylation sites within the adaptor protein linker for activation of T cells (LAT) play a crucial role in determining the outcome of T cell receptor signaling.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Juan Jose Saez, Stephanie Dogniaux, Massiullah Shafaq-Zadah, Ludger Johannes, Claire Hivroz, Andres Ernesto Zucchetti
Summary: The paragraph discusses the important role of LAT in the signaling cascade induced by TCR activation, and its distribution and trafficking pathways in T cells upon activation. It shows that different proteins play specific roles in regulating the retrograde and anterograde transport of LAT during T cell activation.
Editorial Material
Cell Biology
Gregory M. Chen, Jan Joseph Melenhorst, Kai Tan
Summary: CAR T cell therapies targeting CD19 and CD22 have shown success in treating B cell cancers, but not in non-B cell cancers. The interaction between CAR T cells and normal B cells may play a crucial role in determining clinical CAR T cell responses.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Cell Biology
Yikui Li, Helen M. Tunbridge, Graham J. Britton, Elaine V. Hill, Parisa Sinai, Silvia Cirillo, Clare Thompson, Farnaz Fallah-Arani, Simon J. Dovedi, David C. Wraith, Christoph Wulfing
Summary: Peripheral immune regulation is crucial for self-tolerance maintenance. Investigating signaling processes in T cells revealed distinct features between regulatory T cells and effector T cells. Regulatory T cells exhibit more rapid termination of signaling, possibly influenced by attenuation of proximal signaling.
Article
Nanoscience & Nanotechnology
Yulin Du, Yifan Lyu, Jie Lin, Chunran Ma, Qiang Zhang, Yutong Zhang, Liping Qiu, Weihong Tan
Summary: We manipulated the intermembrane distance between antigen-presenting cells (APCs) and T cells using DNA nanostructures of different sizes. Our results show that the axial distance of the contact zone is critical for T-cell activation, likely through modulating protein reorganization and mechanical force.
NATURE NANOTECHNOLOGY
(2023)
Article
Immunology
Tianzhuo Zhang, Qianwen Shi, Huining Gu, Biaoyi Yu, Sha Yin, Qing Ge, Xiaoning Mo, Xiaofeng Liu, Jing Huang
Summary: CCDC134 is a cytokine-like molecule that serves as a positive regulator of TCR-proximal signaling by interacting with CD3e and modulating its ubiquitination and degradation. T cell-specific deletion of Ccdc134 results in decreased mature CD4(+) and CD8(+) T cells, impaired T cell homeostasis, and attenuated response to TCR stimulation in vitro and in vivo. These findings highlight the importance of CCDC134 in T cell development and function, and its role in T cell-mediated inflammatory and antitumor responses.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Elisa E. Sanchez, Maria Tello-Lafoz, Aixuan J. Guo, Miguel de Jesus, Yassmin A. Elbanna, Benjamin Y. Winer, Sadna Budhu, Eric Chan, Eric Rosiek, Taisuke Kondo, Justyn DuSold, Naomi Taylor, Gregoire Altan-Bonnet, Michael F. Olson, Morgan Huse
Summary: Cytotoxic T lymphocytes (CTLs) fight intracellular pathogens and cancer by identifying and destroying infected or transformed target cells. CTLs form a specialized cytotoxic immune synapse (IS) with a target and release toxic proteins to induce target cell death. After the IS dissolves, CTLs can search for other targets and phagocytes can clear the dead cells.
Review
Biochemistry & Molecular Biology
Michel Y. Braun
Summary: T cells, particularly T lymphocytes of the immune system, exhibit characteristics of proliferation and mobility in tissues and organs, requiring metabolic plasticity to fulfill their immune function. This review focuses on the various mechanisms that allow T cells to adapt their metabolism to different real-life circumstances, such as exiting quiescence, differentiating into effector cells, and participating in immune memory formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Wan-Lin Lo, Miriam Kuhlmann, Gabrielle Rizzuto, H. Atakan Ekiz, Elizabeth M. Kolawole, Monica P. Revelo, Rakieb Andargachew, Zhongmei Li, Yuan-Li Tsai, Alexander Marson, Brian D. Evavold, Dietmar Zehn, Arthur Weiss
Summary: Mature T cells need to differentiate between brief interactions with self-peptides and prolonged binding to agonists. By accelerating the phosphorylation of LAT residue Y136, an adjacent Gly135Asp alteration disrupts ligand discrimination in vivo. LAT(G135D) T cells show excessive self-reactivity, leading to negative selection and T-cell anergy.
Review
Cell Biology
Wai Ki Wong, Bohan Yin, Ching Ying Katherine Lam, Yingying Huang, Jiaxiang Yan, Zhiwu Tan, Siu Hong Dexter Wong
Summary: This article discusses the importance of epigenetic regulation of T-cell function in cancer immunotherapy and how to restore their function by modulating the epigenetic switches of T-cells, providing new therapeutic strategies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Immunology
Cameron W. Paterson, Melissa B. Gutierrez, Craig M. Coopersmith, Mandy L. Ford
Summary: Chronic alcohol use leads to T cell dysregulation within the adaptive immune system. In this study, using a murine model, researchers compared rare splenic subpopulations in alcohol-exposed mice and water-fed controls. The results showed decreased naive T cell populations and alterations in effector regulatory T cell phenotypes in chronic alcohol-induced immune dysfunction.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Genetics & Heredity
Kun Chu, Yi He, Ziyuan Li, Zhongxin Jiang, Liang Wang, Yixuan Ji, Xiang Wang, Wenjuan Pang, Ningxia Sun, Fu Yang, Wen Li
Summary: This study identified novel LAT pathogenic variants in a POI pedigree and reported for the first time the presence and functionality of LAT in the GCs of the ovary. The mutation was found to potentially influence GC survival, shedding new light on the role of LAT in GCs and broadening the spectrum of genetic causes of POI.
