Article
Computer Science, Software Engineering
Zhongyun He, Jesus Perez, Miguel A. Otaduy
Summary: This research presents a new approach to accelerate numerical coarsening methods, achieving runtime numerical coarsening simulations under local material updates. By speeding up training data generation and coarsening shape function computation, it improves accuracy and performance significantly.
COMPUTER GRAPHICS FORUM
(2022)
Article
Polymer Science
Jorge-Enrique Rivera-Salinas, Karla-Monzerratt Gregorio-Jauregui, Heidi-Andrea Fonseca-Florido, Carlos-Alberto avila-Orta, Eduardo Ramirez-Vargas, Jose-Antonio Romero-Serrano, Alejandro Cruz-Ramirez, Victor-Hugo Gutierrez-Perez, Seydy-Lizbeth Olvera-Vazquez, Lucero Rosales-Marines
Summary: The thermal performance of closed-cell foams relies on thermal conductivity, with convective contribution often ignored in favor of conductive contribution for analysis. The criteria for disregarding convective heat flux based on cell diameter is inconsistent across literature, while natural convection in porous materials proves worthy of research. Heat transported by convection accounts for about 20% of heat conducted within foam at Ra=10(3), influencing average conductivity by about 4.5%.
Article
Materials Science, Multidisciplinary
Yuanyuan Wang, Jijun Zhao
Summary: This study systematically investigates the thermal conductivity of void-containing tungsten, analyzing the relationship between the topological features of void and the thermal response, exploring the effects of void shapes, arrangements, and rotation angles on heat transmission, and comparing the predicted thermal conductivities with experimental data.
JOURNAL OF NUCLEAR MATERIALS
(2021)
Article
Engineering, Biomedical
Batel Gabay, Klimentiy Levkov, Ariel Berl, Julia Wise, Ofir Shir-az, Edward Vitkin, Gintautas Saulis, Avshalom Shalom, Alexander Golberg
Summary: Molecular sampling with vacuum-assisted tissue electroporation is a minimally invasive method for profiling solid lesions. This study focuses on the design of a battery-powered pulsed electric field generator and electrode configuration for skin cancer diagnostics. The results demonstrate the dependence of electroporated tissue volume and protein diffusion on the electrode's geometry, penetration depths, applied electric field strength, and time after field application. These findings provide essential tools for the development of personalized skin cancer diagnostics using electroporation-based molecular markers sampling devices.
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Article
Chemistry, Physical
Zhengwei Huang, Ying Song, Xiaohua Zhao, Huiming Hou
Summary: A three-dimensional piezoresistive theory for carbon nanotube polymer composites has been developed, considering the quantum tunneling effect and the geometric nonlinearity. The theory calculates the equivalent electrical conductivity of the composites based on the Mori-Tanaka method and incorporates finite element analysis of the elastic and electric fields. Numerical simulations showed good agreement with experimental tests and parameter sensitivity analysis revealed the influences of various physical parameters on the piezoresistivity.
Article
Biotechnology & Applied Microbiology
Elisabetta Sieni, Monica Dettin, Annj Zamuner, Maria Teresa Conconi, Bianca Bazzolo, Cristian Balducci, Paolo Di Barba, Michele Forzan, Patrizia Lamberti, Maria Evelina Mognaschi
Summary: Finite element analysis is used to investigate the effect of media inhomogeneity on the electric field distribution in a sample composed of cells and their extracellular matrix. The study finds that an increase in the transmembrane potential is shown in the case of higher aggregate, and cell aggregates and collagen have an effect on the transmembrane potential.
BIOENGINEERING-BASEL
(2023)
Article
Materials Science, Composites
Abdessamad Belhaouzi, Souad Zyade, Youssef Halimi, Tarfaoui Mostapha, Marwane Rouway, Mohamed Tahiri
Summary: The study aims to improve the properties of building materials by adding nanoparticles for enhanced energy efficiency. Both numerical and analytical modeling methods are offered to analyze the thermal conductivity and mechanical property of composite materials. The results show that the addition of nanoparticles improves the thermomechanical behavior of building materials and has potential applications in various fields.
