期刊
MARINE DRUGS
卷 14, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/md14010006
关键词
Meretrix meretrix Linnaeus; polysaccharide; structure; immunological activity
资金
- twelfth five-year National Science and Technology Support Program [2012BAD33B06]
- Public Science and Technology Research Funds Projects of the Ocean [201305007]
- National Natural Science Foundation of China [31300026]
- Ministry of Education of the People's Republic of China [JUSRP51516]
Polysaccharides from marine clams perform various biological activities, whereas information on structure is scarce. Here, a water-soluble polysaccharide MMPX-B2 was isolated from Meretrix meretrix Linnaeus. The proposed structure was deduced through characterization and its immunological activity was investigated. MMPX-B2 consisted of D-glucose and D-galctose residues at a molar ratio of 3.51:1.00. The average molecular weight of MMPX-B2 was 510 kDa. This polysaccharide possessed a main chain of (1 -> 4)-linked-alpha-D-glucopyranosyl residues, partially substituted at the C-6 position by a few terminal beta-D-galactose residues or branched chains consisting of (1 -> 3)-linked beta-D-galactose residues. Preliminary immunological tests in vitro showed that MMPX-B2 could stimulate the murine macrophages to release various cytokines, and the structure-activity relationship was then established. The present study demonstrated the potential immunological activity of MMPX-B2, and provided references for studying the active ingredients in M. meretrix.
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