FRONTIERS IN GENETICS
(2021)
Article
Immunology
Jian Ding, Wei Zhang, Scott Haskett, Alex Pellerin, Shanqin Xu, Britta Petersen, Luke Jandreski, Stefan Hamann, Taylor L. Reynolds, Timothy S. Zheng, Michael Mingueneau
CLINICAL IMMUNOLOGY
(2016)
Article
Allergy
Michael Mingueneau, Saida Boudaoud, Scott Haskett, Taylor L. Reynolds, Gaetane Nocturne, Elizabeth Norton, Xueli Zhang, Myrtha Constant, Daniel Park, Wenting Wang, Thierry Lazure, Christine Le Pajolec, Ayla Ergun, Xavier Mariette
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2016)
Article
Rheumatology
Linlin Zhao, Gaetane Nocturne, Scott Haskett, Saida Boudaoud, Thierry Lazure, Christine Le Pajolec, Xavier Mariette, Michael Mingueneau, Daliya Banerjee
Article
Immunology
Jessica G. Borger, Vicky L. Morrison, Andrew Filby, Celine Garcia, Liisa M. Uotila, Fabio Simbari, Susanna C. Fagerholm, Rose Zamoyska
JOURNAL OF IMMUNOLOGY
(2017)
Article
Multidisciplinary Sciences
Thomas C. J. Tan, John Knight, Thomas Sbarrato, Kate Dudek, Anne E. Willis, Rose Zamoyska
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Multidisciplinary Sciences
Rebecca J. Brownlie, Celine Garcia, Mate Ravasz, Dietmar Zehn, Robert J. Salmond, Rose Zamoyska
NATURE COMMUNICATIONS
(2017)
Article
Biology
Aleksander D. Szymaniak, Rongjuan Mi, Shannon E. McCarthy, Adam C. Gower, Taylor L. Reynolds, Michael Mingueneau, Maria Kukuruzinska, Xaralabos Varelas
Article
Allergy
Olivier Fogel, Elodie Riviere, Raphaele Seror, Gaetane Nocturne, Saida Boudaoud, Bineta Ly, Jacques-Eric Gottenberg, Veronique Le Guern, Jean-Jacques Dubost, Joanne Nititham, Kimberly E. Taylor, Philippe Chanson, Philippe Dieude, Lindsey A. Criswell, Bernd Jagla, Alice Thai, Michael Mingueneau, Xavier Mariette, Corinne Miceli-Richard
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2018)
Article
Allergy
Annabelle Drouillard, Anne-Laure Mathieu, Antoine Marcais, Alexandre Belot, Sebastien Viel, Michael Mingueneau, Kevin Guckian, Thierry Walzer
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2018)
Article
Multidisciplinary Sciences
Dillon Hawley, Jian Ding, Suharika Thotakura, Scott Haskett, Hema Aluri, Claire Kublin, Audrey Michel, Lisa Clapisson, Michael Mingueneau, Driss Zoukhri
Article
Multidisciplinary Sciences
Fiona Clarke, Christine K. Jordan, Enrique Gutierrez-Martinez, Jack A. Bibby, Cristina Sanchez-Blanco, Georgina H. Cornish, Xuezhi Dai, David J. Rawlings, Rose Zamoyska, Pierre Guermonprez, Andrew P. Cope, Harriet A. Purvis
Article
Immunology
Maarten van der Kroef, Lucas L. van den Hoogen, Jorre S. Mertens, Sofie L. M. Blokland, Scott Haskett, Abhinandan Devaprasad, Tiago Carvalheiro, Eleni Chouri, Nadia Vazirpanah, Marta Cossu, Catherina G. K. Wichers, Sandra C. Silva-Cardoso, Alsya J. Affandi, Cornelis P. J. Bekker, Ana P. Lopes, Maarten R. Hillen, Femke Bonte-Mineur, Marc R. Kok, Lorenzo Beretta, Marzia Rossato, Michael Mingueneau, Joel A. G. van Roon, Timothy R. D. J. Radstake
EUROPEAN JOURNAL OF IMMUNOLOGY
(2020)
Article
Biology
Jeremy Carlos Burns, Bunny Cotleur, Dirk M. Walther, Bekim Bajrami, Stephen J. Rubino, Ru Wei, Nathalie Franchimont, Susan L. Cotman, Richard M. Ransohoff, Michael Mingueneau
Article
Immunology
Scott M. Wemlinger, Chelsea R. Parker Harp, Bo Yu, Ian R. Hardy, Matthew Seefeldt, Jennifer Matsuda, Michael Mingueneau, Kerri A. Spilker, Thomas O. Cameron, James W. Larrick, Andrew Getahun, John C. Cambier
Summary: The BCR is composed of a membrane-bound Ig and a heterodimer of CD79A and CD79B. CD79 subunits mediate intracellular propagation of BCR signals critical for B cell development, survival, and activation. This study generated knockin mice expressing chimeric CD79 and demonstrated their utility in preclinical analysis of anti-human CD79 therapy. Anti-human CD79 treatment prevented disease development in mouse models of autoimmunity and inhibited antibody secretion by terminally differentiated plasma cells in vitro.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Immunology
Harriet A. Purvis, Fiona Clarke, Christine K. Jordan, Cristina Sanchez Blanco, Georgina H. Cornish, Xuezhi Dai, David J. Rawlings, Rose Zamoyska, Andrew P. Cope
EUROPEAN JOURNAL OF IMMUNOLOGY
(2018)
