Article
Chemistry, Multidisciplinary
Phil Opitz, Laura Besch, Martin Panthoefer, Anke Kabelitz, Ronald E. Unger, Franziska Emmerling, Mihail Mondeshki, Wolfgang Tremel
Summary: This study reports a protein-free formation of bone-like apatite from amorphous precursors through ball-milling. Mg2+ ions are crucial to achieve complete amorphization of CaCO3, promoting cell growth through stimulating cell viability ex vivo.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Engineering, Environmental
Pingli Jiang, Ruiqing Hou, Tao Chen, Lingchuang Bai, Jingan Li, Shijie Zhu, Liguo Wang, Regine Willumeit-Roemer, Shaokang Guan
Summary: Novel calcium carbonate (CaCO3) coatings were prepared via the hydrothermal method and optimized with the addition of glutamate acid (Glu) or dopamine (DOPA) to improve the degradation and biological performance of MgZnCa alloy.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Jialin Fu, Jia Xin Yap, Choe Peng Leo, Chun Kiat Chang
Summary: In this study, carboxymethyl cellulose (CMC)/sodium alginate (SA) hydrogel beads were modified with calcium carbonate (CaCO3) and/or bentonite (Be) to improve phosphate adsorption. Incorporation of CaCO3 nanoparticles into CMC/SA/Be hydrogel beads significantly enhanced phosphate adsorption. The kinetics of methylene blue (MB) adsorption by hydrogel beads followed the pseudo-second-order model, while phosphate adsorption followed the Elovich model. Furthermore, Langmuir isotherm fitted the phosphate adsorption by CMC/SA/Be/CaCO3 hydrogel beads, indicating improved phosphate adsorption through chemical interaction.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biophysics
Changgui Huang, Jielin Zhou, Jin Rao, Xinyi Zhao, Xiumei Tian, Fupo He, Haishan Shi
Summary: In this study, composite bioceramics containing strontium-containing phosphate glass (SrP) were fabricated to improve the mechanical strength of strontium carbonate (SrC) bioceramics. The addition of 10 wt% SrP promoted densification, enhanced compressive strength, and facilitated apatite precipitation and sustained ion release. The SrC-SrP bioceramics showed better proliferation and osteogenesis effects on bone cells compared to traditional bioceramics.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Medicine, Research & Experimental
Pascaline Bouzy, Shane O'Grady, Honey Madupalli, Mary Tecklenburg, Keith Rogers, Francesca Palombo, Maria P. Morgan, Nicholas Stone
Summary: The study investigates the mineralization of MDA-MB-231 breast cancer cells using Raman micro-spectroscopy. Results indicate that the uptake of inorganic phosphate (Pi) accelerates mineralization, while the uptake of beta-Glycerophosphate (beta G) suggests the presence of a precursor phase during hydroxyapatite crystal formation.
LABORATORY INVESTIGATION
(2021)
Article
Biotechnology & Applied Microbiology
Youwen Yang, Guoqing Cai, Mingli Yang, Dongsheng Wang, Shuping Peng, Zhigang Liu, Cijun Shuai
Summary: Incorporating calcium chloride (CaCl2) into iron-based biocomposites can accelerate degradation and improve corrosion resistance by enhancing hydrophilicity and releasing chloride ions. The local high concentration of chloride ions effectively destroys the corrosion product layer, resulting in significantly reduced corrosion resistance.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Chun-Sheng Shao, Liang-Jian Chen, Rui-Min Tang, Bo Zhang, Jiang-Jie Tang, Wei-Na Ma
Summary: The combination of biphasic calcium phosphate (BCP) with osteomimetic porous micro-structure obtained via freeze casting is believed to achieve excellent bone regeneration, while the effects of different ratios of HA and beta-TCP on the degradation and biological performance of the BCP scaffolds need to be studied. The BCP scaffolds with varying HA/beta-TCP ratios demonstrated similar microstructure, mechanical performance, and protein absorption capacity, with the HA70/beta-TCP30 ratio showing optimal degradation rate. The in vitro and in vivo experiments confirmed the biocompatibility and bone regeneration capacity of the porous osteomimetic BCP scaffold with a 30:70 HA/beta-TCP ratio.