POLYMER COMPOSITES
(2023)
Article
Thermodynamics
Anuraag Saini, Sreedhar Unnikrishnakurup, C. Krishnamurthy, Krishnan Balasubramanian, T. Sundararajan
Summary: The study evaluates the effective thermal conductivity in 3D heterogeneous media with fillers dispersed randomly in a matrix through FEM based numerical simulations, considering factors like filler concentration, shape, size, and thermal characteristics. Results show that particle distribution, non-spherical particle shape, and the ratio of thermal conductivity between fillers and matrix significantly influence the thermal conductivity and sensitivity to distribution. The numerical assessment is compared with effective medium theories and experimental data for polymer composites, showing robustness in capturing experimental results.
INTERNATIONAL JOURNAL OF THERMAL SCIENCES
(2021)
Article
Construction & Building Technology
Arthur Fanara, Luc Courard, Frederic Collin, Julien Hubert
Summary: This paper analyzes the influence of RCA on durability of concrete through experimental testing and numerical modeling. It is found that RAC is more porous and has higher water absorption compared to regular concrete.
CONSTRUCTION AND BUILDING MATERIALS
(2022)
Article
Chemistry, Physical
Yuta Hori, Shun Dekura, Yoshiya Sunairi, Tomonori Ida, Motohiro Mizuno, Hatsumi Mori, Yasuteru Shigeta
Summary: Quantum chemical calculations were utilized to investigate the proton conduction mechanism in Im-Suc, revealing that the successive coupling of PT and Im rotational motion is crucial for proton conduction. These findings provide molecular-level insights into proton conduction mechanisms for Im-based H-bonding organic proton conductors.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Article
Materials Science, Multidisciplinary
Semin Park, Minsoo Kim, Seon-Gyu Kim, Sangha Shin, Byeongho Ahn, Sung-Soo Ryu, Jaehun Cho, Yunsang Kwak
Summary: In this study, the thermal conduction behavior of aluminum nitride (AlN) ceramics with engineered microstructures is comprehensively investigated. Through experimental observations, a numerical model is developed to accurately predict the thermal conductivity of hot-pressed AlN ceramics with systematically tuned microstructures. Insights gained from this study provide a deeper understanding of microstructure engineering and heat transfer in AlN ceramics.
Article
Construction & Building Technology
Lei He, Longjia Chu, HuiChen Wang, T. F. Fwa
Summary: This research proposed a novel experimental procedure to directly determine the thermal conductivity k(mix) of asphalt paving mixture without requiring accurate known values of other thermal conductivities. Through numerical calculations and optimization techniques, the k(mix) value can be accurately determined.
CONSTRUCTION AND BUILDING MATERIALS
(2022)
Article
Automation & Control Systems
Adria Biosca, Salvador Borros, Vicenc Pedret Clemente, Matthew R. Hyre, Andres-Amador Garcia Granada
Summary: This study evaluates the capabilities of 3D simulations in the blow and blow forming process for glass bottles with more complex geometries. Numerical and experimental analyses were conducted on a non-axisymmetrical glass bottle, confirming the accuracy of the simulations by comparing with experimental measurements. The results show that transitioning from 2D to 3D models can help prevent undesired thickness distributions and fractures in glass containers with low thickness 3D corners.
INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY
(2023)
Article
Mechanics
Tao Meng, Chaoqun Peng, Richu Wang, Yan Feng, Xiaofeng Wang, Zhiyong Cai
Summary: A new prediction model was developed to calculate the effective thermal conductivity of ellipsoidal inclusion-reinforced composites by introducing new shape coefficients and interaction coefficients based on Maxwell-Eucken's model. The model was verified using experimental data and finite element simulation, and the results demonstrated high accuracy (<10%) of the prediction model. The analysis of the model revealed an increase in the effective thermal conductivity of composites with an increase in the aspect ratio of ellipsoidal particles when randomly distributed in the matrix. However, when the ellipsoidal particles were non-randomly distributed, the effective thermal conductivity depended on the angle between the heat flux direction and the long axis of the ellipsoid.
