期刊
MARINE DRUGS
卷 13, 期 6, 页码 3309-3324出版社
MDPI
DOI: 10.3390/md13063309
关键词
lyngbyabellin M; total synthesis; chiral thiazoles; stereoselective anti aldol
资金
- Sao Paulo Research Foundation (FAPESP) [2009/51602-5, 2010/00219-4, 2010/00336-0, 2013/07607-8]
Lyngbyabellin M is a non-ribosomal peptide synthetase/polyketide synthase derived metabolite isolated from the cyanobacterium M. bouillonii displaying thiazole rings and a distinct chlorinated octanoic acid chain. Its absolute configuration was proposed based on the comparison of its spectroscopic data with those of other representatives of this family of marine natural products, as well as degradation and derivatization studies. Here the first total synthesis of (+)-lyngbyabellin M is described based on the coupling of three key intermediates: two chiral thiazole moieties and an anti hydroxycarboxylic acid prepared stereoselectively via a boron enolate mediated aldol reaction directed by Masamune's chiral auxiliary.
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