Article
Materials Science, Multidisciplinary
Nikola Bosnjak, Max Tepermeister, Meredith N. Silberstein
Summary: Ionic conductive polymers, as a promising class of soft materials, possess the ability to transport charges while maintaining desired mechanical and chemical features. Developing a reliable simulation capability for these polymers is challenging due to their complex electro-chemo-mechanical behavior. This work introduces a multiphysics framework to address this challenge and showcase the utility in simulating ion transport and the operation of soft ionotronic devices.
JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS
(2022)
Article
Computer Science, Information Systems
Taehoon Jung, Jaejoon Lee, Jaewook Lee
Summary: This paper presents the design and fabrication schemes of a magnetic system consisting of segmented permanent magnet (PM) blocks, back-iron and frame structures. Non-intuitive design of segmented PMs and back-iron are obtained using multi-material topology optimization formulation, and a non-magnetic frame structure is designed through a post-processing procedure using the smoothed fields of optimized PM and back-iron densities. Two magnetic systems are successfully designed and fabricated for maximizing the magnetic field inside a rectangular cavity, and maximizing the magnetic force generated with a C-core electromagnet.
Article
Computer Science, Interdisciplinary Applications
Changwoo Lee, Jaewook Lee, In Gwun Jang
Summary: This study presents a shape optimization framework for determining the optimal rotor and stator shapes of switched reluctance motors. By linking electromagnetic field and electric circuit analysis modules, the relationship between optimal shapes and target performance is quantitatively investigated.
STRUCTURAL AND MULTIDISCIPLINARY OPTIMIZATION
(2021)
Article
Computer Science, Interdisciplinary Applications
Sebastian Bachmann, Dieter H. Pahr, Alexander Synek
Summary: The objective of this study was to assess the agreement between hFE-based IBR and mu FE-based IBR in predicting hip joint loading. The results showed that using hFE models significantly reduced the computational time and improved the prediction of joint loading history. The study suggests that cortical and trabecular bone should be modeled separately, and at least density-dependent heterogeneous material properties should be used with hFE models to predict joint loading.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Article
Materials Science, Multidisciplinary
Tyler W. Paplham, David W. Greve, Mohendro K. Ghosh, Lauren Wewer, Paul R. Ohodnicki
Summary: The adoption of electric vehicles has shown a significant upward trend in the last decade. A novel technique called transverse induction annealing has been demonstrated as a pathway to continuous spatial variation in microstructure of bulk crystalline soft magnetic alloys, enabling the optimization of magnetic and mechanical properties. This technique offers potential for improved performance and co-optimization of magnetic laminations with motor designs.
ADVANCED ENGINEERING MATERIALS
(2023)
Article
Engineering, Mechanical
H. S. Tran, C. Bouffioux, O. Dedry, C. Rojas-Ulloa, L. Duchene, A. Mertens, A. M. Habraken
Summary: A new procedure for identifying the mechanical behavior of individual phases within a bi-material is presented. The influence of hard inclusions on the material properties is studied using nano-indentation tests and finite element models, and a representative volume element (RVE) is defined. This method can be used to predict the mechanical properties of macroscopic experiments.
INTERNATIONAL JOURNAL OF MECHANICAL SCIENCES
(2022)
Article
Engineering, Mechanical
Atif Zahid, Faisal Khan, Naseer Ahmad, Irfan Sami, Wasiq Ullah, Nasim Ullah, Noman Ullah, Hend Alkhammash
Summary: This article presents a design of dual mover yokeless multi-tooth permanent magnet flux switching motor for ropeless elevator applications, which has high thrust force and cost-effectiveness. The proposed machine is analyzed and compared for various performance parameters in a Finite Element Analysis package, showing good agreement between analytical prediction and simulation results.
