Article
Neurosciences
Julie G. Pilitsis, Krishnan Chakravarthy, Andrew J. Will, Karen C. Trutnau, Kristin N. Hageman, David A. Dinsmoor, Leonid M. Litvak
Summary: This study aims to investigate the relationship between ECAP and perception thresholds under different postures and SCS pulse widths, providing support for automatic control and perceptually referenced programming of SCS systems. Results show that for the assessed postures and pulse widths, the ECAP threshold is closely correlated with perception and discomfort thresholds.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Yuki Niimi, Jose Gomez-Tames, Toshiaki Wasaka, Akimasa Hirata
Summary: This study investigated the optimal parameters for selective stimulation of A delta- and C-fibers using a computational model and experimental results. The results showed that different sensations could be elicited by selectively stimulating different fibers by adjusting the pulse counts and frequencies. The computational model revealed that terminal axon thickness was the most important biophysical factor affecting perception thresholds.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Harold J. A. Nijhuis, Willem-Jan Hofste, Imre P. Krabbenbos, Birte E. Dietz, Dave Mugan, Frank Huygen
Summary: A new closed-loop spinal cord stimulation (SCS) system has been approved for use, which can record evoked compound action potentials (ECAPs) and adjust the stimulation strength in real time based on these recordings. This study evaluates the performance of this closed-loop SCS system in a real-world setting and shows promising results in maintaining pain relief over 12 months.
Article
Neurosciences
Su-Wei Kuo, Tianhe Zhang, Rosana Esteller, Warren M. Grill
Summary: Sub-perception spinal cord stimulation (SCS) achieves pain relief without paresthesia by using high-frequency pulses. This study investigated the mechanisms of high-frequency SCS by quantifying the responses of single neurons in the superficial dorsal horn (SDH) to SCS. The results revealed heterogeneous responses of SDH neurons, with low-threshold units being facilitated and other unit types being suppressed. The effects of SCS were more pronounced with longer stimulation duration. These findings highlight the importance of inhibitory interneurons and local circuits in the analgesic mechanisms of SCS.
Article
Medicine, Research & Experimental
Krishnan Chakravarthy, James FitzGerald, Andrew Will, Karen Trutnau, Robert Corey, David Dinsmoor, Leonid Litvak
Summary: Spinal cord stimulation (SCS) is a treatment for chronic neuropathic pain, and evoked compound action potential (ECAP) sensing has enhanced SCS. The study characterizes sensitivity of ECAP growth curve slope (S) to neural response and stimulation artifact for spinal ECAP estimation methods. Results show that SA reduction schemes using HP and AM methods outperform others in preserving neural signals and reducing artifact misclassification.
Article
Clinical Neurology
Ricardo Vallejo, Krishnan Chakravarthy, Andrew Will, Karen Trutnau, David Dinsmoor
Summary: Spinal cord stimulation (SCS) is a method that treats chronic pain by delivering mild electrical pulses to the spinal cord. Modern SCS therapies focus on reducing paresthesia and improving clinical outcomes. Closed-loop (CL) SCS systems automatically adjust stimulation parameters to improve treatment consistency and effectiveness.
JOURNAL OF PAIN RESEARCH
(2021)
Article
Multidisciplinary Sciences
Xiuhua Chao, Ruijie Wang, Jianfen Luo, Haibo Wang, Zhaomin Fan, Lei Xu
Summary: This study investigated the relationship between ECAP thresholds and behavioral thresholds in children with CND. The results showed a significant correlation between ECAP thresholds and behavioral T-levels, suggesting that ECAP thresholds can help audiologists select stimulation levels more efficiently for children with CND.
SCIENTIFIC REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Lady Christine Ong Sio, Brian Hom, Shuchita Garg, Alaa Abd-Elsayed
Summary: Peripheral nerve stimulation (PNS) has been widely used for treating chronic pain, although its mechanism of action remains largely unknown. The gate control theory proposed by Melzack and Wall in the 1960s has been the mainstay for understanding its mechanism. This review article discusses the mechanism of action, safety, and effectiveness of PNS in treating chronic pain, as well as current PNS devices available in the market.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Jonathan S. Calvert, Radu Darie, Samuel R. Parker, Elias Shaaya, Sohail Syed, Bryan L. McLaughlin, Jared S. Fridley, David A. Borton
Summary: Recent study shows that epidural spinal cord stimulation (SCS) can restore motor function in individuals with chronic spinal cord injury (SCI). The spinal evoked compound action potentials (ECAPs) induced by SCS can be used to understand the mechanisms of chronic pain therapy and optimize stimulation strategies for optimal clinical benefits.