Article
Nanoscience & Nanotechnology
Yifan Liu, Ning Nie, Huanfeng Tang, Congrou Zhang, Kezheng Chen, Wei Wang, Jianfeng Liu
Summary: Copper-containing antimicrobials are highly valuable in medical disinfectants due to their high antimicrobial efficacy. The Cu-PBG nanozyme exhibits excellent antibacterial effects against both Gram-positive and Gram-negative bacteria by generating a ROS storm and releasing copper ions. Being intrinsically degradable, Cu-PBG gradually degrades in vivo and releases copper ions, showing excellent biocompatibility and potential for clinical translation.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Construction & Building Technology
Ting Zhang, Baoguo Ma, Hongbo Tan, Huahui Qi, Tao Shi
Summary: This study found that sodium carbonate and sodium phosphate have different effects on the hydration of cement based on the structure of the precipitates formed, where calcium carbonate precipitate accelerated cement hydration while calcium phosphate precipitate retarded it. The composition and structure of the precipitates were responsible for these effects, with calcium carbonate providing interspace for easier ion dissolution and calcium phosphate forming a more compact layer structure that hindered the transport of water molecules and ions.
JOURNAL OF BUILDING ENGINEERING
(2022)
Article
Materials Science, Biomaterials
Tilman Ahlfeld, Anja Lode, Anna-Maria Placht, Tatjana Fecht, Tobias Wolfram, Stefanie Grom, Andreas Hoess, Corina Vater, Christian Braeuer, Sascha Heinemann, Gunter Lauer, Frank Reinauer, Michael Gelinsky
Summary: This study investigated the feasibility of incorporating bioactive mineral fillers into a poly(l-lactic-co-glycolic) acid (PLLA-PGA) matrix and how it affects degradation and cytocompatibility. The results showed that the fillers had varying degrees of influence on the degradation behavior of the scaffolds, with the calcium phosphate phases showing a clear buffer effect and acceptable dimensional increase. However, adding 10 wt% SrCO3 or SrHAp particles seemed insufficient to release a sufficient amount of strontium ions to exert a biological effect in vitro. Cell culture experiments confirmed the high cytocompatibility of the composites.
BIOMATERIALS SCIENCE
(2023)
Article
Materials Science, Ceramics
Criseida Ruiz-Aguilar, Luz Eugenia Alcantara-Quintana, Ena Athenea Aguilar-Reyes, U. Olivares-Pinto
Summary: Scaffolds have been proven to be an excellent option for bone tissue regeneration, showing excellent results in architecture, composition, and functionality. In this study, different compositions of beta-phase tricalcium phosphate/zirconia-reinforced phosphate-based bioactive glass scaffolds were evaluated. The scaffolds demonstrated excellent bioactivity and osteoconductivity, forming HA crystalline aggregates and promoting cell proliferation and adhesion, particularly with the VZ1.0 composition.
BOLETIN DE LA SOCIEDAD ESPANOLA DE CERAMICA Y VIDRIO
(2022)
Article
Materials Science, Ceramics
Reece N. Oosterbeek, Kalliope Margaronis, Xiang C. Zhang, Serena M. Best, Ruth E. Cameron
Summary: Phosphate glasses for bioresorbable implants exhibit varying dissolution rates based on composition, with a proposed new mechanism involving a two-stage dissolution process influenced by lower Ca concentration and solution pH. This new mechanism suggests an initial diffusion-controlled formation of a conversion layer, followed by rate-limiting layer dissolution reactions once the layer is stabilized. These findings provide insight into the dissolution mechanisms of P2O5-CaO-Na2O glass, particularly regarding the transition between the two dissolution stages.
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
(2021)
Article
Biochemistry & Molecular Biology
Annapaola Coppola, Carmela Vigorito, Patrizia Lombari, Yuselys Garcia Martinez, Margherita Borriello, Francesco Trepiccione, Diego Ingrosso, Alessandra F. Perna
Summary: In this study, the researchers investigated the effect of a new uremic toxin called lanthionine on vascular calcification. The results showed that lanthionine can promote calcification in human endothelial cells by increasing calcium content, inducing the expression of important genes related to mineralization, and affecting the activity of certain proteins. These findings provide insights into the link between uremic toxins and mineral-bone disorder in chronic kidney disease.
Review
Engineering, Biomedical
I. Lodoso-Torrecilla, J. J. J. P. van den Beucken, J. A. Jansen
Summary: Synthetic calcium phosphate ceramics are widely used for bone regenerative treatments due to their bioactivity and osteoconductive properties. Injectable CPCs are appealing for minimally invasive surgery and filling irregular bone defects, but their poor degradability can be addressed by introducing macroporosity to accelerate new bone formation.