COMPOSITE STRUCTURES
(2023)
Article
Engineering, Chemical
Yuting Hou, Die Liu, Taiping Zhao, Jinyu Zhou, Lili Tian, Xiaopan Kou, Baoding Zhu, Xin Nie
Summary: Rock electrical experiments are essential for studying the conductive properties of rocks, and it is particularly challenging to research the conductive properties of carbonate rocks due to their complex pore structures. In this paper, 3D digital rock models with different porosities are generated, and conductive simulations are carried out using the finite element method. The results reveal the importance of pore shape and structure in determining the formation factor of the reservoir.
Article
Biochemistry & Molecular Biology
Peter Kramar, Damijan Miklavcic
Summary: The study aimed to investigate the effects of different cholesterol concentrations on the behavior of planar lipid bilayers under an electric field. The results showed no statistical difference in capacitance but a significant impact on breakdown voltage with the addition of cholesterol.
BIOELECTROCHEMISTRY
(2022)
Article
Engineering, Biomedical
Vitalij Novickij, Austeja Baleviciute, Veronika Malysko, Augustinas Zelvys, Eivina Radzeviciute, Bor Kos, Aukse Zinkeviciene, Damijan Miklavcic, Jurij Novickij, Irute Girkontaite
Summary: This study focuses on the use of high repetition frequency unipolar nanosecond pulses for bleomycin electrochemotherapy. It was found that the efficacy of sub-microsecond electrochemotherapy can be manipulated solely by the time delay between pulses.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2022)
Article
Multidisciplinary Sciences
Helena Cindric, Gorana Gasljevic, Ibrahim Edhemovic, Erik Brecelj, Jan Zmuc, Maja Cemazar, Alenka Seliskar, Damijan Miklavcic, Bor Kos
Summary: This study investigated electroporation in the liver using a numerical mesoscale tissue model. The results showed that liver microstructure does not significantly affect the electric field distribution, but major hepatic vessels and portal spaces do have a significant impact, which should be considered in treatment planning.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Aleksandra Cvetkoska, Alenka Macek-Lebar, Peter Trdina, Damijan Miklavcic, Matej Rebersek
Summary: This study is the first to examine pain sensation in humans using biphasic high-frequency electroporation pulses. The results confirm that biphasic high-frequency pulses with a pulse width of 1 or 2 microseconds reduce muscle contraction and pain sensation compared to longer monophasic pulses. Additionally, the interphase and interpulse delays play a significant role in reducing muscle contraction and/or pain sensation. These findings are important for optimizing the pulse parameters of electroporation treatments.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Sebastien Chaigne, Daniel C. Sigg, Mark T. Stewart, Meleze Hocini, Tina Batista Napotnik, Damijan Miklavcic, Olivier Bernus, David Benoist
Summary: The study evaluated the effects of a monophasic single electric pulse on the contractility, Ca2+ homeostasis, and recovery of cardiac myocytes. Results showed that electroporation increased intracellular Ca2+ levels immediately, leading to changes in myocyte contraction and Ca2+ homeostasis. Sublethal electric pulses also affected cell contractions and Ca2+ levels, with lethal thresholds depending on cell orientation relative to the electric field.
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Brian Howard, Atul Verma, Wendy S. Tzou, Lars Mattison, Bor Kos, Damijan Miklavcic, Birce Onal, Mark T. Stewart, Daniel C. Sigg
Summary: This study evaluated the impact of electrode-tissue proximity on cardiac lesion formation with a biphasic, bipolar PFA system. The results showed that the dimensions of cardiac lesions decreased with a decrease in electrode-tissue distance. Numerical modeling supported the experimental findings. Therefore, close electrode-tissue proximity is beneficial for achieving transmural lesions.
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Matej Kranjc, Janja Dermol-Cerne, Tjasa Potocnik, Vitalij Novickij, Damijan Miklavcic
Summary: This study demonstrates the feasibility of using high-intensity pulsed electromagnetic field (HI-PEMF) for non-viral delivery of genetic material in vitro. The results show that HI-PEMF can cause DNA adsorption to the cell membrane and induce gene electrotransfection. Endocytosis is also identified as a possible mechanism for introducing large molecules into cells by HI-PEMF.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Tjasa Potocnik, Shaurya Sachdev, Tamara Polajzer, Alenka Macek Lebar, Damijan Miklavcic
Summary: In this study, we investigated the potential use of different pulse durations for gene electrotransfer and compared the efficiency and dynamics of transgene expression. We also developed a model for the probability of pDNA and cell membrane contact during electrotransfer.
