期刊
IEEJ TRANSACTIONS ON ELECTRICAL AND ELECTRONIC ENGINEERING
卷 4, 期 6, 页码 710-719出版社
WILEY
DOI: 10.1002/tee.20469
关键词
evaluation of drug bitterness; artificial lipid-based membrane; plasticizer; hydrophobic interaction; bitterness suppression effect; bitter-masking material
This paper reports the development of membrane sensors based on an artificial lipid and plasticizers with high selectivity and sensitivity to drug bitterness by using bis(1-butylpentyl) adipate (BBPA), bis(2-ethylhexyl) sebacate (BEHS), phosphoric acid tris(2-ethylhexyl) ester (PTEH), and tributyl o-acetylcitrate (TBAC) as a plasticizer and phosphoric acid di-n-decyl ester (PADE) as an artificial lipid to optimize surface hydrophobicity of the sensors. In addition, a sensor with highly correlated bitterness sensory score was developed by blending BBPA and TBAC to detect the bitterness suppression effect of sucrose, and other bitter-masking materials. Therefore, this sensor can be used to evaluate the bitterness of various drug formulations with high accuracy. (C) 2009 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.
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