Article
Polymer Science
M. Margarida Cardoso, Ines N. Peca, Telma Lopes, Rui Gardner, A. Bicho
Summary: DWNPs were produced with PLGA and PLLA containing doxorubicin as a model drug. Optical and fluorescence microscopy were used to examine the inner morphology and drug distribution of the double-walled microparticles. The study showed that the double-walled nanoparticles exhibited sustained drug release and the PLLA layer acted as a rate control barrier.
Article
Chemistry, Multidisciplinary
Yihua Pei, Jianping Wang, Nisar Ul Khaliq, Fanfei Meng, Kaoutar A. Oucherif, Jie Xue, Sarena D. Horava, Amy L. Cox, Coralie A. Richard, Monica R. Swinney, Kinam Park, Yoon Yeo
Summary: Poly(lactide-co-glycolide) (PLGA) polymers are commonly used for drug delivery due to their biodegradability and biocompatibility. This study focused on achieving sustained drug release from PLGA microparticles (MPs) for two weeks using meloxicam. By encapsulating meloxicam as a solid and incorporating magnesium hydroxide (Mg(OH)2), the researchers were able to control the drug release kinetics of the MPs. The study demonstrated the feasibility of controlling drug release from PLGA MPs over weeks based on the physical state of the drug and the inclusion of Mg(OH)2 to neutralize the microenvironmental pH of the MPs.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Engineering, Biomedical
Lucy Geddes, Efrosyni Themistou, James F. Burrows, Fraser J. Buchanan, Louise Carson
Summary: This study aimed to develop an in vitro protocol for assessing the long-term cytotoxicity of bioresorbable polymers. Results showed that PDLLGA samples exhibited increasing cytotoxicity at later degradation stages, while PLLGA samples demonstrated significantly less cytotoxic behavior. Additionally, a new dynamic flow culture methodology was developed and validated to test the cytotoxicity of these degradable materials, along with profiling of inflammatory cytokines released by cells in response to degraded PDLLGA and PLLGA.
ACTA BIOMATERIALIA
(2021)
Article
Biotechnology & Applied Microbiology
Anna Czapka, Christian Grune, Patrick Schaedel, Vivien Bachmann, Karl Scheuer, Michael Dirauf, Christine Weber, Alexios-Leandros Skaltsounis, Klaus D. Jandt, Ulrich S. Schubert, Dagmar Fischer, Oliver Werz
Summary: In this study, we encapsulated 6BIGOE into sustainable solvents-based PLGA nanoparticles, which resulted in efficient drug delivery systems with improved cellular uptake and the ability to mask cytotoxic effects. The anti-inflammatory properties of 6BIGOE were fully retained in these nanoparticles.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yue Zhang, Anthony Henry Harker, C. J. Luo, Maryam Parhizkar, Mohan Edirisinghe
Summary: This study presents a single-step coaxial electrospray technique for co-encapsulation of two drugs treating type 2 diabetes into biodegradable poly (D,L-lactide-co-glicolide) nanoparticles. The formulated nanoparticles exhibit prolonged and regulated drug release profiles, and demonstrate good cytocompatibility. The findings suggest that this hybrid nanoparticle-based drug delivery system is promising for effectively co-encapsulating multiple drugs and achieving controlled release for the treatment of type 2 diabetes.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Polymer Science
Arisa Kongprayoon, Gareth Ross, Nanteetip Limpeanchob, Sararat Mahasaranon, Winita Punyodom, Paul D. Topham, Sukunya Ross
Summary: Bio-derived and biocompatible nanogels based on poly(lactic acid) (PLA) and silk sericin (SS) were synthesized and embedded within nanofibers for potential use in tissue regeneration. Higher crosslink densities resulted in smaller nanogel particles with reduced drug release accumulation.
Article
Polymer Science
Xiaohua Chang, Dengwen Hu, Liangren Chen, Yaping Wang, Yutian Zhu
Summary: Thermoresponsive block copolymer micelles have potential in biological applications, with studies showing that changes in hydrophobic/hydrophilic block ratio, micelle concentration and addition of salt can alter the cloud point. Increasing the amount of PLGA hydrophobic block significantly decreases the cloud point, while higher micelle concentration and salt addition also lower the cloud point.