Article
Neurosciences
Jerico V. Matarazzo, Elise A. Ajay, Sophie C. Payne, Ella P. Trang, Alex C. Thompson, Jason B. Marroquin, Andrew K. Wise, James B. Fallon, Rachael T. Richardson
Summary: The study combines optical and electrical stimulation to improve the selectivity and efficiency of neural activation. Results show that light can prime the neural population to reduce the electrical threshold, increasing the therapeutic stimulation window and allowing for selective manipulation of pain transmission pathways.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Chemistry, Medicinal
Tian Tian, Shengyi Zhang, Bingling Luo, Feng Yin, Wenhua Lu, Yiqing Li, Kezhi Huang, Qiao Liu, Peng Huang, G. Garcia-Manero, Shijun Wen, Yumin Hu
Summary: In this study, a benzoimidazole compound was identified as a selective treatment for FLT3/ITD leukemia. The compound HP1328, derived from the benzoimidazole scaffold, demonstrated desirable properties and significantly reduced leukemia burden and prolonged survival in mice.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Geriatrics & Gerontology
Yinpei Luo, Yuwei Sun, Xuelong Tian, Xiaolin Zheng, Xing Wang, Weina Li, Xiaoying Wu, Bin Shu, Wensheng Hou
Summary: Deep brain stimulation is a neurosurgical technique used to regulate neuron activity in specific areas of the brain, showing positive effects in Alzheimer's disease. Determining optimal stimulation parameters and understanding its mechanism of action are crucial for promoting clinical application.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Engineering, Biomedical
Meagan K. Brucker-Hahn, Hans J. Zander, Andrew J. Will, Jayesh C. Vallabh, Jason S. Wolff, David A. Dinsmoor, Scott F. Lempka
Summary: This study investigates the influence of posture and spinal cord-electrode distance on evoked compound action potential (ECAP) recordings during spinal cord stimulation (SCS) for pain management. The results demonstrate that postural shifts significantly affect ECAP recordings and a fixed ECAP amplitude does not necessarily correspond to a constant degree of neural activation. These findings are crucial for improving the efficacy and stability of clinical SCS technologies using ECAP recordings for closed-loop stimulation.
JOURNAL OF NEURAL ENGINEERING
(2023)
Article
Clinical Neurology
Robert D. Graham, Vishwanath Sankarasubramanian, Scott F. Lempka
Summary: Dorsal root ganglion stimulation (DRGS) is a neuromodulation therapy for chronic pain with unknown mechanisms of action. This article summarizes the leading hypotheses of DRGS-induced analgesia and proposes areas of future study to improve its clinical implementation.
Article
Acoustics
Yousef Alamri, Skyler G. G. Jennings
Summary: An approach for predicting recorded compound action potentials (CAPs) in humans is proposed using human-based computational models to simulate auditory nerve activity. The simulations captured many aspects of human CAPs and can be used to refine existing models, aid in experimental design and analysis, and predict the effects of auditory disorders on the CAP.
