期刊
MARINE GENOMICS
卷 24, 期 -, 页码 281-283出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.margen.2015.09.010
关键词
Streptomyces pluripotens; Methycillin-resistant Staphylococcus aureus; MRSA; Bacteriocin; Genome
资金
- MOSTI Science Fund Grant [06-02-10-SF0300]
- External Industry Grant (Biotek Abadi) [GBA-808138]
- University of Malaya for High Impact Research Grant (UM-MOHE HIR Nature Microbiome Grant) [H-50001-A000027, A000001-50001]
Isolated from intertidal soil, Streptomyces pluripotens MUSC 135(T) produces a broad-spectrum bacteriocin against the pathogens methicillin-resistant Staphylococcus aureus (MRSA) ATCC BAA-44(T), Salmonella typhi ATCC 19430(T) and Aeromonas hydrophila ATCC 7966(T). Along with antibacterial activity, fermentation studies on strain MUSC 135(T) revealed production of antioxidant(s). The high quality draft genome of MUSC 135(T) comprises 7,480,269 bp with G + C content of 70.00%. Through bioinformatics analysis, 72 gene clusters identified in the genome were associated with the production of secondary metabolites, which may shed light on the identity of these bioactive compounds. (c) 2015 Elsevier B.V. All rights reserved.
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