Lulling immunity, pain, and stress to sleep with cortistatin

VPAC2 (vasoactive intestinal peptide receptor type 2) receptor deficient mice develop exacerbated experimental autoimmune encephalomyelitis with increased Th1/Th17 and reduced Th2/Treg responses

(2015) Yossan-Var Tan et al.   BRAIN BEHAVIOR AND IMMUNITY

Therapeutic Efficacy of Stable Analogues of Vasoactive Intestinal Peptide against Pathogens

(2014) Jenny Campos-Salinas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ghrelin Protects against Experimental Sepsis by Inhibiting High-Mobility Group Box 1 Release and by Killing Bacteria

(2014) A. Chorny et al.   JOURNAL OF IMMUNOLOGY

Cortistatin is endogenous to the human intervertebral disc and exerts in vitro mitogenic effects on annulus cells and a downregulatory effect on TNF-α expression

(2014) Helen E. Gruber et al.   Spine Journal

Analgesic Effect of the Neuropeptide Cortistatin in Murine Models of Arthritic Inflammatory Pain

(2013) Maria Morell et al.   ARTHRITIS AND RHEUMATISM

Therapeutic effect of ghrelin in experimental autoimmune encephalomyelitis by inhibiting antigen-specific Th1/Th17 responses and inducing regulatory T cells

(2013) Luciana Souza-Moreira et al.   BRAIN BEHAVIOR AND IMMUNITY

Cortistatin Inhibits Migration and Proliferation of Human Vascular Smooth Muscle Cells and Decreases Neointimal Formation on Carotid Artery Ligation

(2013) Mario Duran-Prado et al.   CIRCULATION RESEARCH

Involvement of DDAH/ADMA pathway in the pathogenesis of rheumatoid arthritis in rats

(2013) Xu-Meng Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Paradoxical Effect of Cortistatin Treatment and Its Deficiency on Experimental Autoimmune Encephalomyelitis

(2013) L. Souza-Moreira et al.   JOURNAL OF IMMUNOLOGY

Protective Role of the Neuropeptide Urocortin II against Experimental Sepsis and Leishmaniasis by Direct Killing of Pathogens

(2013) J. Campos-Salinas et al.   JOURNAL OF IMMUNOLOGY

Cortistatin attenuates inflammatory pain via spinal and peripheral actions

(2013) María Morell et al.   NEUROBIOLOGY OF DISEASE

Cortistatin modulates the expression and release of corticotrophin releasing hormone in rat brain. Comparison with somatostatin and octreotide

(2012) Giuseppe Tringali et al.   PEPTIDES

VIP Deficient Mice Exhibit Resistance to Lipopolysaccharide Induced Endotoxemia with an Intrinsic Defect in Proinflammatory Cellular Responses

(2012) Catalina Abad et al.   PLoS One

HMGB1 Is a Therapeutic Target for Sterile Inflammation and Infection

(2011) Ulf Andersson et al.   Annual Review of Immunology

Functional role of brain-derived neurotrophic factor in neuroprotective autoimmunity: therapeutic implications in a model of multiple sclerosis

(2011) R. A. Linker et al.   BRAIN

Cortistatin Is Not a Somatostatin Analogue but Stimulates Prolactin Release and Inhibits GH and ACTH in a Gender-Dependent Fashion: Potential Role of Ghrelin

(2011) José Córdoba-Chacón et al.   ENDOCRINOLOGY

Cortistatin Is Induced in Brain Tissue and Exerts Neuroprotection in a Rat Model of Bacterial Meningoencephalitis

(2011) Chien-Tsai Chiu et al.   JOURNAL OF INFECTIOUS DISEASES

Comparison of the Anti-inflammatory and Anti-nociceptive Effects of Cortistatin-14 and Somatostatin-14 in Distinct In Vitro and In Vivo Model Systems

(2011) Adrienn Markovics et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Identification and characterization of new functional truncated variants of somatostatin receptor subtype 5 in rodents

(2010) Jose Córdoba-Chacón et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Inflammatory bowel disease: Established and evolving considerations on its etiopathogenesis and therapy

(2010) Anja SCHIRBEL et al.   Journal of Digestive Diseases

Rheumatoid arthritis

(2010) David L Scott et al.   LANCET

Neuronal circuitry for pain processing in the dorsal horn

(2010) Andrew J. Todd   NATURE REVIEWS NEUROSCIENCE

Vasoactive intestinal peptide loss leads to impaired CNS parenchymal T-cell infiltration and resistance to experimental autoimmune encephalomyelitis

(2010) C. Abad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification and Characterization of Two Novel Truncated but Functional Isoforms of the Somatostatin Receptor Subtype 5 Differentially Present in Pituitary Tumors

(2009) Mario Durán-Prado et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Induction of Alloantigen-Specific Human T Regulatory Cells by Vasoactive Intestinal Peptide

(2009) D. Pozo et al.   JOURNAL OF IMMUNOLOGY

Diverging effects of cortistatin and somatostatin on the production and release of prostanoids from rat cortical microglia and astrocytes

(2009) Cinzia Dello Russo et al.   JOURNAL OF NEUROIMMUNOLOGY

Cortistatin attenuates vascular calcification in rats

(2009) Yue Liu et al.   REGULATORY PEPTIDES

Control of allograft rejection in mice by applying a novel neuropeptide, cortistatin

(2008) Jiang Wang et al.   ADVANCES IN THERAPY

Neuropeptides Rescue Mice from Lethal Sepsis by Down-regulating Secretion of the Late-Acting Inflammatory Mediator High Mobility Group Box 1

(2008) Alejo Chorny et al.   AMERICAN JOURNAL OF PATHOLOGY

Neuropeptides kill African trypanosomes by targeting intracellular compartments and inducing autophagic-like cell death

(2008) M Delgado et al.   CELL DEATH AND DIFFERENTIATION

Pharmacological profile of somatostatin and cortistatin receptors

(2007) Sandra Siehler et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Are somatostatin and cortistatin two siblings in regulating endocrine secretions? In vitro work ahead

(2007) Manuel D. Gahete et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Modulation of pain transmission by G-protein-coupled receptors

(2007) Hui-Lin Pan et al.   PHARMACOLOGY & THERAPEUTICS