Article
Polymer Science
Jidong Dai, Min Liang, Zhigang Zhang, Katrien Bernaerts, Tianzhu Zhang
Summary: By crosslinking nucleation to prepare crystalline 4arm-PLGA, the degradation rate of PLGA can be effectively controlled, promoting cell growth and potentially having ideal performance in tissue engineering.
Article
Polymer Science
Qingzhen Zhu, Baogang Zhang, Yuandou Wang, Xinghua Liu, Weiwei Li, Feng Su, Suming Li
Summary: PLGA-PEG diblock copolymers with varying compositions were synthesized using ring-opening polymerization, leading to the formation of micelles with different structures. These micelles were used to load valsartan for controlled drug release, with the overall release rate depending on micelle degradation.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2021)
Article
Chemistry, Physical
Bong-Seop Lee
Summary: In a polymer-based drug delivery system, the polymer material entwines the drug and transports it to the desired target. Poly(lactide-co-glycolide) (PLGA) is a widely utilized controlled-release system for drugs with short half-lives, low stability, easy decomposition, and non-toxic side effects. Supercritical fluid (SCF) technology can be employed to prepare or micronize drug-loaded particles without the need for additional purification or cleaning procedures. The liquid-liquid phase transition behavior of PLGA in several supercritical fluids, including dimethyl ether (DME), CO2, chlorodifluoromethane (HCFC-22), and trifluoromethane (HFC-23), has been investigated. The phase behavior of PLGA is primarily controlled by the lactide-to-glycolide ratio in the copolymer backbone.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Multidisciplinary
Lukasz Lamch, Kazimiera A. Wilk, Imre Dekany, Agota Deak, Viktoria Hornok, Laszlo Janovak
Summary: The encapsulation of hydrophilic and amphiphilic drugs in colloidal carrier systems for sustained release is a growing concern. The use of a core-shell approach with nanocarriers can provide a solution for hydrophilic/amphiphilic drugs. Amphiphilic polymers play a key role in stabilizing the system and enhancing the chemical stability and sustained release profiles.
Article
Biotechnology & Applied Microbiology
Tiantang Fan, Jingwen Qin, Xiao Meng, Jiafeng Li, Qing Liu, Guannan Wang
Summary: PLPG membranes with sc-PLA improved the crystallizing behavior of PLLA segments, increased thermal stability and degradation ability, and showed low cytotoxicity.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Yang Zhou, Yuecheng Cui, Li-Qun Wang
Summary: A dual-sensitive hydrogel was developed by introducing a photocrosslinkable group into triblock copolymers, allowing for excellent shear thinning properties and rapid elastic recovery properties. Through a two-step crosslinking strategy, tissue-like constructs with high shape fidelity can be printed using the dual-sensitive inks.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2021)
Article
Pharmacology & Pharmacy
Nguyen Thi Thu Thao, Surha Lee, Gi Ru Shin, Youngji Kang, Sangdun Choi, Moon Suk Kim
Summary: Small intestine submucosa (SIS) was chosen as a drug carrier and electrospun into nanofiber sheets. Poly(epsilon-caprolactone-ran-l-lactide) (PCLA) copolymers were used to improve the electrospinning performance of SIS, resulting in adjustable S/P-NS with different porosities and tensile strengths. The electrospun S/P-NS successfully delivered dexamethasone (Dex) and silver sulfadiazine (AgS) for sustained release over three weeks, suppressing macrophage infiltration.
Article
Biochemistry & Molecular Biology
Gianni Pecorini, Simona Braccini, Gianluca Parrini, Federica Chiellini, Dario Puppi
Summary: Polyhydroxyalkanoates are biopolyesters that can be used as unique scaffolding polymer candidates for tissue engineering due to their biocompatibility, biodegradability, environmental sustainability, processing versatility, and mechanical properties. This study explored the fabrication of tissue engineering scaffolds using a solution-extrusion additive manufacturing technique, called Computer-Aided Wet-Spinning (CAWS), by blending poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and poly(D,L-lactide-co-glycolide) (PLGA). The results showed that the blend composition influenced the morphological, physicochemical, and biological properties of the scaffolds, with increasing PLGA content leading to larger pore size, enhanced wettability, and improved thermal stability. In vitro experiments demonstrated the suitability of the scaffolds for cell colonization and differentiation towards an osteoblastic phenotype, particularly with scaffolds richer in PLGA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)