4.4 Article Proceedings Paper

Preparation of water-dispersible and biocompatible iron oxide nanoparticles for MRI agent

期刊

IEEE TRANSACTIONS ON NANOTECHNOLOGY
卷 7, 期 2, 页码 111-114

出版社

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TNANO.2007.909949

关键词

dextran; MRI agent; SPION; surface modification

资金

  1. Ministry of Education, Science & Technology (MoST), Republic of Korea [2E20680] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
  2. National Research Foundation of Korea [2005-02154] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

向作者/读者索取更多资源

Highly monodisperse superparamagnetic iron oxide nanoparticles (SPIONs, 7.5 nm gamma - Fe2O3) were synthesized by thermal decomposition of iron pentacarbonyl and consecutive aeration in organic medium. By treating with a small amount of iron pentacarbonyl, Fe-rich surface has been formed on SPION. Water-dispersible SPIONs (SPION-MPA) were prepared by Fe-S covalent conjugation between Fe-rich SPION and mercaptopropionic acid (MPA) and then, transformed to SPION - MPA - dextran composite by physical adsorption of biocompatible polymer dextran. The hydrodynamic diameter of SPION - MPA - dextran was in the range of 225 similar to 237 urn in water. MR contrast and spin-spin relaxation intensity of our SPION - MPA - dextran were similar to those of the commercial products, Ferridex and Resovist.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.4
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据