期刊
IEEE TRANSACTIONS ON MAGNETICS
卷 49, 期 1, 页码 349-352出版社
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TMAG.2012.2223202
关键词
Anticancer; drug release; hollow nanocapsule; magnetic nanoparticles; RF field
资金
- Iwama Fund at UC San Diego
- NSF [DMR-1006081]
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [1006081] Funding Source: National Science Foundation
Hollow-sphere-structured magnetic nanocapsules containing intentionally trapped iron oxide nanoparticles and anticancer drugs have been prepared to provide a powerful magnetic vector under moderate gradient magnetic fields. It is shown that these nanocapsules can penetrate into the interior of tumors and allow a controlled ON-OFF switchable release of the anticancer drug cargo via remote 100 KHz RF field. This smart drug delivery system is nanoscale compact, with the drug molecules and magnetic nanoparticles contained within the hollow capsules having similar to 80 similar to 150 nm diameter. In vitro results using a mouse model indicate that such a nanocapsule-mediated, on-demand drug release is effective in reducing tumor cell growth.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据