Article
Computer Science, Interdisciplinary Applications
Mads Emil Moller Andersen, Peter Noe Poulsen, John Forbes Olesen, Linh Cao Hoang
Summary: When designing reinforced concrete structures, the cost is an important consideration. A low-cost structure is desirable, but safety is paramount. This paper aims to solve the structural optimization problem by finding the structure with the lowest cost and ensuring its safety. It combines Finite Element Limit Analysis (FELA) with a yield criterion that incorporates material layout variables to create a strength-based structural optimization framework for reinforced concrete structures.
COMPUTERS & STRUCTURES
(2023)
Article
Energy & Fuels
Shaopeng Wang, Youhua Wang, Chengcheng Liu, Gang Lei, Youguang Guo, Jianguo Zhu
Summary: The magnetic core of a conventional tubular flux-switching permanent magnet machine (TFSPMM) is typically made of axially laminated silicon steel sheets. However, this design leads to a significant amount of eddy current loss. The use of soft magnetic composite (SMC) material as the core can reduce eddy current loss, but it has lower permeability and higher hysteresis loss. By combining the advantages of both materials, a hybrid material magnetic core can improve the machine's thrust force and reduce core loss. The performance of TFSPMM with different cores was studied by finite element method (FEM), and experimental verification was conducted using a prototype machine with a hybrid material magnetic core.
IEEE TRANSACTIONS ON ENERGY CONVERSION
(2023)
Article
Engineering, Manufacturing
Mojtaba Mozaffar, Shuheng Liao, Jihoon Jeong, Tianju Xue, Jian Cao
Summary: This paper presents a differentiable simulation method for optimizing the thermal behavior of materials in additive manufacturing processes. By using automatic differentiation to compute gradients, high-dimensional design spaces can be handled. The methodology is validated through experimental testing.
ADDITIVE MANUFACTURING
(2023)
Article
Engineering, Biomedical
X. Gary Tan, YungChia Chen, Thomas J. O'Shaughnessy
Summary: This study developed a new impact experiment method to efficiently determine mechanical properties of soft gels. The integrated approach of experiment and simulation was used to calibrate material behavior parameters, and its effectiveness was verified.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Review
Engineering, Electrical & Electronic
Mehdi Ouili, Rabia Mehasni, Mouloud Feliachi, Mohamed El Hadi Latreche
Summary: In this study, the electrical conductivity of a material was identified by formulating and solving an inverse problem using Particle Swarm Optimization method. A objective function was defined to minimize the difference between the experimentally measured final ejection position and the numerically computed position. The accuracy of the proposed identification approach was verified by the strong correlation between the computed and measured positions of the separated material.
INTERNATIONAL JOURNAL OF APPLIED ELECTROMAGNETICS AND MECHANICS
(2023)
Article
Engineering, Mechanical
Suhib Abu-Qbeitah, Mahmood Jabareen, Konstantin Y. Volokh
Summary: In this study, a finite element formulation is developed to model quasi-static crack propagation in hyperelastic solids using the material-sink approach. Breakage of molecular bonds leads to material separation and appearance of new crack surfaces. The diffusion of bond breakage causes localized material loss. To account for this, mass density is considered as a variable that decreases in the damaged area. Mathematically, mass balance is included as an additional law to regularize the computational model. The developed finite element formulation has displacement and density degrees of freedom and a monolithic approach is applied for stable solution of the nonlinear problem. Numerical examples demonstrate the robustness of the proposed approach for modeling aneurysm material fracture.
INTERNATIONAL JOURNAL OF MECHANICAL SCIENCES
(2023)
Article
Engineering, Multidisciplinary
Johannes Reiner, Thomas Feser, Matthias Waimer, Anoush Poursartip, Heinz Voggenreiter, Reza Vaziri
Summary: This study explores the challenges of finite element simulation of industrial size composite structures under crush loading, investigating the capabilities, limitations, and challenges of physically-based axial crush simulation of composite structures without the use of non-physical parameters for model calibration. It highlights the unsuitability of crack band scaling in CDM-based material models for axial crushing simulations dominated by fragmentation.