APPLIED SCIENCES-BASEL
(2022)
Article
Oncology
Helena Cindric, Damijan Miklavcic, Francois H. Cornelis, Bor Kos
Summary: Electroporation has sparked great interest in medical applications. This study presents an algorithm that optimizes electrode positions based on spatial information of the electric field distribution in the target tissue. The algorithm successfully applies to different spinal segments, tumor sizes, and locations within the vertebra. It significantly reduces the time and expertise required for treatment planning of vertebral tumors.
Article
Pharmacology & Pharmacy
Aleksandra Cvetkoska, Janja Dermol-Cerne, Damijan Miklavcic, Simona Kranjc Brezar, Bostjan Markelc, Gregor Sersa, Matej Rebersek
Summary: In this study, a new pulse generator, applicator, and pulse delivery protocol for gene electrotransfer (GET) to skin cells were developed. The results showed that the proposed pulse delivery protocol resulted in higher gene expression in mouse skin cells compared to the currently used pulse generator, applicator, and pulse delivery protocol.
Article
Engineering, Biomedical
Rok Smerc, David A. A. Ramirez, Samo Mahnic-Kalamiza, Janja Dermol-Cerne, Daniel C. C. Sigg, Lars M. M. Mattison, Paul A. A. Iaizzo, Damijan Miklavcic
Summary: The aim of this study was to investigate the influence of electric field orientation in anisotropic muscle tissue on irreversible electroporation damage. In vivo experiments were conducted on porcine skeletal muscle, with the electric field applied parallel or perpendicular to the muscle fibers. Results showed that lesions in the parallel group were consistently smaller and narrower than those in the perpendicular group. The study concludes that muscle anisotropy is a significant factor in determining electric field distribution in electroporation applications. Significance: 8/10
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Cardiac & Cardiovascular Systems
Lars Mattison, Atul Verma, Khaldoun G. Tarakji, Tobias Reichlin, Gerhard Hindricks, Kevin L. Sack, Birce Onal, Megan M. Schmidt, Damijan Miklavcic, Daniel C. Sigg
Summary: In this study, it was found that contact force in pulsed field ablation (PFA) had minimal effects on lesion dimensions, with only a small increase in depth, width, and volume of the lesions. The importance lies in achieving tissue contact rather than the force applied.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Tjasa Potocnik, Alenka Macek Lebar, Spela Kos, Matej Rebersek, Eva Pirc, Gregor Sersa, Damijan Miklavcic
Summary: The mechanisms and optimization strategies of nucleic acid delivery with gene electrotransfer (GET) are still not well understood. This article reviews the current state of knowledge through a systematic literature review and meta-analysis of in vitro GET studies, emphasizing the importance of parameter selection and result evaluation.
Article
Chemistry, Applied
Jessica Genovese, Marko Strucic, Igor Sersa, Vitalij Novickij, Pietro Rocculi, Damijan Miklavcic, Samo Mahnic-Kalamiza, Matej Kranjc
Summary: Using magnetic resonance imaging and magnetic resonance electrical impedance tomography, we investigated the non-uniform effect of pulsed electric field (PEF) treatment on plant tissues such as apple, potato, and carrot. The results showed that the distribution of T2 relaxation times became increasingly inhomogeneous as the complexity of the tissue structure increased. The feasibility and potential of using the T2 mapping technique to analyze the effects of PEF on plant tissue structures were demonstrated.
Article
Oncology
Angelika Vizintin, Stefan Markovic, Janez Scancar, Jerneja Kladnik, Iztok Turel, Damijan Miklavcic
Summary: The study found that equivalent nanosecond pulses are equally effective in electrochemotherapy as standardly used 8 x 100 mu s pulses. The number of intracellular cisplatin molecules strongly correlates with cell survival for B16F1 cells, but less for CHO cells, implying the possible involvement of other mechanisms in electrochemotherapy. High-voltage electric pulses do not alter the structure of cisplatin.
RADIOLOGY AND ONCOLOGY
(2022)