期刊
YEAR IN DIABETES AND OBESITY
卷 1353, 期 -, 页码 1-20出版社
BLACKWELL SCIENCE PUBL
DOI: 10.1111/nyas.12787
关键词
alcoholic liver disease; insulin resistance; metabolic syndrome; NAFLD/NASH; steatohepatitis
资金
- NIAAA NIH HHS [K08-AA021424, K08 AA021424] Funding Source: Medline
- NIDDK NIH HHS [P30 DK019525, P30-DK-50306, P30 DK050306] Funding Source: Medline
Alcoholic liver disease (ALD) is the number one cause of liver failure worldwide; its management costs billions of healthcare dollars annually. Since the advent of the obesity epidemic, insulin resistance (IR) and diabetes have become common clinical findings in patients with ALD; and the development of IR predicts the progression from simple steatosis to cirrhosis in ALD patients. Both clinical and experimental data implicate the impairment of several mediators of insulin signaling in ALD, and experimental data suggest that insulin-sensitizing therapies improve liver histology. This review explores the contribution of impaired insulin signaling in ALD and summarizes the current understanding of the synergistic relationship between alcohol and nutrient excess in promoting hepatic inflammation and disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据