COMPOSITES PART B-ENGINEERING
(2021)
Article
Chemistry, Physical
Zhida Zhu, Shuai Sun, Shuai Tang, Sainan Chu, Xu Zhang
Summary: Fe/Se soft magnetic material can be easily obtained by heating equal molar of selenium and iron powders, exhibiting saturation magnetization, residual magnetic field strength, and coercive force in accordance with soft magnetic materials. The material can selectively catalyze phenol oxidation reaction to produce p-benzoquinone, and with its selenium-containing magnetic properties, it may have profound application values in industry.
MOLECULAR CATALYSIS
(2021)
Article
Endocrinology & Metabolism
Louis de Mestier, Thomas Walter, Camille Evrard, Paul de Boissieu, Olivia Hentic, Jerome Cros, David Tougeron, Catherine Lombard-Bohas, Vinciane Rebours, Pascal Hammel, Philippe Ruszniewski
NEUROENDOCRINOLOGY
(2020)
Article
Gastroenterology & Hepatology
Nicolas Pote, Jerome Cros, Samira Laouirem, Jerome Raffenne, Magda Negrao, Miguel Albuquerque, Pierre Bedossa, Miguel Godinho Ferreira, Slimane Ait Si Ali, Rita Fior, Valerie Paradis
LIVER INTERNATIONAL
(2020)
Article
Endocrinology & Metabolism
Louis de Mestier, Anne-Laure Vedie, Matthieu Faron, Jerome Cros, Vinciane Rebours, Olivia Hentic, Christine Do Cao, Pascal Bardet, Philippe Levy, Alain Sauvanet, Philippe Ruszniewski, Pascal Hammel
NEUROENDOCRINOLOGY
(2020)
Article
Endocrinology & Metabolism
Jerome Cros, Nathalie Theou-Anton, Valerie Gounant, Remy Nicolle, Cecile Reyes, Sarah Humez, Segolene Hescot, Vincent Thomas de Montpreville, Serge Guyetant, Jean-Yves Scoazec, Alice Guyard, Louis de Mestier, Solenn Brosseau, Pierre Mordant, Yves Castier, David Gentien, Philippe Ruszniewski, Gerard Zalcman, Anne Couvelard, Aurelie Cazes
NEUROENDOCRINOLOGY
(2020)
Article
Pathology
Jerome Didier, Francisca Joly, Jerome Cros, Nathalie Guedj, Yves Panis, Dominique Cazals-Hatem
ANNALES DE PATHOLOGIE
(2020)
Article
Gastroenterology & Hepatology
David Karsenti, Laurent Palazzo, Bastien Perrot, Jacqueline Zago, Anne-Isabelle Lemaistre, Jerome Cros, Bertrand Napoleon
Article
Endocrinology & Metabolism
Elettra Merola, Wouter Zandee, Louis de Mestier, Heinz Josef Klumpen, Karolina Makulik, Karen Geboes, Marie Louise van Velthuysen, Anne Couvelard, Jerome Cros, Susanne van Eeden, Anne Hoorens, Timothy Stephenson, W. Zajgckil, Wouter de Herder, Alia Munir
NEUROENDOCRINOLOGY
(2020)
Letter
Gastroenterology & Hepatology
Louis de Mestier, Caroline Lacombe, Anne Couvelard, Philippe Ruszniewski, Jerome Cros
Article
Gastroenterology & Hepatology
Remi Samain, Alexia Brunel, Thibault Douche, Marjorie Fanjul, Stephanie Cassant-Sourdy, Julia Rochotte, Jerome Cros, Cindy Neuzillet, Jerome Raffenne, Camille Duluc, Aurelie Perraud, Jeremy Nigri, Veronique Gigoux, Ivan Bieche, Matteo Ponzo, Gilles Carpentier, Ilaria Cascone, Richard Tomasini, Herbert A. Schmid, Muriel Mathonnet, Remy Nicolle, Marie-Pierre Bousquet, Yvan Martineau, Stephane Pyronnet, Christine Jean, Corinne Bousquet
Summary: The study suggests that SOM230 has the potential to be an effective anti-metastatic therapy in PDA by regulating stromal activities, reducing inflammatory responses, and improving the immunosuppressive tumor microenvironment. This pharmacotherapy shows promise in reshaping the tumor environment and enhancing treatment outcomes for pancreatic cancer patients.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Oncology
R. Nicolle, O. Gayet, P. Duconseil, C. Vanbrugghe, J. Roques, M. Bigonnet, Y. Blum, N. Elarouci, L. Armenoult, M. Ayadi, A. de Reynies, F. Puleo, J. Augustin, J. F. Emile, M. Svrcek, T. Arsenijevic, P. Hammel, M. Giovannini, P. Grandval, L. Dahan, V Moutardier, M. Gilabert, J. L. Van Laethem, J. B. Bachet, J. Cros, J. Iovanna, N. J. Dusetti
Summary: The study demonstrates that the RNA-based GemPred stratification can predict the benefit of adjuvant gemcitabine in PDAC patients.
