期刊
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
卷 55, 期 -, 页码 343-359出版社
ELSEVIER
DOI: 10.1016/j.msec.2015.05.023
关键词
Adsorptivity; Antibiotic; Magnetite nanoparticles; Nanocomposite; Silver
资金
- National Centre for Research and Development [PBS1/A9/13/2012]
- Erasmus Mundus EMINENCE program
- National Academy of Sciences of Ukraine [111/10-H(2)]
- Polish Ministry of Science and Higher Education [IP2011 030071]
- National Science Centre of Poland [2012/05/D/ST3/02855]
- Foundation for Polish Science (START)
The article is devoted to preparation and characterization of magnetite/silver/antibiotic nanocomposites for targeted antimicrobial therapy. Magnetite nanopowder was produced by thermochemical technique; silver was deposited on the magnetite nanoparticles in the form of silver clusters. Magnetite/silver nanocomposite was investigated by XRD, SEM, TEM, AFM, XPS, EDX techniques. Adsorptivity of magnetite/silver nanocomposite towards seven antibiotics from five different groups was investigated. It was shown that rifampicin, doxycycline, ceftriaxone, cefotaxime and doxycycline may be attached by physical adsorption to magnetite/silver nanocomposite. Electrostatic surfaces of antibiotics were modeled and possible mechanism of antibiotic attachment is considered in this article. Raman spectra of magnetite, magnetite/silver and magnetite/silver/antibiotic were collected. It was found that it is difficult to detect the bands related to antibiotics in the magnetite/silver/antibiotic nanocomposite spectra due to their overlap by the broad carbon bands of magnetite nanopowder. Magnetic measurements revealed that magnetic saturation of the magnetite/silver/antibiotic nanocomposites decreased on 6-19% in comparison with initial magnetite nanopowder. Pilot study of antimicrobial properties of the magnetite/silver/antibiotic nanocomposites were performed towards Bacillus pumilus. (C) 2015 Elsevier B.V. All rights reserved.
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