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
(2023)
Article
Neurosciences
Sharon E. Norman, Robert J. Butera, Carmen C. Canavier
JOURNAL OF NEUROPHYSIOLOGY
(2016)
Article
Engineering, Biomedical
Yogi A. Patel, Brian S. Kim, William S. Rountree, Robert J. Butera
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2017)
Article
Multidisciplinary Sciences
Yogi A. Patel, Tarun Saxena, Ravi V. Bellamkonda, Robert J. Butera
SCIENTIFIC REPORTS
(2017)
Correction
Multidisciplinary Sciences
Yogi A. Patel, Tarun Saxena, Ravi V. Bellamkonda, Robert J. Butera
SCIENTIFIC REPORTS
(2017)
Article
Biochemical Research Methods
Yogi A. Patel, Ansel George, Alan D. Dorval, John A. White, David J. Christini, Robert J. Butera
PLOS COMPUTATIONAL BIOLOGY
(2017)
Article
Engineering, Biomedical
Yogi A. Patel, Brian S. Kim, Robert J. Butera
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2018)
Review
Engineering, Biomedical
Yogi A. Patel, Robert J. Butera
JOURNAL OF NEURAL ENGINEERING
(2018)
Editorial Material
Engineering, Biomedical
John A. White, Donald P. Gaver, Robert J. Butera, Bernard Choi, Mary J. Dunlop, K. Jane Grande-Allen, Anna Grosberg, Robert W. Hitchcock, Aileen Y. Huang-Saad, Miiri Kotche, Aaron M. Kyle, Amy L. Lerner, John H. Linehan, Robert A. Linsenmeier, Michael I. Miller, Jason A. Papin, Lori Setton, Allyson Sgro, Michael L. Smith, Muhammad Zaman, Abraham P. Lee
ANNALS OF BIOMEDICAL ENGINEERING
(2020)
Article
Neurosciences
Vineet Tiruvadi, Ki Sueng Choi, Robert E. Gross, Robert Butera, Viktor Jirsa, Helen Mayberg
Summary: In this study, the effects of deep brain stimulation (DBS) on the neural dynamics of depressed patients were investigated using novel intracranial recordings. The researchers observed a novel dynamic oscillation (DOs) in the patients' brain activity and found significant variability in DO behavior across patients. The study also reported preliminary observations of DO-like activity in a single patient's electroencephalography (dEEG). These findings support further research on DOs as an objective signal for mechanistic study and connectomics guided DBS.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biology
Nathan J. Kirkpatrick, Robert J. Butera, Young-Hui Chang
Summary: This study used the machine learning tool DeepLabCut to perform markerless tracking in X-ray videos of rats' locomotion, achieving accurate analysis of skeletal movements. The results showed that DeepLabCut had high accuracy and significantly reduced analysis time, making it a valuable tool for processing large amounts of accurate motion data.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2022)
Article
Engineering, Biomedical
Vineet Tiruvadi, Samuel James, Bryan Howell, Mosadoluwa Obatusin, Andrea Crowell, Patricio Riva-Posse, Robert E. Gross, Cameron C. McIntyre, Helen S. Mayberg, Robert Butera
Summary: Deep brain stimulation (DBS) devices with differential local field potentials (LFP) recordings have shown promise for neural recordings and clinical therapy. However, impedance mismatches between recording electrodes can lead to gain compression and distort oscillatory power, affecting the accuracy of disease readouts. In this report, we identified and mitigated this distortion, named mismatch compression (MC), and developed an opensource mitigation pipeline. This work enables more reliable oscillatory readouts for adaptive DBS applications.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2023)
Article
Multidisciplinary Sciences
Sankaraleengam Alagapan, Ki Sueng Choi, Stephen Heisig, Patricio Riva-Posse, Andrea Crowell, Vineet Tiruvadi, Mosadoluwa Obatusin, Ashan Veerakumar, Allison C. Waters, Robert E. Gross, Sinead Quinn, Lydia Denison, Matthew O'Shaughnessy, Marissa Connor, Gregory Canal, Jungho Cha, Rachel Hershenberg, Tanya Nauvel, Faical Isbaine, Muhammad Furqan Afzal, Martijn Figee, Brian H. Kopell, Robert Butera, Helen S. Mayberg, Christopher J. Rozell
Summary: This study demonstrates the utility of objective biomarkers in the management of personalized deep brain stimulation for treatment-resistant depression. The researchers used a new device to record electrophysiology and identified changes in local field potentials as biomarkers for the patient's clinical state. The results provide new insight into the causes of variability in depression treatment.
Meeting Abstract
Neurosciences
Sankaraleengam Alagapan, Allison Waters, Ashan Veerakumar, Mosadoluwa Obatusin, Vineet Tiruvadi, Andrea Crowell, Patricio Riva-Posse, Robert Butera, Helen Mayberg, Christopher Rozell
BIOLOGICAL PSYCHIATRY
(2020)
Proceedings Paper
Engineering, Biomedical
Sagarika Mukesh, Riley Zeller-Townson, Robert J. Butera, Pamela T. Bhatti
2019 9TH INTERNATIONAL IEEE/EMBS CONFERENCE ON NEURAL ENGINEERING (NER)
(2019)
Proceedings Paper
Engineering, Biomedical
Yogi A. Patel, Andrew Willsie, Isaac P. Clements, Ricardo Aguilar, Swaminathan Rajaraman, Robert J. Butera
2016 38TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)
(2016)