ANNALS OF ONCOLOGY
(2021)
Letter
Gastroenterology & Hepatology
Sebastien Gaujoux, Alina Parvanescu, Grazia Fusco, Agnes Linglart, Alain Sauvanet, Anne Couvelard, Philippe Levy, Vinciane Rebours, Jerome Cros
Article
Oncology
Jerome Raffenne, Fernando A. Martin, Remy Nicolle, Marina Konta, Yuna Blum, Jerome Torrisani, Francesco Puleo, Jean Baptiste Bachet, Magali Svrcek, Armel Bardier-Dupas, Jean Francois Emile, Peter Demetter, Miroslav Radman, Jean Luc Van Laethem, Pascal Hammel, Vinciane Rebours, Valerie Paradis, Anne Couvelard, Jerome Cros
Summary: Pancreatic ductal adenocarcinoma (PDAC) is typically diagnosed in the 7th decade, but around 10% of patients are diagnosed before the age of 55. Molecular features of early-onset tumors (<= 55 y.o.) were found to be similar to late-onset tumors (>= 70 y.o.), indicating that younger patients can serve as a good molecular surrogate model for the general older population with PDAC. The study also highlighted the impact of ageing on DNA methylation and proteome integrity, as well as the association of oxidative stress responses with PDAC.
Article
Oncology
Caroline Lacombe, Ophelie De Rycke, Anne Couvelard, Anthony Turpin, Aurelie Cazes, Olivia Hentic, Valerie Gounant, Gerard Zalcman, Philippe Ruszniewski, Jerome Cros, Louis de Mestier
Summary: Grade 3 neuroendocrine neoplasms (G3 NEN) are a heterogeneous subtype of NEN, including well-differentiated tumors (NET) and poorly differentiated large (LCNEC) or small (SCNEC) cell carcinomas. Response to etoposide-platinum (EP) chemotherapy varies among these subtypes, with Rb < 150 identified as the best predictive biomarker for response to EP treatment.
Review
Biochemistry & Molecular Biology
Leo Mas, Renato M. Lupinacci, Jerome Cros, Jean-Baptiste Bachet, Florence Coulet, Magali Svrcek
Summary: IPMCs are a main precursor lesion of PDAC, with distinct subtypes and specific clinical-pathological features and genomic hallmarks. Intestinal IPMNs and associated colloid carcinomas are linked to less aggressive features.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Charlotte Paoli, Fanny Burel-Vandenbos, Aurore Coulom-l'Hermine, Jerome Cros, Morgane Pondrom, Valerie Kubiniek, Florence Pedeutour, Berengere Dadone-Montaudie
Summary: Most molecular data on PACC come from studies of adult cases, with limited data available on pediatric cases. This study reports the comprehensive analysis of a 6-year-old patient with PACC, revealing an AGAP3::BRAF fusion gene. The presence of a BRAF rearrangement in both adult and pediatric cases suggests a molecular link between them.
GENES CHROMOSOMES & CANCER
(2022)