ACTA BIOMATERIALIA
(2021)
Article
Chemistry, Physical
Hung-Yang Lin, Yi-Jung Lu, Hsin-Hua Chou, Keng-Liang Ou, Bai-Hung Huang, Wen-Chien Lan, Takashi Saito, Yung-Chieh Cho, Yu-Hsin Ou, Tzu-Sen Yang, Pei-Wen Peng
Summary: This study successfully synthesized biphasic calcium phosphate ceramics from coral, which showed good biocompatibility and was non-cytotoxic. Different from autogenous bone, this ceramic did not induce significant differences in local tissue reaction.
Article
Biophysics
Jixiang Zhu, Fanwen Yang, Fupo He, Xiumei Tian, Shuo Tang, Xiaoming Chen
COLLOIDS AND SURFACES B-BIOINTERFACES
(2015)
Article
Nanoscience & Nanotechnology
Jun Zeng, Han Wang, Yaru Lin, Jiarong Zhang, Feng Liang, Feiyu Fang, Fanwen Yang, Ping Wang, Ziming Zhu, Xin Chen, Xindu Chen, Zhifeng Wang, Nian Cai, Yadong Tang, Peixuan Wu
MICROFLUIDICS AND NANOFLUIDICS
(2018)
Article
Biochemistry & Molecular Biology
Xiumei Tian, Ermao Li, Fanwen Yang, Ye Peng, Jixiang Zhu, Fupo He, Xiaoming Chen
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2014)
Article
Nanoscience & Nanotechnology
Xiumei Tian, Fanwen Yang, Chuan Yang, Ye Peng, Dihu Chen, Jixiang Zhu, Fupo He, Li Li, Xiaoming Chen
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2014)
Article
Materials Science, Ceramics
Fupo He, Fanwen Yang, Jixiang Zhu, Ye Peng, Xiumei Tian, Xiaoming Chen
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
(2015)
Article
Materials Science, Multidisciplinary
Feng Liang, Han Wang, YaJu Li, Ying Zhou, Zhifeng Wang, Xindu Chen, Nian Gai, Fanwen Yan, Peixuan Wu, Yunbo He, Yadong Tang
MATERIALS RESEARCH EXPRESS
(2019)
Review
Biochemistry & Molecular Biology
Yuan Jiang, Chuanshan Xu, Wingnang Leung, Mei Lin, Xiaowen Cai, Huanhuan Guo, Jiyong Zhang, Fanwen Yang
CURRENT MEDICINAL CHEMISTRY
(2020)
Review
Pharmacology & Pharmacy
Xiaowen Cai, Yuan Jiang, Mei Lin, Jiyong Zhang, Huanhuan Guo, Fanwen Yang, Wingnang Leung, Chuanshan Xu
FRONTIERS IN PHARMACOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Cunjing Zheng, Xiumei Tian, Jing Cai, Long Huang, Shunxin Wang, Fanwen Yang, Yanping Ma, Fukang Xie, Li Li
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2020)
Article
Materials Science, Multidisciplinary
Xiumei Tian, Ziying Liu, Ao Zeng, Haiyan Wang, Jiamin Lou, Yuezi Wei, Yuhong Man, Li Li, Fanwen Yang
MATERIALS TODAY COMMUNICATIONS
(2020)
Article
Nanoscience & Nanotechnology
Xiumei Tian, Ao Zeng, Ziying Liu, Cunjing Zheng, Yuezi Wei, Peiheng Yang, Minru Zhang, Fanwen Yang, Fukang Xie
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2020)
Review
Chemistry, Multidisciplinary
Houhe Liu, Fanwen Yang, Wenjie Chen, Teng Gong, Yi Zhou, Xiaoyan Dai, Wingnang Leung, Chuanshan Xu
Summary: This paper reviews the application of ERM in PDT and discusses the challenges ERM faces as carriers for delivering PS, in order to further advance the development of PDT in the management of malignancies.
FRONTIERS IN CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Jingbo Yang, Guangmeng Li, Jun Yuan, Sibo Jing, Xiangjiang Wang, Fanwen Yang, Yang Liu, Youde Ding, Gang Li, Guoxi Xie, Ailin Tao, Ming Liu, Maobin Xie
Summary: A wearable silk-based microneedle device that integrates synergistic immunity and hydrogen therapy has been developed for the treatment of cancer stem cells. The device demonstrates satisfying anticancer and anti-CSCs efficacy with minimal systemic toxicity.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Proceedings Paper
Materials Science, Multidisciplinary
Ruitian Zhu, Minghao Tan, Peng Zhang, Liang Zhang, Xiaoming Chen, Fanwen Yang
ADVANCES IN TEXTILE ENGINEERING AND MATERIALS IV
(2014)
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)
